Withdrawals in Established RA: Odds Ratios, Risk Ratios and Risk Difference for All Treatment Comparisons‐Random Effects Model
Treatment	Reference	OR (95% CrI)	RR (95% CrI)	RD % (95% Crl)
MTX	PL	4.16 (1.40,14.34)	3.82 (1.39,11.43)	0.07 (0.01,0.21)
DMARD		1.15 (0.35,3.27)	1.15 (0.35,3.11)	0.00 (‐0.02,0.05)
MTX + DMARD		12.33 (3.59,52.86)	9.51 (3.35,26.49)	0.22 (0.05,0.52)
SD ETN SC		4.38 (1.53,13.94)	4.02 (1.51,11.03)	0.07 (0.01,0.23)
SD ADA SC		1.88 (0.74,4.66)	1.83 (0.74,4.34)	0.02 (‐0.01,0.07)
SD TOCI IV		1.10 (0.28,4.22)	1.09 (0.28,3.94)	0.00 (‐0.02,0.06)
SD CERTO SC		2.79 (0.85,13.90)	2.67 (0.86,11.36)	0.04 (0.00,0.19)
SD TOC SC + PL IV		0.74 (0.16,3.46)	0.74 (0.16,3.29)	‐0.01 (‐0.03,0.05)
SD ANA		1.33 (0.43,5.50)	1.31 (0.44,4.98)	0.01 (‐0.02,0.10)
SD ETN SC + MTX		3.99 (1.26,13.55)	3.71 (1.26,10.84)	0.07 (0.01,0.22)
SD INF IV + MTX		10.77 (3.24,41.96)	8.52 (3.04,23.16)	0.19 (0.05,0.47)
SD ABA IV + MTX		4.10 (1.10,17.02)	3.79 (1.10,12.95)	0.07 (0.00,0.25)
SD CERTO SC + MTX		5.89 (1.67,21.44)	5.22 (1.64,14.98)	0.10 (0.02,0.31)
SD ADA SC + MTX		5.65 (1.51,22.53)	5.05 (1.48,15.90)	0.10 (0.01,0.32)
SD GOLI SC + MTX		6.12 (1.21,34.77)	5.38 (1.20,20.95)	0.11 (0.00,0.42)
SD TOFA PO + MTX		7.66 (2.03,28.75)	6.48 (1.98,18.76)	0.14 (0.02,0.37)
SD ABA SC + MTX		2.35 (0.48,10.73)	2.28 (0.49,8.91)	0.03 (‐0.01,0.18)
SD ETN SC + DMARD		2.14 (0.72,6.14)	2.08 (0.73,5.55)	0.03 (‐0.01,0.11)
SD CERTO SC + DMARD		1.56 (0.44,5.61)	1.54 (0.45,5.07)	0.01 (‐0.02,0.10)
SD ADA SC + DMARD		1.38 (0.24,7.00)	1.37 (0.25,6.12)	0.01 (‐0.02,0.12)
LD ETN SC		4.75 (1.40,18.66)	4.33 (1.38,13.86)	0.08 (0.01,0.29)
LD ADA SC		0.67 (0.18,2.27)	0.67 (0.19,2.20)	‐0.01 (‐0.03,0.03)
LD ANA		1.01 (0.30,3.95)	1.01 (0.30,3.68)	0.00 (‐0.02,0.07)
LD ABA IV + MTX		4.98 (1.18,25.38)	4.52 (1.18,17.01)	0.09 (0.00,0.35)
LD CERTO SC + MTX		4.16 (0.64,22.14)	3.85 (0.65,14.79)	0.07 (‐0.01,0.34)
LD ETN SC + MTX		2.59 (0.50,12.69)	2.50 (0.51,10.09)	0.04 (‐0.01,0.21)
HD TOCI IV		2.73 (0.85,8.26)	2.61 (0.86,7.25)	0.04 (0.00,0.13)
HD ADA SC		0.68 (0.18,2.20)	0.68 (0.19,2.14)	‐0.01 (‐0.03,0.02)
HD ANA		2.47 (0.84,8.49)	2.39 (0.84,7.29)	0.03 (0.00,0.15)
HD TOCI IV + MTX		3.65 (0.83,15.79)	3.42 (0.83,12.09)	0.06 (0.00,0.25)
HD GOLI SC + MTX		8.63 (1.73,51.09)	7.22 (1.69,25.93)	0.15 (0.02,0.50)
HD TOFA PO + MTX		5.91 (1.60,21.68)	5.21 (1.57,15.42)	0.11 (0.01,0.31)
HD CERTO SC + MTX		6.36 (1.50,25.92)	5.57 (1.48,17.21)	0.11 (0.01,0.36)
HD INF IV + MTX		11.49 (2.97,47.79)	9.00 (2.82,24.75)	0.20 (0.04,0.51)
HD TOCI IV + DMARD		2.26 (0.57,8.05)	2.19 (0.58,6.96)	0.03 (‐0.01,0.14)
DMARD	MTX	0.27 (0.10,0.74)	0.30 (0.12,0.75)	‐0.06 (‐0.19,‐0.01)
MTX + DMARD		3.04 (1.41,6.63)	2.48 (1.34,4.54)	0.14 (0.03,0.35)
SD ETN SC		1.06 (0.67,1.79)	1.05 (0.70,1.68)	0.00 (‐0.04,0.06)
SD ADA SC		0.44 (0.14,1.36)	0.47 (0.17,1.33)	‐0.05 (‐0.18,0.02)
SD TOCI IV		0.27 (0.05,1.13)	0.29 (0.06,1.13)	‐0.07 (‐0.20,0.01)
SD CERTO SC		0.69 (0.13,4.72)	0.71 (0.16,4.09)	‐0.03 (‐0.18,0.13)
SD TOC SC + PL IV		0.18 (0.03,0.90)	0.20 (0.04,0.91)	‐0.07 (‐0.21,0.00)
SD ANA		0.32 (0.06,1.80)	0.35 (0.07,1.71)	‐0.06 (‐0.21,0.04)
SD ETN SC + MTX		0.97 (0.59,1.57)	0.97 (0.62,1.50)	0.00 (‐0.05,0.05)
SD INF IV + MTX		2.64 (1.44,4.87)	2.24 (1.37,3.66)	0.12 (0.03,0.29)
SD ABA IV + MTX		0.98 (0.49,1.91)	0.98 (0.51,1.75)	0.00 (‐0.05,0.09)
SD CERTO SC + MTX		1.38 (0.78,2.67)	1.32 (0.80,2.34)	0.03 (‐0.02,0.14)
SD ADA SC + MTX		1.36 (0.65,3.10)	1.31 (0.67,2.57)	0.03 (‐0.04,0.17)
SD GOLI SC + MTX		1.52 (0.39,5.54)	1.43 (0.42,3.94)	0.04 (‐0.07,0.29)
SD TOFA PO + MTX		1.82 (0.96,3.36)	1.67 (0.97,2.74)	0.06 (0.00,0.20)
SD ABA SC + MTX		0.55 (0.19,1.57)	0.58 (0.21,1.47)	‐0.03 (‐0.12,0.05)
SD ETN SC + DMARD		0.52 (0.19,1.31)	0.54 (0.22,1.29)	‐0.04 (‐0.15,0.02)
SD CERTO SC + DMARD		0.37 (0.09,1.52)	0.39 (0.11,1.48)	‐0.05 (‐0.19,0.03)
SD ADA SC + DMARD		0.32 (0.07,1.58)	0.35 (0.08,1.51)	‐0.06 (‐0.19,0.04)
LD ETN SC		1.18 (0.55,2.68)	1.15 (0.58,2.33)	0.01 (‐0.05,0.14)
LD ADA SC		0.16 (0.04,0.70)	0.17 (0.04,0.72)	‐0.08 (‐0.22,‐0.01)
LD ANA		0.24 (0.04,1.36)	0.26 (0.05,1.33)	‐0.07 (‐0.21,0.02)
LD ABA IV + MTX		1.24 (0.45,3.45)	1.20 (0.47,2.83)	0.02 (‐0.06,0.19)
LD CERTO SC + MTX		0.97 (0.21,4.35)	0.97 (0.23,3.42)	0.00 (‐0.11,0.22)
LD ETN SC + MTX		0.61 (0.17,2.10)	0.64 (0.18,1.92)	‐0.03 (‐0.13,0.09)
HD TOCI IV		0.66 (0.29,1.33)	0.68 (0.32,1.30)	‐0.03 (‐0.12,0.02)
HD ADA SC		0.17 (0.03,0.74)	0.18 (0.03,0.75)	‐0.08 (‐0.22,‐0.01)
HD ANA		0.59 (0.11,2.75)	0.62 (0.14,2.51)	‐0.03 (‐0.19,0.09)
HD TOCI IV + MTX		0.87 (0.26,2.62)	0.89 (0.28,2.30)	‐0.01 (‐0.11,0.12)
HD GOLI SC + MTX		2.06 (0.61,7.76)	1.84 (0.63,4.84)	0.08 (‐0.04,0.37)
HD TOFA PO + MTX		1.40 (0.76,2.63)	1.34 (0.77,2.28)	0.03 (‐0.02,0.14)
HD CERTO SC + MTX		1.49 (0.61,3.96)	1.41 (0.64,3.12)	0.04 (‐0.04,0.22)
HD INF IV + MTX		2.84 (1.22,6.43)	2.35 (1.19,4.46)	0.13 (0.01,0.34)
HD TOCI IV + DMARD		0.53 (0.17,1.74)	0.56 (0.20,1.66)	‐0.04 (‐0.15,0.05)
MTX + DMARD	DMARD	11.40 (3.26,38.36)	8.53 (2.95,22.99)	0.21 (0.06,0.50)
SD ETN SC		3.98 (1.50,10.12)	3.64 (1.45,8.55)	0.07 (0.02,0.21)
SD ADA SC		1.66 (0.50,5.14)	1.63 (0.51,4.88)	0.02 (‐0.03,0.06)
SD TOCI IV		0.95 (0.21,3.89)	0.95 (0.22,3.69)	0.00 (‐0.04,0.06)
SD CERTO SC		2.53 (0.46,16.45)	2.41 (0.47,13.75)	0.04 (‐0.03,0.19)
SD TOC SC + PL IV		0.65 (0.12,3.28)	0.65 (0.13,3.12)	‐0.01 (‐0.05,0.04)
SD ANA		1.20 (0.24,7.26)	1.19 (0.25,6.54)	0.00 (‐0.05,0.10)
SD ETN SC + MTX		3.57 (1.22,9.72)	3.31 (1.20,8.18)	0.06 (0.01,0.20)
SD INF IV + MTX		9.77 (3.01,30.69)	7.62 (2.76,20.19)	0.19 (0.05,0.45)
SD ABA IV + MTX		3.60 (1.05,12.86)	3.33 (1.05,10.27)	0.06 (0.00,0.24)
