Withdrawals, Short trial duration: Odds Ratios, Risk Ratios and Risk Difference for All Treatment Comparisons‐Random Effects Model
Treatment	Reference	OR (95% CrI)	RR (95% CrI)	RD % (95% Crl)
MTX	PL	1.11 (0.30,3.75)	1.11 (0.31,3.58)	0.00 (‐0.02,0.05)
DMARD + PL		3.39 (0.98,11.24)	3.23 (0.98,9.44)	0.05 (0.00,0.17)
MTX + DMARD		3.08 (0.54,14.28)	2.95 (0.55,11.47)	0.04 (‐0.01,0.20)
SD ETN SC		1.27 (0.34,4.27)	1.26 (0.35,4.03)	0.01 (‐0.02,0.06)
SD ADA SC		2.00 (1.00,4.48)	1.95 (1.00,4.24)	0.02 (0.00,0.06)
SD TOCI IV		0.98 (0.37,2.60)	0.98 (0.38,2.53)	0.00 (‐0.02,0.03)
SD CERTO SC		2.92 (0.85,12.52)	2.81 (0.85,10.59)	0.04 (0.00,0.16)
SD TOC SC + PL IV		0.70 (0.20,2.23)	0.70 (0.20,2.18)	‐0.01 (‐0.02,0.02)
SD RITUX IV		7.58 (0.55,151.10)	6.69 (0.56,38.26)	0.11 (‐0.01,0.74)
SD ETN SC + MTX		1.01 (0.22,3.98)	1.01 (0.23,3.81)	0.00 (‐0.02,0.05)
SD ADA SC + MTX		1.44 (0.31,6.62)	1.43 (0.32,5.97)	0.01 (‐0.02,0.09)
SD INF IV + MTX		2.98 (0.68,11.68)	2.86 (0.68,9.66)	0.04 (‐0.01,0.18)
SD ABA IV + MTX		1.09 (0.22,3.96)	1.09 (0.22,3.76)	0.00 (‐0.02,0.05)
SD CERTO SC + MTX		1.50 (0.35,6.04)	1.49 (0.36,5.52)	0.01 (‐0.02,0.09)
SD RITUX IV + MTX		2.15 (0.38,14.47)	2.10 (0.38,11.41)	0.02 (‐0.01,0.20)
SD GOLI SC + MTX		1.16 (0.22,6.22)	1.16 (0.23,5.69)	0.00 (‐0.02,0.09)
SD TOFA PO + MTX		1.97 (0.39,10.08)	1.93 (0.39,8.63)	0.02 (‐0.01,0.14)
SD ABA SC + MTX		0.61 (0.10,2.67)	0.61 (0.10,2.59)	‐0.01 (‐0.02,0.03)
SD TOCI IV + MTX		1.24 (0.27,5.65)	1.24 (0.28,5.18)	0.00 (‐0.02,0.08)
SD ETN SC + DMARD		2.41 (0.83,7.47)	2.34 (0.83,6.75)	0.03 (0.00,0.11)
SD CERTO SC + DMARD		3.17 (0.85,12.73)	3.03 (0.85,10.52)	0.04 (0.00,0.18)
SD ADA SC + DMARD		4.17 (0.70,22.23)	3.90 (0.70,15.74)	0.06 (‐0.01,0.29)
SD TOCI SC + DMARD		9.78 (1.20,77.69)	8.22 (1.20,33.00)	0.15 (0.00,0.59)
LD ADA SC		0.71 (0.17,2.12)	0.72 (0.17,2.08)	‐0.01 (‐0.02,0.02)
LD ETN SC		2.45 (0.54,11.59)	2.38 (0.55,9.66)	0.03 (‐0.01,0.16)
LD TOCI IV		0.75 (0.14,3.61)	0.76 (0.14,3.44)	0.00 (‐0.02,0.04)
LD RITUX IV + MTX		1.98 (0.34,14.46)	1.94 (0.35,11.35)	0.02 (‐0.02,0.21)
LD ABA IV + MTX		1.36 (0.21,6.99)	1.35 (0.21,6.27)	0.01 (‐0.02,0.10)
LD CERTO SC + MTX		0.98 (0.12,6.19)	0.98 (0.12,5.64)	0.00 (‐0.02,0.09)
LD TOCI IV + MTX		0.53 (0.09,2.70)	0.54 (0.09,2.63)	‐0.01 (‐0.02,0.03)
HD TOCI IV		0.89 (0.26,3.16)	0.90 (0.27,3.03)	0.00 (‐0.02,0.04)
HD ADA SC		0.74 (0.20,2.32)	0.74 (0.20,2.26)	‐0.01 (‐0.02,0.02)
HD GOLI SC		0.59 (0.05,4.89)	0.59 (0.05,4.53)	‐0.01 (‐0.03,0.07)
HD TOCI IV + MTX		1.24 (0.34,4.88)	1.24 (0.35,4.57)	0.00 (‐0.02,0.06)
HD GOLI SC + MTX		1.72 (0.31,8.68)	1.69 (0.32,7.58)	0.01 (‐0.02,0.12)
HD TOFA PO + MTX		1.68 (0.35,9.23)	1.66 (0.35,8.00)	0.01 (‐0.02,0.13)
HD CERTO SC + MTX		1.56 (0.33,7.71)	1.54 (0.34,6.83)	0.01 (‐0.02,0.11)
HD INF IV + MTX		3.17 (0.64,13.94)	3.03 (0.64,11.19)	0.04 (‐0.01,0.20)
HD TOCI IV + DMARD		6.54 (1.64,26.27)	5.85 (1.62,17.84)	0.10 (0.01,0.34)
DMARD + PL	MTX	3.06 (0.54,23.08)	2.91 (0.55,19.70)	0.04 (‐0.02,0.17)
MTX + DMARD		2.92 (0.45,13.15)	2.78 (0.46,11.30)	0.04 (‐0.03,0.19)
SD ETN SC		1.20 (0.25,4.31)	1.19 (0.27,4.13)	0.00 (‐0.04,0.05)
SD ADA SC		1.81 (0.50,8.47)	1.77 (0.52,8.10)	0.02 (‐0.03,0.06)
SD TOCI IV		0.89 (0.32,2.89)	0.89 (0.33,2.85)	0.00 (‐0.04,0.02)
SD CERTO SC		2.69 (0.45,21.20)	2.58 (0.46,18.20)	0.03 (‐0.03,0.16)
SD TOC SC + PL IV		0.62 (0.18,2.43)	0.63 (0.19,2.40)	‐0.01 (‐0.05,0.01)
SD RITUX IV		6.81 (0.71,93.71)	5.84 (0.72,33.71)	0.11 (‐0.01,0.72)
SD ETN SC + MTX		0.92 (0.20,3.52)	0.92 (0.21,3.39)	0.00 (‐0.05,0.04)
SD ADA SC + MTX		1.28 (0.64,2.91)	1.27 (0.64,2.80)	0.01 (‐0.01,0.06)
SD INF IV + MTX		2.69 (1.30,5.51)	2.58 (1.29,4.92)	0.03 (0.00,0.14)
SD ABA IV + MTX		0.95 (0.49,1.87)	0.96 (0.50,1.83)	0.00 (‐0.02,0.02)
SD CERTO SC + MTX		1.35 (0.72,2.59)	1.33 (0.72,2.47)	0.01 (‐0.01,0.05)
SD RITUX IV + MTX		1.96 (0.65,7.23)	1.91 (0.66,6.14)	0.02 (‐0.01,0.17)
SD GOLI SC + MTX		1.07 (0.39,3.04)	1.07 (0.40,2.87)	0.00 (‐0.02,0.06)
SD TOFA PO + MTX		1.75 (0.75,4.46)	1.71 (0.75,4.11)	0.02 (‐0.01,0.10)
SD ABA SC + MTX		0.52 (0.19,1.56)	0.53 (0.19,1.54)	‐0.01 (‐0.04,0.01)
SD TOCI IV + MTX		1.18 (0.34,3.72)	1.17 (0.34,3.55)	0.00 (‐0.02,0.06)
SD ETN SC + DMARD		2.20 (0.44,13.50)	2.14 (0.45,12.30)	0.02 (‐0.03,0.11)
SD CERTO SC + DMARD		2.71 (0.52,26.30)	2.60 (0.54,21.79)	0.04 (‐0.02,0.19)
SD ADA SC + DMARD		3.89 (0.39,40.36)	3.64 (0.41,28.92)	0.06 (‐0.03,0.29)
SD TOCI SC + DMARD		9.51 (0.77,96.91)	7.80 (0.78,47.08)	0.15 (‐0.01,0.58)
LD ADA SC		0.63 (0.10,3.03)	0.64 (0.10,2.96)	‐0.01 (‐0.06,0.02)
LD ETN SC		2.24 (0.34,13.33)	2.17 (0.35,11.70)	0.02 (‐0.03,0.16)
LD TOCI IV		0.70 (0.16,2.25)	0.70 (0.17,2.21)	‐0.01 (‐0.04,0.02)
LD RITUX IV + MTX		1.83 (0.55,7.25)	1.79 (0.56,6.33)	0.02 (‐0.01,0.16)
LD ABA IV + MTX		1.19 (0.40,3.43)	1.19 (0.41,3.25)	0.00 (‐0.02,0.07)
LD CERTO SC + MTX		0.93 (0.17,3.71)	0.93 (0.17,3.51)	0.00 (‐0.03,0.07)
LD TOCI IV + MTX		0.49 (0.08,2.06)	0.50 (0.09,2.03)	‐0.01 (‐0.05,0.02)
HD TOCI IV		0.81 (0.40,1.70)	0.82 (0.41,1.67)	0.00 (‐0.03,0.01)
HD ADA SC		0.66 (0.12,3.48)	0.67 (0.13,3.42)	‐0.01 (‐0.06,0.02)
HD GOLI SC		0.56 (0.05,2.97)	0.57 (0.06,2.83)	‐0.01 (‐0.04,0.05)
HD TOCI IV + MTX		1.12 (0.48,2.77)	1.12 (0.49,2.70)	0.00 (‐0.02,0.04)
HD GOLI SC + MTX		1.50 (0.62,4.60)	1.48 (0.63,4.19)	0.01 (‐0.01,0.10)
HD TOFA PO + MTX		1.57 (0.67,4.11)	1.54 (0.68,3.83)	0.01 (‐0.01,0.09)
HD CERTO SC + MTX		1.46 (0.62,3.50)	1.44 (0.62,3.29)	0.01 (‐0.01,0.08)
HD INF IV + MTX		2.87 (1.22,7.01)	2.73 (1.21,6.14)	0.04 (0.00,0.16)
HD TOCI IV + DMARD		5.90 (0.99,49.48)	5.26 (0.99,34.87)	0.09 (0.00,0.34)
MTX + DMARD	DMARD + PL	0.90 (0.10,6.94)	0.91 (0.12,5.89)	‐0.01 (‐0.15,0.17)
SD ETN SC		0.38 (0.05,2.53)	0.40 (0.07,2.43)	‐0.04 (‐0.17,0.04)
SD ADA SC		0.60 (0.19,1.93)	0.62 (0.21,1.89)	‐0.02 (‐0.14,0.02)
SD TOCI IV		0.29 (0.06,1.44)	0.30 (0.07,1.42)	‐0.05 (‐0.17,0.01)
SD CERTO SC		0.88 (0.14,5.75)	0.88 (0.17,5.10)	‐0.01 (‐0.14,0.12)
SD TOC SC + PL IV		0.20 (0.04,1.13)	0.21 (0.04,1.12)	‐0.05 (‐0.18,0.00)
SD RITUX IV		2.22 (0.10,67.50)	2.03 (0.12,19.44)	0.06 (‐0.13,0.70)
SD ETN SC + MTX		0.30 (0.03,1.88)	0.31 (0.04,1.83)	‐0.04 (‐0.17,0.02)
SD ADA SC + MTX		0.42 (0.05,3.03)	0.44 (0.06,2.81)	‐0.03 (‐0.17,0.07)
SD INF IV + MTX		0.89 (0.10,6.25)	0.90 (0.12,5.16)	‐0.01 (‐0.15,0.14)
SD ABA IV + MTX		0.31 (0.03,2.03)	0.33 (0.04,1.96)	‐0.04 (‐0.17,0.03)
SD CERTO SC + MTX		0.44 (0.06,3.07)	0.46 (0.06,2.87)	‐0.03 (‐0.17,0.06)
SD RITUX IV + MTX		0.61 (0.07,6.67)	0.63 (0.08,5.53)	‐0.02 (‐0.16,0.18)
SD GOLI SC + MTX		0.34 (0.04,2.89)	0.36 (0.04,2.69)	‐0.04 (‐0.17,0.05)
SD TOFA PO + MTX		0.57 (0.06,4.36)	0.59 (0.07,3.86)	‐0.02 (‐0.16,0.11)
SD ABA SC + MTX		0.18 (0.02,1.27)	0.19 (0.02,1.26)	‐0.05 (‐0.18,0.01)
SD TOCI IV + MTX		0.36 (0.05,2.45)	0.38 (0.06,2.34)	‐0.04 (‐0.17,0.05)
SD ETN SC + DMARD		0.71 (0.32,1.70)	0.73 (0.34,1.65)	‐0.02 (‐0.10,0.03)
SD CERTO SC + DMARD		0.93 (0.30,3.16)	0.93 (0.32,2.90)	0.00 (‐0.09,0.10)
SD ADA SC + DMARD		1.27 (0.35,4.05)	1.24 (0.37,3.33)	0.01 (‐0.06,0.19)
