Table 2.
Association results of index markers (variant with lowest p-value for each locus) not previously associated with AR reaching a Bonferroni-corrected significance threshold of 0.05 in the replication phase. Column “Nearest gene” denotes nearest up- and downstream gene (for intergenic variants with two genes listed), or surrounding gene (for intronic variants with one gene listed), with the exception of rs1504215, an exonic synonymous variant within BACH2. EA/OA=effect allele/other allele. P-value is calculated from the logistic regression model. Het.P=p-value for heterogeneity obtained from Cochrane’s Q test. * Variants also reported associated with a combined asthma/eczema/hay fever phenotype by Ferreira et al.29 (within +/− 1Mb).
| Discovery | Replication | Combined | |||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Variant | Locus | Nearest genes | EA/OA | EAF | n (studies) | OR | 95% conf.int | P | Het. P | n (studies) | OR | 95% conf.int | P | FWER | n (studies) | OR | 95% conf.int | P | Het. P |
| rs7717955* | 5p13.2 | CAPSL; IL7R | T/C | 0.27 | 212,120 (18) | 0.95 | 0.93-0.96 | 1.50E-09 | 0.24 | 679,247 (10) | 0.93 | 0.91-0.94 | 4.09E-25 | 1.06E-23 | 891,367 (28) | 0.94 | 0.93-0.95 | 3.78E-32 | 0.09 |
| rs63406760* | 12q24.31 | CDK2AP1; C12orf65 | G/- | 0.26 | 210,652 (17) | 0.93 | 0.91-0.95 | 5.12E-14 | 0.91 | 675,338 (7) | 0.95 | 0.93-0.96 | 3.27E-12 | 8.51E-11 | 885,990 (24) | 0.94 | 0.93-0.95 | 2.54E-24 | 0.89 |
| rs1504215* | 6q15 | BACH2; GJA10 | A/G | 0.34 | 207,604 (16) | 0.95 | 0.94-0.97 | 1.49E-08 | 0.02 | 679,247 (10) | 0.95 | 0.94-0.97 | 1.99E-11 | 5.17E-10 | 886,851 (26) | 0.95 | 0.94-0.96 | 1.54E-18 | 0.05 |
| rs28361986* | 11q23.3 | CXCR5; DDX6 | A/T | 0.20 | 212,120 (18) | 0.93 | 0.91-0.95 | 1.81E-14 | 0.87 | 675,919 (8) | 0.94 | 0.93-0.96 | 7.92E-11 | 2.06E-09 | 888,039 (26) | 0.94 | 0.92-0.95 | 2.32E-23 | 0.91 |
| rs2070902* | 1q23.3 | AL590714.1; FCER1G | T/C | 0.25 | 212,120 (18) | 1.06 | 1.04-1.08 | 1.03E-10 | 0.18 | 679,247 (10) | 1.05 | 1.03-1.06 | 7.27E-10 | 1.89E-08 | 891,367 (28) | 1.05 | 1.04-1.06 | 6.19E-19 | 0.23 |
| rs111371454* | 15q15.1 | ITPKA; RTF1 | G/A | 0.21 | 212,120 (18) | 1.06 | 1.03-1.08 | 1.65E-07 | 0.17 | 675,338 (7) | 1.04 | 1.03-1.06 | 8.47E-09 | 2.20E-07 | 887,458 (25) | 1.05 | 1.03-1.06 | 1.28E-14 | 0.22 |
| rs12509403* | 4q24 | MANBA; NFKB1 | T/C | 0.32 | 212,120 (18) | 0.95 | 0.94-0.97 | 9.97E-09 | 0.27 | 679,247 (10) | 0.96 | 0.95-0.97 | 1.86E-08 | 4.84E-07 | 891,367 (28) | 0.96 | 0.95-0.97 | 1.17E-15 | 0.39 |
| rs9648346* | 7p15.1 | JAZF1; TAX1BP1 | G/C | 0.22 | 207,604 (16) | 1.05 | 1.03-1.07 | 3.62E-08 | 0.74 | 679,247 (10) | 1.04 | 1.03-1.06 | 1.39E-07 | 3.63E-06 | 886,851 (26) | 1.05 | 1.03-1.06 | 3.30E-14 | 0.48 |