SD CERTO SC + MTX		5.09 (1.64,16.53)	4.53 (1.60,12.70)	0.10 (0.02,0.29)
SD ADA SC + MTX		5.10 (1.47,17.33)	4.53 (1.43,12.98)	0.09 (0.01,0.30)
SD GOLI SC + MTX		5.49 (1.09,29.09)	4.79 (1.09,18.35)	0.10 (0.00,0.42)
SD TOFA PO + MTX		6.59 (1.93,21.27)	5.60 (1.84,15.33)	0.13 (0.03,0.35)
SD ABA SC + MTX		1.98 (0.46,8.73)	1.92 (0.47,7.49)	0.02 (‐0.02,0.17)
SD ETN SC + DMARD		1.88 (0.59,5.45)	1.83 (0.60,5.06)	0.02 (‐0.02,0.09)
SD CERTO SC + DMARD		1.38 (0.47,4.20)	1.36 (0.48,3.94)	0.01 (‐0.03,0.07)
SD ADA SC + DMARD		1.20 (0.35,4.15)	1.19 (0.36,3.76)	0.00 (‐0.03,0.10)
LD ETN SC		4.42 (1.34,14.67)	3.99 (1.33,11.28)	0.08 (0.01,0.26)
LD ADA SC		0.59 (0.11,2.75)	0.60 (0.12,2.68)	‐0.01 (‐0.06,0.02)
LD ANA		0.85 (0.16,5.46)	0.86 (0.17,5.11)	0.00 (‐0.05,0.07)
LD ABA IV + MTX		4.52 (1.07,20.02)	4.06 (1.06,14.38)	0.08 (0.00,0.33)
LD CERTO SC + MTX		3.68 (0.56,19.15)	3.39 (0.57,13.89)	0.06 (‐0.02,0.32)
LD ETN SC + MTX		2.34 (0.46,10.32)	2.25 (0.47,8.67)	0.03 (‐0.02,0.19)
HD TOCI IV		2.36 (0.98,5.77)	2.27 (0.98,5.24)	0.03 (0.00,0.11)
HD ADA SC		0.59 (0.12,2.80)	0.60 (0.12,2.74)	‐0.01 (‐0.05,0.03)
HD ANA		2.16 (0.46,11.61)	2.09 (0.47,9.96)	0.03 (‐0.03,0.15)
HD TOCI IV + MTX		3.16 (0.85,10.58)	2.95 (0.86,8.87)	0.05 (0.00,0.22)
HD GOLI SC + MTX		7.85 (1.73,35.07)	6.42 (1.68,20.82)	0.15 (0.02,0.49)
HD TOFA PO + MTX		5.16 (1.56,15.90)	4.55 (1.52,12.28)	0.10 (0.02,0.29)
HD CERTO SC + MTX		5.60 (1.40,19.90)	4.86 (1.38,14.30)	0.11 (0.01,0.34)
HD INF IV + MTX		10.45 (2.75,36.46)	8.01 (2.55,22.09)	0.20 (0.05,0.49)
HD TOCI IV + DMARD		1.96 (1.04,3.88)	1.90 (1.04,3.58)	0.02 (0.00,0.10)
SD ETN SC	MTX + DMARD	0.35 (0.15,0.82)	0.43 (0.22,0.84)	‐0.14 (‐0.35,‐0.02)
SD ADA SC		0.15 (0.04,0.56)	0.19 (0.07,0.59)	‐0.20 (‐0.48,‐0.04)
SD TOCI IV		0.09 (0.01,0.47)	0.11 (0.02,0.51)	‐0.21 (‐0.51,‐0.05)
SD CERTO SC		0.23 (0.04,1.66)	0.29 (0.07,1.56)	‐0.17 (‐0.47,0.05)
SD TOC SC + PL IV		0.06 (0.01,0.37)	0.08 (0.01,0.41)	‐0.22 (‐0.52,‐0.05)
SD ANA		0.11 (0.02,0.68)	0.14 (0.03,0.71)	‐0.20 (‐0.51,‐0.03)
SD ETN SC + MTX		0.32 (0.15,0.67)	0.39 (0.21,0.71)	‐0.14 (‐0.35,‐0.03)
SD INF IV + MTX		0.86 (0.43,1.81)	0.90 (0.52,1.59)	‐0.02 (‐0.17,0.10)
SD ABA IV + MTX		0.32 (0.12,0.92)	0.40 (0.17,0.93)	‐0.14 (‐0.36,‐0.01)
SD CERTO SC + MTX		0.45 (0.18,1.31)	0.53 (0.25,1.25)	‐0.11 (‐0.31,0.03)
SD ADA SC + MTX		0.45 (0.15,1.34)	0.53 (0.21,1.27)	‐0.11 (‐0.33,0.04)
SD GOLI SC + MTX		0.50 (0.11,2.13)	0.58 (0.15,1.75)	‐0.09 (‐0.34,0.13)
SD TOFA PO + MTX		0.60 (0.21,1.60)	0.67 (0.30,1.46)	‐0.08 (‐0.28,0.07)
SD ABA SC + MTX		0.18 (0.05,0.73)	0.23 (0.07,0.77)	‐0.18 (‐0.43,‐0.03)
SD ETN SC + DMARD		0.17 (0.05,0.54)	0.22 (0.08,0.58)	‐0.19 (‐0.46,‐0.04)
SD CERTO SC + DMARD		0.12 (0.03,0.60)	0.16 (0.05,0.63)	‐0.20 (‐0.49,‐0.03)
SD ADA SC + DMARD		0.10 (0.02,0.65)	0.14 (0.03,0.69)	‐0.20 (‐0.48,‐0.03)
LD ETN SC		0.38 (0.14,1.16)	0.47 (0.19,1.13)	‐0.13 (‐0.34,0.02)
LD ADA SC		0.05 (0.01,0.27)	0.07 (0.02,0.30)	‐0.22 (‐0.52,‐0.06)
LD ANA		0.08 (0.01,0.49)	0.10 (0.02,0.53)	‐0.21 (‐0.52,‐0.04)
LD ABA IV + MTX		0.41 (0.11,1.50)	0.48 (0.15,1.36)	‐0.12 (‐0.35,0.06)
LD CERTO SC + MTX		0.32 (0.06,1.72)	0.39 (0.09,1.52)	‐0.14 (‐0.39,0.09)
LD ETN SC + MTX		0.20 (0.05,0.81)	0.26 (0.07,0.85)	‐0.17 (‐0.43,‐0.02)
HD TOCI IV		0.21 (0.07,0.60)	0.27 (0.11,0.64)	‐0.17 (‐0.44,‐0.03)
HD ADA SC		0.05 (0.01,0.28)	0.07 (0.01,0.31)	‐0.22 (‐0.52,‐0.06)
HD ANA		0.20 (0.03,1.08)	0.25 (0.06,1.07)	‐0.17 (‐0.49,0.01)
HD TOCI IV + MTX		0.28 (0.07,1.02)	0.35 (0.11,1.02)	‐0.15 (‐0.42,0.00)
HD GOLI SC + MTX		0.69 (0.16,3.23)	0.75 (0.22,2.35)	‐0.05 (‐0.29,0.23)
HD TOFA PO + MTX		0.47 (0.17,1.21)	0.55 (0.24,1.17)	‐0.10 (‐0.31,0.03)
HD CERTO SC + MTX		0.49 (0.15,1.77)	0.57 (0.22,1.56)	‐0.10 (‐0.32,0.09)
HD INF IV + MTX		0.92 (0.34,2.53)	0.94 (0.43,2.00)	‐0.01 (‐0.20,0.18)
HD TOCI IV + DMARD		0.17 (0.05,0.69)	0.22 (0.07,0.72)	‐0.18 (‐0.46,‐0.03)
SD ADA SC	SD ETN SC	0.42 (0.14,1.21)	0.45 (0.17,1.19)	‐0.05 (‐0.19,0.01)
SD TOCI IV		0.25 (0.05,0.97)	0.27 (0.06,0.97)	‐0.07 (‐0.22,0.00)
SD CERTO SC		0.64 (0.13,4.25)	0.67 (0.15,3.71)	‐0.03 (‐0.19,0.13)
SD TOC SC + PL IV		0.17 (0.03,0.80)	0.19 (0.04,0.81)	‐0.08 (‐0.23,‐0.01)
SD ANA		0.30 (0.06,1.67)	0.33 (0.07,1.59)	‐0.06 (‐0.22,0.04)
SD ETN SC + MTX		0.91 (0.54,1.45)	0.92 (0.57,1.39)	‐0.01 (‐0.06,0.04)
SD INF IV + MTX		2.48 (1.15,5.38)	2.12 (1.12,3.88)	0.11 (0.01,0.30)
SD ABA IV + MTX		0.92 (0.38,2.10)	0.93 (0.41,1.89)	‐0.01 (‐0.09,0.10)
SD CERTO SC + MTX		1.32 (0.59,2.84)	1.27 (0.62,2.47)	0.03 (‐0.05,0.15)
SD ADA SC + MTX		1.29 (0.52,3.11)	1.25 (0.56,2.61)	0.02 (‐0.06,0.17)
SD GOLI SC + MTX		1.39 (0.33,5.60)	1.33 (0.36,4.02)	0.03 (‐0.08,0.29)
SD TOFA PO + MTX		1.70 (0.76,3.63)	1.58 (0.79,2.93)	0.06 (‐0.03,0.20)
SD ABA SC + MTX		0.52 (0.15,1.66)	0.55 (0.17,1.55)	‐0.04 (‐0.14,0.06)
SD ETN SC + DMARD		0.49 (0.20,1.09)	0.52 (0.23,1.08)	‐0.05 (‐0.16,0.01)
SD CERTO SC + DMARD		0.34 (0.09,1.40)	0.37 (0.11,1.36)	‐0.06 (‐0.20,0.02)
SD ADA SC + DMARD		0.30 (0.07,1.42)	0.32 (0.08,1.38)	‐0.06 (‐0.20,0.03)
LD ETN SC		1.11 (0.54,2.35)	1.10 (0.56,2.08)	0.01 (‐0.06,0.12)
LD ADA SC		0.15 (0.03,0.64)	0.17 (0.04,0.66)	‐0.08 (‐0.23,‐0.02)
LD ANA		0.23 (0.04,1.22)	0.25 (0.05,1.20)	‐0.07 (‐0.23,0.01)
LD ABA IV + MTX		1.17 (0.37,3.52)	1.15 (0.40,2.86)	0.01 (‐0.08,0.19)
LD CERTO SC + MTX		0.92 (0.18,4.15)	0.93 (0.20,3.21)	‐0.01 (‐0.13,0.21)
LD ETN SC + MTX		0.58 (0.15,2.02)	0.61 (0.17,1.83)	‐0.03 (‐0.15,0.08)
HD TOCI IV		0.61 (0.26,1.33)	0.64 (0.30,1.30)	‐0.03 (‐0.14,0.02)
HD ADA SC		0.16 (0.03,0.64)	0.17 (0.03,0.65)	‐0.08 (‐0.23,‐0.01)
HD ANA		0.56 (0.11,2.56)	0.59 (0.13,2.34)	‐0.04 (‐0.20,0.09)