SD TOCI SC + DMARD		2.74 (0.57,17.79)	2.39 (0.59,9.33)	0.09 (‐0.03,0.50)
LD ADA SC		0.20 (0.04,1.08)	0.21 (0.04,1.07)	‐0.05 (‐0.17,0.00)
LD ETN SC		0.71 (0.10,6.19)	0.73 (0.11,5.42)	‐0.02 (‐0.15,0.12)
LD TOCI IV		0.22 (0.03,1.87)	0.23 (0.03,1.82)	‐0.05 (‐0.18,0.02)
LD RITUX IV + MTX		0.55 (0.06,5.59)	0.57 (0.07,4.57)	‐0.02 (‐0.16,0.17)
LD ABA IV + MTX		0.39 (0.04,3.22)	0.41 (0.04,2.99)	‐0.04 (‐0.17,0.06)
LD CERTO SC + MTX		0.29 (0.02,2.74)	0.31 (0.03,2.56)	‐0.04 (‐0.17,0.06)
LD TOCI IV + MTX		0.15 (0.02,1.12)	0.16 (0.02,1.12)	‐0.05 (‐0.18,0.00)
HD TOCI IV		0.26 (0.04,1.77)	0.27 (0.05,1.73)	‐0.05 (‐0.17,0.02)
HD ADA SC		0.21 (0.05,1.08)	0.22 (0.05,1.08)	‐0.05 (‐0.17,0.00)
HD GOLI SC		0.18 (0.01,1.90)	0.19 (0.01,1.83)	‐0.05 (‐0.18,0.03)
HD TOCI IV + MTX		0.36 (0.06,2.49)	0.38 (0.07,2.39)	‐0.04 (‐0.17,0.04)
HD GOLI SC + MTX		0.48 (0.06,4.25)	0.50 (0.06,3.81)	‐0.03 (‐0.16,0.09)
HD TOFA PO + MTX		0.50 (0.06,3.97)	0.52 (0.07,3.54)	‐0.03 (‐0.16,0.09)
HD CERTO SC + MTX		0.46 (0.05,3.44)	0.47 (0.06,3.17)	‐0.03 (‐0.16,0.08)
HD INF IV + MTX		0.94 (0.09,6.85)	0.95 (0.11,5.77)	0.00 (‐0.15,0.16)
HD TOCI IV + DMARD		1.91 (1.01,3.79)	1.78 (1.01,3.21)	0.05 (0.00,0.20)
SD ETN SC	MTX + DMARD	0.43 (0.12,1.35)	0.45 (0.14,1.34)	‐0.03 (‐0.18,0.01)
SD ADA SC		0.66 (0.13,4.13)	0.67 (0.15,3.95)	‐0.02 (‐0.18,0.04)
SD TOCI IV		0.33 (0.06,2.20)	0.35 (0.07,2.16)	‐0.04 (‐0.21,0.02)
SD CERTO SC		0.99 (0.13,9.94)	0.99 (0.15,8.63)	0.00 (‐0.18,0.14)
SD TOC SC + PL IV		0.24 (0.03,1.70)	0.25 (0.04,1.67)	‐0.04 (‐0.21,0.01)
SD RITUX IV		2.52 (0.15,60.44)	2.26 (0.17,22.31)	0.07 (‐0.11,0.69)
SD ETN SC + MTX		0.34 (0.12,0.84)	0.36 (0.14,0.84)	‐0.04 (‐0.17,0.00)
SD ADA SC + MTX		0.45 (0.09,3.49)	0.47 (0.10,3.22)	‐0.03 (‐0.18,0.06)
SD INF IV + MTX		0.93 (0.18,6.70)	0.93 (0.21,5.86)	0.00 (‐0.15,0.13)
SD ABA IV + MTX		0.33 (0.06,2.27)	0.34 (0.07,2.21)	‐0.04 (‐0.19,0.03)
SD CERTO SC + MTX		0.47 (0.09,3.17)	0.48 (0.11,3.03)	‐0.03 (‐0.18,0.05)
SD RITUX IV + MTX		0.66 (0.11,8.71)	0.68 (0.12,7.23)	‐0.02 (‐0.16,0.17)
SD GOLI SC + MTX		0.37 (0.06,3.20)	0.39 (0.07,3.04)	‐0.03 (‐0.19,0.05)
SD TOFA PO + MTX		0.62 (0.11,4.75)	0.64 (0.13,4.21)	‐0.02 (‐0.17,0.09)
SD ABA SC + MTX		0.18 (0.03,1.49)	0.19 (0.03,1.47)	‐0.05 (‐0.20,0.01)
SD TOCI IV + MTX		0.39 (0.06,3.43)	0.41 (0.08,3.25)	‐0.03 (‐0.19,0.06)
SD ETN SC + DMARD		0.79 (0.12,5.95)	0.80 (0.14,5.53)	‐0.01 (‐0.18,0.09)
SD CERTO SC + DMARD		1.03 (0.14,10.75)	1.03 (0.17,9.18)	0.00 (‐0.17,0.16)
SD ADA SC + DMARD		1.40 (0.12,16.85)	1.36 (0.14,12.84)	0.02 (‐0.16,0.26)
SD TOCI SC + DMARD		3.35 (0.27,42.87)	2.86 (0.30,23.36)	0.10 (‐0.10,0.55)
LD ADA SC		0.23 (0.03,1.63)	0.24 (0.04,1.61)	‐0.04 (‐0.21,0.01)
LD ETN SC		0.82 (0.12,5.84)	0.83 (0.14,5.26)	‐0.01 (‐0.16,0.11)
LD TOCI IV		0.24 (0.03,2.22)	0.26 (0.04,2.15)	‐0.04 (‐0.20,0.03)
LD RITUX IV + MTX		0.61 (0.10,7.69)	0.63 (0.11,6.64)	‐0.02 (‐0.17,0.16)
LD ABA IV + MTX		0.42 (0.06,3.37)	0.44 (0.07,3.17)	‐0.03 (‐0.18,0.06)
LD CERTO SC + MTX		0.32 (0.03,3.06)	0.34 (0.04,2.85)	‐0.03 (‐0.19,0.05)
LD TOCI IV + MTX		0.18 (0.02,1.40)	0.19 (0.02,1.39)	‐0.05 (‐0.21,0.01)
HD TOCI IV		0.29 (0.06,2.22)	0.30 (0.07,2.16)	‐0.04 (‐0.20,0.02)
HD ADA SC		0.24 (0.03,1.87)	0.25 (0.04,1.84)	‐0.04 (‐0.21,0.01)
HD GOLI SC		0.20 (0.01,2.18)	0.21 (0.01,2.12)	‐0.04 (‐0.21,0.03)
HD TOCI IV + MTX		0.40 (0.08,3.22)	0.41 (0.09,3.10)	‐0.03 (‐0.19,0.04)
HD GOLI SC + MTX		0.55 (0.08,4.15)	0.57 (0.10,3.79)	‐0.02 (‐0.18,0.08)
HD TOFA PO + MTX		0.56 (0.09,4.34)	0.58 (0.11,3.95)	‐0.02 (‐0.18,0.08)
HD CERTO SC + MTX		0.51 (0.09,3.71)	0.53 (0.10,3.48)	‐0.02 (‐0.18,0.07)
HD INF IV + MTX		0.99 (0.17,7.26)	0.99 (0.20,6.40)	0.00 (‐0.15,0.16)
HD TOCI IV + DMARD		2.16 (0.24,21.17)	2.00 (0.28,15.79)	0.05 (‐0.13,0.30)
SD ADA SC	SD ETN SC	1.62 (0.37,7.02)	1.60 (0.38,6.65)	0.01 (‐0.05,0.06)
SD TOCI IV		0.79 (0.19,3.40)	0.79 (0.20,3.30)	‐0.01 (‐0.06,0.03)
SD CERTO SC		2.32 (0.38,17.04)	2.24 (0.40,14.61)	0.03 (‐0.04,0.15)
SD TOC SC + PL IV		0.55 (0.11,2.67)	0.56 (0.11,2.61)	‐0.01 (‐0.06,0.02)
SD RITUX IV		6.17 (0.39,134.40)	5.35 (0.40,39.89)	0.11 (‐0.02,0.74)
SD ETN SC + MTX		0.78 (0.37,1.73)	0.79 (0.38,1.70)	0.00 (‐0.03,0.02)
SD ADA SC + MTX		1.10 (0.26,6.30)	1.09 (0.28,5.77)	0.00 (‐0.05,0.09)
SD INF IV + MTX		2.30 (0.52,10.85)	2.22 (0.53,9.35)	0.03 (‐0.02,0.17)
SD ABA IV + MTX		0.81 (0.19,3.95)	0.81 (0.20,3.78)	0.00 (‐0.05,0.05)
SD CERTO SC + MTX		1.11 (0.28,6.13)	1.11 (0.29,5.61)	0.00 (‐0.04,0.08)
SD RITUX IV + MTX		1.64 (0.32,16.45)	1.61 (0.33,13.21)	0.01 (‐0.03,0.20)
SD GOLI SC + MTX		0.90 (0.18,5.88)	0.90 (0.19,5.40)	0.00 (‐0.06,0.08)
SD TOFA PO + MTX		1.49 (0.32,9.16)	1.47 (0.33,8.08)	0.01 (‐0.04,0.13)
SD ABA SC + MTX		0.44 (0.09,2.63)	0.45 (0.09,2.56)	‐0.01 (‐0.06,0.03)
SD TOCI IV + MTX		0.96 (0.20,6.07)	0.96 (0.21,5.69)	0.00 (‐0.05,0.08)
SD ETN SC + DMARD		1.90 (0.34,11.43)	1.86 (0.36,10.27)	0.02 (‐0.04,0.11)
SD CERTO SC + DMARD		2.44 (0.41,19.48)	2.33 (0.43,16.34)	0.03 (‐0.04,0.19)
SD ADA SC + DMARD		3.25 (0.31,31.78)	3.07 (0.32,23.73)	0.05 (‐0.04,0.29)
SD TOCI SC + DMARD		7.75 (0.69,93.28)	6.45 (0.70,45.67)	0.14 (‐0.01,0.58)
LD ADA SC		0.56 (0.08,2.79)	0.57 (0.09,2.73)	‐0.01 (‐0.07,0.02)
LD ETN SC		1.93 (0.41,9.68)	1.88 (0.43,8.58)	0.02 (‐0.03,0.14)
LD TOCI IV		0.58 (0.09,3.58)	0.59 (0.09,3.44)	‐0.01 (‐0.06,0.04)
LD RITUX IV + MTX		1.48 (0.29,15.74)	1.46 (0.30,12.57)	0.01 (‐0.04,0.20)
LD ABA IV + MTX		0.99 (0.19,6.57)	0.99 (0.19,6.03)	0.00 (‐0.05,0.09)
LD CERTO SC + MTX		0.79 (0.09,5.77)	0.79 (0.10,5.33)	0.00 (‐0.05,0.08)
LD TOCI IV + MTX		0.43 (0.05,2.85)	0.44 (0.06,2.77)	‐0.01 (‐0.07,0.03)
HD TOCI IV		0.69 (0.18,3.35)	0.69 (0.19,3.23)	‐0.01 (‐0.06,0.03)
HD ADA SC		0.58 (0.09,3.10)	0.59 (0.10,3.02)	‐0.01 (‐0.07,0.02)
HD GOLI SC		0.48 (0.03,4.58)	0.49 (0.03,4.33)	‐0.01 (‐0.06,0.06)
HD TOCI IV + MTX		0.94 (0.24,4.81)	0.95 (0.25,4.59)	0.00 (‐0.05,0.06)
HD GOLI SC + MTX		1.30 (0.26,8.54)	1.29 (0.27,7.57)	0.01 (‐0.04,0.12)
HD TOFA PO + MTX		1.34 (0.27,8.65)	1.33 (0.28,7.71)	0.01 (‐0.04,0.11)
HD CERTO SC + MTX		1.21 (0.26,7.19)	1.20 (0.27,6.53)	0.00 (‐0.04,0.10)
HD INF IV + MTX		2.43 (0.52,12.82)	2.33 (0.54,10.65)	0.03 (‐0.02,0.19)
HD TOCI IV + DMARD		4.96 (0.65,42.82)	4.46 (0.67,29.86)	0.09 (‐0.02,0.34)
SD TOCI IV	SD ADA SC	0.48 (0.19,1.31)	0.49 (0.20,1.30)	‐0.02 (‐0.05,0.01)
SD CERTO SC		1.43 (0.32,7.10)	1.41 (0.33,6.07)	0.02 (‐0.04,0.14)
SD TOC SC + PL IV		0.34 (0.10,1.17)	0.35 (0.11,1.16)	‐0.03 (‐0.06,0.00)
SD RITUX IV		3.65 (0.28,85.75)	3.29 (0.30,22.52)	0.09 (‐0.04,0.72)
SD ETN SC + MTX		0.48 (0.10,2.30)	0.49 (0.10,2.22)	‐0.02 (‐0.06,0.03)
SD ADA SC + MTX		0.70 (0.14,3.36)	0.71 (0.15,3.11)	‐0.01 (‐0.05,0.07)
SD INF IV + MTX		1.47 (0.30,6.43)	1.44 (0.31,5.46)	0.02 (‐0.04,0.15)
SD ABA IV + MTX		0.54 (0.10,2.13)	0.55 (0.10,2.05)	‐0.02 (‐0.06,0.03)
SD CERTO SC + MTX		0.74 (0.15,3.28)	0.75 (0.16,3.05)	‐0.01 (‐0.05,0.07)
SD RITUX IV + MTX		1.06 (0.17,7.31)	1.05 (0.18,5.98)	0.00 (‐0.05,0.18)
SD GOLI SC + MTX		0.59 (0.11,3.24)	0.60 (0.11,3.03)	‐0.02 (‐0.05,0.07)
SD TOFA PO + MTX		0.96 (0.16,4.85)	0.96 (0.17,4.25)	0.00 (‐0.05,0.12)
