SAEs Analysis 4 : Odds Ratios, Risk Ratios and Risk Difference for All Treatment Comparisons‐Random Effects Model
Treatment	Reference	OR (95% CrI)	RR (95% CrI)	RD % (95% Crl)
SD	PL	1.28 (0.96,1.75)	1.26 (0.96,1.68)	0.01 (0.00,0.04)
HD		1.21 (0.85,1.72)	1.20 (0.86,1.66)	0.01 (‐0.01,0.04)
LD		1.00 (0.60,1.61)	1.00 (0.62,1.56)	0.00 (‐0.02,0.03)
MTXSD		1.11 (0.95,1.28)	1.10 (0.96,1.27)	0.01 (0.00,0.01)
MTXLD		1.09 (0.81,1.47)	1.08 (0.81,1.43)	0.00 (‐0.01,0.02)
MTXHD		1.33 (1.02,1.74)	1.30 (1.02,1.68)	0.02 (0.00,0.04)
HD	SD	0.94 (0.62,1.44)	0.95 (0.64,1.40)	0.00 (‐0.03,0.02)
LD		0.78 (0.47,1.28)	0.79 (0.49,1.26)	‐0.01 (‐0.04,0.02)
MTXSD		0.86 (0.63,1.16)	0.87 (0.65,1.15)	‐0.01 (‐0.03,0.01)
MTXLD		0.85 (0.57,1.26)	0.86 (0.59,1.24)	‐0.01 (‐0.03,0.01)
MTXHD		1.03 (0.71,1.52)	1.03 (0.72,1.47)	0.00 (‐0.02,0.03)
LD	HD	0.82 (0.47,1.43)	0.83 (0.49,1.39)	‐0.01 (‐0.04,0.02)
MTXSD		0.91 (0.63,1.32)	0.92 (0.66,1.30)	‐0.01 (‐0.03,0.01)
MTXLD		0.90 (0.57,1.40)	0.90 (0.59,1.37)	‐0.01 (‐0.03,0.02)
MTXHD		1.10 (0.73,1.65)	1.09 (0.75,1.60)	0.01 (‐0.02,0.03)
MTXSD	LD	1.11 (0.68,1.83)	1.10 (0.70,1.78)	0.01 (‐0.03,0.03)
MTXLD		1.09 (0.62,1.93)	1.09 (0.64,1.87)	0.00 (‐0.03,0.03)
MTXHD		1.33 (0.78,2.32)	1.31 (0.79,2.22)	0.02 (‐0.02,0.05)
MTXLD	MTXSD	0.98 (0.73,1.33)	0.99 (0.74,1.31)	0.00 (‐0.02,0.02)
MTXHD		1.20 (0.91,1.59)	1.19 (0.91,1.54)	0.01 (‐0.01,0.03)
MTXHD	MTXLD	1.22 (0.83,1.80)	1.21 (0.84,1.73)	0.01 (‐0.01,0.04)
Random‐Effect Model	Residual Deviance	137.2 vs 131 data points
	Deviance Information Criteria	692.326
Fixed‐Effect Model	Residual Deviance	143.1 vs 131 data points
	Deviance Information Criteria	691.715
Note:
Total Patients	22337
Total Studies	53
2‐arm	35
3‐arm	12
4‐arm	5
5‐arm	1