Withdrawals (Analysis‐4): Odds Ratios, Risk Ratios and Risk Difference for All Treatment Comparisons‐Random Effects Model
Treatment	Reference	OR (95% CrI)	RR (95% CrI)	RD % (95% Crl)
SD	PL	1.32 (1.00,1.80)	1.31 (1.00,1.76)	0.01 (0.00,0.02)
HD		1.23 (0.83,1.84)	1.22 (0.84,1.80)	0.01 (0.00,0.02)
LD		0.94 (0.61,1.44)	0.94 (0.62,1.43)	0.00 (‐0.01,0.01)
MTXSD		1.19 (0.98,1.47)	1.19 (0.98,1.45)	0.00 (0.00,0.01)
MTXHD		1.48 (1.08,2.04)	1.47 (1.08,1.99)	0.01 (0.00,0.03)
MTXLD		1.13 (0.69,1.87)	1.13 (0.70,1.83)	0.00 (‐0.01,0.02)
HD	SD	0.93 (0.59,1.43)	0.94 (0.60,1.41)	0.00 (‐0.02,0.01)
LD		0.71 (0.46,1.07)	0.71 (0.47,1.07)	‐0.01 (‐0.02,0.00)
MTXSD		0.90 (0.66,1.21)	0.90 (0.67,1.20)	0.00 (‐0.01,0.01)
MTXHD		1.13 (0.74,1.65)	1.12 (0.75,1.62)	0.00 (‐0.01,0.02)
MTXLD		0.86 (0.49,1.48)	0.86 (0.50,1.46)	0.00 (‐0.02,0.01)
LD	HD	0.76 (0.45,1.30)	0.76 (0.46,1.29)	‐0.01 (‐0.02,0.01)
MTXSD		0.97 (0.63,1.48)	0.97 (0.64,1.46)	0.00 (‐0.02,0.01)
MTXHD		1.20 (0.75,1.90)	1.20 (0.76,1.86)	0.01 (‐0.01,0.02)
MTXLD		0.92 (0.50,1.70)	0.92 (0.51,1.68)	0.00 (‐0.02,0.02)
MTXSD	LD	1.27 (0.81,1.98)	1.27 (0.82,1.95)	0.01 (‐0.01,0.02)
MTXHD		1.58 (0.96,2.61)	1.56 (0.96,2.54)	0.01 (0.00,0.03)
MTXLD		1.22 (0.65,2.29)	1.21 (0.65,2.24)	0.00 (‐0.01,0.02)
MTXHD	MTXSD	1.25 (0.89,1.72)	1.24 (0.90,1.69)	0.01 (0.00,0.02)
MTXLD		0.95 (0.58,1.56)	0.95 (0.59,1.53)	0.00 (‐0.01,0.02)
MTXLD	MTXHD	0.77 (0.44,1.34)	0.77 (0.45,1.33)	‐0.01 (‐0.03,0.01)
Random‐Effect Model	Residual Deviance	155.8 vs 158 data points
	Deviance Information Criteria	764.003
Fixed‐Effect Model	Residual Deviance	179.6 vs 158 data points
	Deviance Information Criteria	771.113
Note:
Total Patients	24137
Total Studies	62
2‐arm	38
3‐arm	17
4‐arm	6
7‐arm	1