SD ABA SC + MTX		0.30 (0.04,1.36)	0.31 (0.05,1.35)	‐0.03 (‐0.07,0.01)
SD TOCI IV + MTX		0.62 (0.13,3.12)	0.63 (0.13,2.91)	‐0.01 (‐0.05,0.06)
SD ETN SC + DMARD		1.20 (0.46,3.11)	1.19 (0.47,2.88)	0.01 (‐0.03,0.08)
SD CERTO SC + DMARD		1.55 (0.43,6.48)	1.51 (0.44,5.53)	0.02 (‐0.03,0.16)
SD ADA SC + DMARD		2.06 (0.35,11.30)	1.97 (0.37,8.29)	0.04 (‐0.03,0.27)
SD TOCI SC + DMARD		4.83 (0.61,35.37)	4.13 (0.62,15.62)	0.13 (‐0.02,0.56)
LD ADA SC		0.34 (0.09,0.97)	0.35 (0.10,0.97)	‐0.03 (‐0.06,0.00)
LD ETN SC		1.21 (0.22,7.27)	1.20 (0.23,6.17)	0.01 (‐0.05,0.15)
LD TOCI IV		0.36 (0.07,1.79)	0.37 (0.07,1.74)	‐0.02 (‐0.06,0.03)
LD RITUX IV + MTX		0.97 (0.16,7.03)	0.97 (0.17,5.65)	0.00 (‐0.05,0.19)
LD ABA IV + MTX		0.66 (0.10,3.49)	0.67 (0.10,3.21)	‐0.01 (‐0.05,0.08)
LD CERTO SC + MTX		0.50 (0.05,3.20)	0.51 (0.06,2.95)	‐0.02 (‐0.06,0.07)
LD TOCI IV + MTX		0.26 (0.04,1.33)	0.27 (0.04,1.31)	‐0.03 (‐0.07,0.01)
HD TOCI IV		0.44 (0.12,1.79)	0.45 (0.12,1.75)	‐0.02 (‐0.06,0.02)
HD ADA SC		0.36 (0.11,1.05)	0.37 (0.12,1.05)	‐0.02 (‐0.06,0.00)
HD GOLI SC		0.29 (0.02,2.64)	0.30 (0.02,2.49)	‐0.03 (‐0.06,0.05)
HD TOCI IV + MTX		0.60 (0.16,2.47)	0.61 (0.16,2.37)	‐0.01 (‐0.05,0.04)
HD GOLI SC + MTX		0.83 (0.14,4.49)	0.84 (0.15,4.05)	‐0.01 (‐0.05,0.10)
HD TOFA PO + MTX		0.87 (0.15,4.22)	0.87 (0.16,3.79)	0.00 (‐0.05,0.10)
HD CERTO SC + MTX		0.79 (0.15,4.15)	0.79 (0.16,3.78)	‐0.01 (‐0.05,0.09)
HD INF IV + MTX		1.59 (0.28,7.28)	1.55 (0.29,5.97)	0.02 (‐0.04,0.17)
HD TOCI IV + DMARD		3.24 (0.86,12.32)	2.96 (0.87,8.70)	0.08 (‐0.01,0.31)
SD CERTO SC	SD TOCI IV	3.02 (0.55,15.80)	2.89 (0.56,13.66)	0.04 (‐0.02,0.16)
SD TOC SC + PL IV		0.69 (0.34,1.40)	0.70 (0.34,1.39)	‐0.01 (‐0.02,0.01)
SD RITUX IV		7.31 (0.68,131.90)	6.42 (0.69,38.38)	0.11 (‐0.01,0.74)
SD ETN SC + MTX		0.96 (0.21,5.03)	0.96 (0.22,4.78)	0.00 (‐0.03,0.05)
SD ADA SC + MTX		1.46 (0.37,5.37)	1.44 (0.37,4.94)	0.01 (‐0.02,0.09)
SD INF IV + MTX		2.99 (0.80,10.91)	2.86 (0.81,9.27)	0.04 (0.00,0.17)
SD ABA IV + MTX		1.09 (0.26,3.56)	1.09 (0.26,3.43)	0.00 (‐0.02,0.04)
SD CERTO SC + MTX		1.50 (0.41,5.06)	1.48 (0.41,4.72)	0.01 (‐0.02,0.08)
SD RITUX IV + MTX		2.24 (0.45,11.73)	2.18 (0.46,9.67)	0.02 (‐0.01,0.19)
SD GOLI SC + MTX		1.17 (0.28,5.58)	1.16 (0.29,5.11)	0.00 (‐0.02,0.08)
SD TOFA PO + MTX		1.99 (0.44,8.07)	1.95 (0.44,7.06)	0.02 (‐0.02,0.13)
SD ABA SC + MTX		0.60 (0.11,2.59)	0.61 (0.11,2.52)	‐0.01 (‐0.03,0.03)
SD TOCI IV + MTX		1.28 (0.33,4.58)	1.27 (0.33,4.30)	0.01 (‐0.02,0.07)
SD ETN SC + DMARD		2.45 (0.65,9.83)	2.38 (0.66,8.88)	0.03 (‐0.01,0.11)
SD CERTO SC + DMARD		3.15 (0.70,17.46)	3.02 (0.71,14.55)	0.04 (‐0.01,0.18)
SD ADA SC + DMARD		4.44 (0.56,28.99)	4.15 (0.57,21.07)	0.06 (‐0.01,0.29)
SD TOCI SC + DMARD		10.45 (0.99,89.45)	8.62 (0.99,41.13)	0.15 (0.00,0.59)
LD ADA SC		0.71 (0.13,2.55)	0.71 (0.13,2.51)	‐0.01 (‐0.03,0.02)
LD ETN SC		2.47 (0.45,13.58)	2.39 (0.46,11.51)	0.03 (‐0.02,0.16)
LD TOCI IV		0.75 (0.17,2.99)	0.75 (0.17,2.90)	0.00 (‐0.03,0.04)
LD RITUX IV + MTX		1.97 (0.40,11.32)	1.93 (0.41,9.46)	0.02 (‐0.02,0.20)
LD ABA IV + MTX		1.35 (0.25,5.66)	1.34 (0.26,5.20)	0.01 (‐0.02,0.09)
LD CERTO SC + MTX		1.01 (0.13,5.92)	1.01 (0.14,5.40)	0.00 (‐0.03,0.09)
LD TOCI IV + MTX		0.53 (0.10,2.50)	0.53 (0.10,2.44)	‐0.01 (‐0.03,0.03)
HD TOCI IV		0.89 (0.34,2.41)	0.89 (0.34,2.35)	0.00 (‐0.02,0.02)
HD ADA SC		0.72 (0.18,2.83)	0.73 (0.18,2.75)	‐0.01 (‐0.03,0.02)
HD GOLI SC		0.61 (0.05,4.55)	0.62 (0.05,4.23)	‐0.01 (‐0.03,0.07)
HD TOCI IV + MTX		1.24 (0.42,3.68)	1.23 (0.43,3.51)	0.00 (‐0.02,0.05)
HD GOLI SC + MTX		1.66 (0.37,7.62)	1.64 (0.38,6.67)	0.01 (‐0.02,0.12)
HD TOFA PO + MTX		1.74 (0.42,7.29)	1.71 (0.42,6.43)	0.01 (‐0.02,0.12)
HD CERTO SC + MTX		1.60 (0.39,6.87)	1.58 (0.40,6.15)	0.01 (‐0.02,0.10)
HD INF IV + MTX		3.18 (0.76,12.25)	3.03 (0.76,10.30)	0.04 (0.00,0.18)
HD TOCI IV + DMARD		6.64 (1.26,36.78)	5.89 (1.25,25.18)	0.10 (0.01,0.34)
SD TOC SC + PL IV	SD CERTO SC	0.23 (0.04,1.44)	0.24 (0.04,1.43)	‐0.04 (‐0.16,0.01)
SD RITUX IV		2.44 (0.14,76.28)	2.22 (0.16,21.26)	0.07 (‐0.10,0.71)
SD ETN SC + MTX		0.34 (0.04,2.10)	0.35 (0.05,2.04)	‐0.04 (‐0.16,0.03)
SD ADA SC + MTX		0.48 (0.06,3.27)	0.49 (0.07,3.07)	‐0.03 (‐0.15,0.06)
SD INF IV + MTX		0.98 (0.11,7.46)	0.98 (0.12,6.43)	0.00 (‐0.13,0.15)
SD ABA IV + MTX		0.36 (0.04,2.42)	0.38 (0.04,2.34)	‐0.03 (‐0.16,0.03)
SD CERTO SC + MTX		0.50 (0.06,3.74)	0.52 (0.07,3.48)	‐0.03 (‐0.15,0.07)
SD RITUX IV + MTX		0.72 (0.09,6.72)	0.73 (0.10,5.65)	‐0.01 (‐0.14,0.16)
SD GOLI SC + MTX		0.39 (0.04,3.32)	0.41 (0.05,3.05)	‐0.03 (‐0.16,0.06)
SD TOFA PO + MTX		0.65 (0.08,5.01)	0.66 (0.09,4.45)	‐0.02 (‐0.15,0.11)
SD ABA SC + MTX		0.21 (0.02,1.54)	0.22 (0.02,1.51)	‐0.04 (‐0.17,0.01)
SD TOCI IV + MTX		0.45 (0.05,2.95)	0.46 (0.06,2.76)	‐0.03 (‐0.16,0.05)
SD ETN SC + DMARD		0.83 (0.15,4.44)	0.84 (0.17,4.10)	‐0.01 (‐0.13,0.09)
SD CERTO SC + DMARD		1.09 (0.16,7.46)	1.09 (0.18,6.30)	0.00 (‐0.13,0.15)
SD ADA SC + DMARD		1.40 (0.16,12.37)	1.36 (0.18,9.47)	0.02 (‐0.11,0.26)
SD TOCI SC + DMARD		3.30 (0.29,36.82)	2.86 (0.32,17.86)	0.11 (‐0.08,0.55)
LD ADA SC		0.23 (0.03,1.33)	0.24 (0.04,1.32)	‐0.04 (‐0.17,0.01)
LD ETN SC		0.83 (0.10,6.50)	0.84 (0.11,5.51)	‐0.01 (‐0.14,0.14)
LD TOCI IV		0.24 (0.03,1.92)	0.25 (0.04,1.86)	‐0.04 (‐0.16,0.02)
LD RITUX IV + MTX		0.70 (0.08,5.92)	0.71 (0.09,5.04)	‐0.01 (‐0.14,0.16)
LD ABA IV + MTX		0.45 (0.04,3.83)	0.46 (0.05,3.55)	‐0.03 (‐0.15,0.07)
LD CERTO SC + MTX		0.33 (0.02,3.24)	0.35 (0.03,3.02)	‐0.03 (‐0.16,0.06)
LD TOCI IV + MTX		0.18 (0.02,1.28)	0.19 (0.02,1.27)	‐0.04 (‐0.17,0.01)
HD TOCI IV		0.31 (0.05,1.88)	0.32 (0.05,1.84)	‐0.04 (‐0.16,0.02)
HD ADA SC		0.25 (0.03,1.38)	0.26 (0.04,1.37)	‐0.04 (‐0.16,0.01)
HD GOLI SC		0.19 (0.01,2.56)	0.21 (0.01,2.46)	‐0.04 (‐0.17,0.04)
HD TOCI IV + MTX		0.41 (0.06,2.64)	0.43 (0.07,2.53)	‐0.03 (‐0.15,0.04)
HD GOLI SC + MTX		0.57 (0.06,4.86)	0.59 (0.07,4.36)	‐0.02 (‐0.15,0.10)
HD TOFA PO + MTX		0.59 (0.07,4.29)	0.60 (0.08,3.94)	‐0.02 (‐0.15,0.10)
HD CERTO SC + MTX		0.55 (0.06,4.54)	0.57 (0.07,4.12)	‐0.02 (‐0.15,0.09)
HD INF IV + MTX		1.05 (0.11,8.22)	1.04 (0.13,6.95)	0.00 (‐0.13,0.17)
HD TOCI IV + DMARD		2.17 (0.30,15.51)	2.02 (0.33,11.21)	0.06 (‐0.09,0.30)
SD RITUX IV	SD TOC SC + PL IV	10.51 (0.89,207.80)	9.09 (0.89,65.09)	0.12 (0.00,0.74)
SD ETN SC + MTX		1.39 (0.27,8.22)	1.38 (0.28,7.82)	0.00 (‐0.03,0.06)
SD ADA SC + MTX		2.09 (0.45,9.00)	2.05 (0.45,8.36)	0.01 (‐0.01,0.09)
SD INF IV + MTX		4.26 (0.98,18.60)	4.05 (0.98,16.17)	0.04 (0.00,0.18)
SD ABA IV + MTX		1.56 (0.31,6.10)	1.55 (0.32,5.83)	0.01 (‐0.02,0.05)
SD CERTO SC + MTX		2.15 (0.51,8.92)	2.11 (0.52,8.35)	0.01 (‐0.01,0.09)
SD RITUX IV + MTX		3.24 (0.57,18.99)	3.12 (0.57,15.36)	0.03 (‐0.01,0.20)
SD GOLI SC + MTX		1.69 (0.35,9.56)	1.67 (0.36,8.67)	0.01 (‐0.02,0.09)
SD TOFA PO + MTX		2.90 (0.57,13.65)	2.81 (0.58,12.22)	0.02 (‐0.01,0.14)
SD ABA SC + MTX		0.86 (0.14,4.47)	0.86 (0.15,4.31)	0.00 (‐0.03,0.03)
SD TOCI IV + MTX		1.88 (0.39,7.68)	1.85 (0.40,7.21)	0.01 (‐0.01,0.08)
