SAEs (Analysis 1): Odds Ratios, Risk Ratios and Risk Difference for All Treatment Comparisons‐Random Effects Model
Treatment	Reference	OR (95% CrI)	RR (95% CrI)	RD % (95% Crl)
MTX	PL	1.32 (0.38,6.19)	1.30 (0.39,5.23)	0.01 (‐0.03,0.15)
DMARD		0.63 (0.20,2.49)	0.63 (0.21,2.37)	‐0.01 (‐0.04,0.05)
MTX + DMARD		0.74 (0.14,4.06)	0.75 (0.14,3.67)	‐0.01 (‐0.04,0.09)
SD ETN SC		1.55 (0.50,6.08)	1.52 (0.51,5.18)	0.02 (‐0.02,0.14)
SD ADA SC		1.08 (0.66,1.94)	1.08 (0.67,1.88)	0.00 (‐0.01,0.03)
SD TOCI IV		1.22 (0.47,3.38)	1.21 (0.48,3.10)	0.01 (‐0.02,0.08)
SD TOFA PO		0.38 (0.15,0.93)	0.39 (0.15,0.94)	‐0.02 (‐0.04,0.00)
SD TOCI SC		1.07 (0.33,3.70)	1.07 (0.34,3.39)	0.00 (‐0.03,0.09)
SD CERTO SC		4.67 (1.33,19.91)	4.11 (1.31,12.87)	0.11 (0.01,0.35)
SD GOLI IV		1.46 (0.17,14.63)	1.43 (0.18,9.91)	0.01 (‐0.03,0.32)
SD RITUX IV		0.55 (0.07,5.11)	0.56 (0.07,4.50)	‐0.01 (‐0.04,0.13)
SD INF IV + MTX		1.16 (0.31,5.32)	1.15 (0.32,4.67)	0.01 (‐0.03,0.13)
SD ETN SC + MTX		1.28 (0.34,5.50)	1.27 (0.35,4.80)	0.01 (‐0.03,0.14)
SD ADA SC + MTX		1.20 (0.34,5.99)	1.19 (0.35,5.12)	0.01 (‐0.03,0.14)
SD ABA IV + MTX		1.07 (0.30,4.66)	1.06 (0.30,4.17)	0.00 (‐0.03,0.11)
SD RITUX IV + MTX		1.43 (0.37,7.39)	1.40 (0.38,6.09)	0.01 (‐0.03,0.17)
SD ABA SC + MTX		0.89 (0.24,4.28)	0.89 (0.25,3.87)	0.00 (‐0.03,0.10)
SD GOLI SC + MTX		2.75 (0.52,20.39)	2.58 (0.53,12.10)	0.06 (‐0.02,0.39)
SD CERTO SC + MTX		2.02 (0.54,11.76)	1.94 (0.55,8.55)	0.03 (‐0.02,0.26)
SD TOFA PO + MTX		2.59 (0.63,14.30)	2.44 (0.64,9.80)	0.05 (‐0.01,0.31)
SD GOLI IV + MTX		4.39 (0.59,34.27)	3.89 (0.60,16.03)	0.10 (‐0.01,0.53)
SD ANA SC + MTX		1.80 (0.35,12.98)	1.75 (0.36,9.03)	0.03 (‐0.02,0.28)
SD ETN SC + DMARD		1.28 (0.44,4.62)	1.26 (0.45,4.11)	0.01 (‐0.02,0.10)
SD ABA IV + DMARD		0.67 (0.18,2.94)	0.68 (0.19,2.77)	‐0.01 (‐0.04,0.06)
SD ADA SC + DMARD		0.45 (0.10,2.35)	0.46 (0.11,2.25)	‐0.02 (‐0.04,0.04)
SD ANA + DMARD		0.64 (0.17,2.85)	0.65 (0.17,2.67)	‐0.01 (‐0.04,0.06)
SD CERTO SC + DMARD		0.44 (0.08,2.73)	0.45 (0.08,2.57)	‐0.02 (‐0.04,0.06)
SD TOCI SC + DMARD		0.81 (0.18,4.36)	0.81 (0.19,3.89)	‐0.01 (‐0.04,0.10)
LD ADA SC		0.64 (0.30,1.38)	0.65 (0.30,1.36)	‐0.01 (‐0.03,0.01)
LD ETN SC		0.99 (0.21,5.85)	0.99 (0.22,5.04)	0.00 (‐0.04,0.14)
LD GOLI IV		6.90 (1.23,55.27)	5.64 (1.22,19.92)	0.17 (0.01,0.64)
LD RITUX IV + MTX		1.23 (0.31,6.12)	1.22 (0.31,5.22)	0.01 (‐0.03,0.15)
LD ABA IV + MTX		1.67 (0.38,8.47)	1.63 (0.39,6.78)	0.02 (‐0.02,0.20)
LD CERTO SC + MTX		2.27 (0.26,18.03)	2.16 (0.26,11.59)	0.04 (‐0.03,0.36)
LD ETN SC + MTX		0.64 (0.13,3.60)	0.65 (0.13,3.31)	‐0.01 (‐0.04,0.08)
LD GOLI IV + MTX		3.95 (0.66,32.35)	3.55 (0.67,15.74)	0.09 (‐0.01,0.51)
HD TOCI IV		1.24 (0.34,5.83)	1.23 (0.35,5.01)	0.01 (‐0.03,0.14)
HD TOFA PO		0.52 (0.23,1.24)	0.53 (0.24,1.23)	‐0.02 (‐0.04,0.01)
HD GOLI SC		1.78 (0.34,12.98)	1.73 (0.35,9.30)	0.03 (‐0.03,0.28)
HD ADA SC		0.96 (0.48,2.09)	0.96 (0.49,2.02)	0.00 (‐0.02,0.03)
HD GOLI SC + MTX		3.85 (0.63,25.39)	3.49 (0.64,14.17)	0.09 (‐0.01,0.44)
HD TOCI IV + MTX		1.44 (0.34,7.89)	1.42 (0.35,6.47)	0.01 (‐0.03,0.19)
HD TOFA PO + MTX		2.11 (0.52,12.09)	2.02 (0.53,8.78)	0.04 (‐0.02,0.27)
HD INF IV + MTX		1.37 (0.35,6.87)	1.36 (0.35,5.76)	0.01 (‐0.03,0.17)
HD CERTO SC + MTX		2.54 (0.59,16.81)	2.40 (0.60,10.92)	0.05 (‐0.02,0.34)
HD TOCI IV + DMARD		0.95 (0.27,3.95)	0.96 (0.28,3.57)	0.00 (‐0.03,0.09)
DMARD	MTX	0.46 (0.20,1.02)	0.47 (0.22,1.02)	‐0.02 (‐0.12,0.00)
MTX + DMARD		0.55 (0.14,1.81)	0.57 (0.15,1.76)	‐0.02 (‐0.12,0.03)
SD ETN SC		1.14 (0.58,2.31)	1.13 (0.60,2.23)	0.01 (‐0.05,0.05)
SD ADA SC		0.82 (0.19,2.78)	0.82 (0.22,2.69)	‐0.01 (‐0.14,0.03)
SD TOCI IV		0.88 (0.19,4.16)	0.88 (0.21,3.92)	‐0.01 (‐0.13,0.06)
SD TOFA PO		0.29 (0.05,1.22)	0.30 (0.06,1.22)	‐0.03 (‐0.17,0.00)
SD TOCI SC		0.77 (0.14,4.64)	0.78 (0.16,4.27)	‐0.01 (‐0.13,0.08)
SD CERTO SC		3.34 (0.45,28.48)	2.98 (0.49,19.53)	0.09 (‐0.07,0.34)
SD GOLI IV		1.04 (0.13,7.94)	1.04 (0.14,6.09)	0.00 (‐0.09,0.25)
SD RITUX IV		0.42 (0.07,1.90)	0.44 (0.08,1.80)	‐0.02 (‐0.11,0.05)
SD INF IV + MTX		0.89 (0.55,1.34)	0.89 (0.57,1.31)	0.00 (‐0.04,0.02)
SD ETN SC + MTX		0.97 (0.43,1.95)	0.97 (0.46,1.86)	0.00 (‐0.06,0.05)
SD ADA SC + MTX		0.92 (0.48,1.67)	0.92 (0.50,1.61)	0.00 (‐0.05,0.04)
SD ABA IV + MTX		0.80 (0.51,1.20)	0.81 (0.53,1.19)	‐0.01 (‐0.05,0.01)
SD RITUX IV + MTX		1.05 (0.65,1.79)	1.05 (0.66,1.70)	0.00 (‐0.03,0.05)
SD ABA SC + MTX		0.68 (0.36,1.20)	0.69 (0.37,1.18)	‐0.01 (‐0.07,0.01)
SD GOLI SC + MTX		1.99 (0.68,6.54)	1.87 (0.69,5.14)	0.04 (‐0.02,0.28)
SD CERTO SC + MTX		1.55 (0.91,2.73)	1.50 (0.91,2.47)	0.02 (0.00,0.13)
SD TOFA PO + MTX		1.93 (0.88,4.43)	1.83 (0.89,3.79)	0.04 (‐0.01,0.20)
SD GOLI IV + MTX		3.06 (0.54,19.59)	2.68 (0.55,12.28)	0.08 (‐0.03,0.45)
SD ANA SC + MTX		1.32 (0.45,4.19)	1.30 (0.46,3.53)	0.01 (‐0.04,0.18)
SD ETN SC + DMARD		0.93 (0.39,2.13)	0.94 (0.42,2.07)	0.00 (‐0.08,0.04)
SD ABA IV + DMARD		0.49 (0.18,1.33)	0.51 (0.19,1.31)	‐0.02 (‐0.12,0.01)
SD ADA SC + DMARD		0.33 (0.09,1.06)	0.34 (0.10,1.06)	‐0.03 (‐0.13,0.00)
SD ANA + DMARD		0.47 (0.15,1.31)	0.48 (0.16,1.29)	‐0.02 (‐0.12,0.01)
SD CERTO SC + DMARD		0.32 (0.06,1.43)	0.33 (0.07,1.40)	‐0.03 (‐0.14,0.02)
SD TOCI SC + DMARD		0.61 (0.16,2.08)	0.62 (0.17,1.99)	‐0.02 (‐0.11,0.05)
LD ADA SC		0.46 (0.09,2.07)	0.48 (0.11,2.04)	‐0.02 (‐0.16,0.02)
LD ETN SC		0.75 (0.28,2.04)	0.76 (0.30,1.93)	‐0.01 (‐0.08,0.05)
LD GOLI IV		5.07 (0.99,30.48)	3.97 (0.99,15.67)	0.15 (0.00,0.57)
LD RITUX IV + MTX		0.90 (0.55,1.57)	0.91 (0.56,1.52)	0.00 (‐0.04,0.04)
LD ABA IV + MTX		1.23 (0.56,2.58)	1.21 (0.58,2.38)	0.01 (‐0.03,0.10)
LD CERTO SC + MTX		1.57 (0.36,6.28)	1.51 (0.37,4.91)	0.02 (‐0.05,0.27)
LD ETN SC + MTX		0.48 (0.16,1.34)	0.49 (0.17,1.31)	‐0.02 (‐0.10,0.01)
LD GOLI IV + MTX		2.88 (0.52,16.55)	2.56 (0.54,11.00)	0.07 (‐0.03,0.43)
HD TOCI IV		0.91 (0.44,1.90)	0.91 (0.46,1.82)	0.00 (‐0.06,0.05)
HD TOFA PO		0.39 (0.07,1.82)	0.41 (0.08,1.80)	‐0.03 (‐0.17,0.01)
HD GOLI SC		1.30 (0.36,4.60)	1.28 (0.37,3.89)	0.01 (‐0.05,0.19)
HD ADA SC		0.73 (0.16,2.78)	0.74 (0.18,2.69)	‐0.01 (‐0.14,0.03)
HD GOLI SC + MTX		2.77 (0.98,8.62)	2.48 (0.99,6.04)	0.07 (0.00,0.34)
HD TOCI IV + MTX		1.04 (0.41,2.80)	1.04 (0.43,2.56)	0.00 (‐0.05,0.10)
HD TOFA PO + MTX		1.62 (0.71,3.71)	1.56 (0.73,3.23)	0.02 (‐0.02,0.16)
HD INF IV + MTX		1.03 (0.59,1.77)	1.03 (0.60,1.68)	0.00 (‐0.03,0.05)
HD CERTO SC + MTX		1.90 (0.89,4.37)	1.80 (0.90,3.55)	0.04 (0.00,0.22)
HD TOCI IV + DMARD		0.69 (0.26,1.84)	0.71 (0.28,1.79)	‐0.01 (‐0.10,0.03)
MTX + DMARD	DMARD	1.23 (0.26,4.52)	1.23 (0.27,4.20)	0.00 (‐0.03,0.08)
SD ETN SC		2.47 (1.21,5.34)	2.38 (1.20,4.94)	0.03 (0.01,0.11)
SD ADA SC		1.75 (0.48,5.24)	1.72 (0.50,5.03)	0.02 (‐0.04,0.05)
SD TOCI IV		1.88 (0.43,7.81)	1.83 (0.45,7.34)	0.02 (‐0.04,0.09)
SD TOFA PO		0.61 (0.11,2.37)	0.62 (0.12,2.34)	‐0.01 (‐0.07,0.01)
SD TOCI SC		1.67 (0.34,8.83)	1.64 (0.35,8.08)	0.01 (‐0.04,0.10)
SD CERTO SC		7.36 (1.10,47.68)	6.36 (1.09,33.14)	0.12 (0.00,0.36)
SD GOLI IV		2.34 (0.26,17.59)	2.25 (0.27,13.34)	0.03 (‐0.03,0.31)
SD RITUX IV		0.93 (0.13,5.38)	0.93 (0.13,4.80)	0.00 (‐0.04,0.12)
SD INF IV + MTX		1.91 (0.78,4.86)	1.87 (0.79,4.43)	0.02 (‐0.01,0.11)
SD ETN SC + MTX		2.10 (0.75,5.64)	2.04 (0.76,5.14)	0.02 (‐0.01,0.12)
SD ADA SC + MTX		1.97 (0.74,5.38)	1.92 (0.75,4.85)	0.02 (‐0.01,0.12)
SD ABA IV + MTX		1.73 (0.72,4.31)	1.69 (0.73,4.00)	0.01 (‐0.01,0.09)
SD RITUX IV + MTX		2.27 (0.89,6.25)	2.19 (0.90,5.56)	0.03 (0.00,0.15)
SD ABA SC + MTX		1.47 (0.55,3.88)	1.45 (0.56,3.61)	0.01 (‐0.02,0.08)
SD GOLI SC + MTX		4.31 (1.18,18.62)	3.93 (1.17,13.56)	0.07 (0.00,0.37)
SD CERTO SC + MTX		3.40 (1.24,9.31)	3.18 (1.23,7.77)	0.05 (0.00,0.23)
SD TOFA PO + MTX		4.19 (1.43,12.67)	3.83 (1.41,10.16)	0.06 (0.01,0.29)
SD GOLI IV + MTX		6.65 (1.04,48.72)	5.71 (1.04,29.61)	0.11 (0.00,0.52)
SD ANA SC + MTX		2.83 (0.75,12.17)	2.70 (0.76,9.57)	0.04 (‐0.01,0.27)
SD ETN SC + DMARD		2.01 (1.07,3.92)	1.95 (1.07,3.73)	0.02 (0.00,0.08)
SD ABA IV + DMARD		1.06 (0.58,1.94)	1.06 (0.59,1.88)	0.00 (‐0.02,0.03)
SD ADA SC + DMARD		0.70 (0.30,1.67)	0.70 (0.31,1.64)	‐0.01 (‐0.03,0.02)
