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Overexpression of GluA1 in central amygdala increases pain. CFA-induced pain responses for thermal pain of hyperalgesia (a) and mechanical pain of allodynia (b) in rats (n = 6 each group) 10 days after bilateral infusion of control vector AAV-GFP or AAV-GluA1 vector into CeA. *p < 0.05. *** p < 0.001 (two-way analysis of variance with Bonferroni post hoc analysis).
CFA: complete Freund’s adjuvant; AAV: adeno-associated virus; GFP: green fluorescent protein.