SD ETN SC + DMARD		3.50 (0.79,16.67)	3.37 (0.80,15.21)	0.03 (‐0.01,0.12)
SD CERTO SC + DMARD		4.58 (0.91,28.39)	4.34 (0.91,23.91)	0.05 (0.00,0.19)
SD ADA SC + DMARD		6.27 (0.70,48.05)	5.77 (0.70,35.39)	0.06 (‐0.01,0.30)
SD TOCI SC + DMARD		14.73 (1.30,149.20)	12.08 (1.29,70.17)	0.15 (0.01,0.59)
LD ADA SC		1.00 (0.16,4.56)	1.00 (0.17,4.44)	0.00 (‐0.03,0.03)
LD ETN SC		3.54 (0.57,22.62)	3.39 (0.58,19.49)	0.03 (‐0.01,0.17)
LD TOCI IV		1.07 (0.21,5.14)	1.07 (0.22,4.96)	0.00 (‐0.02,0.05)
LD RITUX IV + MTX		2.86 (0.49,18.72)	2.77 (0.49,15.58)	0.02 (‐0.01,0.21)
LD ABA IV + MTX		1.91 (0.31,10.00)	1.88 (0.32,9.23)	0.01 (‐0.02,0.09)
LD CERTO SC + MTX		1.45 (0.17,9.86)	1.44 (0.17,8.96)	0.01 (‐0.02,0.09)
LD TOCI IV + MTX		0.76 (0.13,4.19)	0.76 (0.13,4.05)	0.00 (‐0.03,0.03)
HD TOCI IV		1.29 (0.39,4.35)	1.28 (0.40,4.25)	0.00 (‐0.02,0.03)
HD ADA SC		1.03 (0.23,4.93)	1.03 (0.23,4.79)	0.00 (‐0.03,0.03)
HD GOLI SC		0.87 (0.07,7.33)	0.87 (0.07,6.80)	0.00 (‐0.03,0.07)
HD TOCI IV + MTX		1.79 (0.50,6.47)	1.77 (0.50,6.14)	0.01 (‐0.01,0.06)
HD GOLI SC + MTX		2.42 (0.48,13.41)	2.36 (0.48,11.96)	0.02 (‐0.01,0.12)
HD TOFA PO + MTX		2.50 (0.51,12.15)	2.44 (0.52,11.00)	0.02 (‐0.01,0.13)
HD CERTO SC + MTX		2.34 (0.49,11.62)	2.29 (0.49,10.60)	0.02 (‐0.01,0.11)
HD INF IV + MTX		4.61 (0.93,20.76)	4.35 (0.93,17.43)	0.05 (0.00,0.19)
HD TOCI IV + DMARD		9.62 (1.52,58.01)	8.47 (1.50,42.43)	0.10 (0.01,0.34)
SD ETN SC + MTX	SD RITUX IV	0.13 (0.01,2.02)	0.15 (0.02,1.98)	‐0.11 (‐0.74,0.01)
SD ADA SC + MTX		0.18 (0.01,2.01)	0.22 (0.04,1.97)	‐0.10 (‐0.70,0.02)
SD INF IV + MTX		0.39 (0.03,4.05)	0.44 (0.07,3.82)	‐0.07 (‐0.66,0.06)
SD ABA IV + MTX		0.14 (0.01,1.59)	0.16 (0.02,1.57)	‐0.11 (‐0.72,0.01)
SD CERTO SC + MTX		0.19 (0.01,2.30)	0.22 (0.04,2.26)	‐0.10 (‐0.70,0.02)
SD RITUX IV + MTX		0.29 (0.02,2.48)	0.33 (0.06,2.36)	‐0.08 (‐0.66,0.04)
SD GOLI SC + MTX		0.16 (0.01,1.84)	0.19 (0.02,1.81)	‐0.10 (‐0.72,0.01)
SD TOFA PO + MTX		0.25 (0.02,3.22)	0.29 (0.04,3.10)	‐0.09 (‐0.68,0.04)
SD ABA SC + MTX		0.08 (0.00,1.02)	0.09 (0.01,1.02)	‐0.12 (‐0.74,0.00)
SD TOCI IV + MTX		0.17 (0.01,1.79)	0.19 (0.03,1.75)	‐0.10 (‐0.72,0.01)
SD ETN SC + DMARD		0.33 (0.01,6.01)	0.36 (0.04,5.45)	‐0.08 (‐0.72,0.07)
SD CERTO SC + DMARD		0.46 (0.01,8.38)	0.50 (0.05,7.37)	‐0.06 (‐0.71,0.13)
SD ADA SC + DMARD		0.58 (0.01,13.09)	0.63 (0.04,10.38)	‐0.04 (‐0.70,0.22)
SD TOCI SC + DMARD		1.28 (0.03,35.73)	1.22 (0.09,20.39)	0.02 (‐0.64,0.48)
LD ADA SC		0.10 (0.00,1.35)	0.11 (0.01,1.34)	‐0.12 (‐0.75,0.00)
LD ETN SC		0.34 (0.01,6.22)	0.38 (0.03,5.53)	‐0.08 (‐0.72,0.10)
LD TOCI IV		0.10 (0.00,1.21)	0.12 (0.01,1.20)	‐0.11 (‐0.74,0.00)
LD RITUX IV + MTX		0.26 (0.02,2.38)	0.30 (0.06,2.28)	‐0.09 (‐0.65,0.03)
LD ABA IV + MTX		0.18 (0.01,2.30)	0.21 (0.02,2.23)	‐0.10 (‐0.72,0.02)
LD CERTO SC + MTX		0.13 (0.01,1.81)	0.16 (0.02,1.75)	‐0.10 (‐0.72,0.01)
LD TOCI IV + MTX		0.07 (0.00,0.93)	0.09 (0.01,0.93)	‐0.12 (‐0.74,0.00)
HD TOCI IV		0.12 (0.01,1.27)	0.14 (0.02,1.26)	‐0.11 (‐0.73,0.00)
HD ADA SC		0.10 (0.00,1.35)	0.11 (0.01,1.34)	‐0.11 (‐0.75,0.00)
HD GOLI SC		0.08 (0.00,1.34)	0.09 (0.01,1.33)	‐0.11 (‐0.74,0.01)
HD TOCI IV + MTX		0.16 (0.01,1.74)	0.19 (0.03,1.72)	‐0.10 (‐0.72,0.01)
HD GOLI SC + MTX		0.23 (0.01,2.71)	0.26 (0.03,2.60)	‐0.09 (‐0.70,0.03)
HD TOFA PO + MTX		0.22 (0.01,2.86)	0.26 (0.04,2.80)	‐0.09 (‐0.69,0.03)
HD CERTO SC + MTX		0.21 (0.01,2.41)	0.24 (0.04,2.34)	‐0.10 (‐0.70,0.03)
HD INF IV + MTX		0.41 (0.03,4.56)	0.45 (0.07,4.27)	‐0.06 (‐0.65,0.07)
HD TOCI IV + DMARD		0.87 (0.03,19.65)	0.89 (0.09,14.68)	‐0.01 (‐0.65,0.27)
SD ADA SC + MTX	SD ETN SC + MTX	1.45 (0.32,8.40)	1.44 (0.33,7.73)	0.01 (‐0.04,0.09)
SD INF IV + MTX		2.91 (0.65,14.89)	2.80 (0.66,12.53)	0.03 (‐0.02,0.17)
SD ABA IV + MTX		1.03 (0.25,5.18)	1.03 (0.25,4.95)	0.00 (‐0.04,0.05)
SD CERTO SC + MTX		1.48 (0.36,7.67)	1.46 (0.37,7.09)	0.01 (‐0.04,0.08)
SD RITUX IV + MTX		2.12 (0.39,19.71)	2.06 (0.40,16.29)	0.02 (‐0.03,0.20)
SD GOLI SC + MTX		1.16 (0.24,7.64)	1.16 (0.25,7.09)	0.00 (‐0.04,0.08)
SD TOFA PO + MTX		1.96 (0.39,10.92)	1.92 (0.40,9.63)	0.02 (‐0.03,0.14)
SD ABA SC + MTX		0.57 (0.12,3.64)	0.57 (0.12,3.53)	‐0.01 (‐0.05,0.03)
SD TOCI IV + MTX		1.25 (0.23,7.97)	1.24 (0.24,7.49)	0.00 (‐0.04,0.08)
SD ETN SC + DMARD		2.41 (0.41,17.16)	2.35 (0.42,15.45)	0.03 (‐0.03,0.11)
SD CERTO SC + DMARD		3.14 (0.50,28.53)	2.99 (0.52,23.65)	0.04 (‐0.02,0.19)
SD ADA SC + DMARD		4.12 (0.40,44.83)	3.85 (0.41,33.49)	0.06 (‐0.03,0.29)
SD TOCI SC + DMARD		9.94 (0.85,118.40)	8.15 (0.85,60.89)	0.15 (‐0.01,0.59)
LD ADA SC		0.73 (0.11,3.98)	0.73 (0.11,3.89)	‐0.01 (‐0.05,0.02)
LD ETN SC		2.48 (0.45,14.38)	2.40 (0.46,12.84)	0.03 (‐0.02,0.15)
LD TOCI IV		0.75 (0.10,5.00)	0.75 (0.11,4.75)	0.00 (‐0.05,0.04)
LD RITUX IV + MTX		1.89 (0.34,18.95)	1.85 (0.35,15.39)	0.02 (‐0.03,0.20)
LD ABA IV + MTX		1.29 (0.23,8.26)	1.28 (0.24,7.52)	0.01 (‐0.04,0.09)
LD CERTO SC + MTX		1.02 (0.11,7.45)	1.02 (0.11,6.81)	0.00 (‐0.05,0.08)
LD TOCI IV + MTX		0.55 (0.06,3.54)	0.56 (0.06,3.43)	‐0.01 (‐0.06,0.03)
HD TOCI IV		0.89 (0.22,4.38)	0.89 (0.23,4.24)	0.00 (‐0.05,0.04)
HD ADA SC		0.74 (0.11,4.66)	0.75 (0.11,4.55)	0.00 (‐0.06,0.03)
HD GOLI SC		0.62 (0.04,5.74)	0.62 (0.04,5.46)	‐0.01 (‐0.06,0.07)
HD TOCI IV + MTX		1.21 (0.28,6.42)	1.21 (0.29,6.10)	0.00 (‐0.04,0.06)
HD GOLI SC + MTX		1.68 (0.29,10.64)	1.65 (0.30,9.52)	0.01 (‐0.04,0.12)
HD TOFA PO + MTX		1.75 (0.31,10.93)	1.72 (0.32,9.88)	0.01 (‐0.04,0.12)
HD CERTO SC + MTX		1.59 (0.32,8.88)	1.57 (0.33,8.04)	0.01 (‐0.04,0.10)
HD INF IV + MTX		3.15 (0.58,16.51)	3.01 (0.59,13.91)	0.04 (‐0.02,0.19)
HD TOCI IV + DMARD		6.42 (0.89,65.47)	5.72 (0.89,44.98)	0.10 (0.00,0.34)
SD INF IV + MTX	SD ADA SC + MTX	2.10 (0.70,5.68)	2.02 (0.71,5.25)	0.03 (‐0.02,0.13)
SD ABA IV + MTX		0.74 (0.25,1.97)	0.75 (0.26,1.94)	‐0.01 (‐0.06,0.02)
SD CERTO SC + MTX		1.03 (0.38,2.80)	1.03 (0.40,2.71)	0.00 (‐0.04,0.04)
SD RITUX IV + MTX		1.51 (0.42,6.65)	1.48 (0.44,5.93)	0.01 (‐0.03,0.14)
SD GOLI SC + MTX		0.81 (0.22,3.21)	0.82 (0.23,3.03)	0.00 (‐0.06,0.06)
SD TOFA PO + MTX		1.35 (0.58,3.33)	1.33 (0.59,3.16)	0.01 (‐0.02,0.08)
SD ABA SC + MTX		0.41 (0.11,1.49)	0.42 (0.11,1.48)	‐0.01 (‐0.08,0.01)
SD TOCI IV + MTX		0.88 (0.21,3.51)	0.89 (0.22,3.38)	0.00 (‐0.06,0.05)
SD ETN SC + DMARD		1.70 (0.27,12.24)	1.67 (0.29,11.07)	0.02 (‐0.07,0.11)
SD CERTO SC + DMARD		2.20 (0.32,20.20)	2.12 (0.34,16.83)	0.03 (‐0.07,0.18)
SD ADA SC + DMARD		2.99 (0.26,30.76)	2.82 (0.28,22.84)	0.05 (‐0.06,0.29)
SD TOCI SC + DMARD		7.15 (0.47,76.37)	5.94 (0.50,39.68)	0.14 (‐0.04,0.58)
LD ADA SC		0.50 (0.07,2.67)	0.51 (0.07,2.62)	‐0.01 (‐0.10,0.02)
LD ETN SC		1.73 (0.22,12.01)	1.69 (0.23,10.59)	0.02 (‐0.07,0.15)
LD TOCI IV		0.53 (0.10,2.15)	0.54 (0.11,2.11)	‐0.01 (‐0.09,0.02)
LD RITUX IV + MTX		1.40 (0.34,6.80)	1.37 (0.35,6.07)	0.01 (‐0.03,0.13)
LD ABA IV + MTX		0.92 (0.25,3.29)	0.92 (0.26,3.12)	0.00 (‐0.05,0.06)
LD CERTO SC + MTX		0.71 (0.11,3.53)	0.71 (0.11,3.34)	‐0.01 (‐0.07,0.06)
LD TOCI IV + MTX		0.37 (0.06,1.87)	0.38 (0.06,1.85)	‐0.02 (‐0.09,0.01)
