Table 1.
Sample Demographics Bipolar Disorder Family Cohorts
| Relatives |
||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Controls |
Cases |
Total |
MZ Co-twins |
DZ Co-twins |
Offspring |
Siblings |
Parents |
|||||||||||||||||||||
| Sample | n | M/F | Age | Other Diagnoses (Y/N) |
n | M/F | Age | Total N |
n | M/F | Age | Other Diagnoses (Y/N) |
n | M/F | Age | Other Diagnoses (Y/N) |
n | M/F | Age | Other Diagnoses (Y/N) |
n | M/F | Age | Other Diagnoses (Y/N) |
n | M/F | Age | Other Diagnoses (Y/N) |
| BPO_FLB | 7 | 3/4 | 12.9 | 0/7 | 9 | 5/4 | 13.3 | 22 | – | – | 22 | 10/12 | 10.0 | 0/22 | – | – | ||||||||||||
| Cardiff | 79 | 28/51 | 39.8 | 0/79 | 120 | 42/78 | 41.9 | 33 | – | – | – | 33 | 13/20 | 45.9 | 2/31 | – | ||||||||||||
| CliNG-BDa | 19 | 6/13 | 30.9 | 0/19 | – | 19 | – | – | 11 | 4/7 | 23.4 | 0/11 | 8 | 2/6 | 43.8 | 0/8 | – | |||||||||||
| DEU | 29 | 11/18 | 33.1 | 0/29 | 27 | 10/17 | 36.3 | 23 | – | – | 6 | 2/4 | 21.7 | 0/6 | 17 | 9/8 | 34.8 | 0/17 | – | |||||||||
| EGEU | 33 | 13/20 | 33.6 | 0/33 | 27 | 16/11 | 36.7 | 27 | – | – | – | 27 | 10/17 | 34.5 | 0/27 | – | ||||||||||||
| ENBD_UT | 36 | 13/23 | 34.8 | 0/36 | 72 | 23/49 | 36.9 | 52 | – | – | – | 52 | 10/42 | 44.3 | 17/35 | – | ||||||||||||
| HHR | 42 | 17/25 | 21.9 | 0/42 | 8 | 2/6 | 23.3 | 52 | – | – | 52 | 18/34 | 19.5 | 14/38 | – | – | ||||||||||||
| IDIBAPSa | 53 | 21/32 | 12.3 | 12/41 | – | 61 | – | – | 61 | 31/30 | 12.3 | 27/34 | – | – | ||||||||||||||
| IoP-BD | 39 | 9/30 | 35.4 | 9/30 | 34 | 15/19 | 40.6 | 17 | 11 | 2/9 | 43.5 | 6/5 | 6 | 2/4 | 42.4 | 0/6 | – | – | – | |||||||||
| MFS-BDa | 54 | 25/29 | 40.2 | 0/54 | 38 | 15/23 | 41.0 | 41 | – | – | – | 23 | 11/12 | 42.9 | 0/23 | 18 | 6/12 | 57.6 | 0/18 | |||||||||
| MooDS-BDa | 63 | 25/38 | 30.3 | 0/63 | – | 63 | – | – | 53 | 18/35 | 29.2 | 0/53 | 10 | 7/3 | 36.6 | 0/10 | – | |||||||||||
| MSSM | 52 | 25/27 | 35.2 | 0/52 | 41 | 21/20 | 44.3 | 50 | – | – | 27 | 14/13 | 24.9 | 15/12 | 23 | 12/11 | 44.2 | 8/15 | – | |||||||||
| Olin | 68 | 25/43 | 32.2 | 7/61 | 108 | 34/74 | 34.5 | 78 | – | – | – | 78 | 30/48 | 32.0 | 21/57 | – | ||||||||||||
| PHHR | 18 | 7/11 | 23.0 | 0/18 | 8 | 3/5 | 24.0 | 26 | – | – | 26 | 10/16 | 19.9 | 6/20 | – | – | ||||||||||||
| STAR-BDa | 114 | 55/59 | 48.8 | 42/72 | 53 | 19/34 | 49.2 | 38 | 16 | 6/10 | 49.2 | 3/13 | 22 | 10/12 | 50.8 | 6/16 | – | – | – | |||||||||
| SydneyBipolarGroup | 117 | 54/63 | 22.2 | 30/87 | 59 | 17/42 | 25.1 | 150 | – | – | 119 | 53/66 | 19.2 | 58/61 | 31 | 12/19 | 22.6 | 21/10 | – | |||||||||
| UMCU-BD Twinsa | 129 | 55/74 | 39.2 | 4/125 | 62 | 19/43 | 40.3 | 34 | 14 | 4/10 | 38.2 | 6/8 | 20 | 8/12 | 44.3 | 4/16 | – | – | – | |||||||||
| UMCU-DBSOSa | 40 | 21/19 | 12.7 | 7/33 | – | 66 | – | – | 66 | 37/29 | 14.7 | 31/35 | – | – | ||||||||||||||
DZ, dizygotic; F, female; M, male; MZ, monozygotic; N, no; Y, yes.
BPO_FLB, Bipolar Offspring - Fronto-Limbic; Cardiff, Cardiff University; CliNG-BD, Clinical Neuroscience Goettingen- Bipolar Disorder; DEU, Dokuz Eylul University; EGEU, Ege University; ENBD_UT, Endophenotypes of Bipolar Disorder - University of Texas; HHR, Halifax High Risk Study; IDIBAPS, August Pi i Sunyer Biomedical Research Institute; IoP-BD, Institute of Psychiatry - Bipolar Disorder Twin Study; MFS-BD, Maudsley Family Study - Bipolar Disorder; MooDS-BD, Systematic Investigation of the Molecular Causes of Major Mood Disorders and Schizophrenia - Bipolar Disorder; MSSM, Mount Sinai School of Medicine; Olin, Olin Neuropsychiatry Research Center; PHHR, Prague High Risk Study; STAR-BD, Schizophrenia and Bipolar Twin Study in Sweden - Bipolar Disorder; SydneyBipolarGroup, The Sydney Bipolar Kids and Sibs Study; UMCU-BD Twins, University Medical Center Utrecht - Bipolar Disorder Twin Study; UMCU-DBSOS, University Medical Center Utrecht - Dutch Bipolar and Schizophrenia Offspring Study.
Overlapping control subjects with schizophrenia sample from the same site, i.e., with CliNG-SZ (n = 10), IDIBAPS (n = 53), MFS-SZ (n = 54), MooDS-SZ (n = 36), STAR-SZ (n = 100), UMCU-UTWINS (n = 27), UMCU-DBSOS (n = 40).