Value of the Data •This research analyses the effect of gold nanoparticles coupled to infrared laser exposure on a murine melanoma model in order to determine the potential of plasmonic phototherapy as non-invasive alternative treatment to surgery. •In addition, the present article presents complementary information at lower power density (0.2W/cm2) and could be interesting for readers of the Data in Brief journal. A lower power density means less or no side effect on the skin due to the laser. •Such data can be used as a reference series for comparative approaches in plasmonic phototherapy requiring few damages to healthy tissues (no necrosis). This is useful for future studies on melanoma. •Comparison between the reference treatment (anti-PD1 monoclonal antibody) and plasmonic phototherapy.