Remission Analysis 2 : Odds Ratios, Risk Ratios and Risk Difference for All Treatment Comparisons‐Random Effects Model
Treatment	Reference	OR (95% CrI)	RR (95% CrI)	RD % (95% Crl)
TNF	comp	2.11 (1.29,3.54)	1.96 (1.27,3.04)	0.07 (0.02,0.14)
non‐TNF		4.59 (2.08,10.27)	3.66 (1.93,6.36)	0.19 (0.07,0.36)
MTXTNF		4.09 (2.91,5.93)	3.36 (2.54,4.50)	0.17 (0.11,0.23)
MTXnon‐TNF		4.71 (3.02,7.60)	3.73 (2.62,5.32)	0.19 (0.12,0.28)
MTXTOFA		8.15 (1.66,49.85)	5.40 (1.58,11.79)	0.31 (0.04,0.71)
non‐TNF	TNF	2.17 (0.94,4.93)	1.87 (0.95,3.38)	0.12 (‐0.01,0.28)
MTXTNF		1.93 (1.22,3.09)	1.71 (1.17,2.56)	0.10 (0.03,0.16)
MTXnon‐TNF		2.23 (1.20,4.17)	1.90 (1.16,3.17)	0.12 (0.03,0.23)
MTXTOFA		3.85 (0.72,25.04)	2.74 (0.76,6.70)	0.24 (‐0.04,0.65)
MTXTNF	non‐TNF	0.89 (0.40,2.05)	0.92 (0.53,1.78)	‐0.02 (‐0.20,0.11)
MTXnon‐TNF		1.02 (0.48,2.23)	1.02 (0.61,1.88)	0.00 (‐0.16,0.13)
MTXTOFA		1.78 (0.30,12.74)	1.47 (0.39,4.02)	0.12 (‐0.21,0.55)
MTXnon‐TNF	MTXTNF	1.15 (0.69,1.93)	1.11 (0.75,1.62)	0.03 (‐0.07,0.13)
MTXTOFA		1.99 (0.39,12.55)	1.61 (0.46,3.60)	0.14 (‐0.14,0.56)
MTXTOFA	MTXnon‐TNF	1.73 (0.33,11.10)	1.45 (0.41,3.34)	0.12 (‐0.17,0.53)
Random‐Effect Model	Residual Deviance	64.66 vs 63 data points
	Deviance Information Criteria	409.045
Fixed‐Effect Model	Residual Deviance	134.2 vs 63 data points
	Deviance Information Criteria	459.699
Note:
Total Patients	12668
Total Studies	29
2‐arm	24
3‐arm	5