Table 1.
Association results of index markers (variant with lowest p-value for each locus) previously reported in relation to AR or other inhalant allergy. Column “Nearest gene” denotes nearest up- and downstream gene (for intergenic variants with two genes listed), or surrounding gene (for intronic variants with one gene listed), with the exception of rs5743618, an exonic missense variant within TLR1. EA/OA=effect allele/other allele. P-value is calculated from the logistic regression model. Het.P=p-value for heterogeneity obtained from Cochrane’s Q test.
| Discovery |
|||||||||
|---|---|---|---|---|---|---|---|---|---|
| Variant | Locus | Nearest genes | EA/OA | EAF | n (studies) | OR | 95% conf.int | P | Het. P |
| Known | |||||||||
| rs34004019 | 6p21.32 | HLA-DQB1;HLA-DQA1 | G/A | 0.27 | 196,951 (11) | 0.89 | 0.87-0.90 | 1.00E-30 | 0.41 |
| rs950881 | 2q12.1 | IL1RL1;IL1RL1 | T/G | 0.15 | 212,120 (18) | 0.88 | 0.87-0.90 | 1.74E-30 | 0.91 |
| rs5743618 | 4p14 | TLR1;TLR10 | A/C | 0.27 | 210,652 (17) | 0.90 | 0.89-0.92 | 4.38E-27 | 0.70 |
| rs1438673 | 5q22.1 | CAMK4;WDR36 | C/T | 0.50 | 212,120 (18) | 1.08 | 1.07-1.10 | 3.15E-26 | 0.26 |
| rs7936323 | 11q13.5 | LRRC32;C11orf30 | A/G | 0.48 | 212,120 (18) | 1.08 | 1.06-1.09 | 6.53E-24 | 0.0001 |
| rs2428494 | 6p21.33 | HLA-B;HLA-C | A/T | 0.42 | 195,753 (12) | 1.08 | 1.06-1.09 | 7.01E-19 | 0.25 |
| rs11644510 | 16p13.13 | RMI2;CLEC16A | T/C | 0.37 | 212,120 (18) | 0.93 | 0.92-0.95 | 1.58E-17 | 0.65 |
| rs12939457 | 17q12 | GSDMB;ZPBP2 | C/T | 0.44 | 212,120 (18) | 0.94 | 0.92-0.95 | 2.35E-17 | 0.02 |
| rs148505069 | 4q27 | IL21;IL2 | G/A | 0.33 | 212,120 (18) | 1.07 | 1.05-1.08 | 2.54E-15 | 0.02 |
| rs13395467 | 2p25.1 | ID2;RNF144A | G/A | 0.28 | 212,120 (18) | 0.94 | 0.92-0.95 | 9.93E-15 | 0.61 |
| rs9775039 | 9p24.1 | IL33;RANBP6 | A/G | 0.16 | 212,120 (18) | 1.08 | 1.06-1.10 | 2.22E-14 | 0.40 |
| rs2164068 | 2q33.1 | PLCL1 | A/T | 0.49 | 212,120 (18) | 0.94 | 0.93-0.96 | 4.21E-14 | 0.82 |
| rs2030519 | 3q28 | TPRG1;LPP | G/A | 0.49 | 212,120 (18) | 1.06 | 1.04-1.07 | 1.83E-13 | 0.12 |
| rs11256017 | 10p14 | CELF2;GATA3 | T/C | 0.18 | 212,120 (18) | 1.07 | 1.05-1.09 | 2.72E-12 | 0.60 |
| rs17294280 | 15q22.33 | AAGAB;SMAD3 | G/A | 0.25 | 212,120 (18) | 1.07 | 1.05-1.09 | 5.97E-12 | 0.07 |
| rs7824993 | 8q21.13 | ZBTB10;TPD52 | A/G | 0.37 | 212,120 (18) | 1.05 | 1.04-1.07 | 1.86E-10 | 0.56 |
| rs9282864 | 16p11.2 | SULT1A1;SULT1A2 | C/A | 0.33 | 208,761 (16) | 0.94 | 0.93-0.96 | 4.69E-10 | 0.03 |
| rs9687749 | 5q31.1 | IL13;RAD50 | T/G | 0.44 | 207,604 (16) | 1.06 | 1.04-1.09 | 1.84E-09 | 0.19 |
| rs61977073 | 14q21.1 | TTC6 | G/A | 0.22 | 212,120 (18) | 1.06 | 1.04-1.08 | 5.78E-09 | 0.05 |
| rs6470578 | 8q24.21 | TMEM75;MYC | T/A | 0.28 | 212,120 (18) | 1.05 | 1.03-1.07 | 4.36E-08 | 0.02 |
| rs3787184 | 20q13.2 | NFATC2;KCNG1 | G/A | 0.19 | 207,604 (16) | 0.94 | 0.93-0.96 | 4.76E-08 | 0.69 |