HD TOCI IV + MTX		0.82 (0.23,2.51)	0.84 (0.26,2.20)	‐0.01 (‐0.13,0.12)
HD GOLI SC + MTX		1.94 (0.52,7.83)	1.74 (0.55,4.94)	0.07 (‐0.05,0.37)
HD TOFA PO + MTX		1.33 (0.60,2.88)	1.28 (0.63,2.46)	0.03 (‐0.05,0.15)
HD CERTO SC + MTX		1.42 (0.51,3.99)	1.35 (0.55,3.15)	0.03 (‐0.06,0.22)
HD INF IV + MTX		2.69 (1.00,6.71)	2.23 (1.00,4.53)	0.12 (0.00,0.35)
HD TOCI IV + DMARD		0.49 (0.17,1.59)	0.52 (0.19,1.52)	‐0.04 (‐0.17,0.04)
SD TOCI IV	SD ADA SC	0.59 (0.18,1.65)	0.60 (0.19,1.60)	‐0.02 (‐0.06,0.03)
SD CERTO SC		1.52 (0.35,8.50)	1.49 (0.37,7.21)	0.02 (‐0.05,0.17)
SD TOC SC + PL IV		0.40 (0.11,1.39)	0.41 (0.11,1.37)	‐0.02 (‐0.07,0.02)
SD ANA		0.71 (0.16,4.21)	0.72 (0.18,3.82)	‐0.01 (‐0.07,0.09)
SD ETN SC + MTX		2.20 (0.67,6.68)	2.08 (0.69,5.74)	0.05 (‐0.02,0.18)
SD INF IV + MTX		6.02 (1.69,21.72)	4.84 (1.61,13.66)	0.17 (0.03,0.44)
SD ABA IV + MTX		2.22 (0.60,8.65)	2.09 (0.61,7.04)	0.05 (‐0.02,0.22)
SD CERTO SC + MTX		3.17 (0.87,11.36)	2.86 (0.87,8.58)	0.08 (‐0.01,0.28)
SD ADA SC + MTX		3.09 (0.85,11.78)	2.80 (0.86,8.86)	0.08 (‐0.01,0.29)
SD GOLI SC + MTX		3.34 (0.63,19.92)	3.01 (0.65,12.39)	0.09 (‐0.02,0.40)
SD TOFA PO + MTX		4.10 (1.07,14.42)	3.56 (1.07,10.15)	0.12 (0.00,0.34)
SD ABA SC + MTX		1.25 (0.24,6.01)	1.24 (0.25,5.06)	0.01 (‐0.05,0.16)
SD ETN SC + DMARD		1.16 (0.47,2.78)	1.15 (0.49,2.60)	0.01 (‐0.03,0.07)
SD CERTO SC + DMARD		0.83 (0.22,3.65)	0.83 (0.23,3.37)	‐0.01 (‐0.06,0.08)
SD ADA SC + DMARD		0.72 (0.14,4.11)	0.73 (0.14,3.72)	‐0.01 (‐0.06,0.10)
LD ETN SC		2.67 (0.77,9.32)	2.48 (0.78,7.28)	0.06 (‐0.01,0.25)
LD ADA SC		0.36 (0.11,1.10)	0.37 (0.11,1.09)	‐0.03 (‐0.07,0.00)
LD ANA		0.53 (0.11,2.91)	0.54 (0.12,2.75)	‐0.02 (‐0.08,0.05)
LD ABA IV + MTX		2.76 (0.59,13.23)	2.54 (0.60,9.67)	0.07 (‐0.02,0.32)
LD CERTO SC + MTX		2.21 (0.30,12.79)	2.09 (0.32,8.93)	0.05 (‐0.04,0.31)
LD ETN SC + MTX		1.42 (0.24,6.86)	1.40 (0.25,5.62)	0.02 (‐0.05,0.18)
HD TOCI IV		1.43 (0.49,4.51)	1.40 (0.50,4.08)	0.02 (‐0.03,0.11)
HD ADA SC		0.36 (0.10,1.12)	0.37 (0.11,1.11)	‐0.03 (‐0.07,0.00)
HD ANA		1.32 (0.32,5.93)	1.30 (0.34,5.23)	0.01 (‐0.05,0.13)
HD TOCI IV + MTX		1.91 (0.47,8.16)	1.82 (0.49,6.50)	0.04 (‐0.03,0.21)
HD GOLI SC + MTX		4.72 (0.87,25.90)	3.98 (0.88,14.16)	0.13 (‐0.01,0.48)
HD TOFA PO + MTX		3.18 (0.88,11.05)	2.87 (0.88,8.41)	0.08 (‐0.01,0.27)
HD CERTO SC + MTX		3.37 (0.79,13.32)	3.01 (0.80,9.47)	0.09 (‐0.01,0.33)
HD INF IV + MTX		6.51 (1.52,25.77)	5.11 (1.47,14.75)	0.18 (0.03,0.47)
HD TOCI IV + DMARD		1.20 (0.33,4.67)	1.19 (0.34,4.23)	0.01 (‐0.04,0.11)
SD CERTO SC	SD TOCI IV	2.68 (0.41,19.00)	2.55 (0.43,16.33)	0.04 (‐0.04,0.19)
SD TOC SC + PL IV		0.68 (0.34,1.37)	0.69 (0.35,1.35)	‐0.01 (‐0.03,0.01)
SD ANA		1.23 (0.20,9.09)	1.22 (0.21,8.32)	0.01 (‐0.06,0.10)
SD ETN SC + MTX		3.66 (0.80,19.86)	3.40 (0.81,16.57)	0.06 (‐0.01,0.20)
SD INF IV + MTX		10.03 (1.96,59.04)	7.87 (1.86,38.07)	0.19 (0.04,0.46)
SD ABA IV + MTX		3.73 (0.70,22.24)	3.44 (0.72,17.77)	0.06 (‐0.02,0.24)
SD CERTO SC + MTX		5.29 (0.99,31.10)	4.68 (0.99,23.45)	0.10 (0.00,0.30)
SD ADA SC + MTX		5.06 (1.19,30.49)	4.50 (1.18,22.84)	0.09 (0.01,0.31)
SD GOLI SC + MTX		5.65 (0.91,43.68)	4.95 (0.92,28.00)	0.10 (0.00,0.42)
SD TOFA PO + MTX		6.78 (1.52,38.03)	5.78 (1.46,27.53)	0.13 (0.02,0.36)
SD ABA SC + MTX		2.18 (0.29,14.06)	2.10 (0.31,11.88)	0.03 (‐0.04,0.18)
SD ETN SC + DMARD		1.98 (0.52,8.46)	1.92 (0.54,7.84)	0.02 (‐0.03,0.10)
SD CERTO SC + DMARD		1.47 (0.25,7.41)	1.45 (0.26,6.83)	0.01 (‐0.05,0.09)
SD ADA SC + DMARD		1.23 (0.17,9.90)	1.22 (0.19,8.87)	0.01 (‐0.05,0.11)
LD ETN SC		4.44 (1.09,25.96)	4.03 (1.08,19.92)	0.08 (0.00,0.27)
LD ADA SC		0.61 (0.13,3.05)	0.62 (0.14,2.98)	‐0.01 (‐0.07,0.02)
LD ANA		0.90 (0.16,5.80)	0.91 (0.17,5.45)	0.00 (‐0.07,0.07)
LD ABA IV + MTX		4.67 (0.74,33.52)	4.18 (0.75,24.35)	0.08 (‐0.01,0.34)
LD CERTO SC + MTX		3.87 (0.38,28.37)	3.55 (0.39,20.57)	0.06 (‐0.03,0.33)
LD ETN SC + MTX		2.36 (0.35,17.59)	2.26 (0.36,14.29)	0.03 (‐0.03,0.20)
HD TOCI IV		2.50 (0.63,10.96)	2.39 (0.65,10.03)	0.04 (‐0.02,0.12)
HD ADA SC		0.63 (0.13,2.99)	0.64 (0.14,2.92)	‐0.01 (‐0.07,0.02)
HD ANA		2.28 (0.38,14.45)	2.20 (0.40,12.67)	0.03 (‐0.05,0.15)
HD TOCI IV + MTX		3.28 (0.68,20.69)	3.06 (0.70,17.13)	0.05 (‐0.02,0.23)
HD GOLI SC + MTX		8.12 (1.32,66.92)	6.67 (1.30,36.81)	0.15 (0.01,0.49)
HD TOFA PO + MTX		5.31 (1.17,30.10)	4.69 (1.15,23.16)	0.10 (0.01,0.30)
HD CERTO SC + MTX		5.80 (1.02,35.17)	5.03 (1.02,24.92)	0.11 (0.00,0.35)
HD INF IV + MTX		10.98 (1.76,71.90)	8.40 (1.68,41.28)	0.20 (0.03,0.50)
HD TOCI IV + DMARD		2.09 (0.46,10.33)	2.02 (0.48,9.30)	0.03 (‐0.03,0.13)
SD TOC SC + PL IV	SD CERTO SC	0.25 (0.03,1.97)	0.27 (0.04,1.92)	‐0.05 (‐0.19,0.03)
SD ANA		0.46 (0.07,2.99)	0.48 (0.09,2.79)	‐0.03 (‐0.18,0.07)
SD ETN SC + MTX		1.40 (0.20,7.14)	1.36 (0.23,5.99)	0.02 (‐0.13,0.18)
SD INF IV + MTX		3.85 (0.51,21.76)	3.18 (0.56,13.11)	0.15 (‐0.07,0.43)
SD ABA IV + MTX		1.41 (0.17,8.32)	1.37 (0.20,6.72)	0.02 (‐0.13,0.21)
SD CERTO SC + MTX		2.04 (0.28,11.93)	1.89 (0.32,8.85)	0.06 (‐0.11,0.28)
SD ADA SC + MTX		2.03 (0.26,11.15)	1.88 (0.29,8.30)	0.06 (‐0.11,0.28)
SD GOLI SC + MTX		2.17 (0.23,16.64)	1.98 (0.26,10.56)	0.06 (‐0.11,0.38)
SD TOFA PO + MTX		2.72 (0.34,13.73)	2.42 (0.38,9.93)	0.09 (‐0.10,0.32)
SD ABA SC + MTX		0.79 (0.09,5.50)	0.80 (0.10,4.78)	‐0.01 (‐0.16,0.15)
SD ETN SC + DMARD		0.74 (0.12,3.87)	0.75 (0.14,3.57)	‐0.02 (‐0.17,0.08)
SD CERTO SC + DMARD		0.51 (0.08,3.54)	0.53 (0.09,3.29)	‐0.03 (‐0.17,0.08)
SD ADA SC + DMARD		0.48 (0.04,3.96)	0.50 (0.05,3.58)	‐0.03 (‐0.18,0.09)
LD ETN SC		1.72 (0.23,10.93)	1.63 (0.27,8.27)	0.04 (‐0.13,0.25)
LD ADA SC		0.23 (0.03,1.32)	0.25 (0.04,1.31)	‐0.05 (‐0.19,0.01)
