Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Mar 12;16:1744806920911543. doi: 10.1177/1744806920911543

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2020

Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

PMC Copyright notice

Figure 4. — Overexpression of GluA1 in central amygdala inhibits morphine withdrawal-induced aversion. (a) Schematic illustration of experimental procedures for induction of CPA by naloxone-precipitated morphine withdrawal. S, saline; M, morphine; N, naloxone; Hab, habituation. (b) CPA behavior in rats with naloxone (nlx)-precipitated morphine (mor) withdrawal after bilateral infusion of saline (n = 6 rats) or AMPA (100 ng each side, n = 8 rats) into CeA. (c, d) CPA behavior in rats with naloxone-precipitated morphine withdrawal (c, n = 9 rats each group) and in rats conditioned with saline (sal) and naloxone (d, n = 6 rats each group) after bilateral infusion of AAV-GFP or AAV-GluA1 into CeA. **p < 0.01, ****p < 0.0001 (two-way analysis of variance).

CPA: conditioned place aversion; AAV: adeno-associated virus; GFP: green fluorescent protein.