Radiographic: Mean Difference for All Treatments
Treatment	Reference	MD (95% Crl)
MTX + DMARD	MTX	‐5.72 (‐13.53,2.31)
SD ETN SC		‐4.32 (‐11.12,2.40)
SD INF IV + MTX		‐6.43 (‐13.22,‐0.37)
SD ADA SC + MTX		‐2.60 (‐8.84,3.59)
SD CERTO SC + MTX		‐0.99 (‐7.19,5.21)
SD ABA SC + MTX		‐2.38 (‐11.26,6.33)
SD ETN SC + MTX		‐6.10 (‐12.86,0.67)
LD ADA SC + MTX		‐1.90 (‐8.14,4.30)
LD CERTO SC + MTX		0.14 (‐195.40,196.50)
HD CERTO SC + MTX		‐1.61 (‐7.78,4.60)
HD INF IV + MTX		‐6.75 (‐13.30,‐1.60)
SD ETN SC	MTX + DMARD	1.39 (‐9.06,11.60)
SD INF IV + MTX		‐0.64 (‐5.79,3.47)
SD ADA SC + MTX		3.15 (‐7.06,13.06)
SD CERTO SC + MTX		4.75 (‐5.35,14.56)
SD ABA SC + MTX		3.37 (‐8.61,15.01)
SD ETN SC + MTX		‐0.37 (‐10.79,9.83)
LD ADA SC + MTX		3.86 (‐6.37,13.74)
LD CERTO SC + MTX		5.70 (‐189.80,202.20)
HD CERTO SC + MTX		4.15 (‐5.93,13.98)
HD INF IV + MTX		‐0.99 (‐9.73,5.92)
SD INF IV + MTX	SD ETN SC	‐2.09 (‐11.71,6.86)
SD ADA SC + MTX		1.75 (‐7.44,10.93)
SD CERTO SC + MTX		3.32 (‐5.79,12.55)
SD ABA SC + MTX		1.94 (‐9.10,12.98)
SD ETN SC + MTX		‐1.76 (‐8.05,4.61)
LD ADA SC + MTX		2.42 (‐6.76,11.69)
LD CERTO SC + MTX		4.46 (‐191.10,201.20)
HD CERTO SC + MTX		2.71 (‐6.46,11.95)
HD INF IV + MTX		‐2.44 (‐12.06,5.83)
SD ADA SC + MTX	SD INF IV + MTX	3.82 (‐4.77,13.13)
SD CERTO SC + MTX		5.42 (‐3.08,14.65)
SD ABA SC + MTX		4.02 (‐6.50,15.27)
SD ETN SC + MTX		0.32 (‐8.55,9.91)
LD ADA SC + MTX		4.51 (‐4.05,13.80)
LD CERTO SC + MTX		6.50 (‐189.00,203.10)
HD CERTO SC + MTX		4.80 (‐3.70,14.05)
HD INF IV + MTX		‐0.30 (‐7.03,5.57)
SD CERTO SC + MTX	SD ADA SC + MTX	1.59 (‐7.15,10.45)
SD ABA SC + MTX		0.20 (‐5.96,6.42)
SD ETN SC + MTX		‐3.49 (‐12.60,5.71)
LD ADA SC + MTX		0.69 (‐5.44,6.93)
LD CERTO SC + MTX		2.74 (‐193.00,199.40)
HD CERTO SC + MTX		0.98 (‐7.83,9.81)
HD INF IV + MTX		‐4.11 (‐13.28,3.62)
SD ABA SC + MTX	SD CERTO SC + MTX	‐1.39 (‐12.21,9.28)
SD ETN SC + MTX		‐5.10 (‐14.26,4.11)
LD ADA SC + MTX		‐0.89 (‐9.76,7.88)
LD CERTO SC + MTX		1.14 (‐194.50,197.60)
HD CERTO SC + MTX		‐0.61 (‐6.82,5.60)
HD INF IV + MTX		‐5.70 (‐14.95,1.96)
SD ETN SC + MTX	SD ABA SC + MTX	‐3.69 (‐14.76,7.32)
LD ADA SC + MTX		0.50 (‐8.19,9.33)
LD CERTO SC + MTX		2.40 (‐193.40,199.20)
HD CERTO SC + MTX		0.78 (‐9.91,11.55)
HD INF IV + MTX		‐4.29 (‐15.50,5.40)
LD ADA SC + MTX	SD ETN SC + MTX	4.19 (‐4.98,13.39)
LD CERTO SC + MTX		6.34 (‐189.20,202.80)
HD CERTO SC + MTX		4.49 (‐4.69,13.62)
HD INF IV + MTX		‐0.66 (‐10.28,7.52)
LD CERTO SC + MTX	LD ADA SC + MTX	2.08 (‐193.40,198.80)
HD CERTO SC + MTX		0.28 (‐8.50,9.11)
HD INF IV + MTX		‐4.81 (‐14.08,2.90)
HD CERTO SC + MTX	LD CERTO SC + MTX	‐1.79 (‐198.40,193.90)
HD INF IV + MTX		‐6.93 (‐203.50,188.50)
HD INF IV + MTX	HD CERTO SC + MTX	‐5.07 (‐14.33,2.54)
Random‐Effect Model	Total Residual Deviance	20.57 vs 20 data points
	Deviance Information Criteria	52.379
Fixed‐Effect Model	Total Residual Deviance	23.04 vs 20 data points
	Deviance Information Criteria	53.62
Note:
Total Patients	3267
Total Studies	8
2‐arm	4
3‐arm	4