Table 1.
Subject Demographics and Disease Characteristics of Patients with Non–Cystic Fibrosis Bronchiectasis and Healthy Individuals Included in the Study
| BLESS |
UNC |
|||
|---|---|---|---|---|
| Bronchiectasis | Healthy | Bronchiectasis | Healthy | |
| Demographics | ||||
| n | 99 | 20 | 15 | 15 |
| Age, yr, mean (±SD) | 62 (±10) | 36 (±12) | 66 (±13) | 42 (±19) |
| Sex, F, No. (%) | 59 (60) | 12 (60) | 13 (86) | 12 (80) |
| Lung function measurements | ||||
| FEV1, L, mean (±SD) | 1.8 (±0.7) | 3.5 (±0.8) | 1.7 (±0.7) | 3.7 (±0.8) |
| FEV1,% predicted, mean (±SD) | 66 (±18) | 98 (±13) | 69 (±21) | 100 (±9) |
| Sputum microbiology, No. (%) | ||||
| Normal flora (no pathogens) | 53 (45) | 20 (100) | 8 (53) | NA |
| P. aeruginosa | 41 (35) | 0 | 3 (20) | NA |
| H. influenzae | 23 (20) | 0 | 1 (7) | NA |
| S. maltophilia | 3 (2.6) | 0 | 0 (0) | NA |
| Others | 5 (4.3) | 0 | 3 (20) | NA |
| Mucus parameters, median (interquartile range) | ||||
| Solids, % | 2.7 (2.0) | NA | 2.6 (3.3) | 1.0 (0.6) |
| Total mucins, μg/ml | 4,594 (3,139) | NA | 3,951 (2,770) | 1,820 (1,954) |
| Total DNA, μg/ml | 279 (482) | NA | 213 (619) | 9.2 (20.1) |
| Osmotic pressure, Pa | 439 (362) | NA | 420 (537) | 145 (72) |
| Complex viscosity, Pa ⋅ s | 0.2 (0.3) | NA | 0.2 (0.2) | 0.1 (0.1) |
Definition of abbreviations: BLESS = Bronchiectasis and Low-Dose Erythromycin Study; H. influenzae = Haemophilus influenzae; NA = not applicable; P. aeruginosa = Pseudomonas aeruginosa; S. maltophilia = Stenotrophomonas maltophilia; UNC = University of North Carolina at Chapel Hill.