Remission Analysis 4 : Odds Ratios, Risk Ratios and Risk Difference for All Treatment Comparisons‐Random Effects Model
Treatment	Reference	OR (95% CrI)	RR (95% CrI)	RD % (95% Crl)
SD	PL	1.90 (1.18,3.15)	1.78 (1.16,2.73)	0.06 (0.01,0.12)
HD		4.14 (2.25,7.68)	3.34 (2.05,5.22)	0.18 (0.08,0.30)
LD		2.79 (1.02,7.63)	2.45 (1.02,5.15)	0.11 (0.00,0.30)
MTXSD		4.15 (3.10,5.68)	3.35 (2.64,4.31)	0.18 (0.13,0.23)
MTXHD		5.82 (3.57,9.92)	4.27 (2.96,6.14)	0.25 (0.15,0.36)
MTXLD		2.26 (1.30,3.95)	2.07 (1.27,3.26)	0.08 (0.02,0.16)
HD	SD	2.17 (1.12,4.19)	1.87 (1.10,3.12)	0.12 (0.02,0.24)
LD		1.46 (0.52,4.11)	1.38 (0.56,3.02)	0.05 (‐0.07,0.24)
MTXSD		2.17 (1.38,3.45)	1.88 (1.29,2.81)	0.12 (0.05,0.18)
MTXHD		3.06 (1.65,5.82)	2.39 (1.47,3.95)	0.19 (0.08,0.30)
MTXLD		1.19 (0.60,2.30)	1.16 (0.65,2.02)	0.02 (‐0.06,0.11)
LD	HD	0.67 (0.22,2.10)	0.73 (0.28,1.72)	‐0.07 (‐0.23,0.14)
MTXSD		1.00 (0.54,1.85)	1.00 (0.65,1.63)	0.00 (‐0.13,0.10)
MTXHD		1.41 (0.78,2.62)	1.27 (0.84,2.03)	0.07 (‐0.05,0.19)
MTXLD		0.55 (0.25,1.20)	0.62 (0.33,1.16)	‐0.10 (‐0.23,0.03)
MTXSD	LD	1.49 (0.56,4.06)	1.36 (0.67,3.27)	0.07 (‐0.12,0.18)
MTXHD		2.09 (0.71,6.32)	1.74 (0.79,4.39)	0.13 (‐0.07,0.29)
MTXLD		0.81 (0.28,2.33)	0.84 (0.38,2.09)	‐0.03 (‐0.22,0.10)
MTXHD	MTXSD	1.40 (0.86,2.35)	1.27 (0.89,1.79)	0.07 (‐0.03,0.18)
MTXLD		0.55 (0.31,0.93)	0.62 (0.38,0.95)	‐0.10 (‐0.17,‐0.01)
MTXLD	MTXHD	0.39 (0.19,0.78)	0.48 (0.27,0.83)	‐0.16 (‐0.29,‐0.04)
Random‐Effect Model	Residual Deviance	68.24 vs 68 data points
	Deviance Information Criteria	427.568
Fixed‐Effect Model	Residual Deviance	137.3 vs 68 data points
	Deviance Information Criteria	475.55
Note:
Total Patients	11225
Total Studies	27
2‐arm	16
3‐arm	9
4‐arm	1
5‐arm	1