LD ANA		0.35 (0.05,2.17)	0.37 (0.06,2.09)	‐0.04 (‐0.19,0.04)
LD ABA IV + MTX		1.78 (0.21,12.49)	1.68 (0.24,8.89)	0.04 (‐0.13,0.30)
LD CERTO SC + MTX		1.43 (0.14,11.25)	1.39 (0.17,7.97)	0.02 (‐0.14,0.30)
LD ETN SC + MTX		0.91 (0.09,6.45)	0.92 (0.11,5.41)	0.00 (‐0.15,0.17)
HD TOCI IV		0.95 (0.13,4.84)	0.96 (0.16,4.35)	0.00 (‐0.16,0.11)
HD ADA SC		0.24 (0.03,1.25)	0.26 (0.03,1.24)	‐0.05 (‐0.19,0.01)
HD ANA		0.86 (0.13,4.89)	0.87 (0.15,4.35)	‐0.01 (‐0.16,0.12)
HD TOCI IV + MTX		1.24 (0.15,8.44)	1.21 (0.17,6.67)	0.01 (‐0.14,0.21)
HD GOLI SC + MTX		3.00 (0.33,23.62)	2.60 (0.37,13.39)	0.10 (‐0.09,0.46)
HD TOFA PO + MTX		2.12 (0.27,10.88)	1.95 (0.30,8.36)	0.06 (‐0.11,0.26)
HD CERTO SC + MTX		2.14 (0.27,14.72)	1.98 (0.31,10.09)	0.06 (‐0.11,0.33)
HD INF IV + MTX		4.07 (0.51,24.65)	3.31 (0.55,14.20)	0.16 (‐0.07,0.47)
HD TOCI IV + DMARD		0.76 (0.10,4.67)	0.78 (0.11,4.20)	‐0.01 (‐0.16,0.11)
SD ANA	SD TOC SC + PL IV	1.80 (0.27,14.61)	1.77 (0.28,13.22)	0.01 (‐0.05,0.11)
SD ETN SC + MTX		5.49 (1.00,31.67)	5.00 (1.00,26.65)	0.07 (0.00,0.22)
SD INF IV + MTX		14.95 (2.51,95.09)	11.53 (2.31,61.42)	0.20 (0.05,0.47)
SD ABA IV + MTX		5.54 (0.91,35.38)	5.04 (0.92,28.47)	0.07 (0.00,0.25)
SD CERTO SC + MTX		7.83 (1.28,49.12)	6.86 (1.25,37.88)	0.11 (0.01,0.31)
SD ADA SC + MTX		7.49 (1.44,50.57)	6.60 (1.40,37.92)	0.10 (0.01,0.32)
SD GOLI SC + MTX		8.23 (1.19,69.88)	7.17 (1.17,46.33)	0.11 (0.01,0.43)
SD TOFA PO + MTX		9.99 (1.84,62.80)	8.42 (1.75,45.86)	0.14 (0.03,0.37)
SD ABA SC + MTX		3.21 (0.38,22.77)	3.07 (0.40,19.26)	0.04 (‐0.03,0.19)
SD ETN SC + DMARD		2.94 (0.63,14.61)	2.83 (0.64,13.47)	0.03 (‐0.02,0.11)
SD CERTO SC + DMARD		2.17 (0.31,12.32)	2.11 (0.32,11.32)	0.02 (‐0.04,0.10)
SD ADA SC + DMARD		1.82 (0.23,15.61)	1.78 (0.24,13.89)	0.01 (‐0.04,0.12)
LD ETN SC		6.63 (1.32,42.11)	5.95 (1.30,32.66)	0.09 (0.01,0.28)
LD ADA SC		0.90 (0.17,5.28)	0.90 (0.18,5.14)	0.00 (‐0.05,0.03)
LD ANA		1.34 (0.19,9.24)	1.33 (0.20,8.68)	0.01 (‐0.05,0.07)
LD ABA IV + MTX		6.84 (0.99,52.99)	6.10 (0.99,38.94)	0.09 (0.00,0.35)
LD CERTO SC + MTX		5.60 (0.50,46.64)	5.08 (0.52,34.66)	0.07 (‐0.02,0.33)
LD ETN SC + MTX		3.44 (0.46,28.88)	3.27 (0.47,24.09)	0.04 (‐0.02,0.21)
HD TOCI IV		3.67 (0.78,19.07)	3.48 (0.79,17.25)	0.04 (‐0.01,0.13)
HD ADA SC		0.91 (0.16,4.99)	0.91 (0.17,4.81)	0.00 (‐0.06,0.03)
HD ANA		3.37 (0.50,23.43)	3.23 (0.51,20.50)	0.04 (‐0.03,0.16)
HD TOCI IV + MTX		4.87 (0.80,34.83)	4.49 (0.81,27.96)	0.06 (‐0.01,0.24)
HD GOLI SC + MTX		11.77 (1.71,109.60)	9.59 (1.64,62.61)	0.16 (0.02,0.50)
HD TOFA PO + MTX		7.86 (1.40,49.76)	6.88 (1.37,38.21)	0.11 (0.01,0.31)
HD CERTO SC + MTX		8.37 (1.33,55.91)	7.24 (1.30,40.16)	0.12 (0.01,0.36)
HD INF IV + MTX		16.24 (2.30,110.50)	12.33 (2.14,66.29)	0.21 (0.04,0.50)
HD TOCI IV + DMARD		3.05 (0.56,16.80)	2.92 (0.57,15.06)	0.03 (‐0.02,0.14)
SD ETN SC + MTX	SD ANA	2.94 (0.51,16.94)	2.75 (0.54,13.83)	0.05 (‐0.04,0.21)
SD INF IV + MTX		7.78 (1.37,51.01)	6.27 (1.31,30.15)	0.18 (0.02,0.46)
SD ABA IV + MTX		3.03 (0.47,19.87)	2.83 (0.50,15.70)	0.06 (‐0.04,0.25)
SD CERTO SC + MTX		4.42 (0.67,25.87)	3.94 (0.70,19.35)	0.09 (‐0.03,0.31)
SD ADA SC + MTX		4.28 (0.61,25.46)	3.82 (0.63,18.80)	0.09 (‐0.03,0.31)
SD GOLI SC + MTX		4.72 (0.42,39.83)	4.18 (0.45,24.37)	0.10 (‐0.05,0.42)
SD TOFA PO + MTX		5.57 (0.87,33.21)	4.79 (0.88,22.98)	0.12 (‐0.01,0.36)
SD ABA SC + MTX		1.71 (0.23,12.07)	1.67 (0.24,10.10)	0.02 (‐0.07,0.18)
SD ETN SC + DMARD		1.59 (0.26,7.75)	1.55 (0.29,7.09)	0.02 (‐0.08,0.10)
SD CERTO SC + DMARD		1.19 (0.17,7.10)	1.18 (0.18,6.46)	0.01 (‐0.09,0.09)
SD ADA SC + DMARD		1.05 (0.11,7.48)	1.05 (0.12,6.66)	0.00 (‐0.10,0.11)
LD ETN SC		3.64 (0.56,21.91)	3.34 (0.59,16.88)	0.07 (‐0.04,0.28)
LD ADA SC		0.48 (0.08,2.79)	0.49 (0.09,2.72)	‐0.02 (‐0.11,0.03)
LD ANA		0.75 (0.21,2.44)	0.75 (0.22,2.36)	‐0.01 (‐0.07,0.03)
LD ABA IV + MTX		3.63 (0.53,31.01)	3.32 (0.56,21.28)	0.07 (‐0.04,0.34)
LD CERTO SC + MTX		3.10 (0.29,23.29)	2.88 (0.31,16.91)	0.06 (‐0.06,0.32)
LD ETN SC + MTX		1.90 (0.22,14.40)	1.84 (0.23,11.78)	0.03 (‐0.07,0.20)
HD TOCI IV		2.01 (0.35,10.73)	1.94 (0.37,9.47)	0.03 (‐0.07,0.13)
HD ADA SC		0.50 (0.07,2.65)	0.51 (0.07,2.59)	‐0.01 (‐0.11,0.03)
HD ANA		1.80 (0.62,5.47)	1.74 (0.63,5.05)	0.02 (‐0.03,0.10)
HD TOCI IV + MTX		2.65 (0.31,18.29)	2.51 (0.33,14.37)	0.05 (‐0.07,0.24)
HD GOLI SC + MTX		6.47 (0.74,53.84)	5.39 (0.75,30.22)	0.14 (‐0.02,0.50)
HD TOFA PO + MTX		4.32 (0.65,25.79)	3.86 (0.68,19.21)	0.09 (‐0.03,0.30)
HD CERTO SC + MTX		4.72 (0.62,30.94)	4.17 (0.65,21.43)	0.10 (‐0.03,0.36)
HD INF IV + MTX		8.30 (1.37,56.91)	6.57 (1.32,32.12)	0.19 (0.02,0.50)
HD TOCI IV + DMARD		1.62 (0.25,9.74)	1.58 (0.27,8.41)	0.02 (‐0.08,0.13)
SD INF IV + MTX	SD ETN SC + MTX	2.73 (1.34,5.75)	2.30 (1.29,4.24)	0.12 (0.02,0.31)
SD ABA IV + MTX		1.01 (0.43,2.41)	1.01 (0.46,2.15)	0.00 (‐0.07,0.11)
SD CERTO SC + MTX		1.43 (0.68,3.28)	1.37 (0.71,2.82)	0.03 (‐0.04,0.16)
SD ADA SC + MTX		1.43 (0.57,3.65)	1.37 (0.61,3.00)	0.03 (‐0.05,0.18)
SD GOLI SC + MTX		1.55 (0.36,6.33)	1.47 (0.38,4.54)	0.04 (‐0.07,0.30)
SD TOFA PO + MTX		1.89 (0.83,4.04)	1.73 (0.85,3.31)	0.06 (‐0.02,0.21)
SD ABA SC + MTX		0.57 (0.17,1.90)	0.60 (0.19,1.76)	‐0.03 (‐0.13,0.07)
SD ETN SC + DMARD		0.53 (0.20,1.41)	0.56 (0.23,1.37)	‐0.04 (‐0.16,0.02)
SD CERTO SC + DMARD		0.38 (0.10,1.69)	0.41 (0.11,1.62)	‐0.05 (‐0.19,0.04)
SD ADA SC + DMARD		0.33 (0.07,1.71)	0.35 (0.08,1.62)	‐0.05 (‐0.19,0.04)
LD ETN SC		1.22 (0.53,2.87)	1.20 (0.56,2.53)	0.02 (‐0.06,0.14)
LD ADA SC		0.16 (0.04,0.75)	0.18 (0.04,0.76)	‐0.07 (‐0.22,‐0.01)
LD ANA		0.25 (0.04,1.41)	0.27 (0.05,1.38)	‐0.06 (‐0.22,0.02)