| rs35350651* | 12q24.12 | ATXN2; SH2B3 | C/- | 0.49 | 206,136 (15) | 1.04 | 1.03-1.06 | 6.63E-08 | 0.60 | 672,701 (6) | 1.04 | 1.02-1.05 | 1.41E-07 | 3.66E-06 | 878,837 (21) | 1.04 | 1.03-1.05 | 5.82E-14 | 0.43 |
| rs2519093* | 9q34.2 | ABO; OBP2B | T/C | 0.20 | 212,120 (18) | 1.06 | 1.04-1.09 | 4.96E-11 | 0.38 | 675,919 (8) | 1.04 | 1.03-1.06 | 2.96E-07 | 7.68E-06 | 888,039 (26) | 1.05 | 1.04-1.07 | 2.79E-16 | 0.61 |
| rs62257549 | 3p21.2 | VPRBP | A/G | 0.20 | 212,120 (18) | 0.95 | 0.93-0.97 | 7.13E-08 | 0.45 | 677,615 (9) | 0.96 | 0.94-0.97 | 3.37E-07 | 8.76E-06 | 889,735 (27) | 0.95 | 0.94-0.97 | 1.84E-13 | 0.53 |
| rs11677002 | 2p23.2 | FOSL2; RBKS | C/T | 0.45 | 212,120 (18) | 0.96 | 0.95-0.98 | 3.80E-07 | 0.21 | 679,247 (10) | 0.97 | 0.96-0.98 | 3.54E-07 | 9.20E-06 | 891,367 (28) | 0.97 | 0.96-0.97 | 7.08E-13 | 0.36 |
| rs35597970* | 10q24.32 | ACTR1A; TMEM180 | -/A | 0.45 | 210,652 (17) | 1.06 | 1.04-1.07 | 1.34E-13 | 0.96 | 676,970 (8) | 1.03 | 1.02-1.05 | 4.37E-07 | 1.14E-05 | 887,622 (25) | 1.04 | 1.03-1.05 | 5.42E-18 | 0.53 |
| rs2815765 | 1p31.1 | LRRIQ3; NEGR1 | T/C | 0.37 | 212,120 (18) | 0.95 | 0.94-0.97 | 1.18E-09 | 0.59 | 679,247 (10) | 0.97 | 0.95-0.98 | 6.16E-07 | 1.60E-05 | 891,367 (28) | 0.96 | 0.95-0.97 | 9.45E-15 | 0.52 |
| rs11671925* | 19q13.11 | CEBPA; SLC7A10 | A/G | 0.17 | 206,136 (15) | 0.94 | 0.92-0.96 | 1.80E-08 | 0.97 | 677,551 (9) | 0.96 | 0.94-0.98 | 2.80E-06 | 7.29E-05 | 883,687 (24) | 0.95 | 0.94-0.96 | 5.91E-13 | 0.60 |
| rs2461475* | 12q24.31 | SPPL3; ACADS | C/T | 0.47 | 212,120 (18) | 1.04 | 1.02-1.05 | 9.19E-07 | 0.97 | 677,551 (9) | 1.03 | 1.02-1.04 | 6.52E-06 | 0.0002 | 889,671 (27) | 1.03 | 1.02-1.04 | 3.81E-11 | 0.83 |
| rs6738964* | 2q36.3 | SPHKAP; DAW1 | G/T | 0.24 | 212,120 (18) | 0.96 | 0.94-0.97 | 4.51E-07 | 0.72 | 679,247 (10) | 0.97 | 0.96-0.98 | 4.96E-05 | 0.0013 | 891,367 (28) | 0.96 | 0.95-0.97 | 1.86E-10 | 0.87 |
| rs10519067* | 15q22.2 | RORA | A/- | 0.13 | 212,120 (18) | 0.93 | 0.91-0.96 | 1.78E-09 | 0.37 | 442,354 (7) | 0.93 | 0.90-0.96 | 7.53E-05 | 0.0020 | 654,474 (25) | 0.93 | 0.92-0.95 | 5.53E-13 | 0.36 |
| rs138050288* | 1p36.23 | RERE; SLC45A1 | -/CA | 0.29 | 210,652 (17) | 1.05 | 1.04-1.07 | 5.96E-10 | 0.71 | 675,338 (7) | 1.03 | 1.01-1.04 | 0.0002 | 0.0046 | 885,990 (24) | 1.04 | 1.03-1.05 | 6.62E-12 | 0.63 |
| rs7328203 | 13q14.11 | TNFSF11; AKAP11 | G/T | 0.46 | 212,120 (18) | 1.05 | 1.03-1.06 | 5.94E-09 | 0.90 | 677,551 (9) | 1.02 | 1.01-1.04 | 0.0005 | 0.0134 | 889,671 (27) | 1.03 | 1.02-1.04 | 1.28E-10 | 0.78 |