SD ANA + DMARD		1.00 (0.50,2.08)	1.00 (0.50,2.00)	0.00 (‐0.02,0.03)
SD CERTO SC + DMARD		0.69 (0.18,2.56)	0.69 (0.18,2.44)	‐0.01 (‐0.04,0.04)
SD TOCI SC + DMARD		1.28 (0.48,3.49)	1.27 (0.49,3.26)	0.01 (‐0.02,0.08)
LD ADA SC		1.00 (0.22,3.79)	1.00 (0.24,3.68)	0.00 (‐0.06,0.03)
LD ETN SC		1.61 (0.52,5.00)	1.58 (0.53,4.49)	0.01 (‐0.02,0.12)
LD GOLI IV		10.93 (1.79,72.89)	8.52 (1.74,36.66)	0.18 (0.02,0.63)
LD RITUX IV + MTX		1.93 (0.77,5.40)	1.88 (0.77,4.86)	0.02 (‐0.01,0.12)
LD ABA IV + MTX		2.66 (0.90,8.38)	2.54 (0.90,7.24)	0.03 (0.00,0.18)
LD CERTO SC + MTX		3.33 (0.61,18.14)	3.11 (0.61,12.90)	0.05 (‐0.01,0.34)
LD ETN SC + MTX		1.05 (0.27,3.72)	1.05 (0.28,3.53)	0.00 (‐0.03,0.07)
LD GOLI IV + MTX		6.26 (0.97,42.72)	5.46 (0.97,25.22)	0.10 (0.00,0.50)
HD TOCI IV		1.95 (1.00,4.21)	1.90 (1.00,3.89)	0.02 (0.00,0.11)
HD TOFA PO		0.83 (0.18,3.68)	0.83 (0.19,3.60)	0.00 (‐0.06,0.02)
HD GOLI SC		2.76 (0.71,12.48)	2.62 (0.72,9.84)	0.04 (‐0.01,0.26)
HD ADA SC		1.56 (0.38,5.47)	1.54 (0.40,5.21)	0.01 (‐0.04,0.05)
HD GOLI SC + MTX		6.03 (1.61,24.27)	5.27 (1.58,16.49)	0.10 (0.01,0.42)
HD TOCI IV + MTX		2.25 (0.85,6.67)	2.18 (0.85,5.70)	0.03 (0.00,0.16)
HD TOFA PO + MTX		3.49 (1.15,10.74)	3.26 (1.14,8.78)	0.05 (0.00,0.25)
HD INF IV + MTX		2.21 (0.84,6.17)	2.14 (0.84,5.57)	0.02 (0.00,0.14)
HD CERTO SC + MTX		4.14 (1.31,13.83)	3.79 (1.30,10.42)	0.06 (0.01,0.32)
HD TOCI IV + DMARD		1.51 (0.87,2.64)	1.49 (0.88,2.52)	0.01 (0.00,0.06)
SD ETN SC	MTX + DMARD	2.07 (0.61,8.51)	1.99 (0.63,7.91)	0.02 (‐0.03,0.11)
SD ADA SC		1.45 (0.29,7.77)	1.44 (0.32,7.46)	0.01 (‐0.09,0.05)
SD TOCI IV		1.62 (0.28,9.88)	1.59 (0.30,9.28)	0.01 (‐0.08,0.08)
SD TOFA PO		0.51 (0.07,3.22)	0.52 (0.08,3.17)	‐0.01 (‐0.12,0.02)
SD TOCI SC		1.41 (0.22,10.26)	1.39 (0.23,9.55)	0.01 (‐0.09,0.09)
SD CERTO SC		6.03 (0.71,62.12)	5.22 (0.74,44.98)	0.11 (‐0.03,0.35)
SD GOLI IV		1.88 (0.17,22.71)	1.82 (0.18,17.86)	0.02 (‐0.06,0.30)
SD RITUX IV		0.77 (0.09,5.73)	0.78 (0.10,5.25)	0.00 (‐0.08,0.11)
SD INF IV + MTX		1.59 (0.48,6.58)	1.56 (0.50,6.12)	0.01 (‐0.04,0.10)
SD ETN SC + MTX		1.72 (0.66,5.48)	1.68 (0.67,5.18)	0.02 (‐0.02,0.09)
SD ADA SC + MTX		1.64 (0.46,7.91)	1.61 (0.48,7.20)	0.01 (‐0.04,0.12)
SD ABA IV + MTX		1.44 (0.41,6.00)	1.41 (0.42,5.69)	0.01 (‐0.05,0.09)
SD RITUX IV + MTX		1.89 (0.55,8.74)	1.83 (0.57,8.00)	0.02 (‐0.03,0.14)
SD ABA SC + MTX		1.21 (0.32,5.57)	1.20 (0.34,5.24)	0.00 (‐0.06,0.08)
SD GOLI SC + MTX		3.67 (0.71,22.21)	3.33 (0.73,17.24)	0.06 (‐0.01,0.35)
SD CERTO SC + MTX		2.81 (0.73,13.04)	2.64 (0.76,11.29)	0.04 (‐0.01,0.23)
SD TOFA PO + MTX		3.53 (0.79,17.73)	3.23 (0.80,14.86)	0.06 (‐0.01,0.28)
SD GOLI IV + MTX		5.66 (0.71,56.08)	4.81 (0.73,34.07)	0.10 (‐0.02,0.51)
SD ANA SC + MTX		2.41 (0.48,13.72)	2.29 (0.50,11.11)	0.03 (‐0.03,0.24)
SD ETN SC + DMARD		1.65 (0.44,7.67)	1.62 (0.46,7.31)	0.01 (‐0.05,0.08)
SD ABA IV + DMARD		0.87 (0.20,4.57)	0.87 (0.21,4.41)	0.00 (‐0.08,0.05)
SD ADA SC + DMARD		0.59 (0.11,3.41)	0.60 (0.12,3.35)	‐0.01 (‐0.10,0.03)
SD ANA + DMARD		0.82 (0.19,4.49)	0.83 (0.20,4.36)	0.00 (‐0.08,0.05)
SD CERTO SC + DMARD		0.59 (0.08,4.47)	0.60 (0.09,4.23)	‐0.01 (‐0.10,0.05)
SD TOCI SC + DMARD		1.08 (0.20,6.42)	1.08 (0.21,5.99)	0.00 (‐0.08,0.08)
LD ADA SC		0.85 (0.14,5.65)	0.85 (0.16,5.47)	0.00 (‐0.10,0.03)
LD ETN SC		1.39 (0.28,6.71)	1.36 (0.30,6.18)	0.01 (‐0.06,0.11)
LD GOLI IV		8.93 (1.27,83.42)	6.96 (1.25,44.05)	0.17 (0.01,0.62)
LD RITUX IV + MTX		1.63 (0.44,7.33)	1.59 (0.46,6.82)	0.01 (‐0.04,0.12)
LD ABA IV + MTX		2.25 (0.55,10.90)	2.16 (0.57,9.69)	0.03 (‐0.03,0.17)
LD CERTO SC + MTX		2.90 (0.38,20.52)	2.72 (0.39,15.39)	0.04 (‐0.03,0.34)
LD ETN SC + MTX		0.86 (0.20,4.02)	0.87 (0.21,3.83)	0.00 (‐0.07,0.06)
LD GOLI IV + MTX		5.16 (0.64,51.52)	4.50 (0.66,31.65)	0.09 (‐0.02,0.49)
HD TOCI IV		1.62 (0.43,7.95)	1.59 (0.45,7.35)	0.01 (‐0.05,0.11)
HD TOFA PO		0.71 (0.11,4.62)	0.72 (0.12,4.56)	‐0.01 (‐0.11,0.03)
HD GOLI SC		2.32 (0.42,14.31)	2.22 (0.44,11.65)	0.03 (‐0.04,0.25)
HD ADA SC		1.27 (0.23,7.35)	1.26 (0.25,7.04)	0.01 (‐0.09,0.05)
HD GOLI SC + MTX		5.02 (1.02,28.62)	4.36 (1.02,20.17)	0.09 (0.00,0.40)
HD TOCI IV + MTX		1.89 (0.46,10.81)	1.83 (0.48,9.52)	0.02 (‐0.04,0.16)
HD TOFA PO + MTX		2.94 (0.63,15.21)	2.76 (0.65,12.87)	0.04 (‐0.02,0.24)
HD INF IV + MTX		1.84 (0.52,8.32)	1.79 (0.54,7.66)	0.02 (‐0.03,0.13)
HD CERTO SC + MTX		3.39 (0.85,17.96)	3.11 (0.86,14.44)	0.05 (‐0.01,0.31)
HD TOCI IV + DMARD		1.26 (0.29,6.68)	1.25 (0.31,6.34)	0.01 (‐0.07,0.07)
SD ADA SC	SD ETN SC	0.70 (0.20,2.02)	0.71 (0.24,1.98)	‐0.02 (‐0.13,0.02)
SD TOCI IV		0.77 (0.19,2.97)	0.78 (0.21,2.82)	‐0.01 (‐0.12,0.06)
SD TOFA PO		0.25 (0.05,0.90)	0.26 (0.06,0.90)	‐0.04 (‐0.16,0.00)
SD TOCI SC		0.68 (0.14,3.30)	0.69 (0.16,3.04)	‐0.02 (‐0.13,0.07)
SD CERTO SC		3.00 (0.44,17.80)	2.69 (0.49,12.42)	0.09 (‐0.07,0.33)
SD GOLI IV		0.95 (0.11,6.84)	0.96 (0.12,5.27)	0.00 (‐0.09,0.25)
SD RITUX IV		0.37 (0.05,2.05)	0.39 (0.06,1.91)	‐0.03 (‐0.11,0.06)
SD INF IV + MTX		0.77 (0.34,1.74)	0.78 (0.35,1.66)	‐0.01 (‐0.07,0.04)
SD ETN SC + MTX		0.84 (0.35,1.88)	0.85 (0.37,1.77)	‐0.01 (‐0.06,0.05)
SD ADA SC + MTX		0.79 (0.33,1.98)	0.80 (0.35,1.86)	‐0.01 (‐0.06,0.06)
SD ABA IV + MTX		0.69 (0.32,1.55)	0.70 (0.33,1.50)	‐0.01 (‐0.07,0.03)
SD RITUX IV + MTX		0.92 (0.39,2.26)	0.93 (0.40,2.09)	0.00 (‐0.05,0.08)
SD ABA SC + MTX		0.58 (0.25,1.43)	0.60 (0.26,1.40)	‐0.02 (‐0.08,0.02)
SD GOLI SC + MTX		1.73 (0.50,6.33)	1.64 (0.51,4.73)	0.03 (‐0.03,0.29)
SD CERTO SC + MTX		1.36 (0.57,3.20)	1.33 (0.58,2.78)	0.02 (‐0.03,0.15)
SD TOFA PO + MTX		1.66 (0.63,4.87)	1.59 (0.64,4.06)	0.03 (‐0.03,0.22)
SD GOLI IV + MTX		2.73 (0.45,18.38)	2.42 (0.46,10.85)	0.08 (‐0.04,0.46)
SD ANA SC + MTX		1.15 (0.32,4.39)	1.14 (0.34,3.61)	0.01 (‐0.06,0.20)
SD ETN SC + DMARD		0.80 (0.41,1.58)	0.81 (0.43,1.54)	‐0.01 (‐0.07,0.03)
SD ABA IV + DMARD		0.43 (0.16,1.06)	0.44 (0.18,1.06)	‐0.03 (‐0.11,0.00)
SD ADA SC + DMARD		0.28 (0.09,0.87)	0.30 (0.09,0.88)	‐0.04 (‐0.13,0.00)
SD ANA + DMARD		0.41 (0.14,1.06)	0.42 (0.15,1.06)	‐0.03 (‐0.12,0.00)
SD CERTO SC + DMARD		0.28 (0.06,1.17)	0.30 (0.06,1.15)	‐0.03 (‐0.13,0.01)
SD TOCI SC + DMARD		0.51 (0.15,1.80)	0.53 (0.16,1.71)	‐0.02 (‐0.11,0.04)
LD ADA SC		0.41 (0.10,1.42)	0.42 (0.11,1.41)	‐0.03 (‐0.15,0.01)
LD ETN SC		0.65 (0.24,1.75)	0.67 (0.25,1.66)	‐0.02 (‐0.07,0.05)
LD GOLI IV		4.37 (0.83,26.03)	3.51 (0.84,13.41)	0.14 (‐0.01,0.56)
LD RITUX IV + MTX		0.79 (0.32,1.93)	0.80 (0.34,1.82)	‐0.01 (‐0.06,0.06)
LD ABA IV + MTX		1.07 (0.38,2.98)	1.06 (0.40,2.63)	0.00 (‐0.05,0.12)
LD CERTO SC + MTX		1.36 (0.26,6.57)	1.33 (0.27,4.86)	0.02 (‐0.06,0.27)
LD ETN SC + MTX		0.42 (0.12,1.33)	0.44 (0.13,1.30)	‐0.03 (‐0.10,0.02)
LD GOLI IV + MTX		2.56 (0.41,15.02)	2.32 (0.43,9.33)	0.07 (‐0.04,0.44)
HD TOCI IV		0.79 (0.34,1.92)	0.80 (0.35,1.82)	‐0.01 (‐0.07,0.05)
HD TOFA PO		0.33 (0.07,1.28)	0.35 (0.09,1.27)	‐0.03 (‐0.16,0.01)
HD GOLI SC		1.13 (0.28,4.72)	1.12 (0.30,3.82)	0.01 (‐0.06,0.19)
HD ADA SC		0.61 (0.16,2.11)	0.63 (0.18,2.06)	‐0.02 (‐0.14,0.03)
HD GOLI SC + MTX		2.49 (0.69,8.84)	2.26 (0.70,6.11)	0.06 (‐0.02,0.35)
HD TOCI IV + MTX		0.91 (0.31,2.82)	0.92 (0.33,2.53)	0.00 (‐0.06,0.11)
HD TOFA PO + MTX		1.36 (0.50,4.12)	1.33 (0.52,3.53)	0.02 (‐0.04,0.18)
HD INF IV + MTX		0.89 (0.36,2.23)	0.89 (0.37,2.07)	‐0.01 (‐0.06,0.08)
HD CERTO SC + MTX		1.65 (0.59,4.87)	1.58 (0.60,3.85)	0.03 (‐0.02,0.24)
HD TOCI IV + DMARD		0.62 (0.24,1.47)	0.63 (0.25,1.43)	‐0.02 (‐0.09,0.02)
SD TOCI IV	SD ADA SC	1.11 (0.50,2.57)	1.11 (0.51,2.40)	0.00 (‐0.02,0.06)
SD TOFA PO		0.35 (0.12,0.97)	0.36 (0.12,0.97)	‐0.02 (‐0.06,0.00)
SD TOCI SC		0.98 (0.34,2.96)	0.98 (0.35,2.75)	0.00 (‐0.03,0.07)
SD CERTO SC		4.27 (1.05,18.66)	3.78 (1.05,12.53)	0.11 (0.00,0.34)
SD GOLI IV		1.32 (0.15,13.23)	1.30 (0.16,9.17)	0.01 (‐0.04,0.31)
SD RITUX IV		0.51 (0.06,4.56)	0.52 (0.07,4.00)	‐0.02 (‐0.05,0.12)
SD INF IV + MTX		1.09 (0.29,4.61)	1.08 (0.30,4.07)	0.00 (‐0.03,0.12)
SD ETN SC + MTX		1.18 (0.32,4.97)	1.17 (0.33,4.34)	0.01 (‐0.03,0.13)
SD ADA SC + MTX		1.12 (0.31,5.13)	1.12 (0.32,4.44)	0.00 (‐0.04,0.14)
SD ABA IV + MTX		0.98 (0.27,3.98)	0.98 (0.28,3.60)	0.00 (‐0.04,0.10)