LD ABA IV + MTX		1.28 (0.42,4.02)	1.24 (0.44,3.22)	0.02 (‐0.07,0.20)
LD CERTO SC + MTX		1.00 (0.20,4.70)	1.00 (0.22,3.67)	0.00 (‐0.12,0.22)
LD ETN SC + MTX		0.63 (0.18,2.13)	0.66 (0.19,1.93)	‐0.03 (‐0.13,0.09)
HD TOCI IV		0.67 (0.28,1.60)	0.69 (0.31,1.53)	‐0.03 (‐0.13,0.03)
HD ADA SC		0.17 (0.03,0.80)	0.19 (0.03,0.81)	‐0.07 (‐0.22,‐0.01)
HD ANA		0.62 (0.11,2.93)	0.64 (0.14,2.69)	‐0.03 (‐0.19,0.09)
HD TOCI IV + MTX		0.90 (0.25,2.94)	0.91 (0.28,2.56)	‐0.01 (‐0.12,0.13)
HD GOLI SC + MTX		2.12 (0.58,8.85)	1.89 (0.61,5.57)	0.08 (‐0.04,0.38)
HD TOFA PO + MTX		1.47 (0.64,3.21)	1.40 (0.67,2.74)	0.03 (‐0.04,0.15)
HD CERTO SC + MTX		1.54 (0.55,4.66)	1.46 (0.58,3.63)	0.04 (‐0.05,0.23)
HD INF IV + MTX		2.93 (1.15,7.44)	2.43 (1.13,5.14)	0.13 (0.01,0.36)
HD TOCI IV + DMARD		0.54 (0.18,1.92)	0.57 (0.20,1.81)	‐0.04 (‐0.16,0.05)
SD ABA IV + MTX	SD INF IV + MTX	0.37 (0.16,0.85)	0.44 (0.20,0.88)	‐0.12 (‐0.30,‐0.02)
SD CERTO SC + MTX		0.52 (0.23,1.35)	0.59 (0.30,1.28)	‐0.08 (‐0.25,0.04)
SD ADA SC + MTX		0.51 (0.19,1.47)	0.58 (0.25,1.37)	‐0.08 (‐0.28,0.05)
SD GOLI SC + MTX		0.57 (0.13,2.29)	0.64 (0.17,1.87)	‐0.07 (‐0.29,0.15)
SD TOFA PO + MTX		0.68 (0.28,1.61)	0.74 (0.36,1.47)	‐0.05 (‐0.23,0.07)
SD ABA SC + MTX		0.21 (0.07,0.67)	0.26 (0.09,0.72)	‐0.15 (‐0.37,‐0.03)
SD ETN SC + DMARD		0.20 (0.06,0.59)	0.24 (0.09,0.62)	‐0.16 (‐0.41,‐0.03)
SD CERTO SC + DMARD		0.14 (0.03,0.65)	0.18 (0.05,0.68)	‐0.17 (‐0.44,‐0.03)
SD ADA SC + DMARD		0.12 (0.02,0.67)	0.15 (0.03,0.71)	‐0.18 (‐0.43,‐0.03)
LD ETN SC		0.44 (0.17,1.29)	0.51 (0.22,1.24)	‐0.10 (‐0.29,0.03)
LD ADA SC		0.06 (0.01,0.30)	0.08 (0.02,0.32)	‐0.20 (‐0.47,‐0.05)
LD ANA		0.09 (0.01,0.57)	0.12 (0.02,0.60)	‐0.19 (‐0.47,‐0.03)
LD ABA IV + MTX		0.46 (0.14,1.52)	0.53 (0.18,1.39)	‐0.09 (‐0.29,0.07)
LD CERTO SC + MTX		0.36 (0.07,1.88)	0.43 (0.10,1.62)	‐0.11 (‐0.34,0.10)
LD ETN SC + MTX		0.23 (0.06,0.94)	0.29 (0.08,0.95)	‐0.15 (‐0.38,‐0.01)
HD TOCI IV		0.25 (0.09,0.62)	0.30 (0.13,0.66)	‐0.15 (‐0.38,‐0.03)
HD ADA SC		0.06 (0.01,0.30)	0.08 (0.02,0.33)	‐0.20 (‐0.48,‐0.05)
HD ANA		0.23 (0.04,1.16)	0.28 (0.06,1.14)	‐0.15 (‐0.44,0.01)
HD TOCI IV + MTX		0.33 (0.09,1.15)	0.39 (0.12,1.12)	‐0.12 (‐0.35,0.02)
HD GOLI SC + MTX		0.77 (0.19,3.72)	0.82 (0.25,2.53)	‐0.04 (‐0.25,0.26)
HD TOFA PO + MTX		0.53 (0.23,1.24)	0.60 (0.29,1.19)	‐0.08 (‐0.26,0.03)
HD CERTO SC + MTX		0.57 (0.19,1.91)	0.64 (0.24,1.63)	‐0.07 (‐0.28,0.11)
HD INF IV + MTX		1.07 (0.49,2.28)	1.06 (0.56,1.85)	0.01 (‐0.12,0.16)
HD TOCI IV + DMARD		0.20 (0.06,0.79)	0.25 (0.08,0.81)	‐0.16 (‐0.40,‐0.02)
SD CERTO SC + MTX	SD ABA IV + MTX	1.41 (0.56,3.91)	1.35 (0.60,3.37)	0.03 (‐0.07,0.16)
SD ADA SC + MTX		1.38 (0.50,4.02)	1.33 (0.55,3.37)	0.03 (‐0.08,0.18)
SD GOLI SC + MTX		1.53 (0.30,7.38)	1.44 (0.33,5.22)	0.04 (‐0.11,0.30)
SD TOFA PO + MTX		1.83 (0.73,4.69)	1.67 (0.76,3.88)	0.06 (‐0.04,0.22)
SD ABA SC + MTX		0.56 (0.25,1.25)	0.59 (0.27,1.21)	‐0.03 (‐0.13,0.02)
SD ETN SC + DMARD		0.53 (0.14,1.61)	0.56 (0.18,1.56)	‐0.04 (‐0.20,0.02)
SD CERTO SC + DMARD		0.39 (0.08,1.90)	0.42 (0.09,1.82)	‐0.05 (‐0.23,0.04)
SD ADA SC + DMARD		0.33 (0.06,1.92)	0.36 (0.07,1.80)	‐0.05 (‐0.22,0.05)
LD ETN SC		1.19 (0.44,3.64)	1.17 (0.49,3.18)	0.01 (‐0.09,0.15)
LD ADA SC		0.17 (0.03,0.82)	0.18 (0.04,0.83)	‐0.08 (‐0.25,‐0.01)
LD ANA		0.25 (0.04,1.69)	0.27 (0.05,1.64)	‐0.07 (‐0.25,0.03)
LD ABA IV + MTX		1.25 (0.43,3.75)	1.22 (0.46,3.10)	0.02 (‐0.07,0.19)
LD CERTO SC + MTX		0.96 (0.19,5.92)	0.96 (0.21,4.52)	0.00 (‐0.14,0.23)
LD ETN SC + MTX		0.62 (0.15,2.72)	0.64 (0.17,2.44)	‐0.03 (‐0.17,0.10)
HD TOCI IV		0.67 (0.21,1.82)	0.69 (0.25,1.74)	‐0.03 (‐0.17,0.04)
HD ADA SC		0.17 (0.02,0.86)	0.18 (0.03,0.86)	‐0.08 (‐0.26,0.00)
HD ANA		0.62 (0.10,3.49)	0.64 (0.12,3.15)	‐0.03 (‐0.22,0.09)
HD TOCI IV + MTX		0.90 (0.20,3.21)	0.91 (0.23,2.82)	‐0.01 (‐0.15,0.13)
HD GOLI SC + MTX		2.13 (0.48,10.08)	1.89 (0.52,6.28)	0.08 (‐0.07,0.38)
HD TOFA PO + MTX		1.43 (0.57,3.62)	1.37 (0.61,3.11)	0.03 (‐0.06,0.16)
HD CERTO SC + MTX		1.53 (0.50,5.03)	1.45 (0.54,4.12)	0.04 (‐0.07,0.22)
HD INF IV + MTX		2.87 (1.05,8.09)	2.39 (1.04,5.83)	0.13 (0.01,0.35)
HD TOCI IV + DMARD		0.54 (0.14,2.26)	0.57 (0.17,2.12)	‐0.04 (‐0.20,0.06)
SD ADA SC + MTX	SD CERTO SC + MTX	0.98 (0.37,2.66)	0.98 (0.42,2.30)	0.00 (‐0.13,0.14)
SD GOLI SC + MTX		1.07 (0.28,4.14)	1.06 (0.32,3.12)	0.01 (‐0.14,0.24)
SD TOFA PO + MTX		1.30 (0.52,3.03)	1.24 (0.58,2.53)	0.03 (‐0.09,0.16)
SD ABA SC + MTX		0.40 (0.11,1.27)	0.44 (0.13,1.23)	‐0.07 (‐0.22,0.02)
SD ETN SC + DMARD		0.37 (0.11,1.09)	0.41 (0.15,1.08)	‐0.07 (‐0.25,0.01)
SD CERTO SC + DMARD		0.26 (0.06,1.16)	0.30 (0.08,1.15)	‐0.08 (‐0.29,0.01)
SD ADA SC + DMARD		0.23 (0.04,1.19)	0.26 (0.05,1.18)	‐0.09 (‐0.28,0.01)
LD ETN SC		0.85 (0.32,2.34)	0.87 (0.37,2.07)	‐0.02 (‐0.14,0.11)
LD ADA SC		0.11 (0.02,0.54)	0.13 (0.03,0.56)	‐0.11 (‐0.32,‐0.02)
LD ANA		0.17 (0.03,1.09)	0.20 (0.04,1.09)	‐0.10 (‐0.31,0.00)
LD ABA IV + MTX		0.88 (0.26,2.89)	0.90 (0.30,2.46)	‐0.01 (‐0.15,0.16)
LD CERTO SC + MTX		0.72 (0.15,2.75)	0.75 (0.18,2.28)	‐0.03 (‐0.17,0.15)
LD ETN SC + MTX		0.44 (0.11,1.73)	0.48 (0.12,1.61)	‐0.06 (‐0.23,0.06)
HD TOCI IV		0.47 (0.16,1.14)	0.51 (0.20,1.13)	‐0.06 (‐0.23,0.01)
HD ADA SC		0.12 (0.02,0.60)	0.14 (0.03,0.62)	‐0.11 (‐0.32,‐0.02)
HD ANA		0.42 (0.07,2.30)	0.46 (0.10,2.12)	‐0.07 (‐0.29,0.07)
HD TOCI IV + MTX		0.62 (0.16,2.16)	0.66 (0.19,1.94)	‐0.04 (‐0.21,0.09)
HD GOLI SC + MTX		1.47 (0.42,6.21)	1.37 (0.46,4.06)	0.04 (‐0.10,0.33)
HD TOFA PO + MTX		1.01 (0.41,2.38)	1.01 (0.46,2.10)	0.00 (‐0.12,0.11)
HD CERTO SC + MTX		1.09 (0.45,2.50)	1.08 (0.50,2.12)	0.01 (‐0.10,0.15)
HD INF IV + MTX		2.06 (0.68,5.54)	1.77 (0.72,3.94)	0.10 (‐0.05,0.30)
