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. 2011 Jun 9;82(3):273–287. doi: 10.1159/000327719

Fig. 3.

Fig. 3

Effects of imatinib and nilotinib treatments on inflammatory cytokines. The levels of IL-6 (a), IL-1β (b) and TNF-α (c) were measured in BAL fluid. Intratracheal administration of bleomycin induced increased levels of IL-6, IL-1β and TNF-α. Compared with the bleomycin treatment group, the level of IL-6 was significantly lower in the imatinib treatment group on days 3 and 7 and in the nilotinib treatment group on days 7, 14 and 21. The level of IL-1β was significantly lower in the imatinib treatment group on days 3 and 7 and in the nilotinib treatment group on day 7. The level of TNF-α was significantly lower in the nilotinib treatment group on day 7. The numbers of mice analyzed in each group ranged from 3 to 5. Abbreviations are as in figure 1. * p < 0.05 for BLM vs. BLM + I or for BLM vs. BLM + N; ** p < 0.01 for BLM vs. BLM + I or for BLM vs. BLM + N.