SD RITUX IV + MTX		1.33 (0.34,6.06)	1.31 (0.35,5.04)	0.01 (‐0.03,0.16)
SD ABA SC + MTX		0.83 (0.22,3.65)	0.84 (0.23,3.33)	‐0.01 (‐0.04,0.09)
SD GOLI SC + MTX		2.57 (0.47,17.20)	2.42 (0.48,10.44)	0.05 (‐0.02,0.38)
SD CERTO SC + MTX		1.89 (0.50,9.64)	1.82 (0.51,7.22)	0.03 (‐0.02,0.25)
SD TOFA PO + MTX		2.38 (0.62,11.91)	2.25 (0.64,8.45)	0.05 (‐0.02,0.30)
SD GOLI IV + MTX		4.04 (0.52,33.18)	3.59 (0.54,15.66)	0.10 (‐0.02,0.53)
SD ANA SC + MTX		1.65 (0.33,10.63)	1.61 (0.34,7.73)	0.02 (‐0.03,0.27)
SD ETN SC + DMARD		1.17 (0.41,3.76)	1.16 (0.42,3.42)	0.01 (‐0.03,0.10)
SD ABA IV + DMARD		0.61 (0.17,2.53)	0.62 (0.18,2.40)	‐0.01 (‐0.05,0.05)
SD ADA SC + DMARD		0.41 (0.10,2.04)	0.42 (0.10,1.96)	‐0.02 (‐0.05,0.04)
SD ANA + DMARD		0.59 (0.15,2.47)	0.60 (0.16,2.33)	‐0.01 (‐0.05,0.05)
SD CERTO SC + DMARD		0.40 (0.07,2.51)	0.41 (0.07,2.36)	‐0.02 (‐0.05,0.05)
SD TOCI SC + DMARD		0.73 (0.17,3.86)	0.74 (0.18,3.45)	‐0.01 (‐0.04,0.10)
LD ADA SC		0.59 (0.26,1.29)	0.60 (0.27,1.28)	‐0.01 (‐0.04,0.01)
LD ETN SC		0.93 (0.20,4.96)	0.93 (0.20,4.30)	0.00 (‐0.04,0.13)
LD GOLI IV		6.29 (1.07,49.60)	5.15 (1.07,18.65)	0.16 (0.00,0.64)
LD RITUX IV + MTX		1.14 (0.28,5.13)	1.14 (0.29,4.36)	0.01 (‐0.03,0.14)
LD ABA IV + MTX		1.54 (0.36,7.36)	1.51 (0.37,6.00)	0.02 (‐0.03,0.19)
LD CERTO SC + MTX		2.06 (0.25,15.74)	1.97 (0.25,10.23)	0.04 (‐0.04,0.35)
LD ETN SC + MTX		0.59 (0.12,3.21)	0.60 (0.12,2.95)	‐0.01 (‐0.05,0.08)
LD GOLI IV + MTX		3.65 (0.56,29.09)	3.29 (0.57,14.53)	0.09 (‐0.02,0.50)
HD TOCI IV		1.13 (0.31,4.81)	1.13 (0.32,4.20)	0.00 (‐0.03,0.13)
HD TOFA PO		0.48 (0.18,1.33)	0.49 (0.18,1.32)	‐0.02 (‐0.05,0.01)
HD GOLI SC		1.68 (0.32,10.68)	1.63 (0.33,7.71)	0.02 (‐0.03,0.27)
HD ADA SC		0.89 (0.45,1.82)	0.90 (0.46,1.77)	0.00 (‐0.03,0.03)
HD GOLI SC + MTX		3.54 (0.62,20.74)	3.20 (0.64,11.83)	0.08 (‐0.01,0.43)
HD TOCI IV + MTX		1.30 (0.31,6.77)	1.28 (0.32,5.57)	0.01 (‐0.03,0.18)
HD TOFA PO + MTX		1.98 (0.50,10.20)	1.90 (0.51,7.58)	0.03 (‐0.02,0.26)
HD INF IV + MTX		1.27 (0.33,5.82)	1.26 (0.34,4.91)	0.01 (‐0.03,0.16)
HD CERTO SC + MTX		2.34 (0.56,13.33)	2.22 (0.57,9.02)	0.05 (‐0.02,0.33)
HD TOCI IV + DMARD		0.87 (0.25,3.30)	0.88 (0.26,3.04)	0.00 (‐0.04,0.08)
SD TOFA PO	SD TOCI IV	0.31 (0.08,1.15)	0.32 (0.08,1.15)	‐0.03 (‐0.10,0.00)
SD TOCI SC		0.88 (0.44,1.81)	0.89 (0.45,1.73)	0.00 (‐0.04,0.04)
SD CERTO SC		3.92 (0.73,21.61)	3.45 (0.75,15.00)	0.10 (‐0.02,0.34)
SD GOLI IV		1.16 (0.11,13.04)	1.15 (0.12,9.53)	0.01 (‐0.08,0.30)
SD RITUX IV		0.45 (0.05,4.54)	0.46 (0.06,4.04)	‐0.02 (‐0.09,0.11)
SD INF IV + MTX		1.01 (0.21,4.72)	1.01 (0.22,4.24)	0.00 (‐0.07,0.11)
SD ETN SC + MTX		1.07 (0.24,5.27)	1.06 (0.25,4.66)	0.00 (‐0.07,0.12)
SD ADA SC + MTX		1.05 (0.22,5.40)	1.05 (0.23,4.74)	0.00 (‐0.07,0.13)
SD ABA IV + MTX		0.92 (0.19,4.16)	0.93 (0.20,3.80)	0.00 (‐0.07,0.09)
SD RITUX IV + MTX		1.21 (0.24,6.23)	1.19 (0.26,5.32)	0.01 (‐0.06,0.15)
SD ABA SC + MTX		0.78 (0.15,3.75)	0.79 (0.16,3.46)	‐0.01 (‐0.08,0.08)
SD GOLI SC + MTX		2.31 (0.36,17.01)	2.18 (0.38,11.04)	0.05 (‐0.05,0.37)
SD CERTO SC + MTX		1.72 (0.34,9.55)	1.67 (0.36,7.47)	0.03 (‐0.05,0.24)
SD TOFA PO + MTX		2.21 (0.45,11.93)	2.09 (0.47,8.99)	0.04 (‐0.04,0.29)
SD GOLI IV + MTX		3.63 (0.36,32.71)	3.20 (0.38,17.27)	0.09 (‐0.05,0.52)
SD ANA SC + MTX		1.50 (0.25,10.21)	1.46 (0.26,7.55)	0.02 (‐0.06,0.27)
SD ETN SC + DMARD		1.05 (0.28,4.15)	1.05 (0.30,3.82)	0.00 (‐0.06,0.09)
SD ABA IV + DMARD		0.56 (0.12,2.74)	0.57 (0.13,2.62)	‐0.02 (‐0.09,0.05)
SD ADA SC + DMARD		0.38 (0.07,2.10)	0.39 (0.08,2.01)	‐0.02 (‐0.09,0.03)
SD ANA + DMARD		0.53 (0.11,2.65)	0.54 (0.12,2.53)	‐0.02 (‐0.09,0.05)
SD CERTO SC + DMARD		0.36 (0.05,2.78)	0.37 (0.06,2.65)	‐0.02 (‐0.09,0.05)
SD TOCI SC + DMARD		0.66 (0.12,4.24)	0.67 (0.13,3.84)	‐0.01 (‐0.08,0.09)
LD ADA SC		0.53 (0.16,1.61)	0.55 (0.18,1.59)	‐0.02 (‐0.09,0.01)
LD ETN SC		0.84 (0.15,5.15)	0.84 (0.16,4.48)	‐0.01 (‐0.08,0.12)
LD GOLI IV		5.66 (0.78,51.04)	4.61 (0.79,21.30)	0.16 (‐0.01,0.63)
LD RITUX IV + MTX		1.04 (0.20,5.24)	1.04 (0.21,4.63)	0.00 (‐0.07,0.13)
LD ABA IV + MTX		1.42 (0.25,7.65)	1.39 (0.27,6.38)	0.02 (‐0.06,0.18)
LD CERTO SC + MTX		1.84 (0.19,15.72)	1.76 (0.20,10.42)	0.03 (‐0.06,0.34)
LD ETN SC + MTX		0.55 (0.08,3.39)	0.56 (0.09,3.15)	‐0.02 (‐0.09,0.07)
LD GOLI IV + MTX		3.26 (0.40,30.45)	2.92 (0.42,16.40)	0.08 (‐0.04,0.50)
HD TOCI IV		1.04 (0.22,5.24)	1.03 (0.24,4.64)	0.00 (‐0.07,0.12)
HD TOFA PO		0.43 (0.12,1.55)	0.44 (0.13,1.53)	‐0.02 (‐0.10,0.01)
HD GOLI SC		1.49 (0.21,10.95)	1.46 (0.22,8.15)	0.02 (‐0.06,0.26)
HD ADA SC		0.80 (0.27,2.38)	0.81 (0.29,2.31)	‐0.01 (‐0.07,0.03)
HD GOLI SC + MTX		3.20 (0.46,21.06)	2.89 (0.48,13.02)	0.08 (‐0.03,0.42)
HD TOCI IV + MTX		1.18 (0.22,7.12)	1.17 (0.24,5.82)	0.01 (‐0.07,0.17)
HD TOFA PO + MTX		1.84 (0.37,10.27)	1.77 (0.39,7.89)	0.03 (‐0.05,0.26)
HD INF IV + MTX		1.19 (0.23,5.88)	1.18 (0.24,5.10)	0.01 (‐0.06,0.15)
HD CERTO SC + MTX		2.09 (0.37,13.28)	1.99 (0.39,9.35)	0.04 (‐0.05,0.32)
HD TOCI IV + DMARD		0.80 (0.17,3.74)	0.81 (0.18,3.44)	‐0.01 (‐0.08,0.08)
SD TOCI SC	SD TOFA PO	2.84 (0.63,13.82)	2.76 (0.64,12.44)	0.02 (‐0.01,0.11)
SD CERTO SC		12.27 (2.90,70.20)	10.49 (2.78,46.77)	0.13 (0.03,0.37)
SD GOLI IV		3.97 (0.39,46.38)	3.80 (0.40,31.97)	0.04 (‐0.01,0.34)
SD RITUX IV		1.45 (0.16,15.81)	1.44 (0.16,13.70)	0.01 (‐0.02,0.15)
SD INF IV + MTX		3.08 (0.68,19.11)	2.98 (0.68,16.68)	0.03 (‐0.01,0.15)
SD ETN SC + MTX		3.40 (0.73,20.80)	3.29 (0.73,18.03)	0.03 (‐0.01,0.16)
SD ADA SC + MTX		3.16 (0.73,20.78)	3.06 (0.74,17.66)	0.03 (‐0.01,0.17)
SD ABA IV + MTX		2.77 (0.64,16.88)	2.69 (0.65,14.98)	0.02 (‐0.01,0.13)
SD RITUX IV + MTX		3.78 (0.83,24.29)	3.63 (0.83,20.20)	0.04 (0.00,0.20)
SD ABA SC + MTX		2.36 (0.54,14.79)	2.31 (0.55,13.28)	0.02 (‐0.01,0.12)
SD GOLI SC + MTX		7.05 (1.17,68.25)	6.49 (1.16,41.07)	0.08 (0.00,0.41)
SD CERTO SC + MTX		5.42 (1.18,37.02)	5.09 (1.17,27.85)	0.06 (0.00,0.28)
SD TOFA PO + MTX		6.80 (1.55,46.08)	6.25 (1.53,32.52)	0.07 (0.01,0.33)
SD GOLI IV + MTX		11.17 (1.38,111.20)	9.61 (1.37,56.64)	0.13 (0.01,0.55)
SD ANA SC + MTX		4.71 (0.79,41.17)	4.45 (0.79,29.17)	0.05 (0.00,0.31)
SD ETN SC + DMARD		3.33 (0.93,16.14)	3.21 (0.94,14.62)	0.03 (0.00,0.13)
SD ABA IV + DMARD		1.70 (0.40,10.47)	1.68 (0.40,9.72)	0.01 (‐0.01,0.08)
SD ADA SC + DMARD		1.18 (0.24,7.51)	1.17 (0.24,7.06)	0.00 (‐0.02,0.06)
SD ANA + DMARD		1.64 (0.35,9.45)	1.62 (0.36,8.73)	0.01 (‐0.02,0.08)
SD CERTO SC + DMARD		1.11 (0.18,9.34)	1.11 (0.19,8.48)	0.00 (‐0.02,0.08)
SD TOCI SC + DMARD		2.10 (0.39,13.79)	2.06 (0.40,12.27)	0.01 (‐0.01,0.13)
LD ADA SC		1.69 (0.51,6.16)	1.67 (0.52,5.95)	0.01 (‐0.01,0.04)
LD ETN SC		2.60 (0.51,19.38)	2.53 (0.52,16.63)	0.02 (‐0.01,0.16)
LD GOLI IV		18.17 (2.62,186.60)	14.36 (2.54,74.34)	0.19 (0.02,0.66)
LD RITUX IV + MTX		3.20 (0.70,21.37)	3.10 (0.71,18.13)	0.03 (‐0.01,0.17)
LD ABA IV + MTX		4.31 (0.87,29.92)	4.11 (0.88,24.05)	0.04 (0.00,0.22)
LD CERTO SC + MTX		5.77 (0.69,54.24)	5.35 (0.70,35.20)	0.06 (‐0.01,0.38)
LD ETN SC + MTX		1.71 (0.28,12.36)	1.69 (0.28,11.15)	0.01 (‐0.02,0.11)
LD GOLI IV + MTX		10.45 (1.43,104.60)	9.13 (1.42,55.26)	0.11 (0.01,0.53)
HD TOCI IV		3.24 (0.76,20.29)	3.12 (0.76,17.30)	0.03 (0.00,0.16)
HD TOFA PO		1.38 (0.54,3.62)	1.37 (0.54,3.55)	0.00 (‐0.01,0.03)
HD GOLI SC		4.68 (0.74,38.28)	4.40 (0.75,28.30)	0.05 (0.00,0.30)
HD ADA SC		2.56 (0.81,8.50)	2.51 (0.81,8.09)	0.02 (‐0.01,0.06)
HD GOLI SC + MTX		9.72 (1.53,81.82)	8.60 (1.52,47.54)	0.11 (0.01,0.46)
HD TOCI IV + MTX		3.74 (0.74,27.08)	3.59 (0.74,22.00)	0.04 (‐0.01,0.21)
HD TOFA PO + MTX		5.59 (1.34,40.53)	5.22 (1.33,29.59)	0.06 (0.01,0.30)
HD INF IV + MTX		3.67 (0.80,23.77)	3.53 (0.80,19.77)	0.03 (0.00,0.19)
HD CERTO SC + MTX		6.58 (1.28,50.90)	6.04 (1.27,34.89)	0.07 (0.01,0.36)
HD TOCI IV + DMARD		2.51 (0.55,13.87)	2.45 (0.55,12.66)	0.02 (‐0.01,0.11)
SD CERTO SC	SD TOCI SC	4.45 (0.71,28.16)	3.90 (0.73,19.68)	0.11 (‐0.03,0.35)
SD GOLI IV		1.30 (0.11,16.36)	1.28 (0.12,11.99)	0.01 (‐0.08,0.31)
SD RITUX IV		0.51 (0.05,5.93)	0.53 (0.05,5.21)	‐0.01 (‐0.10,0.12)
SD INF IV + MTX		1.15 (0.19,6.36)	1.14 (0.20,5.67)	0.00 (‐0.08,0.12)