HD TOCI IV + DMARD		0.38 (0.11,1.41)	0.42 (0.13,1.36)	‐0.07 (‐0.26,0.03)
SD GOLI SC + MTX	SD ADA SC + MTX	1.11 (0.21,5.08)	1.09 (0.25,3.71)	0.01 (‐0.17,0.27)
SD TOFA PO + MTX		1.30 (0.61,3.02)	1.24 (0.66,2.57)	0.03 (‐0.07,0.16)
SD ABA SC + MTX		0.40 (0.11,1.44)	0.44 (0.13,1.38)	‐0.06 (‐0.23,0.04)
SD ETN SC + DMARD		0.37 (0.11,1.22)	0.41 (0.14,1.20)	‐0.07 (‐0.27,0.01)
SD CERTO SC + DMARD		0.27 (0.06,1.35)	0.30 (0.08,1.32)	‐0.08 (‐0.29,0.02)
SD ADA SC + DMARD		0.24 (0.04,1.32)	0.27 (0.05,1.29)	‐0.08 (‐0.29,0.02)
LD ETN SC		0.87 (0.30,2.59)	0.89 (0.35,2.27)	‐0.01 (‐0.16,0.12)
LD ADA SC		0.11 (0.02,0.62)	0.13 (0.03,0.64)	‐0.11 (‐0.32,‐0.02)
LD ANA		0.18 (0.03,1.17)	0.20 (0.04,1.16)	‐0.10 (‐0.32,0.01)
LD ABA IV + MTX		0.92 (0.24,2.98)	0.93 (0.28,2.52)	‐0.01 (‐0.17,0.16)
LD CERTO SC + MTX		0.72 (0.13,3.46)	0.75 (0.16,2.86)	‐0.03 (‐0.21,0.18)
LD ETN SC + MTX		0.45 (0.09,1.92)	0.49 (0.12,1.76)	‐0.06 (‐0.24,0.07)
HD TOCI IV		0.48 (0.15,1.33)	0.51 (0.19,1.31)	‐0.06 (‐0.24,0.02)
HD ADA SC		0.12 (0.02,0.67)	0.13 (0.03,0.68)	‐0.11 (‐0.32,‐0.01)
HD ANA		0.44 (0.07,2.46)	0.47 (0.10,2.29)	‐0.06 (‐0.29,0.08)
HD TOCI IV + MTX		0.63 (0.15,2.43)	0.66 (0.18,2.15)	‐0.04 (‐0.22,0.10)
HD GOLI SC + MTX		1.53 (0.34,6.42)	1.41 (0.40,4.41)	0.05 (‐0.13,0.32)
HD TOFA PO + MTX		1.01 (0.46,2.37)	1.01 (0.52,2.12)	0.00 (‐0.11,0.11)
HD CERTO SC + MTX		1.07 (0.34,3.87)	1.06 (0.38,3.09)	0.01 (‐0.14,0.20)
HD INF IV + MTX		2.10 (0.61,6.08)	1.80 (0.67,4.32)	0.10 (‐0.06,0.31)
HD TOCI IV + DMARD		0.39 (0.10,1.58)	0.43 (0.12,1.51)	‐0.07 (‐0.26,0.03)
SD TOFA PO + MTX	SD GOLI SC + MTX	1.18 (0.26,5.22)	1.15 (0.35,4.32)	0.02 (‐0.24,0.19)
SD ABA SC + MTX		0.37 (0.06,2.32)	0.41 (0.08,2.17)	‐0.07 (‐0.35,0.06)
SD ETN SC + DMARD		0.35 (0.06,1.73)	0.39 (0.10,1.68)	‐0.08 (‐0.38,0.03)
SD CERTO SC + DMARD		0.26 (0.04,1.50)	0.29 (0.05,1.46)	‐0.09 (‐0.41,0.02)
SD ADA SC + DMARD		0.23 (0.02,1.66)	0.26 (0.03,1.59)	‐0.09 (‐0.41,0.03)
LD ETN SC		0.80 (0.17,3.36)	0.82 (0.24,3.02)	‐0.02 (‐0.28,0.12)
LD ADA SC		0.10 (0.02,0.69)	0.12 (0.02,0.70)	‐0.12 (‐0.43,‐0.01)
LD ANA		0.16 (0.02,1.65)	0.18 (0.03,1.61)	‐0.11 (‐0.43,0.02)
LD ABA IV + MTX		0.83 (0.15,4.66)	0.85 (0.20,3.97)	‐0.02 (‐0.27,0.18)
LD CERTO SC + MTX		0.64 (0.10,4.03)	0.68 (0.13,3.34)	‐0.04 (‐0.30,0.18)
LD ETN SC + MTX		0.41 (0.07,2.34)	0.45 (0.09,2.16)	‐0.07 (‐0.34,0.07)
HD TOCI IV		0.43 (0.09,1.94)	0.48 (0.13,1.86)	‐0.07 (‐0.37,0.04)
HD ADA SC		0.11 (0.01,0.79)	0.13 (0.02,0.79)	‐0.12 (‐0.43,‐0.01)
HD ANA		0.40 (0.05,3.78)	0.43 (0.07,3.42)	‐0.07 (‐0.39,0.10)
HD TOCI IV + MTX		0.57 (0.10,2.97)	0.61 (0.15,2.64)	‐0.05 (‐0.33,0.11)
HD GOLI SC + MTX		1.40 (0.43,4.95)	1.31 (0.50,3.80)	0.04 (‐0.13,0.25)
HD TOFA PO + MTX		0.93 (0.20,4.03)	0.94 (0.27,3.49)	‐0.01 (‐0.27,0.15)
HD CERTO SC + MTX		1.02 (0.23,4.37)	1.02 (0.29,3.72)	0.00 (‐0.24,0.19)
HD INF IV + MTX		1.87 (0.39,9.22)	1.64 (0.48,6.66)	0.08 (‐0.16,0.33)
HD TOCI IV + DMARD		0.36 (0.06,2.02)	0.40 (0.09,1.92)	‐0.08 (‐0.38,0.04)
SD ABA SC + MTX	SD TOFA PO + MTX	0.31 (0.09,1.05)	0.35 (0.11,1.04)	‐0.10 (‐0.28,0.01)
SD ETN SC + DMARD		0.28 (0.09,0.92)	0.32 (0.12,0.93)	‐0.11 (‐0.31,0.00)
SD CERTO SC + DMARD		0.20 (0.05,1.00)	0.24 (0.07,1.00)	‐0.12 (‐0.34,0.00)
SD ADA SC + DMARD		0.18 (0.03,1.04)	0.21 (0.04,1.04)	‐0.12 (‐0.34,0.00)
LD ETN SC		0.66 (0.24,1.88)	0.70 (0.29,1.72)	‐0.04 (‐0.20,0.08)
LD ADA SC		0.09 (0.02,0.45)	0.10 (0.03,0.47)	‐0.14 (‐0.37,‐0.03)
LD ANA		0.13 (0.02,0.88)	0.16 (0.03,0.89)	‐0.13 (‐0.37,‐0.01)
LD ABA IV + MTX		0.68 (0.21,2.22)	0.73 (0.25,1.91)	‐0.04 (‐0.19,0.13)
LD CERTO SC + MTX		0.54 (0.10,2.69)	0.59 (0.13,2.24)	‐0.06 (‐0.24,0.15)
LD ETN SC + MTX		0.34 (0.08,1.40)	0.39 (0.10,1.34)	‐0.09 (‐0.28,0.04)
HD TOCI IV		0.36 (0.13,0.93)	0.41 (0.17,0.94)	‐0.09 (‐0.28,0.00)
HD ADA SC		0.09 (0.01,0.47)	0.11 (0.02,0.49)	‐0.14 (‐0.37,‐0.03)
HD ANA		0.32 (0.06,1.76)	0.37 (0.08,1.66)	‐0.10 (‐0.34,0.05)
HD TOCI IV + MTX		0.48 (0.12,1.68)	0.53 (0.15,1.56)	‐0.07 (‐0.26,0.06)
HD GOLI SC + MTX		1.17 (0.30,4.64)	1.13 (0.35,3.13)	0.02 (‐0.15,0.28)
HD TOFA PO + MTX		0.78 (0.46,1.36)	0.81 (0.51,1.29)	‐0.03 (‐0.12,0.04)
HD CERTO SC + MTX		0.82 (0.28,2.66)	0.85 (0.34,2.19)	‐0.02 (‐0.18,0.15)
HD INF IV + MTX		1.57 (0.56,4.36)	1.42 (0.62,3.24)	0.06 (‐0.08,0.27)
HD TOCI IV + DMARD		0.30 (0.08,1.17)	0.34 (0.11,1.15)	‐0.10 (‐0.31,0.01)
SD ETN SC + DMARD	SD ABA SC + MTX	0.93 (0.22,3.79)	0.94 (0.25,3.63)	0.00 (‐0.14,0.06)
SD CERTO SC + DMARD		0.69 (0.12,4.29)	0.71 (0.14,4.01)	‐0.01 (‐0.16,0.07)
SD ADA SC + DMARD		0.59 (0.09,4.03)	0.60 (0.10,3.73)	‐0.02 (‐0.16,0.08)
LD ETN SC		2.13 (0.60,8.40)	1.99 (0.64,7.20)	0.05 (‐0.05,0.21)
LD ADA SC		0.30 (0.05,1.87)	0.31 (0.06,1.85)	‐0.04 (‐0.19,0.01)
LD ANA		0.46 (0.05,3.64)	0.47 (0.06,3.46)	‐0.03 (‐0.19,0.05)
LD ABA IV + MTX		2.26 (0.59,8.74)	2.08 (0.62,7.19)	0.05 (‐0.04,0.25)
LD CERTO SC + MTX		1.71 (0.28,12.60)	1.63 (0.30,9.56)	0.03 (‐0.09,0.27)
LD ETN SC + MTX		1.09 (0.22,6.05)	1.08 (0.24,5.23)	0.00 (‐0.12,0.15)
HD TOCI IV		1.20 (0.30,4.59)	1.18 (0.33,4.31)	0.01 (‐0.12,0.08)
HD ADA SC		0.30 (0.04,2.03)	0.31 (0.05,2.00)	‐0.04 (‐0.19,0.02)
HD ANA		1.09 (0.16,8.11)	1.09 (0.18,7.29)	0.00 (‐0.16,0.12)
HD TOCI IV + MTX		1.62 (0.31,7.06)	1.55 (0.34,6.04)	0.02 (‐0.10,0.18)
HD GOLI SC + MTX		3.78 (0.73,21.88)	3.19 (0.76,14.15)	0.11 (‐0.02,0.44)
HD TOFA PO + MTX		2.54 (0.77,8.87)	2.30 (0.80,7.40)	0.07 (‐0.03,0.22)
HD CERTO SC + MTX		2.71 (0.71,11.35)	2.43 (0.74,9.16)	0.07 (‐0.03,0.27)
HD INF IV + MTX		5.13 (1.43,18.96)	4.03 (1.33,13.25)	0.17 (0.03,0.42)
HD TOCI IV + DMARD		0.98 (0.20,4.88)	0.98 (0.23,4.49)	0.00 (‐0.13,0.10)
