Figure 4.

Categorical changes from baseline in World Health Organization (WHO) functional class, Borg dyspnea score, and risk stratification criteria. (A) WHO functional class categorical change from baseline by study visit; participants who had a missing assessment at Week 24 and had deteriorated were assigned functional class IV; P value was obtained from Fisher’s exact test. (B) Borg dyspnea score categorical change from baseline by study visit; participants who had a missing assessment at Week 24 and had deteriorated were assigned worst case of 10; P value was obtained from Fisher’s exact test. (C) Risk categorical change from baseline through Week 60. Percentages are calculated based on the number of participants at each visit within each treatment group. Low-risk criteria are defined as WHO functional class I or II, 6-minute-walk distance >440 m, or N-terminal pro–brain natriuretic peptide <300 pg/ml. Low-risk criteria met were only counted for subjects with all three measures. “Improved” indicates any increase in the number of low-risk criteria met; “no change” indicates the same number of low-risk criteria met; and “deteriorated” indicates any decrease in the number of low-risk criteria met. P values were obtained from Fisher’s exact test. PBO = placebo; TRE = oral treprostinil.