SD ETN SC + MTX		1.23 (0.21,7.03)	1.22 (0.23,6.16)	0.01 (‐0.08,0.13)
SD ADA SC + MTX		1.20 (0.20,6.90)	1.19 (0.22,6.10)	0.01 (‐0.08,0.14)
SD ABA IV + MTX		1.04 (0.17,5.48)	1.04 (0.18,5.01)	0.00 (‐0.08,0.10)
SD RITUX IV + MTX		1.38 (0.21,8.05)	1.35 (0.23,6.98)	0.01 (‐0.08,0.16)
SD ABA SC + MTX		0.89 (0.14,4.93)	0.89 (0.15,4.54)	0.00 (‐0.09,0.09)
SD GOLI SC + MTX		2.63 (0.34,21.44)	2.46 (0.36,14.39)	0.05 (‐0.06,0.38)
SD CERTO SC + MTX		1.96 (0.33,12.48)	1.88 (0.35,9.94)	0.03 (‐0.06,0.24)
SD TOFA PO + MTX		2.54 (0.41,15.93)	2.39 (0.43,11.97)	0.05 (‐0.05,0.30)
SD GOLI IV + MTX		4.02 (0.36,43.09)	3.52 (0.38,23.51)	0.10 (‐0.05,0.52)
SD ANA SC + MTX		1.72 (0.22,13.22)	1.67 (0.24,9.98)	0.02 (‐0.07,0.27)
SD ETN SC + DMARD		1.19 (0.25,5.55)	1.18 (0.27,5.08)	0.01 (‐0.07,0.10)
SD ABA IV + DMARD		0.64 (0.11,3.62)	0.65 (0.12,3.43)	‐0.01 (‐0.10,0.06)
SD ADA SC + DMARD		0.43 (0.07,2.68)	0.44 (0.07,2.56)	‐0.02 (‐0.10,0.04)
SD ANA + DMARD		0.60 (0.10,3.41)	0.61 (0.11,3.21)	‐0.01 (‐0.10,0.05)
SD CERTO SC + DMARD		0.41 (0.05,3.40)	0.42 (0.06,3.22)	‐0.02 (‐0.10,0.06)
SD TOCI SC + DMARD		0.76 (0.12,5.40)	0.76 (0.13,4.91)	‐0.01 (‐0.09,0.10)
LD ADA SC		0.60 (0.15,2.23)	0.61 (0.17,2.19)	‐0.01 (‐0.10,0.02)
LD ETN SC		0.96 (0.13,6.45)	0.96 (0.15,5.69)	0.00 (‐0.09,0.13)
LD GOLI IV		6.55 (0.75,67.05)	5.21 (0.77,28.89)	0.16 (‐0.02,0.63)
LD RITUX IV + MTX		1.17 (0.18,6.85)	1.16 (0.20,6.08)	0.01 (‐0.08,0.13)
LD ABA IV + MTX		1.63 (0.23,10.03)	1.59 (0.25,8.48)	0.02 (‐0.07,0.19)
LD CERTO SC + MTX		2.08 (0.18,19.56)	1.97 (0.20,13.31)	0.04 (‐0.07,0.35)
LD ETN SC + MTX		0.61 (0.08,4.40)	0.62 (0.09,4.02)	‐0.01 (‐0.10,0.08)
LD GOLI IV + MTX		3.63 (0.39,39.12)	3.24 (0.41,21.84)	0.08 (‐0.05,0.50)
HD TOCI IV		1.17 (0.21,6.70)	1.17 (0.22,5.87)	0.01 (‐0.08,0.13)
HD TOFA PO		0.49 (0.11,2.09)	0.50 (0.12,2.05)	‐0.02 (‐0.10,0.02)
HD GOLI SC		1.65 (0.20,14.59)	1.60 (0.21,10.90)	0.02 (‐0.07,0.27)
HD ADA SC		0.92 (0.25,3.19)	0.92 (0.28,3.07)	0.00 (‐0.08,0.04)
HD GOLI SC + MTX		3.62 (0.45,27.61)	3.23 (0.48,17.42)	0.08 (‐0.04,0.42)
HD TOCI IV + MTX		1.34 (0.21,9.16)	1.33 (0.23,7.69)	0.01 (‐0.08,0.17)
HD TOFA PO + MTX		2.06 (0.34,13.42)	1.98 (0.37,10.48)	0.03 (‐0.06,0.26)
HD INF IV + MTX		1.35 (0.21,7.75)	1.33 (0.23,6.77)	0.01 (‐0.08,0.16)
HD CERTO SC + MTX		2.41 (0.34,16.62)	2.27 (0.37,12.03)	0.04 (‐0.06,0.33)
HD TOCI IV + DMARD		0.91 (0.16,4.82)	0.92 (0.17,4.42)	0.00 (‐0.09,0.09)
SD GOLI IV	SD CERTO SC	0.32 (0.02,4.48)	0.36 (0.03,3.45)	‐0.08 (‐0.34,0.22)
SD RITUX IV		0.12 (0.01,1.83)	0.14 (0.01,1.72)	‐0.12 (‐0.36,0.06)
SD INF IV + MTX		0.27 (0.03,2.00)	0.31 (0.04,1.84)	‐0.10 (‐0.34,0.06)
SD ETN SC + MTX		0.28 (0.03,2.10)	0.31 (0.05,1.92)	‐0.10 (‐0.34,0.07)
SD ADA SC + MTX		0.27 (0.04,2.22)	0.30 (0.05,2.00)	‐0.10 (‐0.34,0.08)
SD ABA IV + MTX		0.24 (0.03,1.75)	0.28 (0.04,1.66)	‐0.10 (‐0.35,0.05)
SD RITUX IV + MTX		0.32 (0.03,2.58)	0.36 (0.05,2.28)	‐0.09 (‐0.34,0.10)
SD ABA SC + MTX		0.20 (0.03,1.53)	0.23 (0.04,1.48)	‐0.11 (‐0.35,0.03)
SD GOLI SC + MTX		0.59 (0.05,7.42)	0.63 (0.08,4.77)	‐0.05 (‐0.32,0.33)
SD CERTO SC + MTX		0.45 (0.05,4.23)	0.49 (0.07,3.38)	‐0.07 (‐0.33,0.19)
SD TOFA PO + MTX		0.57 (0.07,5.23)	0.61 (0.10,3.92)	‐0.05 (‐0.32,0.24)
SD GOLI IV + MTX		0.91 (0.07,10.37)	0.92 (0.09,5.76)	‐0.01 (‐0.29,0.43)
SD ANA SC + MTX		0.38 (0.04,4.46)	0.42 (0.06,3.50)	‐0.08 (‐0.33,0.20)
SD ETN SC + DMARD		0.27 (0.05,1.73)	0.30 (0.07,1.62)	‐0.10 (‐0.34,0.04)
SD ABA IV + DMARD		0.14 (0.02,1.07)	0.17 (0.03,1.06)	‐0.12 (‐0.36,0.00)
SD ADA SC + DMARD		0.09 (0.01,0.83)	0.11 (0.02,0.84)	‐0.13 (‐0.36,‐0.01)
SD ANA + DMARD		0.14 (0.02,1.04)	0.16 (0.03,1.03)	‐0.12 (‐0.36,0.00)
SD CERTO SC + DMARD		0.09 (0.01,0.93)	0.10 (0.01,0.94)	‐0.13 (‐0.36,0.00)
SD TOCI SC + DMARD		0.17 (0.02,1.47)	0.20 (0.03,1.42)	‐0.11 (‐0.35,0.03)
LD ADA SC		0.14 (0.03,0.65)	0.16 (0.04,0.67)	‐0.12 (‐0.36,‐0.02)
LD ETN SC		0.21 (0.03,2.01)	0.24 (0.04,1.85)	‐0.11 (‐0.35,0.07)
LD GOLI IV		1.51 (0.12,17.57)	1.38 (0.17,7.40)	0.05 (‐0.26,0.55)
LD RITUX IV + MTX		0.27 (0.03,2.17)	0.30 (0.04,1.99)	‐0.10 (‐0.34,0.08)
LD ABA IV + MTX		0.36 (0.04,3.05)	0.40 (0.06,2.63)	‐0.08 (‐0.33,0.13)
LD CERTO SC + MTX		0.46 (0.04,6.19)	0.51 (0.05,4.20)	‐0.07 (‐0.32,0.28)
LD ETN SC + MTX		0.14 (0.01,1.31)	0.16 (0.02,1.28)	‐0.12 (‐0.36,0.02)
LD GOLI IV + MTX		0.84 (0.08,9.26)	0.86 (0.10,5.38)	‐0.02 (‐0.29,0.40)
HD TOCI IV		0.27 (0.03,2.08)	0.30 (0.05,1.92)	‐0.10 (‐0.34,0.07)
HD TOFA PO		0.11 (0.02,0.51)	0.13 (0.03,0.53)	‐0.13 (‐0.36,‐0.03)
HD GOLI SC		0.38 (0.03,4.22)	0.42 (0.05,3.28)	‐0.08 (‐0.34,0.20)
HD ADA SC		0.21 (0.05,0.93)	0.24 (0.07,0.94)	‐0.11 (‐0.35,0.00)
HD GOLI SC + MTX		0.81 (0.06,9.63)	0.83 (0.09,5.72)	‐0.02 (‐0.31,0.37)
HD TOCI IV + MTX		0.30 (0.04,2.71)	0.34 (0.06,2.39)	‐0.09 (‐0.34,0.11)
HD TOFA PO + MTX		0.44 (0.06,4.61)	0.49 (0.09,3.62)	‐0.07 (‐0.32,0.20)
HD INF IV + MTX		0.31 (0.03,2.44)	0.35 (0.04,2.17)	‐0.09 (‐0.34,0.09)
HD CERTO SC + MTX		0.56 (0.05,5.92)	0.60 (0.08,4.22)	‐0.06 (‐0.32,0.27)
HD TOCI IV + DMARD		0.20 (0.03,1.43)	0.23 (0.04,1.38)	‐0.11 (‐0.35,0.03)
SD RITUX IV	SD GOLI IV	0.38 (0.03,5.73)	0.40 (0.03,5.39)	‐0.03 (‐0.29,0.08)
SD INF IV + MTX		0.84 (0.10,6.86)	0.85 (0.13,6.52)	‐0.01 (‐0.26,0.08)
SD ETN SC + MTX		0.91 (0.12,8.29)	0.92 (0.15,7.71)	0.00 (‐0.26,0.09)
SD ADA SC + MTX		0.82 (0.11,7.87)	0.83 (0.14,7.37)	‐0.01 (‐0.25,0.09)
SD ABA IV + MTX		0.76 (0.09,6.22)	0.77 (0.12,5.85)	‐0.01 (‐0.27,0.07)
SD RITUX IV + MTX		1.00 (0.13,8.42)	1.00 (0.17,7.81)	0.00 (‐0.24,0.11)
SD ABA SC + MTX		0.63 (0.08,5.56)	0.64 (0.10,5.34)	‐0.02 (‐0.28,0.06)
SD GOLI SC + MTX		1.98 (0.19,22.32)	1.85 (0.23,17.70)	0.03 (‐0.20,0.29)
SD CERTO SC + MTX		1.51 (0.18,13.58)	1.46 (0.23,11.67)	0.02 (‐0.21,0.18)
SD TOFA PO + MTX		1.81 (0.23,17.33)	1.71 (0.29,14.57)	0.03 (‐0.20,0.24)
SD GOLI IV + MTX		2.83 (0.50,21.68)	2.45 (0.54,16.80)	0.07 (‐0.08,0.37)
SD ANA SC + MTX		1.25 (0.12,11.97)	1.23 (0.16,10.38)	0.01 (‐0.23,0.21)
SD ETN SC + DMARD		0.85 (0.12,7.56)	0.86 (0.16,7.17)	‐0.01 (‐0.27,0.07)
SD ABA IV + DMARD		0.46 (0.06,4.38)	0.47 (0.07,4.25)	‐0.02 (‐0.30,0.04)
SD ADA SC + DMARD		0.30 (0.03,3.25)	0.32 (0.04,3.17)	‐0.03 (‐0.32,0.02)
SD ANA + DMARD		0.43 (0.05,4.27)	0.44 (0.07,4.18)	‐0.03 (‐0.30,0.04)
SD CERTO SC + DMARD		0.30 (0.03,3.86)	0.32 (0.03,3.67)	‐0.03 (‐0.32,0.04)
SD TOCI SC + DMARD		0.57 (0.06,5.87)	0.58 (0.08,5.48)	‐0.02 (‐0.29,0.07)
LD ADA SC		0.48 (0.04,4.31)	0.49 (0.05,4.21)	‐0.03 (‐0.33,0.03)
LD ETN SC		0.70 (0.08,7.60)	0.71 (0.10,7.20)	‐0.01 (‐0.27,0.10)
LD GOLI IV		4.58 (1.04,30.01)	3.62 (1.03,21.69)	0.13 (0.00,0.48)
LD RITUX IV + MTX		0.83 (0.11,7.49)	0.84 (0.14,7.01)	‐0.01 (‐0.25,0.09)
LD ABA IV + MTX		1.14 (0.13,10.94)	1.13 (0.17,9.94)	0.01 (‐0.24,0.14)
LD CERTO SC + MTX		1.46 (0.11,22.72)	1.41 (0.13,17.78)	0.02 (‐0.24,0.30)
LD ETN SC + MTX		0.46 (0.05,4.79)	0.48 (0.06,4.49)	‐0.02 (‐0.30,0.05)
LD GOLI IV + MTX		2.69 (0.51,18.96)	2.35 (0.56,14.97)	0.06 (‐0.07,0.36)
HD TOCI IV		0.83 (0.11,7.70)	0.84 (0.15,7.24)	‐0.01 (‐0.26,0.09)
HD TOFA PO		0.36 (0.03,3.75)	0.38 (0.04,3.67)	‐0.03 (‐0.34,0.02)
HD GOLI SC		1.20 (0.12,15.08)	1.19 (0.15,12.76)	0.01 (‐0.23,0.21)
HD ADA SC		0.68 (0.06,6.47)	0.70 (0.09,6.25)	‐0.02 (‐0.32,0.04)
HD GOLI SC + MTX		2.78 (0.28,30.13)	2.49 (0.34,22.16)	0.06 (‐0.16,0.37)
HD TOCI IV + MTX		0.92 (0.12,10.84)	0.93 (0.15,9.73)	0.00 (‐0.24,0.14)
HD TOFA PO + MTX		1.46 (0.19,14.57)	1.41 (0.24,12.41)	0.02 (‐0.21,0.20)
HD INF IV + MTX		0.97 (0.12,8.78)	0.98 (0.15,8.09)	0.00 (‐0.25,0.11)
HD CERTO SC + MTX		1.83 (0.19,18.85)	1.73 (0.24,15.58)	0.03 (‐0.20,0.27)
HD TOCI IV + DMARD		0.63 (0.08,6.18)	0.65 (0.11,5.85)	‐0.02 (‐0.28,0.06)
SD INF IV + MTX	SD RITUX IV	2.12 (0.42,12.74)	2.05 (0.45,11.91)	0.02 (‐0.06,0.10)
SD ETN SC + MTX		2.27 (0.41,15.08)	2.20 (0.44,14.09)	0.02 (‐0.07,0.12)
SD ADA SC + MTX		2.16 (0.41,13.79)	2.09 (0.43,13.07)	0.02 (‐0.07,0.12)
SD ABA IV + MTX		1.88 (0.39,11.60)	1.84 (0.42,11.02)	0.01 (‐0.07,0.09)
SD RITUX IV + MTX		2.49 (0.57,15.78)	2.39 (0.60,14.65)	0.02 (‐0.04,0.13)
SD ABA SC + MTX		1.59 (0.30,9.80)	1.56 (0.33,9.43)	0.01 (‐0.09,0.07)