SD CERTO SC + DMARD	SD ETN SC + DMARD	0.73 (0.19,3.11)	0.74 (0.21,2.90)	‐0.01 (‐0.09,0.07)
SD ADA SC + DMARD		0.63 (0.13,3.47)	0.64 (0.14,3.15)	‐0.02 (‐0.09,0.08)
LD ETN SC		2.32 (0.79,7.27)	2.16 (0.80,5.78)	0.06 (‐0.01,0.23)
LD ADA SC		0.32 (0.07,1.21)	0.33 (0.08,1.20)	‐0.03 (‐0.11,0.01)
LD ANA		0.47 (0.09,2.82)	0.48 (0.10,2.69)	‐0.02 (‐0.11,0.05)
LD ABA IV + MTX		2.43 (0.59,10.18)	2.24 (0.60,7.61)	0.06 (‐0.03,0.29)
LD CERTO SC + MTX		1.95 (0.32,10.32)	1.85 (0.34,7.67)	0.04 (‐0.05,0.29)
LD ETN SC + MTX		1.21 (0.25,5.31)	1.20 (0.26,4.49)	0.01 (‐0.06,0.16)
HD TOCI IV		1.26 (0.47,3.72)	1.24 (0.49,3.40)	0.01 (‐0.05,0.09)
HD ADA SC		0.32 (0.06,1.26)	0.33 (0.07,1.25)	‐0.03 (‐0.11,0.01)
HD ANA		1.15 (0.24,5.74)	1.14 (0.26,5.06)	0.01 (‐0.08,0.13)
HD TOCI IV + MTX		1.70 (0.43,6.49)	1.64 (0.45,5.33)	0.03 (‐0.05,0.19)
HD GOLI SC + MTX		4.11 (0.85,22.42)	3.48 (0.86,12.51)	0.12 (‐0.01,0.46)
HD TOFA PO + MTX		2.75 (0.88,8.37)	2.50 (0.88,6.62)	0.07 (‐0.01,0.25)
HD CERTO SC + MTX		2.90 (0.80,11.04)	2.62 (0.81,8.10)	0.08 (‐0.01,0.31)
HD INF IV + MTX		5.53 (1.54,19.06)	4.37 (1.47,11.80)	0.18 (0.03,0.45)
HD TOCI IV + DMARD		1.06 (0.31,3.76)	1.05 (0.33,3.46)	0.00 (‐0.06,0.09)
SD ADA SC + DMARD	SD CERTO SC + DMARD	0.87 (0.17,4.47)	0.87 (0.18,4.08)	0.00 (‐0.08,0.10)
LD ETN SC		3.26 (0.68,14.59)	2.98 (0.70,11.42)	0.07 (‐0.02,0.26)
LD ADA SC		0.43 (0.06,2.38)	0.44 (0.06,2.34)	‐0.02 (‐0.11,0.02)
LD ANA		0.64 (0.11,4.35)	0.64 (0.12,4.07)	‐0.01 (‐0.10,0.06)
LD ABA IV + MTX		3.24 (0.58,19.34)	2.95 (0.60,13.98)	0.07 (‐0.03,0.33)
LD CERTO SC + MTX		2.61 (0.34,17.40)	2.43 (0.35,12.75)	0.05 (‐0.05,0.32)
LD ETN SC + MTX		1.66 (0.24,9.45)	1.61 (0.25,7.83)	0.02 (‐0.07,0.19)
HD TOCI IV		1.75 (0.47,5.92)	1.70 (0.50,5.38)	0.02 (‐0.05,0.11)
HD ADA SC		0.42 (0.08,2.44)	0.43 (0.08,2.38)	‐0.02 (‐0.10,0.02)
HD ANA		1.54 (0.29,10.14)	1.51 (0.32,8.63)	0.02 (‐0.07,0.15)
HD TOCI IV + MTX		2.30 (0.47,11.24)	2.18 (0.50,9.15)	0.04 (‐0.04,0.22)
HD GOLI SC + MTX		5.61 (0.92,35.60)	4.71 (0.93,21.37)	0.13 (‐0.01,0.48)
HD TOFA PO + MTX		3.85 (0.77,16.28)	3.44 (0.79,12.54)	0.09 (‐0.02,0.28)
HD CERTO SC + MTX		4.01 (0.77,19.98)	3.55 (0.78,14.41)	0.09 (‐0.01,0.34)
HD INF IV + MTX		7.55 (1.54,36.27)	5.86 (1.48,21.72)	0.19 (0.03,0.48)
HD TOCI IV + DMARD		1.42 (0.40,5.17)	1.39 (0.42,4.71)	0.01 (‐0.05,0.11)
LD ETN SC	SD ADA SC + DMARD	3.71 (0.67,19.35)	3.36 (0.70,16.02)	0.07 (‐0.03,0.26)
LD ADA SC		0.50 (0.07,3.64)	0.51 (0.08,3.57)	‐0.02 (‐0.13,0.02)
LD ANA		0.71 (0.09,6.60)	0.71 (0.10,6.20)	‐0.01 (‐0.12,0.07)
LD ABA IV + MTX		3.82 (0.62,22.35)	3.44 (0.65,17.55)	0.07 (‐0.03,0.32)
LD CERTO SC + MTX		2.97 (0.33,24.44)	2.75 (0.36,18.94)	0.06 (‐0.06,0.30)
LD ETN SC + MTX		1.92 (0.24,13.82)	1.85 (0.27,11.72)	0.02 (‐0.08,0.18)
HD TOCI IV		2.00 (0.44,8.92)	1.92 (0.47,8.26)	0.03 (‐0.06,0.11)
HD ADA SC		0.50 (0.07,3.63)	0.51 (0.08,3.53)	‐0.02 (‐0.13,0.02)
HD ANA		1.77 (0.25,14.77)	1.72 (0.28,13.03)	0.02 (‐0.09,0.15)
HD TOCI IV + MTX		2.69 (0.44,14.78)	2.52 (0.47,12.76)	0.04 (‐0.05,0.21)
HD GOLI SC + MTX		6.44 (0.90,47.97)	5.29 (0.91,31.43)	0.14 (‐0.01,0.48)
HD TOFA PO + MTX		4.45 (0.76,22.61)	3.92 (0.77,18.48)	0.09 (‐0.02,0.28)
HD CERTO SC + MTX		4.70 (0.78,26.70)	4.09 (0.80,20.69)	0.10 (‐0.02,0.33)
HD INF IV + MTX		8.93 (1.42,51.00)	6.82 (1.36,33.32)	0.19 (0.03,0.47)
HD TOCI IV + DMARD		1.64 (0.42,6.67)	1.60 (0.45,6.23)	0.02 (‐0.06,0.11)
LD ADA SC	LD ETN SC	0.13 (0.03,0.64)	0.15 (0.04,0.66)	‐0.09 (‐0.29,‐0.01)
LD ANA		0.20 (0.03,1.31)	0.23 (0.04,1.29)	‐0.08 (‐0.29,0.02)
LD ABA IV + MTX		1.06 (0.28,3.66)	1.05 (0.32,3.03)	0.00 (‐0.14,0.18)
LD CERTO SC + MTX		0.82 (0.15,4.12)	0.84 (0.17,3.30)	‐0.02 (‐0.19,0.20)
LD ETN SC + MTX		0.52 (0.11,2.06)	0.55 (0.13,1.88)	‐0.04 (‐0.21,0.08)
HD TOCI IV		0.55 (0.19,1.45)	0.58 (0.23,1.40)	‐0.04 (‐0.21,0.02)
HD ADA SC		0.14 (0.02,0.68)	0.15 (0.03,0.68)	‐0.09 (‐0.29,‐0.01)
HD ANA		0.51 (0.08,2.69)	0.54 (0.11,2.47)	‐0.05 (‐0.26,0.09)
HD TOCI IV + MTX		0.72 (0.18,2.65)	0.75 (0.21,2.34)	‐0.02 (‐0.19,0.11)
HD GOLI SC + MTX		1.75 (0.40,8.10)	1.60 (0.45,5.29)	0.06 (‐0.10,0.35)
HD TOFA PO + MTX		1.18 (0.42,3.21)	1.15 (0.47,2.76)	0.02 (‐0.11,0.15)
HD CERTO SC + MTX		1.27 (0.39,4.03)	1.23 (0.44,3.36)	0.02 (‐0.12,0.20)
HD INF IV + MTX		2.41 (0.70,7.54)	2.05 (0.75,5.18)	0.11 (‐0.04,0.34)
HD TOCI IV + DMARD		0.45 (0.13,1.70)	0.48 (0.15,1.63)	‐0.05 (‐0.22,0.04)
LD ANA	LD ADA SC	1.54 (0.27,9.03)	1.53 (0.28,8.47)	0.01 (‐0.03,0.08)
LD ABA IV + MTX		7.75 (1.31,43.87)	6.86 (1.30,32.11)	0.10 (0.01,0.35)
LD CERTO SC + MTX		6.18 (0.79,46.45)	5.60 (0.79,33.25)	0.08 (‐0.01,0.34)
LD ETN SC + MTX		3.94 (0.57,25.49)	3.73 (0.58,20.90)	0.04 (‐0.01,0.21)
HD TOCI IV		4.00 (0.90,19.67)	3.78 (0.91,17.85)	0.05 (0.00,0.14)
HD ADA SC		1.01 (0.24,4.75)	1.01 (0.24,4.65)	0.00 (‐0.03,0.03)
HD ANA		3.84 (0.71,17.97)	3.65 (0.72,15.84)	0.04 (‐0.01,0.16)
HD TOCI IV + MTX		5.36 (0.87,36.14)	4.96 (0.88,29.48)	0.07 (0.00,0.25)
HD GOLI SC + MTX		13.44 (1.89,96.52)	10.86 (1.83,53.58)	0.16 (0.02,0.51)
HD TOFA PO + MTX		8.95 (1.82,41.65)	7.76 (1.76,31.67)	0.11 (0.02,0.31)
HD CERTO SC + MTX		9.49 (1.74,51.76)	8.16 (1.69,38.07)	0.12 (0.02,0.36)
HD INF IV + MTX		18.00 (3.26,96.45)	13.61 (3.01,58.71)	0.21 (0.05,0.51)
HD TOCI IV + DMARD		3.38 (0.62,18.86)	3.24 (0.63,16.78)	0.03 (‐0.01,0.14)
LD ABA IV + MTX	LD ANA	4.88 (0.72,43.50)	4.41 (0.73,30.76)	0.08 (‐0.02,0.35)
LD CERTO SC + MTX		4.08 (0.43,36.38)	3.74 (0.45,25.78)	0.07 (‐0.03,0.34)
LD ETN SC + MTX		2.55 (0.29,21.37)	2.44 (0.30,17.43)	0.03 (‐0.04,0.21)
HD TOCI IV		2.70 (0.45,15.69)	2.59 (0.47,13.98)	0.04 (‐0.04,0.14)
HD ADA SC		0.67 (0.10,3.83)	0.68 (0.10,3.69)	‐0.01 (‐0.08,0.03)