HD TOCI IV		0.63 (0.22,1.77)	0.64 (0.24,1.75)	‐0.01 (‐0.08,0.01)
HD ADA SC		0.51 (0.07,2.96)	0.52 (0.08,2.90)	‐0.01 (‐0.10,0.02)
HD GOLI SC		0.42 (0.04,2.90)	0.43 (0.04,2.74)	‐0.01 (‐0.08,0.05)
HD TOCI IV + MTX		0.86 (0.27,2.83)	0.86 (0.29,2.75)	0.00 (‐0.07,0.03)
HD GOLI SC + MTX		1.16 (0.36,4.50)	1.16 (0.37,4.11)	0.00 (‐0.04,0.09)
HD TOFA PO + MTX		1.20 (0.52,3.16)	1.19 (0.53,3.01)	0.00 (‐0.02,0.07)
HD CERTO SC + MTX		1.12 (0.36,3.67)	1.11 (0.37,3.43)	0.00 (‐0.04,0.07)
HD INF IV + MTX		2.20 (0.66,7.04)	2.11 (0.67,6.33)	0.03 (‐0.02,0.15)
HD TOCI IV + DMARD		4.49 (0.61,41.34)	4.04 (0.63,29.17)	0.09 (‐0.03,0.33)
SD ABA IV + MTX	SD INF IV + MTX	0.35 (0.14,0.85)	0.37 (0.16,0.86)	‐0.03 (‐0.14,0.00)
SD CERTO SC + MTX		0.50 (0.18,1.36)	0.52 (0.20,1.34)	‐0.03 (‐0.13,0.01)
SD RITUX IV + MTX		0.71 (0.19,3.30)	0.73 (0.21,2.91)	‐0.01 (‐0.11,0.12)
SD GOLI SC + MTX		0.39 (0.12,1.47)	0.41 (0.13,1.43)	‐0.03 (‐0.14,0.02)
SD TOFA PO + MTX		0.65 (0.21,2.03)	0.66 (0.23,1.93)	‐0.02 (‐0.11,0.05)
SD ABA SC + MTX		0.20 (0.06,0.64)	0.21 (0.07,0.65)	‐0.04 (‐0.16,‐0.01)
SD TOCI IV + MTX		0.43 (0.10,1.71)	0.45 (0.11,1.66)	‐0.03 (‐0.15,0.02)
SD ETN SC + DMARD		0.80 (0.14,5.44)	0.81 (0.16,4.95)	‐0.01 (‐0.15,0.09)
SD CERTO SC + DMARD		1.01 (0.16,11.39)	1.01 (0.19,9.71)	0.00 (‐0.14,0.16)
SD ADA SC + DMARD		1.43 (0.13,16.55)	1.39 (0.15,12.63)	0.02 (‐0.14,0.26)
SD TOCI SC + DMARD		3.44 (0.27,40.63)	2.93 (0.30,19.51)	0.11 (‐0.10,0.54)
LD ADA SC		0.24 (0.03,1.37)	0.25 (0.04,1.36)	‐0.04 (‐0.18,0.01)
LD ETN SC		0.81 (0.13,5.80)	0.82 (0.15,4.92)	‐0.01 (‐0.14,0.13)
LD TOCI IV		0.26 (0.05,1.03)	0.27 (0.06,1.03)	‐0.04 (‐0.16,0.00)
LD RITUX IV + MTX		0.68 (0.15,3.26)	0.69 (0.17,2.87)	‐0.02 (‐0.11,0.12)
LD ABA IV + MTX		0.44 (0.13,1.51)	0.46 (0.14,1.48)	‐0.03 (‐0.13,0.02)
LD CERTO SC + MTX		0.33 (0.06,1.63)	0.35 (0.06,1.57)	‐0.03 (‐0.14,0.03)
LD TOCI IV + MTX		0.18 (0.03,0.95)	0.19 (0.03,0.95)	‐0.05 (‐0.17,0.00)
HD TOCI IV		0.30 (0.11,0.84)	0.32 (0.12,0.84)	‐0.04 (‐0.16,0.00)
HD ADA SC		0.24 (0.04,1.50)	0.26 (0.05,1.48)	‐0.04 (‐0.18,0.01)
HD GOLI SC		0.20 (0.02,1.34)	0.22 (0.02,1.30)	‐0.04 (‐0.16,0.02)
HD TOCI IV + MTX		0.41 (0.13,1.38)	0.43 (0.14,1.36)	‐0.03 (‐0.15,0.01)
HD GOLI SC + MTX		0.56 (0.17,2.17)	0.58 (0.19,2.02)	‐0.02 (‐0.12,0.05)
HD TOFA PO + MTX		0.58 (0.19,1.92)	0.60 (0.21,1.83)	‐0.02 (‐0.11,0.04)
HD CERTO SC + MTX		0.54 (0.17,1.71)	0.55 (0.19,1.65)	‐0.02 (‐0.12,0.03)
HD INF IV + MTX		1.08 (0.49,2.25)	1.07 (0.51,2.11)	0.00 (‐0.05,0.07)
HD TOCI IV + DMARD		2.19 (0.29,22.07)	2.04 (0.32,15.50)	0.06 (‐0.11,0.31)
SD CERTO SC + MTX	SD ABA IV + MTX	1.40 (0.57,3.57)	1.39 (0.57,3.42)	0.01 (‐0.02,0.06)
SD RITUX IV + MTX		1.99 (0.55,9.38)	1.94 (0.56,8.14)	0.02 (‐0.02,0.18)
SD GOLI SC + MTX		1.14 (0.32,4.03)	1.13 (0.33,3.79)	0.00 (‐0.03,0.07)
SD TOFA PO + MTX		1.84 (0.64,5.70)	1.80 (0.65,5.35)	0.02 (‐0.01,0.10)
SD ABA SC + MTX		0.55 (0.24,1.27)	0.56 (0.25,1.26)	‐0.01 (‐0.04,0.01)
SD TOCI IV + MTX		1.22 (0.31,4.69)	1.21 (0.32,4.49)	0.00 (‐0.03,0.06)
SD ETN SC + DMARD		2.25 (0.43,16.91)	2.18 (0.45,15.36)	0.02 (‐0.03,0.11)
SD CERTO SC + DMARD		2.90 (0.51,33.96)	2.77 (0.53,28.74)	0.04 (‐0.02,0.19)
SD ADA SC + DMARD		4.01 (0.36,50.25)	3.74 (0.38,37.99)	0.06 (‐0.03,0.29)
SD TOCI SC + DMARD		9.66 (0.78,109.60)	7.90 (0.79,58.74)	0.15 (‐0.01,0.58)
LD ADA SC		0.67 (0.09,4.03)	0.67 (0.09,3.94)	‐0.01 (‐0.06,0.02)
LD ETN SC		2.30 (0.36,17.41)	2.23 (0.38,14.95)	0.02 (‐0.03,0.16)
LD TOCI IV		0.73 (0.14,2.85)	0.73 (0.14,2.78)	‐0.01 (‐0.05,0.03)
LD RITUX IV + MTX		1.90 (0.46,9.12)	1.85 (0.47,8.10)	0.02 (‐0.02,0.17)
LD ABA IV + MTX		1.23 (0.45,3.65)	1.23 (0.45,3.49)	0.00 (‐0.02,0.07)
LD CERTO SC + MTX		0.95 (0.15,4.55)	0.95 (0.16,4.29)	0.00 (‐0.04,0.07)
LD TOCI IV + MTX		0.51 (0.08,2.66)	0.52 (0.08,2.62)	‐0.01 (‐0.05,0.02)
HD TOCI IV		0.84 (0.32,2.34)	0.84 (0.34,2.31)	0.00 (‐0.04,0.02)
HD ADA SC		0.68 (0.12,4.34)	0.69 (0.13,4.24)	‐0.01 (‐0.06,0.02)
HD GOLI SC		0.57 (0.05,3.42)	0.58 (0.05,3.20)	‐0.01 (‐0.05,0.06)
HD TOCI IV + MTX		1.16 (0.41,3.87)	1.15 (0.42,3.77)	0.00 (‐0.03,0.04)
HD GOLI SC + MTX		1.56 (0.52,5.99)	1.54 (0.53,5.36)	0.01 (‐0.02,0.10)
HD TOFA PO + MTX		1.62 (0.57,5.30)	1.59 (0.58,4.92)	0.01 (‐0.01,0.09)
HD CERTO SC + MTX		1.53 (0.50,4.70)	1.51 (0.51,4.38)	0.01 (‐0.02,0.08)
HD INF IV + MTX		3.03 (1.06,8.79)	2.87 (1.06,7.86)	0.04 (0.00,0.16)
HD TOCI IV + DMARD		6.08 (0.88,65.01)	5.42 (0.88,47.28)	0.09 (0.00,0.34)
SD RITUX IV + MTX	SD CERTO SC + MTX	1.44 (0.39,6.06)	1.42 (0.40,5.29)	0.01 (‐0.03,0.15)
SD GOLI SC + MTX		0.81 (0.24,2.77)	0.82 (0.25,2.60)	0.00 (‐0.05,0.05)
SD TOFA PO + MTX		1.30 (0.45,3.97)	1.28 (0.46,3.72)	0.01 (‐0.03,0.09)
SD ABA SC + MTX		0.39 (0.11,1.39)	0.40 (0.12,1.37)	‐0.02 (‐0.08,0.01)
SD TOCI IV + MTX		0.86 (0.20,3.23)	0.87 (0.21,3.11)	0.00 (‐0.06,0.05)
SD ETN SC + DMARD		1.63 (0.27,10.75)	1.60 (0.30,9.88)	0.02 (‐0.07,0.10)
SD CERTO SC + DMARD		2.00 (0.34,20.65)	1.93 (0.36,17.12)	0.03 (‐0.06,0.18)
SD ADA SC + DMARD		2.91 (0.24,31.58)	2.73 (0.26,23.67)	0.05 (‐0.06,0.28)
SD TOCI SC + DMARD		6.97 (0.49,74.76)	5.73 (0.52,39.56)	0.14 (‐0.04,0.57)
LD ADA SC		0.48 (0.06,2.60)	0.48 (0.07,2.56)	‐0.01 (‐0.09,0.02)
LD ETN SC		1.66 (0.22,10.92)	1.63 (0.23,9.61)	0.02 (‐0.07,0.15)
LD TOCI IV		0.51 (0.10,1.96)	0.52 (0.11,1.92)	‐0.01 (‐0.08,0.02)
LD RITUX IV + MTX		1.33 (0.35,5.87)	1.31 (0.36,5.31)	0.01 (‐0.03,0.15)
LD ABA IV + MTX		0.88 (0.25,2.99)	0.89 (0.26,2.87)	0.00 (‐0.05,0.05)
LD CERTO SC + MTX		0.68 (0.13,2.60)	0.69 (0.13,2.46)	‐0.01 (‐0.06,0.05)
LD TOCI IV + MTX		0.36 (0.05,1.75)	0.37 (0.06,1.73)	‐0.02 (‐0.09,0.01)
HD TOCI IV		0.60 (0.23,1.57)	0.61 (0.24,1.55)	‐0.01 (‐0.07,0.01)
HD ADA SC		0.49 (0.08,2.82)	0.50 (0.09,2.77)	‐0.01 (‐0.09,0.02)
HD GOLI SC		0.40 (0.04,2.39)	0.41 (0.04,2.27)	‐0.01 (‐0.08,0.04)
HD TOCI IV + MTX		0.84 (0.29,2.45)	0.84 (0.30,2.40)	0.00 (‐0.06,0.03)
HD GOLI SC + MTX		1.13 (0.36,3.85)	1.12 (0.38,3.52)	0.00 (‐0.04,0.08)
HD TOFA PO + MTX		1.17 (0.39,3.71)	1.16 (0.40,3.46)	0.00 (‐0.03,0.07)
HD CERTO SC + MTX		1.08 (0.48,2.41)	1.07 (0.49,2.30)	0.00 (‐0.03,0.05)
HD INF IV + MTX		2.13 (0.70,6.78)	2.05 (0.71,6.14)	0.03 (‐0.01,0.15)
HD TOCI IV + DMARD		4.33 (0.60,39.11)	3.90 (0.62,28.12)	0.08 (‐0.03,0.33)
SD GOLI SC + MTX	SD RITUX IV + MTX	0.54 (0.10,2.49)	0.55 (0.12,2.40)	‐0.02 (‐0.16,0.04)
SD TOFA PO + MTX		0.89 (0.21,3.52)	0.90 (0.23,3.36)	0.00 (‐0.13,0.06)
SD ABA SC + MTX		0.27 (0.05,1.32)	0.28 (0.06,1.31)	‐0.03 (‐0.20,0.00)
SD TOCI IV + MTX		0.60 (0.10,2.89)	0.62 (0.11,2.78)	‐0.01 (‐0.16,0.03)
SD ETN SC + DMARD		1.15 (0.13,9.29)	1.14 (0.15,8.49)	0.01 (‐0.18,0.10)
SD CERTO SC + DMARD		1.42 (0.14,15.13)	1.39 (0.17,12.81)	0.02 (‐0.17,0.17)
SD ADA SC + DMARD		2.07 (0.11,22.08)	1.97 (0.14,17.07)	0.04 (‐0.17,0.27)
SD TOCI SC + DMARD		4.77 (0.27,60.57)	3.99 (0.30,30.37)	0.12 (‐0.13,0.56)
LD ADA SC		0.33 (0.03,2.14)	0.35 (0.04,2.10)	‐0.03 (‐0.21,0.01)
LD ETN SC		1.11 (0.11,9.72)	1.10 (0.13,8.32)	0.00 (‐0.17,0.14)
LD TOCI IV		0.35 (0.05,1.74)	0.36 (0.05,1.72)	‐0.03 (‐0.19,0.01)