SD GOLI SC + MTX		4.90 (0.68,36.64)	4.39 (0.70,30.32)	0.06 (‐0.02,0.35)
SD CERTO SC + MTX		3.82 (0.70,22.45)	3.53 (0.73,19.95)	0.04 (‐0.03,0.22)
SD TOFA PO + MTX		4.55 (0.79,32.27)	4.15 (0.81,27.50)	0.06 (‐0.02,0.28)
SD GOLI IV + MTX		7.54 (0.65,97.23)	6.30 (0.67,65.26)	0.11 (‐0.02,0.51)
SD ANA SC + MTX		3.15 (0.43,22.82)	2.95 (0.46,20.15)	0.03 (‐0.05,0.24)
SD ETN SC + DMARD		2.24 (0.38,16.18)	2.16 (0.42,15.52)	0.02 (‐0.08,0.09)
SD ABA IV + DMARD		1.16 (0.18,8.50)	1.15 (0.20,8.21)	0.00 (‐0.12,0.05)
SD ADA SC + DMARD		0.76 (0.11,6.61)	0.77 (0.12,6.44)	0.00 (‐0.13,0.04)
SD ANA + DMARD		1.10 (0.16,8.53)	1.10 (0.18,8.27)	0.00 (‐0.12,0.05)
SD CERTO SC + DMARD		0.75 (0.08,8.38)	0.76 (0.09,8.13)	0.00 (‐0.13,0.05)
SD TOCI SC + DMARD		1.44 (0.18,12.21)	1.42 (0.20,11.52)	0.01 (‐0.11,0.09)
LD ADA SC		1.13 (0.11,10.42)	1.13 (0.12,10.16)	0.00 (‐0.14,0.04)
LD ETN SC		1.80 (0.29,12.98)	1.76 (0.32,12.29)	0.01 (‐0.08,0.11)
LD GOLI IV		12.36 (1.19,152.20)	9.52 (1.18,85.34)	0.17 (0.01,0.61)
LD RITUX IV + MTX		2.10 (0.49,12.69)	2.04 (0.52,11.93)	0.02 (‐0.05,0.11)
LD ABA IV + MTX		2.90 (0.50,19.26)	2.75 (0.53,17.83)	0.03 (‐0.05,0.17)
LD CERTO SC + MTX		3.72 (0.44,32.20)	3.43 (0.46,25.64)	0.04 (‐0.05,0.34)
LD ETN SC + MTX		1.14 (0.18,8.36)	1.14 (0.20,8.08)	0.00 (‐0.11,0.07)
LD GOLI IV + MTX		7.10 (0.57,85.63)	6.03 (0.60,61.31)	0.10 (‐0.03,0.48)
HD TOCI IV		2.13 (0.39,15.30)	2.07 (0.42,14.36)	0.02 (‐0.07,0.11)
HD TOFA PO		0.96 (0.09,8.01)	0.96 (0.10,7.79)	0.00 (‐0.15,0.03)
HD GOLI SC		3.17 (0.41,27.83)	2.97 (0.43,23.50)	0.03 (‐0.06,0.25)
HD ADA SC		1.73 (0.19,16.10)	1.71 (0.22,15.40)	0.01 (‐0.12,0.06)
HD GOLI SC + MTX		6.60 (0.99,50.10)	5.68 (0.99,37.38)	0.09 (0.00,0.40)
HD TOCI IV + MTX		2.41 (0.43,20.11)	2.32 (0.46,18.37)	0.02 (‐0.06,0.16)
HD TOFA PO + MTX		3.77 (0.62,26.53)	3.52 (0.65,23.64)	0.05 (‐0.03,0.24)
HD INF IV + MTX		2.48 (0.48,15.41)	2.39 (0.50,14.33)	0.02 (‐0.06,0.13)
HD CERTO SC + MTX		4.61 (0.78,29.98)	4.19 (0.80,25.76)	0.06 (‐0.02,0.29)
HD TOCI IV + DMARD		1.63 (0.27,13.23)	1.60 (0.30,12.58)	0.01 (‐0.10,0.08)
SD ETN SC + MTX	SD INF IV + MTX	1.09 (0.46,2.51)	1.09 (0.48,2.39)	0.00 (‐0.05,0.07)
SD ADA SC + MTX		1.05 (0.49,2.21)	1.04 (0.50,2.10)	0.00 (‐0.04,0.06)
SD ABA IV + MTX		0.90 (0.52,1.58)	0.91 (0.54,1.54)	0.00 (‐0.05,0.02)
SD RITUX IV + MTX		1.19 (0.64,2.42)	1.18 (0.65,2.27)	0.01 (‐0.03,0.07)
SD ABA SC + MTX		0.76 (0.36,1.54)	0.77 (0.38,1.51)	‐0.01 (‐0.06,0.02)
SD GOLI SC + MTX		2.26 (0.69,7.83)	2.11 (0.70,6.17)	0.05 (‐0.01,0.30)
SD CERTO SC + MTX		1.76 (0.88,3.73)	1.69 (0.88,3.31)	0.03 (‐0.01,0.15)
SD TOFA PO + MTX		2.18 (0.91,5.69)	2.04 (0.91,4.73)	0.04 (0.00,0.22)
SD GOLI IV + MTX		3.52 (0.58,24.65)	3.04 (0.60,15.51)	0.09 (‐0.02,0.47)
SD ANA SC + MTX		1.51 (0.47,4.87)	1.47 (0.49,4.08)	0.02 (‐0.04,0.19)
SD ETN SC + DMARD		1.05 (0.41,2.72)	1.05 (0.43,2.62)	0.00 (‐0.07,0.05)
SD ABA IV + DMARD		0.56 (0.19,1.65)	0.57 (0.20,1.62)	‐0.02 (‐0.10,0.02)
SD ADA SC + DMARD		0.37 (0.10,1.33)	0.38 (0.11,1.31)	‐0.02 (‐0.12,0.01)
SD ANA + DMARD		0.53 (0.16,1.61)	0.54 (0.17,1.58)	‐0.02 (‐0.11,0.02)
SD CERTO SC + DMARD		0.37 (0.07,1.78)	0.38 (0.07,1.72)	‐0.02 (‐0.13,0.02)
SD TOCI SC + DMARD		0.69 (0.18,2.53)	0.70 (0.19,2.39)	‐0.01 (‐0.10,0.05)
LD ADA SC		0.52 (0.10,2.43)	0.54 (0.12,2.38)	‐0.02 (‐0.14,0.02)
LD ETN SC		0.85 (0.28,2.61)	0.86 (0.30,2.47)	0.00 (‐0.07,0.07)
LD GOLI IV		5.64 (1.13,36.21)	4.42 (1.11,18.80)	0.15 (0.01,0.58)
LD RITUX IV + MTX		1.02 (0.54,2.09)	1.02 (0.56,1.98)	0.00 (‐0.04,0.05)
LD ABA IV + MTX		1.39 (0.60,3.29)	1.36 (0.62,2.99)	0.01 (‐0.03,0.12)
LD CERTO SC + MTX		1.75 (0.40,7.77)	1.68 (0.41,5.96)	0.03 (‐0.04,0.29)
LD ETN SC + MTX		0.54 (0.17,1.69)	0.56 (0.18,1.66)	‐0.02 (‐0.09,0.03)
LD GOLI IV + MTX		3.27 (0.57,20.03)	2.88 (0.59,12.96)	0.08 (‐0.02,0.45)
HD TOCI IV		1.02 (0.44,2.46)	1.02 (0.46,2.33)	0.00 (‐0.05,0.06)
HD TOFA PO		0.45 (0.08,2.13)	0.46 (0.09,2.10)	‐0.02 (‐0.15,0.02)
HD GOLI SC		1.46 (0.37,5.86)	1.43 (0.39,4.80)	0.02 (‐0.05,0.21)
HD ADA SC		0.83 (0.18,3.35)	0.84 (0.21,3.24)	‐0.01 (‐0.12,0.04)
HD GOLI SC + MTX		3.15 (1.02,10.20)	2.80 (1.02,7.42)	0.08 (0.00,0.36)
HD TOCI IV + MTX		1.17 (0.43,3.54)	1.16 (0.45,3.20)	0.01 (‐0.05,0.11)
HD TOFA PO + MTX		1.84 (0.77,4.74)	1.76 (0.78,4.14)	0.03 (‐0.01,0.18)
HD INF IV + MTX		1.16 (0.67,2.08)	1.15 (0.68,1.96)	0.01 (‐0.02,0.06)
HD CERTO SC + MTX		2.16 (0.89,5.72)	2.02 (0.89,4.69)	0.04 (0.00,0.25)
HD TOCI IV + DMARD		0.79 (0.27,2.28)	0.80 (0.29,2.19)	‐0.01 (‐0.09,0.04)
SD ADA SC + MTX	SD ETN SC + MTX	0.94 (0.37,2.65)	0.94 (0.39,2.48)	0.00 (‐0.07,0.07)
SD ABA IV + MTX		0.82 (0.35,2.07)	0.83 (0.38,1.98)	‐0.01 (‐0.08,0.04)
SD RITUX IV + MTX		1.09 (0.46,3.00)	1.09 (0.48,2.73)	0.00 (‐0.05,0.09)
SD ABA SC + MTX		0.70 (0.27,1.95)	0.71 (0.29,1.87)	‐0.01 (‐0.09,0.04)
SD GOLI SC + MTX		2.06 (0.57,8.59)	1.94 (0.59,6.64)	0.04 (‐0.03,0.30)
SD CERTO SC + MTX		1.63 (0.66,4.15)	1.57 (0.68,3.61)	0.02 (‐0.02,0.16)
SD TOFA PO + MTX		2.01 (0.73,6.26)	1.90 (0.74,5.24)	0.04 (‐0.02,0.22)
SD GOLI IV + MTX		3.25 (0.48,21.79)	2.85 (0.50,13.68)	0.08 (‐0.04,0.47)
SD ANA SC + MTX		1.39 (0.36,5.36)	1.36 (0.38,4.47)	0.01 (‐0.05,0.20)
SD ETN SC + DMARD		0.95 (0.37,2.65)	0.96 (0.40,2.55)	0.00 (‐0.08,0.05)
SD ABA IV + DMARD		0.50 (0.16,1.65)	0.52 (0.18,1.61)	‐0.02 (‐0.12,0.02)
SD ADA SC + DMARD		0.34 (0.09,1.28)	0.35 (0.10,1.27)	‐0.03 (‐0.13,0.01)
SD ANA + DMARD		0.49 (0.14,1.67)	0.50 (0.16,1.64)	‐0.02 (‐0.12,0.02)
SD CERTO SC + DMARD		0.34 (0.06,1.67)	0.35 (0.06,1.63)	‐0.03 (‐0.13,0.02)
SD TOCI SC + DMARD		0.62 (0.15,2.46)	0.64 (0.17,2.31)	‐0.01 (‐0.11,0.05)
LD ADA SC		0.49 (0.09,2.25)	0.50 (0.11,2.21)	‐0.02 (‐0.15,0.02)
LD ETN SC		0.79 (0.24,2.43)	0.80 (0.25,2.28)	‐0.01 (‐0.09,0.06)
LD GOLI IV		5.29 (0.89,34.38)	4.18 (0.90,17.42)	0.15 (‐0.01,0.58)
LD RITUX IV + MTX		0.93 (0.40,2.53)	0.93 (0.42,2.34)	0.00 (‐0.06,0.07)
LD ABA IV + MTX		1.27 (0.43,3.97)	1.25 (0.46,3.53)	0.01 (‐0.06,0.13)
LD CERTO SC + MTX		1.66 (0.31,7.96)	1.59 (0.33,5.90)	0.02 (‐0.05,0.28)
LD ETN SC + MTX		0.51 (0.16,1.39)	0.52 (0.16,1.35)	‐0.02 (‐0.10,0.02)
LD GOLI IV + MTX		3.13 (0.45,19.11)	2.75 (0.47,12.09)	0.08 (‐0.04,0.44)
HD TOCI IV		0.94 (0.36,2.72)	0.95 (0.38,2.56)	0.00 (‐0.07,0.07)
HD TOFA PO		0.41 (0.08,1.95)	0.42 (0.09,1.91)	‐0.03 (‐0.15,0.02)
HD GOLI SC		1.39 (0.31,5.82)	1.36 (0.33,4.69)	0.01 (‐0.07,0.20)
HD ADA SC		0.75 (0.16,2.90)	0.76 (0.18,2.80)	‐0.01 (‐0.14,0.03)
HD GOLI SC + MTX		2.89 (0.80,11.15)	2.59 (0.82,7.80)	0.07 (‐0.01,0.36)
HD TOCI IV + MTX		1.08 (0.34,3.80)	1.08 (0.36,3.37)	0.00 (‐0.06,0.12)
HD TOFA PO + MTX		1.68 (0.57,5.29)	1.61 (0.59,4.55)	0.02 (‐0.03,0.19)
HD INF IV + MTX		1.07 (0.45,2.78)	1.06 (0.47,2.57)	0.00 (‐0.06,0.08)
HD CERTO SC + MTX		1.95 (0.73,6.04)	1.85 (0.75,4.92)	0.04 (‐0.02,0.25)
HD TOCI IV + DMARD		0.73 (0.23,2.33)	0.74 (0.25,2.24)	‐0.01 (‐0.10,0.04)
SD ABA IV + MTX	SD ADA SC + MTX	0.87 (0.45,1.69)	0.88 (0.47,1.65)	0.00 (‐0.06,0.03)
SD RITUX IV + MTX		1.16 (0.53,2.65)	1.15 (0.55,2.51)	0.01 (‐0.04,0.07)
SD ABA SC + MTX		0.74 (0.41,1.29)	0.75 (0.43,1.27)	‐0.01 (‐0.07,0.01)
SD GOLI SC + MTX		2.20 (0.65,8.78)	2.05 (0.66,6.93)	0.04 (‐0.02,0.30)
SD CERTO SC + MTX		1.69 (0.78,4.13)	1.62 (0.79,3.72)	0.03 (‐0.01,0.15)
SD TOFA PO + MTX		2.12 (0.93,5.06)	1.98 (0.93,4.34)	0.04 (0.00,0.21)
SD GOLI IV + MTX		3.45 (0.53,22.58)	3.03 (0.55,14.59)	0.09 (‐0.03,0.47)
SD ANA SC + MTX		1.45 (0.39,5.40)	1.41 (0.41,4.60)	0.02 (‐0.05,0.19)
SD ETN SC + DMARD		1.02 (0.37,2.72)	1.02 (0.40,2.62)	0.00 (‐0.09,0.05)
SD ABA IV + DMARD		0.54 (0.17,1.69)	0.55 (0.19,1.66)	‐0.02 (‐0.12,0.02)
SD ADA SC + DMARD		0.36 (0.09,1.30)	0.37 (0.10,1.30)	‐0.02 (‐0.14,0.01)
SD ANA + DMARD		0.51 (0.14,1.68)	0.52 (0.16,1.65)	‐0.02 (‐0.13,0.02)
SD CERTO SC + DMARD		0.35 (0.06,1.74)	0.36 (0.07,1.69)	‐0.02 (‐0.14,0.02)
SD TOCI SC + DMARD		0.66 (0.16,2.68)	0.67 (0.18,2.50)	‐0.01 (‐0.11,0.05)
LD ADA SC		0.52 (0.09,2.35)	0.53 (0.11,2.30)	‐0.02 (‐0.16,0.02)
LD ETN SC		0.82 (0.26,2.61)	0.83 (0.29,2.47)	‐0.01 (‐0.09,0.07)
LD GOLI IV		5.68 (1.01,36.39)	4.44 (1.01,18.67)	0.15 (0.00,0.57)
LD RITUX IV + MTX		0.99 (0.44,2.29)	0.99 (0.46,2.18)	0.00 (‐0.06,0.06)