HD ANA		2.43 (0.83,7.61)	2.33 (0.84,6.98)	0.03 (‐0.01,0.12)
HD TOCI IV + MTX		3.64 (0.39,24.25)	3.40 (0.41,19.48)	0.06 (‐0.04,0.24)
HD GOLI SC + MTX		8.39 (0.98,80.29)	6.96 (0.98,44.53)	0.15 (0.00,0.51)
HD TOFA PO + MTX		5.99 (0.89,36.38)	5.26 (0.90,27.40)	0.10 (‐0.01,0.31)
HD CERTO SC + MTX		6.21 (0.90,42.89)	5.44 (0.91,30.30)	0.11 (0.00,0.36)
HD INF IV + MTX		11.36 (1.66,82.92)	8.85 (1.59,46.36)	0.20 (0.03,0.51)
HD TOCI IV + DMARD		2.28 (0.31,13.22)	2.20 (0.33,11.80)	0.03 (‐0.05,0.14)
LD CERTO SC + MTX	LD ABA IV + MTX	0.77 (0.12,4.94)	0.80 (0.15,3.92)	‐0.02 (‐0.24,0.20)
LD ETN SC + MTX		0.49 (0.10,2.67)	0.53 (0.12,2.41)	‐0.05 (‐0.26,0.09)
HD TOCI IV		0.52 (0.14,1.86)	0.56 (0.19,1.79)	‐0.05 (‐0.27,0.04)
HD ADA SC		0.13 (0.02,0.82)	0.15 (0.02,0.82)	‐0.09 (‐0.35,‐0.01)
HD ANA		0.51 (0.06,3.18)	0.54 (0.09,2.92)	‐0.05 (‐0.32,0.08)
HD TOCI IV + MTX		0.71 (0.14,3.06)	0.74 (0.18,2.72)	‐0.03 (‐0.24,0.11)
HD GOLI SC + MTX		1.68 (0.33,9.35)	1.53 (0.38,6.24)	0.06 (‐0.14,0.36)
HD TOFA PO + MTX		1.12 (0.37,3.82)	1.10 (0.43,3.33)	0.01 (‐0.16,0.14)
HD CERTO SC + MTX		1.22 (0.30,4.91)	1.19 (0.36,4.04)	0.02 (‐0.16,0.20)
HD INF IV + MTX		2.30 (0.60,8.38)	1.95 (0.66,6.14)	0.10 (‐0.07,0.33)
HD TOCI IV + DMARD		0.44 (0.09,2.16)	0.47 (0.12,2.05)	‐0.05 (‐0.29,0.05)
LD ETN SC + MTX	LD CERTO SC + MTX	0.63 (0.09,4.48)	0.66 (0.11,3.95)	‐0.03 (‐0.25,0.12)
HD TOCI IV		0.64 (0.13,3.64)	0.67 (0.17,3.40)	‐0.03 (‐0.27,0.07)
HD ADA SC		0.17 (0.02,1.36)	0.18 (0.03,1.35)	‐0.08 (‐0.34,0.01)
HD ANA		0.60 (0.07,6.05)	0.63 (0.11,5.35)	‐0.03 (‐0.31,0.12)
HD TOCI IV + MTX		0.87 (0.14,5.80)	0.88 (0.18,5.02)	‐0.01 (‐0.25,0.15)
HD GOLI SC + MTX		2.13 (0.36,16.41)	1.86 (0.42,10.89)	0.08 (‐0.13,0.39)
HD TOFA PO + MTX		1.46 (0.29,7.82)	1.39 (0.35,6.63)	0.03 (‐0.18,0.19)
HD CERTO SC + MTX		1.53 (0.38,7.09)	1.44 (0.45,5.81)	0.04 (‐0.14,0.21)
HD INF IV + MTX		2.99 (0.50,16.18)	2.45 (0.58,11.51)	0.13 (‐0.10,0.38)
HD TOCI IV + DMARD		0.53 (0.10,3.94)	0.56 (0.13,3.66)	‐0.04 (‐0.28,0.08)
HD TOCI IV	LD ETN SC + MTX	1.04 (0.27,4.60)	1.04 (0.31,4.33)	0.00 (‐0.14,0.08)
HD ADA SC		0.25 (0.04,1.96)	0.27 (0.04,1.93)	‐0.04 (‐0.21,0.01)
HD ANA		0.96 (0.13,7.30)	0.97 (0.16,6.58)	0.00 (‐0.18,0.12)
HD TOCI IV + MTX		1.41 (0.26,7.53)	1.36 (0.30,6.43)	0.02 (‐0.12,0.17)
HD GOLI SC + MTX		3.42 (0.63,19.26)	2.89 (0.67,13.47)	0.11 (‐0.04,0.41)
HD TOFA PO + MTX		2.30 (0.57,9.28)	2.11 (0.61,7.87)	0.06 (‐0.06,0.22)
HD CERTO SC + MTX		2.41 (0.55,12.18)	2.18 (0.60,9.63)	0.07 (‐0.06,0.28)
HD INF IV + MTX		4.68 (1.01,21.09)	3.70 (1.01,14.81)	0.16 (0.00,0.42)
HD TOCI IV + DMARD		0.87 (0.17,4.86)	0.88 (0.20,4.50)	‐0.01 (‐0.16,0.09)
HD ADA SC	HD TOCI IV	0.26 (0.05,1.10)	0.27 (0.05,1.10)	‐0.05 (‐0.14,0.00)
HD ANA		0.94 (0.19,4.46)	0.94 (0.22,3.96)	0.00 (‐0.11,0.12)
HD TOCI IV + MTX		1.34 (0.48,3.67)	1.31 (0.50,3.12)	0.02 (‐0.04,0.16)
HD GOLI SC + MTX		3.26 (0.80,14.57)	2.80 (0.81,8.80)	0.11 (‐0.01,0.43)
HD TOFA PO + MTX		2.14 (0.84,5.92)	1.97 (0.86,4.84)	0.06 (‐0.01,0.22)
HD CERTO SC + MTX		2.33 (0.74,7.94)	2.12 (0.76,5.94)	0.07 (‐0.02,0.29)
HD INF IV + MTX		4.35 (1.45,14.16)	3.47 (1.39,9.01)	0.16 (0.02,0.42)
HD TOCI IV + DMARD		0.84 (0.29,2.43)	0.85 (0.31,2.28)	‐0.01 (‐0.08,0.07)
HD ANA	HD ADA SC	3.67 (0.72,21.32)	3.51 (0.73,18.39)	0.04 (‐0.01,0.16)
HD TOCI IV + MTX		5.15 (0.96,35.80)	4.76 (0.96,28.99)	0.07 (0.00,0.25)
HD GOLI SC + MTX		12.95 (1.77,115.10)	10.61 (1.72,64.66)	0.16 (0.02,0.51)
HD TOFA PO + MTX		8.79 (1.73,50.82)	7.66 (1.68,39.38)	0.11 (0.02,0.31)
HD CERTO SC + MTX		9.24 (1.63,61.35)	7.95 (1.59,42.40)	0.12 (0.02,0.37)
HD INF IV + MTX		17.57 (3.18,112.80)	13.18 (2.95,66.15)	0.21 (0.05,0.51)
HD TOCI IV + DMARD		3.31 (0.61,19.74)	3.16 (0.62,17.49)	0.04 (‐0.01,0.14)
HD TOCI IV + MTX	HD ANA	1.47 (0.20,9.19)	1.42 (0.22,7.27)	0.02 (‐0.12,0.22)
HD GOLI SC + MTX		3.36 (0.42,29.91)	2.91 (0.46,16.31)	0.11 (‐0.06,0.48)
HD TOFA PO + MTX		2.39 (0.42,13.63)	2.20 (0.46,10.07)	0.07 (‐0.07,0.28)
HD CERTO SC + MTX		2.53 (0.41,16.39)	2.30 (0.44,11.42)	0.07 (‐0.07,0.33)
HD INF IV + MTX		4.64 (0.83,29.95)	3.77 (0.85,16.58)	0.16 (‐0.02,0.48)
HD TOCI IV + DMARD		0.90 (0.15,5.07)	0.91 (0.16,4.53)	0.00 (‐0.13,0.11)
HD GOLI SC + MTX	HD TOCI IV + MTX	2.48 (0.44,12.93)	2.17 (0.49,8.68)	0.09 (‐0.08,0.40)
HD TOFA PO + MTX		1.63 (0.46,6.29)	1.53 (0.51,5.27)	0.04 (‐0.09,0.21)
HD CERTO SC + MTX		1.72 (0.43,7.79)	1.60 (0.48,6.01)	0.05 (‐0.09,0.27)
HD INF IV + MTX		3.25 (0.77,13.96)	2.66 (0.81,9.43)	0.14 (‐0.03,0.40)
HD TOCI IV + DMARD		0.62 (0.16,2.73)	0.64 (0.19,2.54)	‐0.03 (‐0.19,0.07)
HD TOFA PO + MTX	HD GOLI SC + MTX	0.68 (0.16,2.60)	0.73 (0.24,2.32)	‐0.04 (‐0.32,0.11)
HD CERTO SC + MTX		0.71 (0.15,3.14)	0.76 (0.22,2.66)	‐0.04 (‐0.33,0.15)
HD INF IV + MTX		1.38 (0.25,6.03)	1.28 (0.36,4.39)	0.04 (‐0.26,0.30)
HD TOCI IV + DMARD		0.25 (0.05,1.36)	0.30 (0.08,1.32)	‐0.12 (‐0.44,0.02)
HD CERTO SC + MTX	HD TOFA PO + MTX	1.05 (0.36,3.44)	1.05 (0.41,2.82)	0.01 (‐0.12,0.18)
HD INF IV + MTX		2.03 (0.72,5.44)	1.75 (0.76,3.98)	0.10 (‐0.04,0.30)
HD TOCI IV + DMARD		0.38 (0.11,1.44)	0.42 (0.13,1.40)	‐0.07 (‐0.25,0.03)
HD INF IV + MTX	HD CERTO SC + MTX	1.88 (0.50,6.44)	1.65 (0.58,4.56)	0.08 (‐0.10,0.31)
HD TOCI IV + DMARD		0.35 (0.09,1.60)	0.39 (0.12,1.54)	‐0.08 (‐0.30,0.04)
HD TOCI IV + DMARD	HD INF IV + MTX	0.19 (0.04,0.85)	0.24 (0.07,0.86)	‐0.17 (‐0.45,‐0.01)
Random‐Effect Model	Residual Deviance	119.1 vs 119 data points
	Deviance Information Criteria	622.675
Fixed‐Effect Model	Residual Deviance	123.8 vs 119 data points
	Deviance Information Criteria	622.968
Note:
Total Patients	20301
Total Studies	48
2‐arm	30
3‐arm	13
4‐arm	5