Table 1.
Day 3 |
Day 7 |
|||||||
---|---|---|---|---|---|---|---|---|
Control | BLM | BLM + I | BLM + N | Control | BLM | BLM + I | BLM + N | |
Total cells | 11.20 ± 1.31 | 78.00 ± 14.01 | 49.80 ± 6.94 | 16.00 ± 2.94** | 18.40 ± 0.81 | 307.60 ± 45.10 | 114.60 ± 11.39** | 65.20 ± 7.02** |
Macrophages | 11.08 ± 1.30 | 46.16 ± 5.85 | 35.24 ± 4.97 | 12.72 ± 2.42** | 18.18 ± 0.77 | 138.30 ± 19.06 | 85.12 ± 17.26 | 53.70 ± 5.66** |
Lymphocytes | 0.06 ± 0.02 | 9.56 ± 1.27 | 4.62 ± 0.48** | 1.27 ± 0.26** | 0.16 ± 0.04 | 51.088 ±.23 | 9.22 ± 1.88** | 3.80 ± 0.74** |
Neutrophils | 0.00 ± 0.00 | 21.88 ± 12.31 | 9.84 ± 2.99 | 1.90 ± 0.50 | 0.06 ± 0.04 | 115.70 ± 45.72 | 20.18 ± 8.50* | 7.42 ± 1.41* |
Eosinophils | 0.00 ± 0.00 | 0.42 ± 0.10 | 0.12 ± 0.07** | 0.07 ± 0.02** | 0.00 ± 0.00 | 2.52 ± 0.66 | 0.08 ± 0.08** | 0.26 ± 0.09** |
Day 14 |
Day 21 |
|||||||
---|---|---|---|---|---|---|---|---|
Control | BLM | BLM + I | BLM + N | Control | BLM | BLM + I | BLM + N | |
Total cells | 21.60 ± 2.01 | 194.60 ± 17.97 | 147.25 ± 23.38 | 88.80 ± 4.06** | 16.80 ± 0.12 | 187.00 ± 42.29 | 113.66 ± 12.41 | 43.66 ± 6.76* |
Macrophages | 21.32 ± 1.96 | 101.83 ± 13.90 | 122.70 ± 25.21 | 82.18 ± 4.18 | 16.68 ± 3.09 | 128.06 ± 9.21 | 93.06 ± 9.39* | 41.30 ± 5.18** |
Lymphocytes | 0.18 ± 0.04 | 71.30 ± 25.38 | 17.97 ± 8.96** | 2.58 ± 0.30** | 0.08 ± 0.03 | 50.66 ± 31.88 | 14.90 ± 3.21 | 1.76 ± 1.12 |
Neutrophils | 0.12 ± 0.03 | 20.16 ± 6.66 | 6.05 ± 4.28* | 3.96 ± 0.81** | 0.02 ± 0.02 | 6.80 ± 3.05 | 4.43 ± 0.08 | 0.53 ± 0.43* |
Eosinophils | 0.00 ± 0.00 | 1.36 ± 0.48 | 0.47 ± 0.35 | 0.08 ± 0.04** | 0.00 ± 0.00 | 1.43 ± 0.69 | 1.30 ± 0.34 | 0.06 ± 0.06* |
BLM = Bleomycin; BLM+I = bleomycin plus imatinib; BLM+N = bleomycin plus nilotinib.
p < 0.05 for BLM vs. BLM+I or for BLM vs. BLM+N;
p < 0.01 for BLM vs. BLM+I or for BLM vs. BLM+N (n = 3 −5 for each group).