LD ABA IV + MTX		1.35 (0.51,3.37)	1.33 (0.53,3.08)	0.01 (‐0.04,0.11)
LD CERTO SC + MTX		1.69 (0.34,8.53)	1.62 (0.36,6.60)	0.03 (‐0.05,0.28)
LD ETN SC + MTX		0.52 (0.15,1.74)	0.54 (0.17,1.69)	‐0.02 (‐0.11,0.03)
LD GOLI IV + MTX		3.22 (0.51,20.51)	2.86 (0.54,13.14)	0.08 (‐0.04,0.45)
HD TOCI IV		0.98 (0.40,2.65)	0.98 (0.43,2.51)	0.00 (‐0.07,0.06)
HD TOFA PO		0.42 (0.07,1.97)	0.43 (0.08,1.94)	‐0.02 (‐0.16,0.01)
HD GOLI SC		1.42 (0.34,5.82)	1.39 (0.36,4.85)	0.02 (‐0.06,0.20)
HD ADA SC		0.80 (0.15,3.29)	0.80 (0.18,3.17)	‐0.01 (‐0.14,0.04)
HD GOLI SC + MTX		3.01 (0.90,11.42)	2.69 (0.91,8.50)	0.07 (0.00,0.35)
HD TOCI IV + MTX		1.13 (0.39,3.69)	1.12 (0.41,3.32)	0.00 (‐0.06,0.11)
HD TOFA PO + MTX		1.76 (0.77,4.21)	1.69 (0.78,3.70)	0.03 (‐0.01,0.16)
HD INF IV + MTX		1.12 (0.49,2.57)	1.11 (0.51,2.41)	0.00 (‐0.05,0.07)
HD CERTO SC + MTX		2.06 (0.79,6.21)	1.93 (0.81,5.24)	0.04 (‐0.01,0.24)
HD TOCI IV + DMARD		0.76 (0.25,2.35)	0.77 (0.27,2.26)	‐0.01 (‐0.10,0.04)
SD RITUX IV + MTX	SD ABA IV + MTX	1.33 (0.69,2.68)	1.31 (0.71,2.50)	0.01 (‐0.02,0.09)
SD ABA SC + MTX		0.84 (0.47,1.48)	0.85 (0.49,1.45)	0.00 (‐0.04,0.02)
SD GOLI SC + MTX		2.48 (0.78,9.26)	2.31 (0.79,6.89)	0.05 (‐0.01,0.31)
SD CERTO SC + MTX		1.94 (1.00,4.06)	1.85 (1.00,3.58)	0.03 (0.00,0.16)
SD TOFA PO + MTX		2.43 (1.05,5.95)	2.26 (1.05,5.08)	0.05 (0.00,0.23)
SD GOLI IV + MTX		3.89 (0.67,26.04)	3.35 (0.68,16.14)	0.09 (‐0.02,0.48)
SD ANA SC + MTX		1.66 (0.51,5.57)	1.60 (0.53,4.63)	0.02 (‐0.03,0.21)
SD ETN SC + DMARD		1.18 (0.47,2.92)	1.17 (0.49,2.81)	0.01 (‐0.05,0.05)
SD ABA IV + DMARD		0.61 (0.21,1.79)	0.62 (0.22,1.74)	‐0.01 (‐0.09,0.02)
SD ADA SC + DMARD		0.40 (0.12,1.43)	0.42 (0.13,1.41)	‐0.02 (‐0.11,0.01)
SD ANA + DMARD		0.59 (0.18,1.80)	0.60 (0.19,1.75)	‐0.01 (‐0.09,0.02)
SD CERTO SC + DMARD		0.40 (0.07,1.92)	0.41 (0.08,1.84)	‐0.02 (‐0.11,0.03)
SD TOCI SC + DMARD		0.76 (0.20,2.90)	0.77 (0.21,2.70)	‐0.01 (‐0.08,0.06)
LD ADA SC		0.58 (0.12,2.61)	0.59 (0.13,2.55)	‐0.01 (‐0.12,0.02)
LD ETN SC		0.93 (0.32,2.84)	0.94 (0.34,2.66)	0.00 (‐0.06,0.08)
LD GOLI IV		6.30 (1.24,40.25)	4.95 (1.22,19.94)	0.16 (0.01,0.58)
LD RITUX IV + MTX		1.13 (0.60,2.34)	1.12 (0.62,2.20)	0.00 (‐0.03,0.07)
LD ABA IV + MTX		1.53 (0.72,3.35)	1.49 (0.73,3.06)	0.02 (‐0.01,0.12)
LD CERTO SC + MTX		1.94 (0.43,8.74)	1.86 (0.45,6.53)	0.03 (‐0.03,0.30)
LD ETN SC + MTX		0.60 (0.18,1.86)	0.61 (0.19,1.81)	‐0.01 (‐0.08,0.03)
LD GOLI IV + MTX		3.58 (0.63,22.53)	3.16 (0.65,14.45)	0.08 (‐0.02,0.46)
HD TOCI IV		1.13 (0.50,2.76)	1.12 (0.53,2.58)	0.00 (‐0.04,0.07)
HD TOFA PO		0.49 (0.09,2.31)	0.50 (0.10,2.27)	‐0.02 (‐0.13,0.02)
HD GOLI SC		1.63 (0.41,6.48)	1.58 (0.42,5.26)	0.02 (‐0.04,0.22)
HD ADA SC		0.90 (0.20,3.69)	0.91 (0.22,3.52)	0.00 (‐0.11,0.04)
HD GOLI SC + MTX		3.46 (1.09,12.03)	3.05 (1.09,8.52)	0.08 (0.00,0.36)
HD TOCI IV + MTX		1.30 (0.49,3.82)	1.28 (0.50,3.47)	0.01 (‐0.03,0.12)
HD TOFA PO + MTX		2.03 (0.85,5.12)	1.94 (0.86,4.38)	0.03 (‐0.01,0.19)
HD INF IV + MTX		1.29 (0.67,2.56)	1.27 (0.68,2.38)	0.01 (‐0.02,0.08)
HD CERTO SC + MTX		2.36 (0.99,6.39)	2.20 (0.99,5.15)	0.05 (0.00,0.26)
HD TOCI IV + DMARD		0.87 (0.31,2.49)	0.88 (0.33,2.39)	0.00 (‐0.07,0.05)
SD ABA SC + MTX	SD RITUX IV + MTX	0.64 (0.28,1.37)	0.65 (0.30,1.35)	‐0.02 (‐0.10,0.01)
SD GOLI SC + MTX		1.86 (0.56,6.73)	1.76 (0.58,5.32)	0.04 (‐0.03,0.27)
SD CERTO SC + MTX		1.48 (0.70,3.10)	1.43 (0.72,2.81)	0.02 (‐0.02,0.13)
SD TOFA PO + MTX		1.84 (0.70,4.82)	1.75 (0.73,4.19)	0.03 (‐0.02,0.20)
SD GOLI IV + MTX		2.92 (0.46,20.20)	2.57 (0.48,12.96)	0.08 (‐0.04,0.45)
SD ANA SC + MTX		1.25 (0.37,4.20)	1.24 (0.39,3.58)	0.01 (‐0.06,0.17)
SD ETN SC + DMARD		0.88 (0.31,2.27)	0.88 (0.34,2.20)	‐0.01 (‐0.11,0.04)
SD ABA IV + DMARD		0.47 (0.14,1.36)	0.48 (0.16,1.34)	‐0.02 (‐0.15,0.01)
SD ADA SC + DMARD		0.31 (0.08,1.09)	0.33 (0.09,1.08)	‐0.03 (‐0.16,0.00)
SD ANA + DMARD		0.45 (0.13,1.39)	0.47 (0.14,1.37)	‐0.03 (‐0.15,0.01)
SD CERTO SC + DMARD		0.30 (0.05,1.46)	0.32 (0.06,1.44)	‐0.03 (‐0.16,0.02)
SD TOCI SC + DMARD		0.58 (0.13,2.10)	0.59 (0.15,2.00)	‐0.02 (‐0.14,0.04)
LD ADA SC		0.43 (0.08,2.19)	0.45 (0.09,2.16)	‐0.03 (‐0.18,0.02)
LD ETN SC		0.71 (0.24,2.06)	0.72 (0.26,1.97)	‐0.01 (‐0.10,0.05)
LD GOLI IV		4.74 (0.90,29.07)	3.81 (0.91,16.09)	0.14 (‐0.01,0.56)
LD RITUX IV + MTX		0.85 (0.51,1.45)	0.86 (0.54,1.41)	‐0.01 (‐0.05,0.02)
LD ABA IV + MTX		1.16 (0.45,2.80)	1.15 (0.48,2.59)	0.01 (‐0.06,0.10)
LD CERTO SC + MTX		1.48 (0.31,6.46)	1.44 (0.33,4.91)	0.02 (‐0.07,0.26)
LD ETN SC + MTX		0.45 (0.13,1.40)	0.47 (0.14,1.37)	‐0.02 (‐0.13,0.02)
LD GOLI IV + MTX		2.73 (0.43,16.96)	2.44 (0.46,11.26)	0.07 (‐0.04,0.43)
HD TOCI IV		0.86 (0.34,2.04)	0.87 (0.37,1.95)	‐0.01 (‐0.09,0.05)
HD TOFA PO		0.37 (0.06,1.82)	0.38 (0.07,1.80)	‐0.03 (‐0.19,0.01)
HD GOLI SC		1.22 (0.31,4.73)	1.21 (0.33,3.88)	0.01 (‐0.07,0.19)
HD ADA SC		0.68 (0.14,2.96)	0.69 (0.16,2.85)	‐0.01 (‐0.17,0.03)
HD GOLI SC + MTX		2.59 (0.83,9.14)	2.33 (0.84,6.53)	0.07 (‐0.01,0.33)
HD TOCI IV + MTX		0.98 (0.35,2.96)	0.98 (0.37,2.72)	0.00 (‐0.08,0.09)
HD TOFA PO + MTX		1.53 (0.60,3.96)	1.47 (0.62,3.50)	0.02 (‐0.04,0.16)
HD INF IV + MTX		0.98 (0.45,2.01)	0.98 (0.47,1.92)	0.00 (‐0.06,0.05)
HD CERTO SC + MTX		1.81 (0.73,4.73)	1.72 (0.74,3.87)	0.03 (‐0.02,0.21)
HD TOCI IV + DMARD		0.67 (0.22,1.93)	0.68 (0.24,1.86)	‐0.01 (‐0.12,0.03)
SD GOLI SC + MTX	SD ABA SC + MTX	2.95 (0.88,11.72)	2.71 (0.89,8.91)	0.06 (0.00,0.33)
SD CERTO SC + MTX		2.28 (1.07,5.45)	2.15 (1.07,4.78)	0.04 (0.00,0.18)
SD TOFA PO + MTX		2.86 (1.22,7.48)	2.65 (1.21,6.30)	0.05 (0.01,0.24)
SD GOLI IV + MTX		4.71 (0.76,32.59)	4.00 (0.77,19.95)	0.10 (‐0.01,0.49)
SD ANA SC + MTX		1.95 (0.57,7.11)	1.88 (0.58,5.89)	0.03 (‐0.02,0.22)
SD ETN SC + DMARD		1.39 (0.50,3.77)	1.36 (0.53,3.59)	0.01 (‐0.04,0.06)
SD ABA IV + DMARD		0.72 (0.23,2.28)	0.73 (0.25,2.20)	‐0.01 (‐0.08,0.03)
SD ADA SC + DMARD		0.49 (0.13,1.81)	0.50 (0.14,1.78)	‐0.01 (‐0.09,0.02)
SD ANA + DMARD		0.70 (0.20,2.30)	0.71 (0.21,2.22)	‐0.01 (‐0.08,0.03)
SD CERTO SC + DMARD		0.48 (0.09,2.32)	0.49 (0.09,2.25)	‐0.01 (‐0.09,0.03)
SD TOCI SC + DMARD		0.88 (0.22,3.64)	0.89 (0.24,3.41)	0.00 (‐0.07,0.07)
LD ADA SC		0.69 (0.13,3.15)	0.70 (0.14,3.08)	‐0.01 (‐0.11,0.03)
LD ETN SC		1.11 (0.36,3.59)	1.10 (0.37,3.35)	0.00 (‐0.05,0.09)
LD GOLI IV		7.54 (1.41,50.69)	5.85 (1.37,26.19)	0.16 (0.01,0.60)
LD RITUX IV + MTX		1.33 (0.61,3.19)	1.31 (0.63,3.02)	0.01 (‐0.02,0.08)
LD ABA IV + MTX		1.82 (0.73,4.57)	1.76 (0.75,4.10)	0.02 (‐0.01,0.14)
LD CERTO SC + MTX		2.28 (0.49,10.87)	2.16 (0.50,8.46)	0.04 (‐0.02,0.31)
LD ETN SC + MTX		0.71 (0.21,2.36)	0.72 (0.22,2.28)	‐0.01 (‐0.07,0.04)
LD GOLI IV + MTX		4.26 (0.70,28.12)	3.73 (0.71,18.64)	0.09 (‐0.01,0.47)
HD TOCI IV		1.33 (0.55,3.61)	1.31 (0.57,3.37)	0.01 (‐0.03,0.08)
HD TOFA PO		0.58 (0.10,2.72)	0.59 (0.12,2.66)	‐0.01 (‐0.12,0.02)
HD GOLI SC		1.97 (0.46,7.91)	1.89 (0.47,6.46)	0.03 (‐0.03,0.23)
HD ADA SC		1.07 (0.22,4.64)	1.07 (0.24,4.44)	0.00 (‐0.09,0.05)
HD GOLI SC + MTX		4.09 (1.26,15.06)	3.59 (1.24,10.89)	0.09 (0.01,0.38)
HD TOCI IV + MTX		1.54 (0.53,5.07)	1.51 (0.54,4.49)	0.01 (‐0.03,0.14)
HD TOFA PO + MTX		2.39 (0.98,6.30)	2.26 (0.98,5.41)	0.04 (0.00,0.20)
HD INF IV + MTX		1.52 (0.70,3.53)	1.48 (0.71,3.26)	0.01 (‐0.02,0.10)
HD CERTO SC + MTX		2.81 (1.07,8.50)	2.59 (1.07,6.85)	0.05 (0.00,0.27)
HD TOCI IV + DMARD		1.03 (0.34,3.18)	1.03 (0.35,3.03)	0.00 (‐0.06,0.06)
SD CERTO SC + MTX	SD GOLI SC + MTX	0.78 (0.22,2.53)	0.80 (0.27,2.31)	‐0.02 (‐0.23,0.09)
SD TOFA PO + MTX		0.97 (0.22,3.91)	0.97 (0.28,3.46)	0.00 (‐0.22,0.15)
SD GOLI IV + MTX		1.55 (0.18,12.61)	1.44 (0.21,8.27)	0.04 (‐0.19,0.39)
SD ANA SC + MTX		0.66 (0.14,3.21)	0.69 (0.17,2.82)	‐0.02 (‐0.25,0.11)
SD ETN SC + DMARD		0.47 (0.11,1.80)	0.50 (0.15,1.74)	‐0.04 (‐0.33,0.02)
SD ABA IV + DMARD		0.24 (0.05,1.02)	0.27 (0.07,1.02)	‐0.06 (‐0.37,0.00)
SD ADA SC + DMARD		0.16 (0.03,0.78)	0.18 (0.04,0.79)	‐0.07 (‐0.39,0.00)
SD ANA + DMARD		0.23 (0.05,1.04)	0.25 (0.06,1.04)	‐0.07 (‐0.37,0.00)
SD CERTO SC + DMARD		0.16 (0.02,1.09)	0.18 (0.02,1.09)	‐0.07 (‐0.39,0.00)
SD TOCI SC + DMARD		0.30 (0.05,1.50)	0.33 (0.07,1.46)	‐0.06 (‐0.35,0.02)