LD RITUX IV + MTX		0.91 (0.28,2.83)	0.91 (0.29,2.67)	0.00 (‐0.08,0.07)
LD ABA IV + MTX		0.61 (0.11,2.71)	0.62 (0.12,2.60)	‐0.01 (‐0.17,0.04)
LD CERTO SC + MTX		0.46 (0.05,2.78)	0.48 (0.05,2.65)	‐0.02 (‐0.18,0.04)
LD TOCI IV + MTX		0.25 (0.03,1.44)	0.26 (0.03,1.43)	‐0.03 (‐0.20,0.01)
HD TOCI IV		0.42 (0.09,1.47)	0.43 (0.11,1.46)	‐0.02 (‐0.19,0.01)
HD ADA SC		0.35 (0.03,2.26)	0.36 (0.04,2.22)	‐0.03 (‐0.21,0.01)
HD GOLI SC		0.27 (0.02,2.29)	0.28 (0.02,2.20)	‐0.03 (‐0.19,0.03)
HD TOCI IV + MTX		0.57 (0.12,2.26)	0.58 (0.14,2.22)	‐0.02 (‐0.17,0.02)
HD GOLI SC + MTX		0.77 (0.15,3.75)	0.78 (0.17,3.46)	‐0.01 (‐0.15,0.07)
HD TOFA PO + MTX		0.80 (0.18,3.17)	0.81 (0.20,3.01)	‐0.01 (‐0.13,0.05)
HD CERTO SC + MTX		0.74 (0.16,3.09)	0.75 (0.18,2.96)	‐0.01 (‐0.14,0.05)
HD INF IV + MTX		1.48 (0.30,5.91)	1.44 (0.34,5.38)	0.01 (‐0.11,0.13)
HD TOCI IV + DMARD		3.10 (0.27,32.15)	2.83 (0.32,23.28)	0.07 (‐0.14,0.32)
SD TOFA PO + MTX	SD GOLI SC + MTX	1.68 (0.36,6.34)	1.65 (0.37,5.96)	0.01 (‐0.05,0.10)
SD ABA SC + MTX		0.49 (0.11,2.38)	0.50 (0.12,2.33)	‐0.01 (‐0.08,0.02)
SD TOCI IV + MTX		1.11 (0.22,4.32)	1.10 (0.24,4.17)	0.00 (‐0.07,0.05)
SD ETN SC + DMARD		2.09 (0.29,14.85)	2.03 (0.31,13.63)	0.02 (‐0.06,0.11)
SD CERTO SC + DMARD		2.64 (0.34,25.59)	2.54 (0.36,21.85)	0.03 (‐0.06,0.18)
SD ADA SC + DMARD		3.57 (0.28,41.74)	3.31 (0.30,31.20)	0.05 (‐0.05,0.29)
SD TOCI SC + DMARD		8.39 (0.61,111.10)	6.85 (0.62,56.25)	0.14 (‐0.02,0.58)
LD ADA SC		0.59 (0.07,3.79)	0.59 (0.08,3.73)	‐0.01 (‐0.09,0.02)
LD ETN SC		2.15 (0.24,16.00)	2.08 (0.26,13.92)	0.02 (‐0.07,0.15)
LD TOCI IV		0.64 (0.10,2.90)	0.65 (0.11,2.82)	‐0.01 (‐0.08,0.03)
LD RITUX IV + MTX		1.71 (0.34,8.96)	1.68 (0.36,8.05)	0.01 (‐0.04,0.15)
LD ABA IV + MTX		1.11 (0.24,4.67)	1.11 (0.25,4.45)	0.00 (‐0.06,0.07)
LD CERTO SC + MTX		0.85 (0.11,4.67)	0.85 (0.11,4.44)	0.00 (‐0.07,0.06)
LD TOCI IV + MTX		0.47 (0.05,2.56)	0.48 (0.05,2.51)	‐0.01 (‐0.09,0.02)
HD TOCI IV		0.77 (0.21,2.59)	0.78 (0.23,2.54)	0.00 (‐0.08,0.02)
HD ADA SC		0.62 (0.09,3.84)	0.63 (0.10,3.75)	‐0.01 (‐0.09,0.02)
HD GOLI SC		0.50 (0.06,2.96)	0.51 (0.06,2.84)	‐0.01 (‐0.07,0.04)
HD TOCI IV + MTX		1.07 (0.26,3.67)	1.07 (0.28,3.56)	0.00 (‐0.07,0.04)
HD GOLI SC + MTX		1.40 (0.52,4.07)	1.38 (0.54,3.84)	0.01 (‐0.02,0.07)
HD TOFA PO + MTX		1.45 (0.34,6.13)	1.42 (0.36,5.71)	0.01 (‐0.05,0.09)
HD CERTO SC + MTX		1.33 (0.35,5.21)	1.32 (0.36,4.90)	0.01 (‐0.04,0.08)
HD INF IV + MTX		2.71 (0.65,10.12)	2.58 (0.66,8.95)	0.03 (‐0.02,0.16)
HD TOCI IV + DMARD		5.45 (0.62,54.43)	4.88 (0.65,39.70)	0.09 (‐0.03,0.33)
SD ABA SC + MTX	SD TOFA PO + MTX	0.30 (0.08,1.17)	0.31 (0.08,1.16)	‐0.02 (‐0.13,0.00)
SD TOCI IV + MTX		0.65 (0.15,2.73)	0.66 (0.16,2.64)	‐0.01 (‐0.11,0.04)
SD ETN SC + DMARD		1.28 (0.19,9.68)	1.26 (0.21,8.84)	0.01 (‐0.12,0.10)
SD CERTO SC + DMARD		1.57 (0.24,16.86)	1.54 (0.27,14.15)	0.02 (‐0.10,0.17)
SD ADA SC + DMARD		2.23 (0.15,22.92)	2.12 (0.17,17.33)	0.04 (‐0.11,0.28)
SD TOCI SC + DMARD		5.24 (0.35,61.42)	4.38 (0.38,31.90)	0.13 (‐0.07,0.57)
LD ADA SC		0.37 (0.04,2.20)	0.38 (0.05,2.16)	‐0.02 (‐0.15,0.01)
LD ETN SC		1.28 (0.15,10.16)	1.26 (0.16,8.97)	0.01 (‐0.11,0.14)
LD TOCI IV		0.39 (0.07,1.74)	0.40 (0.08,1.72)	‐0.02 (‐0.13,0.01)
LD RITUX IV + MTX		1.05 (0.23,5.10)	1.04 (0.24,4.65)	0.00 (‐0.06,0.11)
LD ABA IV + MTX		0.68 (0.18,2.52)	0.69 (0.19,2.44)	‐0.01 (‐0.09,0.04)
LD CERTO SC + MTX		0.51 (0.07,2.95)	0.52 (0.08,2.77)	‐0.02 (‐0.11,0.05)
LD TOCI IV + MTX		0.29 (0.04,1.42)	0.29 (0.04,1.40)	‐0.02 (‐0.14,0.01)
HD TOCI IV		0.46 (0.15,1.44)	0.47 (0.16,1.43)	‐0.02 (‐0.12,0.01)
HD ADA SC		0.38 (0.05,2.35)	0.39 (0.06,2.31)	‐0.02 (‐0.14,0.02)
HD GOLI SC		0.31 (0.03,2.23)	0.32 (0.03,2.12)	‐0.02 (‐0.12,0.04)
HD TOCI IV + MTX		0.64 (0.18,2.24)	0.65 (0.20,2.19)	‐0.01 (‐0.11,0.02)
HD GOLI SC + MTX		0.86 (0.25,3.53)	0.86 (0.27,3.30)	0.00 (‐0.08,0.07)
HD TOFA PO + MTX		0.90 (0.40,2.02)	0.90 (0.42,1.97)	0.00 (‐0.05,0.04)
HD CERTO SC + MTX		0.82 (0.24,2.95)	0.83 (0.26,2.81)	‐0.01 (‐0.08,0.05)
HD INF IV + MTX		1.62 (0.48,5.69)	1.57 (0.50,5.11)	0.02 (‐0.04,0.13)
HD TOCI IV + DMARD		3.31 (0.40,34.04)	3.01 (0.44,25.25)	0.08 (‐0.08,0.32)
SD TOCI IV + MTX	SD ABA SC + MTX	2.19 (0.39,10.76)	2.16 (0.40,10.28)	0.01 (‐0.02,0.08)
SD ETN SC + DMARD		3.97 (0.68,37.58)	3.82 (0.70,34.13)	0.03 (‐0.01,0.12)
SD CERTO SC + DMARD		5.08 (0.76,70.23)	4.79 (0.77,59.89)	0.05 (‐0.01,0.19)
SD ADA SC + DMARD		7.25 (0.61,104.80)	6.67 (0.62,80.67)	0.06 (‐0.01,0.30)
SD TOCI SC + DMARD		16.82 (1.33,239.10)	13.58 (1.32,133.60)	0.15 (0.01,0.59)
LD ADA SC		1.19 (0.15,8.61)	1.18 (0.16,8.39)	0.00 (‐0.04,0.03)
LD ETN SC		4.03 (0.55,35.89)	3.87 (0.57,31.34)	0.03 (‐0.01,0.17)
LD TOCI IV		1.32 (0.20,6.33)	1.31 (0.21,6.16)	0.00 (‐0.03,0.04)
LD RITUX IV + MTX		3.43 (0.62,20.07)	3.30 (0.63,18.11)	0.03 (‐0.01,0.19)
LD ABA IV + MTX		2.23 (0.62,9.10)	2.18 (0.62,8.61)	0.01 (‐0.01,0.09)
LD CERTO SC + MTX		1.75 (0.21,10.16)	1.74 (0.21,9.45)	0.01 (‐0.02,0.09)
LD TOCI IV + MTX		0.91 (0.12,5.85)	0.91 (0.12,5.72)	0.00 (‐0.03,0.03)
HD TOCI IV		1.54 (0.41,5.70)	1.52 (0.42,5.59)	0.01 (‐0.02,0.03)
HD ADA SC		1.23 (0.20,9.65)	1.23 (0.21,9.42)	0.00 (‐0.03,0.03)
HD GOLI SC		1.02 (0.08,6.93)	1.02 (0.08,6.54)	0.00 (‐0.03,0.07)
HD TOCI IV + MTX		2.09 (0.52,8.73)	2.06 (0.53,8.45)	0.01 (‐0.02,0.06)
HD GOLI SC + MTX		2.86 (0.71,13.35)	2.78 (0.72,12.02)	0.02 (‐0.01,0.12)
HD TOFA PO + MTX		2.91 (0.78,11.82)	2.83 (0.78,11.04)	0.02 (0.00,0.12)
HD CERTO SC + MTX		2.76 (0.70,10.72)	2.68 (0.71,9.99)	0.02 (‐0.01,0.10)
HD INF IV + MTX		5.40 (1.47,20.63)	5.05 (1.44,18.46)	0.05 (0.01,0.19)
HD TOCI IV + DMARD		10.91 (1.42,138.90)	9.56 (1.40,101.60)	0.10 (0.01,0.35)
SD ETN SC + DMARD	SD TOCI IV + MTX	1.97 (0.32,12.41)	1.92 (0.34,11.26)	0.02 (‐0.06,0.10)
SD CERTO SC + DMARD		2.53 (0.36,21.24)	2.43 (0.39,17.95)	0.03 (‐0.05,0.18)
SD ADA SC + DMARD		3.49 (0.31,33.03)	3.24 (0.33,24.56)	0.05 (‐0.05,0.29)
SD TOCI SC + DMARD		8.22 (0.61,101.50)	6.77 (0.62,49.38)	0.14 (‐0.02,0.58)
LD ADA SC		0.56 (0.07,2.99)	0.57 (0.08,2.94)	‐0.01 (‐0.09,0.02)
LD ETN SC		1.99 (0.24,13.21)	1.94 (0.26,11.45)	0.02 (‐0.06,0.16)
LD TOCI IV		0.58 (0.12,2.56)	0.59 (0.12,2.51)	‐0.01 (‐0.07,0.02)
LD RITUX IV + MTX		1.57 (0.30,9.88)	1.54 (0.31,8.59)	0.01 (‐0.04,0.16)
LD ABA IV + MTX		1.03 (0.21,5.12)	1.03 (0.21,4.81)	0.00 (‐0.06,0.07)
LD CERTO SC + MTX		0.78 (0.10,5.14)	0.79 (0.11,4.82)	0.00 (‐0.06,0.07)
LD TOCI IV + MTX		0.43 (0.07,1.94)	0.43 (0.07,1.91)	‐0.01 (‐0.08,0.01)
HD TOCI IV		0.71 (0.23,2.39)	0.71 (0.24,2.36)	‐0.01 (‐0.06,0.02)
HD ADA SC		0.59 (0.08,3.31)	0.60 (0.09,3.27)	‐0.01 (‐0.09,0.02)
HD GOLI SC		0.46 (0.04,3.78)	0.47 (0.04,3.58)	‐0.01 (‐0.07,0.05)
HD TOCI IV + MTX		0.97 (0.31,3.59)	0.97 (0.32,3.47)	0.00 (‐0.05,0.03)
HD GOLI SC + MTX		1.31 (0.31,6.31)	1.30 (0.32,5.73)	0.01 (‐0.04,0.10)
HD TOFA PO + MTX		1.36 (0.32,6.42)	1.35 (0.33,6.00)	0.01 (‐0.04,0.10)
HD CERTO SC + MTX		1.25 (0.29,5.96)	1.24 (0.30,5.59)	0.01 (‐0.04,0.09)
HD INF IV + MTX		2.46 (0.57,11.59)	2.35 (0.59,10.26)	0.03 (‐0.02,0.17)
HD TOCI IV + DMARD		5.23 (0.72,42.60)	4.67 (0.74,31.27)	0.09 (‐0.02,0.33)