LD ADA SC		0.22 (0.03,1.44)	0.24 (0.05,1.43)	‐0.07 (‐0.40,0.01)
LD ETN SC		0.36 (0.09,1.68)	0.39 (0.11,1.62)	‐0.05 (‐0.31,0.03)
LD GOLI IV		2.62 (0.35,18.37)	2.17 (0.41,10.49)	0.09 (‐0.13,0.50)
LD RITUX IV + MTX		0.46 (0.12,1.54)	0.49 (0.15,1.51)	‐0.04 (‐0.30,0.02)
LD ABA IV + MTX		0.62 (0.14,2.30)	0.65 (0.17,2.15)	‐0.03 (‐0.27,0.06)
LD CERTO SC + MTX		0.75 (0.12,4.20)	0.78 (0.15,3.47)	‐0.02 (‐0.23,0.20)
LD ETN SC + MTX		0.24 (0.05,1.02)	0.26 (0.06,1.02)	‐0.06 (‐0.35,0.00)
LD GOLI IV + MTX		1.51 (0.17,11.67)	1.42 (0.20,7.80)	0.03 (‐0.19,0.37)
HD TOCI IV		0.46 (0.11,1.63)	0.49 (0.15,1.59)	‐0.04 (‐0.31,0.02)
HD TOFA PO		0.19 (0.02,1.22)	0.20 (0.04,1.21)	‐0.07 (‐0.41,0.01)
HD GOLI SC		0.62 (0.18,2.32)	0.66 (0.21,2.14)	‐0.03 (‐0.22,0.08)
HD ADA SC		0.35 (0.05,2.18)	0.37 (0.08,2.11)	‐0.06 (‐0.39,0.02)
HD GOLI SC + MTX		1.36 (0.53,3.57)	1.30 (0.58,2.98)	0.02 (‐0.09,0.20)
HD TOCI IV + MTX		0.53 (0.11,2.19)	0.56 (0.14,2.08)	‐0.04 (‐0.29,0.05)
HD TOFA PO + MTX		0.82 (0.18,3.20)	0.84 (0.22,2.90)	‐0.01 (‐0.23,0.11)
HD INF IV + MTX		0.52 (0.14,1.76)	0.55 (0.18,1.70)	‐0.04 (‐0.29,0.03)
HD CERTO SC + MTX		0.93 (0.23,3.46)	0.94 (0.29,3.02)	0.00 (‐0.20,0.15)
HD TOCI IV + DMARD		0.35 (0.07,1.39)	0.38 (0.09,1.37)	‐0.05 (‐0.34,0.01)
SD TOFA PO + MTX	SD CERTO SC + MTX	1.24 (0.47,3.28)	1.21 (0.51,2.93)	0.01 (‐0.07,0.14)
SD GOLI IV + MTX		1.97 (0.32,14.28)	1.79 (0.36,8.69)	0.06 (‐0.10,0.42)
SD ANA SC + MTX		0.85 (0.25,3.00)	0.86 (0.28,2.58)	‐0.01 (‐0.12,0.12)
SD ETN SC + DMARD		0.59 (0.21,1.59)	0.61 (0.25,1.55)	‐0.03 (‐0.18,0.02)
SD ABA IV + DMARD		0.31 (0.10,0.99)	0.33 (0.12,0.99)	‐0.05 (‐0.23,0.00)
SD ADA SC + DMARD		0.21 (0.05,0.78)	0.23 (0.07,0.79)	‐0.05 (‐0.24,‐0.01)
SD ANA + DMARD		0.30 (0.08,0.99)	0.32 (0.10,0.99)	‐0.05 (‐0.23,0.00)
SD CERTO SC + DMARD		0.20 (0.04,1.03)	0.22 (0.04,1.02)	‐0.05 (‐0.25,0.00)
SD TOCI SC + DMARD		0.39 (0.09,1.49)	0.41 (0.11,1.46)	‐0.04 (‐0.22,0.02)
LD ADA SC		0.31 (0.05,1.46)	0.32 (0.07,1.45)	‐0.05 (‐0.27,0.01)
LD ETN SC		0.48 (0.15,1.51)	0.51 (0.17,1.47)	‐0.03 (‐0.18,0.03)
LD GOLI IV		3.16 (0.59,22.08)	2.63 (0.63,11.15)	0.11 (‐0.04,0.53)
LD RITUX IV + MTX		0.58 (0.27,1.25)	0.60 (0.30,1.23)	‐0.03 (‐0.15,0.01)
LD ABA IV + MTX		0.78 (0.30,1.96)	0.80 (0.33,1.85)	‐0.01 (‐0.13,0.06)
LD CERTO SC + MTX		1.02 (0.22,3.73)	1.02 (0.24,3.07)	0.00 (‐0.11,0.20)
LD ETN SC + MTX		0.31 (0.09,0.96)	0.33 (0.10,0.96)	‐0.04 (‐0.21,0.00)
LD GOLI IV + MTX		1.80 (0.30,12.15)	1.67 (0.34,7.95)	0.05 (‐0.10,0.40)
HD TOCI IV		0.58 (0.23,1.47)	0.60 (0.26,1.43)	‐0.03 (‐0.16,0.02)
HD TOFA PO		0.26 (0.04,1.29)	0.27 (0.05,1.28)	‐0.05 (‐0.28,0.01)
HD GOLI SC		0.84 (0.20,3.36)	0.86 (0.22,2.83)	‐0.01 (‐0.14,0.15)
HD ADA SC		0.46 (0.09,1.99)	0.48 (0.12,1.94)	‐0.04 (‐0.26,0.02)
HD GOLI SC + MTX		1.76 (0.53,6.62)	1.63 (0.57,4.72)	0.04 (‐0.05,0.29)
HD TOCI IV + MTX		0.65 (0.23,2.10)	0.68 (0.26,1.97)	‐0.02 (‐0.15,0.06)
HD TOFA PO + MTX		1.04 (0.38,2.78)	1.03 (0.41,2.53)	0.00 (‐0.09,0.11)
HD INF IV + MTX		0.66 (0.30,1.40)	0.68 (0.34,1.35)	‐0.02 (‐0.13,0.02)
HD CERTO SC + MTX		1.22 (0.61,2.45)	1.19 (0.63,2.19)	0.01 (‐0.04,0.13)
HD TOCI IV + DMARD		0.44 (0.14,1.42)	0.47 (0.17,1.40)	‐0.04 (‐0.21,0.02)
SD GOLI IV + MTX	SD TOFA PO + MTX	1.63 (0.26,10.42)	1.50 (0.29,6.85)	0.04 (‐0.14,0.38)
SD ANA SC + MTX		0.68 (0.17,2.72)	0.71 (0.20,2.41)	‐0.02 (‐0.18,0.11)
SD ETN SC + DMARD		0.49 (0.15,1.37)	0.51 (0.19,1.35)	‐0.04 (‐0.24,0.02)
SD ABA IV + DMARD		0.26 (0.07,0.85)	0.28 (0.09,0.86)	‐0.06 (‐0.28,‐0.01)
SD ADA SC + DMARD		0.17 (0.04,0.64)	0.19 (0.05,0.65)	‐0.07 (‐0.30,‐0.01)
SD ANA + DMARD		0.24 (0.06,0.85)	0.27 (0.08,0.86)	‐0.06 (‐0.29,‐0.01)
SD CERTO SC + DMARD		0.17 (0.03,0.85)	0.18 (0.03,0.86)	‐0.07 (‐0.30,‐0.01)
SD TOCI SC + DMARD		0.31 (0.07,1.34)	0.33 (0.08,1.31)	‐0.06 (‐0.27,0.02)
LD ADA SC		0.25 (0.04,1.17)	0.26 (0.06,1.16)	‐0.06 (‐0.32,0.00)
LD ETN SC		0.39 (0.10,1.26)	0.42 (0.12,1.24)	‐0.05 (‐0.24,0.01)
LD GOLI IV		2.70 (0.43,16.94)	2.26 (0.49,9.26)	0.10 (‐0.09,0.50)
LD RITUX IV + MTX		0.47 (0.18,1.21)	0.50 (0.21,1.19)	‐0.04 (‐0.21,0.01)
LD ABA IV + MTX		0.63 (0.20,1.86)	0.66 (0.23,1.77)	‐0.03 (‐0.19,0.05)
LD CERTO SC + MTX		0.80 (0.14,4.11)	0.82 (0.16,3.27)	‐0.01 (‐0.19,0.20)
LD ETN SC + MTX		0.24 (0.06,0.93)	0.27 (0.07,0.93)	‐0.06 (‐0.27,0.00)
LD GOLI IV + MTX		1.53 (0.23,9.91)	1.43 (0.26,6.41)	0.03 (‐0.15,0.36)
HD TOCI IV		0.46 (0.17,1.36)	0.49 (0.20,1.33)	‐0.04 (‐0.22,0.02)
HD TOFA PO		0.20 (0.03,0.97)	0.22 (0.04,0.97)	‐0.07 (‐0.33,0.00)
HD GOLI SC		0.66 (0.15,3.17)	0.69 (0.18,2.72)	‐0.02 (‐0.21,0.13)
HD ADA SC		0.38 (0.07,1.52)	0.40 (0.09,1.49)	‐0.05 (‐0.31,0.02)
HD GOLI SC + MTX		1.44 (0.37,5.51)	1.36 (0.41,4.24)	0.03 (‐0.11,0.26)
HD TOCI IV + MTX		0.54 (0.17,1.89)	0.57 (0.19,1.77)	‐0.03 (‐0.20,0.05)
HD TOFA PO + MTX		0.83 (0.41,1.71)	0.85 (0.45,1.60)	‐0.01 (‐0.11,0.05)
HD INF IV + MTX		0.53 (0.20,1.36)	0.56 (0.23,1.33)	‐0.03 (‐0.20,0.02)
HD CERTO SC + MTX		0.97 (0.32,3.10)	0.98 (0.35,2.68)	0.00 (‐0.13,0.14)
HD TOCI IV + DMARD		0.36 (0.10,1.20)	0.39 (0.13,1.18)	‐0.05 (‐0.26,0.01)
SD ANA SC + MTX	SD GOLI IV + MTX	0.43 (0.05,3.71)	0.48 (0.08,3.16)	‐0.06 (‐0.43,0.13)
SD ETN SC + DMARD		0.30 (0.04,1.95)	0.33 (0.07,1.88)	‐0.09 (‐0.48,0.03)
SD ABA IV + DMARD		0.16 (0.02,1.13)	0.19 (0.03,1.13)	‐0.11 (‐0.52,0.00)
SD ADA SC + DMARD		0.10 (0.01,0.80)	0.12 (0.02,0.81)	‐0.12 (‐0.53,0.00)
SD ANA + DMARD		0.15 (0.02,1.06)	0.18 (0.03,1.06)	‐0.11 (‐0.51,0.00)
SD CERTO SC + DMARD		0.10 (0.01,1.04)	0.12 (0.02,1.04)	‐0.12 (‐0.52,0.00)
SD TOCI SC + DMARD		0.20 (0.02,1.52)	0.23 (0.03,1.46)	‐0.10 (‐0.51,0.02)
LD ADA SC		0.15 (0.02,1.22)	0.17 (0.03,1.21)	‐0.12 (‐0.54,0.00)
LD ETN SC		0.24 (0.03,1.76)	0.28 (0.05,1.70)	‐0.09 (‐0.48,0.03)
LD GOLI IV		1.66 (0.47,6.30)	1.46 (0.55,4.85)	0.06 (‐0.12,0.31)
LD RITUX IV + MTX		0.29 (0.04,1.86)	0.34 (0.07,1.80)	‐0.09 (‐0.46,0.03)
LD ABA IV + MTX		0.40 (0.05,2.91)	0.45 (0.09,2.66)	‐0.07 (‐0.45,0.07)
LD CERTO SC + MTX		0.51 (0.05,5.40)	0.56 (0.07,4.23)	‐0.05 (‐0.42,0.19)
LD ETN SC + MTX		0.16 (0.02,1.06)	0.19 (0.03,1.05)	‐0.11 (‐0.51,0.00)
LD GOLI IV + MTX		0.93 (0.25,3.96)	0.94 (0.31,3.35)	‐0.01 (‐0.22,0.20)
HD TOCI IV		0.29 (0.04,1.99)	0.34 (0.07,1.92)	‐0.09 (‐0.47,0.03)
HD TOFA PO		0.12 (0.01,1.05)	0.14 (0.03,1.05)	‐0.12 (‐0.55,0.00)
HD GOLI SC		0.41 (0.05,3.42)	0.46 (0.07,3.01)	‐0.07 (‐0.43,0.13)
HD ADA SC		0.23 (0.02,1.84)	0.25 (0.05,1.80)	‐0.10 (‐0.53,0.02)
HD GOLI SC + MTX		0.91 (0.12,7.69)	0.92 (0.17,5.80)	‐0.01 (‐0.35,0.26)
HD TOCI IV + MTX		0.34 (0.04,2.45)	0.38 (0.07,2.26)	‐0.08 (‐0.45,0.06)
HD TOFA PO + MTX		0.51 (0.08,3.53)	0.56 (0.13,3.18)	‐0.05 (‐0.40,0.12)
HD INF IV + MTX		0.34 (0.05,2.09)	0.38 (0.07,2.00)	‐0.08 (‐0.45,0.04)
HD CERTO SC + MTX		0.62 (0.08,4.49)	0.66 (0.12,3.83)	‐0.04 (‐0.39,0.16)
HD TOCI IV + DMARD		0.23 (0.03,1.53)	0.26 (0.05,1.50)	‐0.10 (‐0.49,0.02)
SD ETN SC + DMARD	SD ANA SC + MTX	0.70 (0.17,2.81)	0.72 (0.22,2.69)	‐0.02 (‐0.22,0.04)
SD ABA IV + DMARD		0.37 (0.08,1.65)	0.39 (0.10,1.61)	‐0.04 (‐0.26,0.01)
SD ADA SC + DMARD		0.25 (0.05,1.26)	0.26 (0.06,1.25)	‐0.04 (‐0.27,0.01)
SD ANA + DMARD		0.35 (0.07,1.57)	0.37 (0.09,1.53)	‐0.04 (‐0.26,0.01)
SD CERTO SC + DMARD		0.25 (0.03,1.62)	0.26 (0.04,1.57)	‐0.04 (‐0.27,0.02)
SD TOCI SC + DMARD		0.46 (0.08,2.37)	0.48 (0.10,2.25)	‐0.03 (‐0.25,0.04)
LD ADA SC		0.36 (0.04,2.25)	0.37 (0.06,2.21)	‐0.04 (‐0.30,0.02)
LD ETN SC		0.56 (0.12,2.51)	0.58 (0.14,2.35)	‐0.02 (‐0.22,0.05)
LD GOLI IV		3.83 (0.55,31.58)	3.09 (0.61,17.01)	0.12 (‐0.06,0.55)
LD RITUX IV + MTX		0.68 (0.18,2.40)	0.70 (0.22,2.30)	‐0.02 (‐0.19,0.05)
LD ABA IV + MTX		0.93 (0.23,3.40)	0.93 (0.26,3.15)	0.00 (‐0.16,0.09)
LD CERTO SC + MTX		1.19 (0.19,6.81)	1.17 (0.22,5.50)	0.01 (‐0.14,0.24)
LD ETN SC + MTX		0.36 (0.08,1.61)	0.38 (0.09,1.58)	‐0.04 (‐0.24,0.02)
LD GOLI IV + MTX		2.20 (0.28,17.70)	1.99 (0.33,11.53)	0.06 (‐0.13,0.42)
HD TOCI IV		0.68 (0.18,2.73)	0.70 (0.21,2.61)	‐0.02 (‐0.20,0.05)
HD TOFA PO		0.28 (0.04,1.92)	0.30 (0.05,1.89)	‐0.04 (‐0.30,0.01)
HD GOLI SC		0.99 (0.18,5.06)	1.00 (0.20,4.43)	0.00 (‐0.16,0.16)
HD ADA SC		0.55 (0.08,2.91)	0.56 (0.11,2.82)	‐0.03 (‐0.28,0.03)