SD CERTO SC + DMARD	SD ETN SC + DMARD	1.29 (0.37,5.39)	1.27 (0.39,4.66)	0.01 (‐0.05,0.13)
SD ADA SC + DMARD		1.74 (0.37,7.43)	1.67 (0.38,5.74)	0.03 (‐0.04,0.24)
SD TOCI SC + DMARD		3.92 (0.61,26.92)	3.35 (0.62,13.27)	0.12 (‐0.02,0.54)
LD ADA SC		0.28 (0.06,1.21)	0.29 (0.06,1.20)	‐0.03 (‐0.11,0.00)
LD ETN SC		1.00 (0.14,7.23)	1.00 (0.15,6.28)	0.00 (‐0.09,0.14)
LD TOCI IV		0.30 (0.04,2.21)	0.31 (0.05,2.15)	‐0.03 (‐0.12,0.03)
LD RITUX IV + MTX		0.80 (0.09,7.31)	0.81 (0.10,6.03)	‐0.01 (‐0.10,0.18)
LD ABA IV + MTX		0.54 (0.06,3.59)	0.55 (0.07,3.34)	‐0.02 (‐0.11,0.07)
LD CERTO SC + MTX		0.40 (0.04,3.56)	0.42 (0.05,3.26)	‐0.03 (‐0.11,0.07)
LD TOCI IV + MTX		0.21 (0.03,1.44)	0.22 (0.03,1.42)	‐0.03 (‐0.12,0.01)
HD TOCI IV		0.36 (0.07,1.92)	0.37 (0.08,1.87)	‐0.03 (‐0.11,0.02)
HD ADA SC		0.30 (0.07,1.24)	0.31 (0.08,1.23)	‐0.03 (‐0.11,0.01)
HD GOLI SC		0.25 (0.01,2.71)	0.26 (0.02,2.56)	‐0.03 (‐0.12,0.05)
HD TOCI IV + MTX		0.50 (0.10,2.74)	0.52 (0.11,2.62)	‐0.02 (‐0.11,0.04)
HD GOLI SC + MTX		0.68 (0.09,4.95)	0.69 (0.10,4.48)	‐0.01 (‐0.10,0.10)
HD TOFA PO + MTX		0.70 (0.10,4.95)	0.71 (0.11,4.42)	‐0.01 (‐0.10,0.10)
HD CERTO SC + MTX		0.65 (0.09,4.34)	0.66 (0.10,3.96)	‐0.01 (‐0.10,0.09)
HD INF IV + MTX		1.33 (0.17,7.96)	1.31 (0.19,6.75)	0.01 (‐0.08,0.17)
HD TOCI IV + DMARD		2.66 (0.92,7.61)	2.44 (0.92,5.92)	0.07 (0.00,0.27)
SD ADA SC + DMARD	SD CERTO SC + DMARD	1.37 (0.21,6.53)	1.34 (0.23,5.15)	0.02 (‐0.10,0.22)
SD TOCI SC + DMARD		3.06 (0.38,24.04)	2.65 (0.41,12.27)	0.10 (‐0.06,0.52)
LD ADA SC		0.22 (0.03,1.17)	0.24 (0.04,1.16)	‐0.05 (‐0.19,0.00)
LD ETN SC		0.79 (0.09,6.25)	0.80 (0.10,5.42)	‐0.01 (‐0.16,0.13)
LD TOCI IV		0.24 (0.03,1.83)	0.25 (0.03,1.79)	‐0.04 (‐0.19,0.02)
LD RITUX IV + MTX		0.65 (0.06,6.01)	0.67 (0.07,5.07)	‐0.02 (‐0.17,0.17)
LD ABA IV + MTX		0.44 (0.03,2.82)	0.45 (0.04,2.66)	‐0.03 (‐0.18,0.05)
LD CERTO SC + MTX		0.32 (0.02,2.84)	0.34 (0.02,2.66)	‐0.04 (‐0.18,0.06)
LD TOCI IV + MTX		0.16 (0.02,1.27)	0.17 (0.02,1.26)	‐0.05 (‐0.19,0.01)
HD TOCI IV		0.29 (0.04,1.48)	0.30 (0.05,1.46)	‐0.04 (‐0.19,0.01)
HD ADA SC		0.23 (0.04,1.26)	0.24 (0.05,1.25)	‐0.05 (‐0.19,0.01)
HD GOLI SC		0.19 (0.01,2.45)	0.20 (0.01,2.34)	‐0.04 (‐0.19,0.04)
HD TOCI IV + MTX		0.40 (0.05,2.30)	0.42 (0.06,2.21)	‐0.03 (‐0.18,0.03)
HD GOLI SC + MTX		0.54 (0.05,4.20)	0.56 (0.06,3.80)	‐0.02 (‐0.17,0.09)
HD TOFA PO + MTX		0.55 (0.05,3.76)	0.57 (0.07,3.37)	‐0.02 (‐0.17,0.09)
HD CERTO SC + MTX		0.53 (0.05,3.72)	0.55 (0.06,3.39)	‐0.02 (‐0.18,0.08)
HD INF IV + MTX		1.04 (0.09,6.44)	1.04 (0.10,5.55)	0.00 (‐0.16,0.15)
HD TOCI IV + DMARD		2.08 (0.52,7.65)	1.93 (0.55,6.07)	0.05 (‐0.06,0.25)
SD TOCI SC + DMARD	SD ADA SC + DMARD	2.19 (0.34,21.65)	1.94 (0.38,13.85)	0.07 (‐0.12,0.48)
LD ADA SC		0.16 (0.02,1.32)	0.17 (0.03,1.30)	‐0.06 (‐0.30,0.01)
LD ETN SC		0.58 (0.06,7.71)	0.61 (0.08,6.71)	‐0.03 (‐0.26,0.12)
LD TOCI IV		0.17 (0.02,2.21)	0.18 (0.02,2.15)	‐0.06 (‐0.30,0.03)
LD RITUX IV + MTX		0.44 (0.04,8.02)	0.47 (0.05,6.54)	‐0.04 (‐0.27,0.16)
LD ABA IV + MTX		0.30 (0.02,4.07)	0.32 (0.03,3.76)	‐0.05 (‐0.29,0.07)
LD CERTO SC + MTX		0.22 (0.01,3.43)	0.24 (0.02,3.20)	‐0.06 (‐0.29,0.05)
LD TOCI IV + MTX		0.12 (0.01,1.49)	0.13 (0.01,1.48)	‐0.07 (‐0.30,0.01)
HD TOCI IV		0.20 (0.03,2.11)	0.22 (0.03,2.07)	‐0.06 (‐0.29,0.02)
HD ADA SC		0.17 (0.03,1.29)	0.18 (0.03,1.28)	‐0.06 (‐0.30,0.01)
HD GOLI SC		0.13 (0.01,2.51)	0.15 (0.01,2.36)	‐0.06 (‐0.30,0.03)
HD TOCI IV + MTX		0.30 (0.03,2.85)	0.32 (0.05,2.73)	‐0.05 (‐0.29,0.04)
HD GOLI SC + MTX		0.38 (0.03,5.33)	0.40 (0.04,4.69)	‐0.04 (‐0.28,0.09)
HD TOFA PO + MTX		0.40 (0.04,5.84)	0.42 (0.05,5.16)	‐0.04 (‐0.28,0.09)
HD CERTO SC + MTX		0.36 (0.03,4.47)	0.38 (0.04,4.15)	‐0.05 (‐0.28,0.07)
HD INF IV + MTX		0.74 (0.06,8.95)	0.76 (0.08,7.46)	‐0.02 (‐0.26,0.16)
HD TOCI IV + DMARD		1.54 (0.40,6.56)	1.46 (0.47,5.47)	0.03 (‐0.13,0.20)
LD ADA SC	SD TOCI SC + DMARD	0.07 (0.01,0.80)	0.08 (0.01,0.81)	‐0.15 (‐0.59,‐0.01)
LD ETN SC		0.25 (0.02,3.29)	0.29 (0.04,2.99)	‐0.11 (‐0.57,0.09)
LD TOCI IV		0.07 (0.01,1.06)	0.09 (0.01,1.06)	‐0.15 (‐0.59,0.00)
LD RITUX IV + MTX		0.20 (0.01,3.64)	0.24 (0.03,3.22)	‐0.12 (‐0.57,0.11)
LD ABA IV + MTX		0.13 (0.01,2.02)	0.16 (0.02,1.92)	‐0.14 (‐0.58,0.04)
LD CERTO SC + MTX		0.09 (0.01,1.81)	0.12 (0.01,1.73)	‐0.14 (‐0.58,0.03)
LD TOCI IV + MTX		0.05 (0.00,0.82)	0.06 (0.01,0.83)	‐0.16 (‐0.60,‐0.01)
HD TOCI IV		0.08 (0.01,1.05)	0.10 (0.02,1.04)	‐0.15 (‐0.59,0.00)
HD ADA SC		0.07 (0.01,0.74)	0.09 (0.02,0.75)	‐0.15 (‐0.59,‐0.01)
HD GOLI SC		0.06 (0.00,1.19)	0.08 (0.00,1.18)	‐0.15 (‐0.59,0.01)
HD TOCI IV + MTX		0.12 (0.01,1.52)	0.15 (0.02,1.48)	‐0.14 (‐0.58,0.02)
HD GOLI SC + MTX		0.17 (0.01,2.41)	0.20 (0.03,2.28)	‐0.13 (‐0.57,0.05)
HD TOFA PO + MTX		0.17 (0.02,2.64)	0.20 (0.03,2.42)	‐0.13 (‐0.56,0.06)
HD CERTO SC + MTX		0.16 (0.01,2.27)	0.19 (0.03,2.13)	‐0.13 (‐0.57,0.05)
HD INF IV + MTX		0.31 (0.03,4.12)	0.36 (0.05,3.63)	‐0.10 (‐0.54,0.12)
HD TOCI IV + DMARD		0.69 (0.10,3.93)	0.73 (0.17,3.47)	‐0.04 (‐0.43,0.14)
LD ETN SC	LD ADA SC	3.55 (0.54,22.64)	3.41 (0.55,19.87)	0.03 (‐0.01,0.17)
LD TOCI IV		1.09 (0.15,7.77)	1.09 (0.16,7.44)	0.00 (‐0.03,0.05)
LD RITUX IV + MTX		2.66 (0.43,29.58)	2.59 (0.44,24.04)	0.02 (‐0.02,0.22)
LD ABA IV + MTX		1.90 (0.25,16.00)	1.87 (0.25,14.73)	0.01 (‐0.02,0.10)
LD CERTO SC + MTX		1.41 (0.15,13.12)	1.40 (0.15,12.07)	0.01 (‐0.02,0.10)
LD TOCI IV + MTX		0.73 (0.10,6.56)	0.73 (0.10,6.29)	0.00 (‐0.03,0.04)
HD TOCI IV		1.23 (0.29,8.12)	1.22 (0.29,7.76)	0.00 (‐0.02,0.04)
HD ADA SC		1.04 (0.28,4.33)	1.04 (0.28,4.24)	0.00 (‐0.02,0.03)
HD GOLI SC		0.83 (0.06,12.86)	0.83 (0.06,12.01)	0.00 (‐0.03,0.08)
HD TOCI IV + MTX		1.69 (0.38,11.29)	1.67 (0.39,10.64)	0.01 (‐0.02,0.07)
HD GOLI SC + MTX		2.41 (0.35,20.58)	2.36 (0.35,18.19)	0.02 (‐0.02,0.13)
HD TOFA PO + MTX		2.37 (0.42,25.52)	2.33 (0.43,22.58)	0.02 (‐0.01,0.14)
HD CERTO SC + MTX		2.19 (0.38,19.66)	2.15 (0.39,17.88)	0.02 (‐0.02,0.12)
HD INF IV + MTX		4.40 (0.73,36.52)	4.16 (0.74,30.80)	0.05 (‐0.01,0.20)
HD TOCI IV + DMARD		9.65 (1.66,55.55)	8.50 (1.63,41.19)	0.10 (0.01,0.34)
LD TOCI IV	LD ETN SC	0.31 (0.03,2.07)	0.32 (0.04,2.02)	‐0.03 (‐0.17,0.02)
LD RITUX IV + MTX		0.79 (0.10,8.70)	0.80 (0.11,7.21)	‐0.01 (‐0.14,0.18)
LD ABA IV + MTX		0.54 (0.06,4.59)	0.55 (0.07,4.33)	‐0.02 (‐0.15,0.07)
LD CERTO SC + MTX		0.41 (0.04,3.60)	0.43 (0.04,3.32)	‐0.02 (‐0.15,0.06)
LD TOCI IV + MTX		0.21 (0.02,2.05)	0.22 (0.03,2.01)	‐0.04 (‐0.17,0.02)
HD TOCI IV		0.36 (0.06,2.20)	0.38 (0.07,2.17)	‐0.03 (‐0.16,0.02)
HD ADA SC		0.30 (0.04,2.09)	0.31 (0.05,2.05)	‐0.03 (‐0.17,0.01)
HD GOLI SC		0.24 (0.01,2.81)	0.26 (0.02,2.68)	‐0.03 (‐0.16,0.04)
HD TOCI IV + MTX		0.52 (0.08,3.07)	0.53 (0.09,2.95)	‐0.02 (‐0.16,0.04)
HD GOLI SC + MTX		0.67 (0.09,6.12)	0.68 (0.10,5.53)	‐0.01 (‐0.14,0.10)
HD TOFA PO + MTX		0.71 (0.09,6.08)	0.72 (0.11,5.57)	‐0.01 (‐0.14,0.10)
HD CERTO SC + MTX		0.64 (0.10,5.01)	0.65 (0.11,4.62)	‐0.01 (‐0.14,0.09)
HD INF IV + MTX		1.28 (0.18,8.98)	1.26 (0.21,7.63)	0.01 (‐0.12,0.16)
HD TOCI IV + DMARD		2.58 (0.27,22.63)	2.38 (0.30,16.75)	0.06 (‐0.10,0.31)
LD RITUX IV + MTX	LD TOCI IV	2.54 (0.49,21.10)	2.46 (0.50,18.63)	0.02 (‐0.02,0.19)
LD ABA IV + MTX		1.75 (0.34,10.05)	1.72 (0.35,9.37)	0.01 (‐0.02,0.08)
LD CERTO SC + MTX		1.30 (0.18,9.93)	1.30 (0.19,9.41)	0.00 (‐0.03,0.08)
LD TOCI IV + MTX		0.71 (0.11,3.93)	0.72 (0.11,3.86)	0.00 (‐0.04,0.03)
HD TOCI IV		1.18 (0.38,4.93)	1.18 (0.39,4.86)	0.00 (‐0.03,0.03)
HD ADA SC		0.99 (0.15,6.59)	0.99 (0.15,6.46)	0.00 (‐0.05,0.03)
HD GOLI SC		0.80 (0.07,6.92)	0.80 (0.07,6.65)	0.00 (‐0.04,0.06)
HD TOCI IV + MTX		1.66 (0.50,6.99)	1.64 (0.51,6.77)	0.01 (‐0.02,0.05)
HD GOLI SC + MTX		2.23 (0.51,12.84)	2.17 (0.52,11.56)	0.02 (‐0.01,0.11)
HD TOFA PO + MTX		2.26 (0.52,13.28)	2.21 (0.53,11.95)	0.02 (‐0.02,0.12)
HD CERTO SC + MTX		2.13 (0.48,11.19)	2.08 (0.49,10.39)	0.01 (‐0.02,0.10)
HD INF IV + MTX		4.12 (0.94,22.44)	3.90 (0.94,20.02)	0.04 (0.00,0.18)
HD TOCI IV + DMARD		9.02 (0.98,83.30)	7.89 (0.98,60.86)	0.10 (0.00,0.34)
LD ABA IV + MTX	LD RITUX IV + MTX	0.67 (0.11,3.36)	0.68 (0.12,3.21)	‐0.01 (‐0.15,0.05)
LD CERTO SC + MTX		0.50 (0.05,3.42)	0.52 (0.06,3.28)	‐0.02 (‐0.17,0.05)
LD TOCI IV + MTX		0.27 (0.03,1.61)	0.28 (0.04,1.60)	‐0.03 (‐0.19,0.01)
HD TOCI IV		0.45 (0.09,1.82)	0.46 (0.11,1.80)	‐0.02 (‐0.18,0.01)
HD ADA SC		0.38 (0.04,2.46)	0.39 (0.05,2.42)	‐0.02 (‐0.21,0.02)
HD GOLI SC		0.31 (0.02,2.34)	0.32 (0.03,2.23)	‐0.02 (‐0.19,0.03)
HD TOCI IV + MTX		0.61 (0.13,2.72)	0.63 (0.14,2.66)	‐0.01 (‐0.17,0.03)
HD GOLI SC + MTX		0.85 (0.15,4.06)	0.86 (0.17,3.81)	0.00 (‐0.14,0.07)
HD TOFA PO + MTX		0.85 (0.17,4.17)	0.86 (0.19,3.94)	0.00 (‐0.12,0.06)
HD CERTO SC + MTX		0.81 (0.16,3.57)	0.82 (0.18,3.39)	‐0.01 (‐0.14,0.06)
HD INF IV + MTX		1.58 (0.31,7.33)	1.54 (0.35,6.63)	0.02 (‐0.10,0.13)
HD TOCI IV + DMARD		3.45 (0.31,36.59)	3.11 (0.36,26.63)	0.07 (‐0.12,0.32)
LD CERTO SC + MTX	LD ABA IV + MTX	0.77 (0.09,4.51)	0.78 (0.10,4.25)	0.00 (‐0.08,0.06)
LD TOCI IV + MTX		0.41 (0.05,2.61)	0.42 (0.06,2.56)	‐0.01 (‐0.09,0.02)
HD TOCI IV		0.68 (0.20,2.62)	0.69 (0.21,2.60)	‐0.01 (‐0.08,0.02)
HD ADA SC		0.54 (0.08,4.28)	0.55 (0.09,4.16)	‐0.01 (‐0.10,0.02)
HD GOLI SC		0.46 (0.04,3.35)	0.47 (0.04,3.17)	‐0.01 (‐0.09,0.05)
HD TOCI IV + MTX		0.93 (0.25,3.85)	0.93 (0.27,3.73)	0.00 (‐0.07,0.04)
HD GOLI SC + MTX		1.27 (0.32,5.68)	1.26 (0.34,5.22)	0.01 (‐0.05,0.09)
HD TOFA PO + MTX		1.33 (0.35,5.24)	1.31 (0.36,4.90)	0.01 (‐0.05,0.09)
HD CERTO SC + MTX		1.22 (0.31,4.90)	1.21 (0.33,4.62)	0.00 (‐0.05,0.08)
HD INF IV + MTX		2.40 (0.63,8.96)	2.29 (0.65,8.15)	0.03 (‐0.02,0.15)
HD TOCI IV + DMARD		4.92 (0.56,58.39)	4.40 (0.58,42.34)	0.09 (‐0.03,0.33)
LD TOCI IV + MTX	LD CERTO SC + MTX	0.54 (0.06,4.77)	0.55 (0.07,4.66)	‐0.01 (‐0.09,0.03)
HD TOCI IV		0.91 (0.18,5.50)	0.91 (0.19,5.39)	0.00 (‐0.08,0.02)
HD ADA SC		0.74 (0.08,6.79)	0.75 (0.09,6.66)	0.00 (‐0.10,0.03)
HD GOLI SC		0.62 (0.04,5.52)	0.63 (0.04,5.25)	‐0.01 (‐0.08,0.05)
HD TOCI IV + MTX		1.24 (0.23,8.46)	1.23 (0.25,8.19)	0.00 (‐0.07,0.04)
HD GOLI SC + MTX		1.66 (0.31,13.02)	1.63 (0.33,12.31)	0.01 (‐0.05,0.10)
HD TOFA PO + MTX		1.71 (0.32,13.32)	1.68 (0.34,11.98)	0.01 (‐0.05,0.10)
HD CERTO SC + MTX		1.57 (0.38,8.66)	1.55 (0.39,8.27)	0.01 (‐0.04,0.08)
HD INF IV + MTX		3.24 (0.61,21.17)	3.06 (0.63,19.24)	0.04 (‐0.02,0.17)
HD TOCI IV + DMARD		6.84 (0.65,88.72)	6.04 (0.67,65.43)	0.09 (‐0.03,0.34)
HD TOCI IV	LD TOCI IV + MTX	1.64 (0.43,8.55)	1.62 (0.44,8.34)	0.01 (‐0.02,0.03)
HD ADA SC		1.35 (0.21,10.50)	1.34 (0.22,10.18)	0.00 (‐0.04,0.03)
HD GOLI SC		1.11 (0.09,12.12)	1.11 (0.09,11.47)	0.00 (‐0.03,0.07)
HD TOCI IV + MTX		2.29 (0.57,13.30)	2.26 (0.58,12.88)	0.01 (‐0.01,0.06)
HD GOLI SC + MTX		3.20 (0.52,25.25)	3.10 (0.53,22.96)	0.02 (‐0.01,0.12)
HD TOFA PO + MTX		3.19 (0.55,22.26)	3.09 (0.56,20.61)	0.02 (‐0.01,0.13)
HD CERTO SC + MTX		2.98 (0.54,23.00)	2.91 (0.55,21.48)	0.02 (‐0.01,0.11)
HD INF IV + MTX		5.91 (1.03,40.58)	5.53 (1.03,35.84)	0.05 (0.00,0.19)
HD TOCI IV + DMARD		12.37 (1.61,104.90)	10.84 (1.58,78.96)	0.10 (0.01,0.35)
HD ADA SC	HD TOCI IV	0.83 (0.17,3.61)	0.83 (0.17,3.53)	0.00 (‐0.04,0.03)
HD GOLI SC		0.66 (0.07,4.19)	0.66 (0.07,3.90)	‐0.01 (‐0.03,0.06)
HD TOCI IV + MTX		1.39 (0.64,2.92)	1.37 (0.65,2.86)	0.01 (‐0.01,0.04)
HD GOLI SC + MTX		1.86 (0.60,6.64)	1.83 (0.61,5.79)	0.01 (‐0.01,0.11)
HD TOFA PO + MTX		1.96 (0.62,6.46)	1.92 (0.63,5.86)	0.02 (‐0.01,0.11)
HD CERTO SC + MTX		1.77 (0.58,5.60)	1.74 (0.59,5.16)	0.01 (‐0.01,0.09)
HD INF IV + MTX		3.51 (1.17,10.94)	3.33 (1.17,9.37)	0.04 (0.00,0.18)
HD TOCI IV + DMARD		7.28 (1.06,52.01)	6.47 (1.06,36.95)	0.10 (0.00,0.34)
HD GOLI SC	HD ADA SC	0.79 (0.05,8.97)	0.79 (0.06,8.35)	0.00 (‐0.03,0.08)
HD TOCI IV + MTX		1.66 (0.34,8.86)	1.64 (0.35,8.37)	0.01 (‐0.02,0.06)
HD GOLI SC + MTX		2.37 (0.35,15.50)	2.31 (0.35,13.80)	0.02 (‐0.02,0.13)
HD TOFA PO + MTX		2.33 (0.38,17.76)	2.28 (0.39,15.68)	0.02 (‐0.02,0.13)
HD CERTO SC + MTX		2.14 (0.35,14.86)	2.10 (0.35,13.44)	0.01 (‐0.02,0.11)
HD INF IV + MTX		4.42 (0.67,26.42)	4.17 (0.68,22.23)	0.05 (‐0.01,0.20)
HD TOCI IV + DMARD		9.33 (1.63,49.48)	8.25 (1.60,35.54)	0.10 (0.01,0.34)
HD TOCI IV + MTX	HD GOLI SC	2.12 (0.32,21.15)	2.09 (0.34,20.51)	0.01 (‐0.05,0.05)
HD GOLI SC + MTX		2.69 (0.59,24.71)	2.60 (0.60,23.79)	0.02 (‐0.02,0.10)
HD TOFA PO + MTX		2.94 (0.38,37.19)	2.85 (0.41,34.95)	0.02 (‐0.04,0.11)
HD CERTO SC + MTX		2.63 (0.43,27.76)	2.57 (0.45,26.47)	0.02 (‐0.03,0.09)
HD INF IV + MTX		5.22 (0.76,61.62)	4.89 (0.77,56.54)	0.04 (‐0.01,0.18)
HD TOCI IV + DMARD		10.78 (0.86,228.60)	9.41 (0.87,171.10)	0.10 (‐0.01,0.34)
HD GOLI SC + MTX	HD TOCI IV + MTX	1.38 (0.39,5.21)	1.37 (0.40,4.67)	0.01 (‐0.03,0.10)
HD TOFA PO + MTX		1.39 (0.40,5.14)	1.38 (0.41,4.60)	0.01 (‐0.03,0.10)
HD CERTO SC + MTX		1.30 (0.35,4.44)	1.29 (0.36,4.08)	0.01 (‐0.03,0.08)
HD INF IV + MTX		2.60 (0.72,8.87)	2.49 (0.73,7.77)	0.04 (‐0.01,0.17)
HD TOCI IV + DMARD		5.27 (0.75,37.47)	4.71 (0.76,26.81)	0.09 (‐0.02,0.33)
HD TOFA PO + MTX	HD GOLI SC + MTX	1.04 (0.26,3.64)	1.04 (0.28,3.43)	0.00 (‐0.08,0.07)
HD CERTO SC + MTX		0.97 (0.24,3.38)	0.97 (0.26,3.22)	0.00 (‐0.08,0.06)
HD INF IV + MTX		1.90 (0.44,6.86)	1.84 (0.47,6.16)	0.02 (‐0.05,0.14)
HD TOCI IV + DMARD		3.96 (0.40,39.07)	3.58 (0.44,28.51)	0.08 (‐0.06,0.32)
HD CERTO SC + MTX	HD TOFA PO + MTX	0.91 (0.26,3.43)	0.92 (0.27,3.24)	0.00 (‐0.07,0.06)
HD INF IV + MTX		1.82 (0.52,6.26)	1.76 (0.54,5.62)	0.02 (‐0.04,0.14)
HD TOCI IV + DMARD		3.85 (0.42,36.87)	3.47 (0.46,26.58)	0.08 (‐0.07,0.32)
HD INF IV + MTX	HD CERTO SC + MTX	2.00 (0.55,6.87)	1.92 (0.56,6.22)	0.03 (‐0.03,0.14)
HD TOCI IV + DMARD		4.22 (0.52,38.97)	3.79 (0.54,28.18)	0.08 (‐0.05,0.33)
HD TOCI IV + DMARD	HD INF IV + MTX	2.01 (0.26,22.03)	1.88 (0.30,16.07)	0.05 (‐0.13,0.30)
Random‐Effect Model	Residual Deviance	128 vs 132 data points
	Deviance Information Criteria	641.601
Fixed‐Effect Model	Residual Deviance	131 vs 132 data points
	Deviance Information Criteria	641.171
Note:
Total Patients	20850
Total Studies	52
2‐arm	34
3‐arm	11
4‐arm	6
7‐arm	1