HD GOLI SC + MTX		2.07 (0.47,9.26)	1.88 (0.52,7.19)	0.05 (‐0.07,0.31)
HD TOCI IV + MTX		0.80 (0.18,3.42)	0.81 (0.21,3.13)	‐0.01 (‐0.18,0.09)
HD TOFA PO + MTX		1.22 (0.30,4.91)	1.20 (0.34,4.34)	0.01 (‐0.13,0.15)
HD INF IV + MTX		0.78 (0.22,2.66)	0.79 (0.26,2.52)	‐0.01 (‐0.18,0.06)
HD CERTO SC + MTX		1.42 (0.35,5.88)	1.37 (0.41,5.02)	0.02 (‐0.11,0.20)
HD TOCI IV + DMARD		0.53 (0.11,2.29)	0.55 (0.14,2.22)	‐0.03 (‐0.24,0.03)
SD ABA IV + DMARD	SD ETN SC + DMARD	0.53 (0.22,1.24)	0.54 (0.23,1.22)	‐0.02 (‐0.08,0.01)
SD ADA SC + DMARD		0.35 (0.12,0.99)	0.36 (0.13,0.99)	‐0.03 (‐0.10,0.00)
SD ANA + DMARD		0.50 (0.19,1.28)	0.51 (0.20,1.26)	‐0.02 (‐0.08,0.01)
SD CERTO SC + DMARD		0.35 (0.08,1.42)	0.36 (0.08,1.37)	‐0.03 (‐0.10,0.02)
SD TOCI SC + DMARD		0.63 (0.20,2.22)	0.64 (0.21,2.11)	‐0.01 (‐0.07,0.05)
LD ADA SC		0.50 (0.12,1.77)	0.51 (0.14,1.74)	‐0.02 (‐0.12,0.02)
LD ETN SC		0.81 (0.26,2.48)	0.82 (0.27,2.31)	‐0.01 (‐0.06,0.08)
LD GOLI IV		5.45 (0.94,33.63)	4.39 (0.95,16.67)	0.15 (0.00,0.59)
LD RITUX IV + MTX		0.97 (0.36,2.72)	0.97 (0.37,2.49)	0.00 (‐0.05,0.08)
LD ABA IV + MTX		1.30 (0.43,4.19)	1.28 (0.45,3.57)	0.01 (‐0.04,0.14)
LD CERTO SC + MTX		1.68 (0.29,9.16)	1.62 (0.31,6.62)	0.03 (‐0.05,0.30)
LD ETN SC + MTX		0.53 (0.13,1.80)	0.54 (0.14,1.73)	‐0.02 (‐0.08,0.04)
LD GOLI IV + MTX		3.12 (0.47,20.12)	2.80 (0.49,12.01)	0.08 (‐0.03,0.47)
HD TOCI IV		0.97 (0.41,2.40)	0.97 (0.43,2.24)	0.00 (‐0.04,0.07)
HD TOFA PO		0.42 (0.09,1.53)	0.43 (0.11,1.52)	‐0.02 (‐0.12,0.01)
HD GOLI SC		1.40 (0.32,6.48)	1.37 (0.34,5.09)	0.02 (‐0.05,0.22)
HD ADA SC		0.77 (0.21,2.41)	0.78 (0.23,2.33)	‐0.01 (‐0.10,0.03)
HD GOLI SC + MTX		3.00 (0.79,11.92)	2.70 (0.80,8.13)	0.07 (‐0.01,0.38)
HD TOCI IV + MTX		1.13 (0.37,3.53)	1.12 (0.38,3.09)	0.00 (‐0.05,0.13)
HD TOFA PO + MTX		1.72 (0.59,5.47)	1.66 (0.60,4.62)	0.03 (‐0.03,0.20)
HD INF IV + MTX		1.11 (0.40,3.12)	1.10 (0.41,2.83)	0.00 (‐0.04,0.10)
HD CERTO SC + MTX		2.05 (0.66,6.90)	1.94 (0.68,5.29)	0.04 (‐0.02,0.27)
HD TOCI IV + DMARD		0.76 (0.32,1.69)	0.77 (0.33,1.65)	‐0.01 (‐0.06,0.03)
SD ADA SC + DMARD	SD ABA IV + DMARD	0.66 (0.23,1.89)	0.67 (0.24,1.85)	‐0.01 (‐0.05,0.02)
SD ANA + DMARD		0.95 (0.37,2.40)	0.95 (0.39,2.31)	0.00 (‐0.04,0.03)
SD CERTO SC + DMARD		0.66 (0.15,2.70)	0.66 (0.16,2.59)	‐0.01 (‐0.05,0.04)
SD TOCI SC + DMARD		1.21 (0.39,3.91)	1.20 (0.40,3.66)	0.00 (‐0.03,0.08)
LD ADA SC		0.94 (0.19,4.08)	0.94 (0.20,3.95)	0.00 (‐0.07,0.03)
LD ETN SC		1.51 (0.43,5.52)	1.49 (0.45,5.09)	0.01 (‐0.03,0.12)
LD GOLI IV		10.09 (1.53,75.14)	7.91 (1.50,38.29)	0.17 (0.02,0.62)
LD RITUX IV + MTX		1.82 (0.61,6.07)	1.78 (0.63,5.55)	0.02 (‐0.02,0.12)
LD ABA IV + MTX		2.51 (0.70,9.02)	2.40 (0.72,7.73)	0.03 (‐0.01,0.18)
LD CERTO SC + MTX		3.14 (0.52,18.76)	2.93 (0.53,13.87)	0.05 (‐0.02,0.34)
LD ETN SC + MTX		0.98 (0.22,4.02)	0.98 (0.23,3.80)	0.00 (‐0.05,0.07)
LD GOLI IV + MTX		5.91 (0.83,45.07)	5.13 (0.84,27.29)	0.10 (‐0.01,0.49)
HD TOCI IV		1.82 (0.77,5.12)	1.78 (0.78,4.68)	0.02 (‐0.01,0.10)
HD TOFA PO		0.78 (0.15,3.82)	0.79 (0.16,3.74)	0.00 (‐0.08,0.03)
HD GOLI SC		2.62 (0.58,12.98)	2.49 (0.59,10.41)	0.03 (‐0.02,0.26)
HD ADA SC		1.47 (0.32,5.79)	1.45 (0.34,5.55)	0.01 (‐0.06,0.05)
HD GOLI SC + MTX		5.69 (1.34,26.59)	4.95 (1.32,17.60)	0.10 (0.01,0.42)
HD TOCI IV + MTX		2.13 (0.68,7.44)	2.05 (0.69,6.54)	0.02 (‐0.01,0.16)
HD TOFA PO + MTX		3.29 (0.97,11.66)	3.07 (0.97,9.70)	0.05 (0.00,0.24)
HD INF IV + MTX		2.09 (0.69,6.86)	2.02 (0.70,6.22)	0.02 (‐0.01,0.14)
HD CERTO SC + MTX		3.91 (1.09,15.15)	3.58 (1.08,11.68)	0.06 (0.00,0.31)
HD TOCI IV + DMARD		1.44 (0.63,3.23)	1.42 (0.65,3.10)	0.01 (‐0.02,0.06)
SD ANA + DMARD	SD ADA SC + DMARD	1.43 (0.46,4.34)	1.42 (0.48,4.20)	0.01 (‐0.02,0.05)
SD CERTO SC + DMARD		0.98 (0.20,4.76)	0.98 (0.20,4.51)	0.00 (‐0.04,0.05)
SD TOCI SC + DMARD		1.81 (0.48,6.66)	1.78 (0.49,6.24)	0.01 (‐0.02,0.09)
LD ADA SC		1.44 (0.24,7.20)	1.43 (0.25,6.94)	0.01 (‐0.06,0.04)
LD ETN SC		2.25 (0.55,9.63)	2.20 (0.56,8.79)	0.02 (‐0.02,0.13)
LD GOLI IV		16.15 (1.98,122.00)	12.22 (1.91,62.43)	0.18 (0.02,0.64)
LD RITUX IV + MTX		2.75 (0.78,10.76)	2.65 (0.79,9.78)	0.03 (‐0.01,0.14)
LD ABA IV + MTX		3.77 (0.94,15.63)	3.58 (0.94,13.76)	0.04 (0.00,0.19)
LD CERTO SC + MTX		4.77 (0.70,32.76)	4.40 (0.71,23.85)	0.06 (‐0.01,0.36)
LD ETN SC + MTX		1.47 (0.29,6.93)	1.46 (0.30,6.51)	0.01 (‐0.03,0.08)
LD GOLI IV + MTX		9.17 (1.06,72.09)	7.80 (1.06,45.57)	0.11 (0.00,0.51)
HD TOCI IV		2.75 (0.97,9.19)	2.66 (0.97,8.40)	0.03 (0.00,0.12)
HD TOFA PO		1.18 (0.19,6.10)	1.17 (0.20,5.97)	0.00 (‐0.06,0.03)
HD GOLI SC		3.93 (0.76,23.07)	3.67 (0.77,18.71)	0.04 (‐0.01,0.27)
HD ADA SC		2.20 (0.41,9.67)	2.16 (0.43,9.22)	0.02 (‐0.04,0.06)
HD GOLI SC + MTX		8.53 (1.73,46.07)	7.31 (1.68,31.81)	0.10 (0.01,0.43)
HD TOCI IV + MTX		3.19 (0.88,12.82)	3.05 (0.89,11.09)	0.03 (0.00,0.18)
HD TOFA PO + MTX		4.88 (1.33,21.39)	4.52 (1.31,17.87)	0.05 (0.01,0.26)
HD INF IV + MTX		3.18 (0.84,12.23)	3.03 (0.85,11.01)	0.03 (0.00,0.16)
HD CERTO SC + MTX		5.81 (1.42,26.15)	5.28 (1.39,20.12)	0.07 (0.01,0.33)
HD TOCI IV + DMARD		2.16 (0.76,5.90)	2.11 (0.76,5.65)	0.02 (‐0.01,0.08)
SD CERTO SC + DMARD	SD ANA + DMARD	0.70 (0.15,3.00)	0.71 (0.15,2.89)	‐0.01 (‐0.05,0.04)
SD TOCI SC + DMARD		1.25 (0.39,4.40)	1.25 (0.40,4.08)	0.00 (‐0.03,0.08)
LD ADA SC		1.01 (0.20,4.45)	1.01 (0.21,4.33)	0.00 (‐0.07,0.03)
LD ETN SC		1.57 (0.45,6.44)	1.55 (0.46,5.94)	0.01 (‐0.03,0.12)
LD GOLI IV		11.02 (1.58,82.43)	8.43 (1.54,41.91)	0.18 (0.02,0.62)
LD RITUX IV + MTX		1.92 (0.61,6.90)	1.86 (0.62,6.33)	0.02 (‐0.02,0.13)
LD ABA IV + MTX		2.64 (0.73,10.38)	2.52 (0.74,8.95)	0.03 (‐0.01,0.18)
LD CERTO SC + MTX		3.37 (0.52,21.60)	3.14 (0.53,15.79)	0.05 (‐0.02,0.34)
LD ETN SC + MTX		1.04 (0.22,4.60)	1.04 (0.23,4.33)	0.00 (‐0.04,0.07)
LD GOLI IV + MTX		6.34 (0.82,49.57)	5.47 (0.84,29.87)	0.10 (‐0.01,0.50)
HD TOCI IV		1.95 (0.72,5.47)	1.90 (0.73,5.06)	0.02 (‐0.01,0.11)
HD TOFA PO		0.82 (0.15,4.15)	0.83 (0.17,4.04)	0.00 (‐0.08,0.03)
HD GOLI SC		2.80 (0.59,14.12)	2.66 (0.61,11.41)	0.04 (‐0.02,0.26)
HD ADA SC		1.54 (0.32,6.46)	1.52 (0.34,6.24)	0.01 (‐0.06,0.05)
HD GOLI SC + MTX		6.05 (1.41,29.32)	5.25 (1.38,19.59)	0.10 (0.01,0.42)
HD TOCI IV + MTX		2.23 (0.66,8.36)	2.16 (0.67,7.30)	0.02 (‐0.01,0.16)
HD TOFA PO + MTX		3.46 (0.97,13.39)	3.21 (0.97,11.04)	0.05 (0.00,0.25)
HD INF IV + MTX		2.19 (0.66,7.82)	2.12 (0.68,7.05)	0.02 (‐0.01,0.15)
HD CERTO SC + MTX		4.07 (1.07,16.84)	3.73 (1.06,13.00)	0.06 (0.00,0.32)
HD TOCI IV + DMARD		1.51 (0.60,3.67)	1.49 (0.61,3.51)	0.01 (‐0.02,0.06)
SD TOCI SC + DMARD	SD CERTO SC + DMARD	1.84 (0.36,10.22)	1.81 (0.37,9.67)	0.01 (‐0.04,0.10)
LD ADA SC		1.45 (0.21,10.21)	1.44 (0.22,9.85)	0.01 (‐0.07,0.04)
LD ETN SC		2.35 (0.40,13.39)	2.29 (0.42,12.27)	0.02 (‐0.03,0.13)
LD GOLI IV		16.49 (1.62,145.80)	12.41 (1.56,80.73)	0.18 (0.02,0.64)
LD RITUX IV + MTX		2.81 (0.58,15.17)	2.71 (0.60,13.86)	0.02 (‐0.02,0.14)
LD ABA IV + MTX		3.91 (0.69,22.50)	3.69 (0.71,19.30)	0.04 (‐0.01,0.19)
LD CERTO SC + MTX		4.84 (0.51,48.28)	4.41 (0.53,35.63)	0.05 (‐0.02,0.36)
LD ETN SC + MTX		1.46 (0.23,9.21)	1.45 (0.25,8.69)	0.01 (‐0.05,0.09)
LD GOLI IV + MTX		9.44 (0.88,90.20)	7.94 (0.88,56.94)	0.11 (0.00,0.50)
HD TOCI IV		2.88 (0.64,13.40)	2.77 (0.66,12.30)	0.02 (‐0.02,0.13)
HD TOFA PO		1.21 (0.16,8.49)	1.21 (0.17,8.27)	0.00 (‐0.08,0.03)
HD GOLI SC		3.93 (0.55,34.46)	3.71 (0.57,27.35)	0.04 (‐0.02,0.28)
HD ADA SC		2.22 (0.34,14.61)	2.17 (0.36,13.97)	0.02 (‐0.06,0.06)
HD GOLI SC + MTX		8.51 (1.28,71.10)	7.35 (1.25,48.69)	0.10 (0.01,0.44)
HD TOCI IV + MTX		3.25 (0.63,19.14)	3.10 (0.65,16.82)	0.03 (‐0.02,0.18)
HD TOFA PO + MTX		5.08 (0.98,28.44)	4.67 (0.98,24.43)	0.05 (0.00,0.26)
HD INF IV + MTX		3.24 (0.65,18.74)	3.09 (0.67,16.57)	0.03 (‐0.02,0.16)
HD CERTO SC + MTX		5.91 (1.05,37.13)	5.38 (1.04,28.90)	0.07 (0.00,0.33)
HD TOCI IV + DMARD		2.18 (0.52,9.76)	2.13 (0.54,9.11)	0.02 (‐0.03,0.08)
LD ADA SC	SD TOCI SC + DMARD	0.80 (0.13,4.09)	0.80 (0.14,3.96)	‐0.01 (‐0.12,0.03)
LD ETN SC		1.25 (0.27,5.83)	1.24 (0.30,5.30)	0.01 (‐0.07,0.11)
LD GOLI IV		8.47 (1.16,73.25)	6.58 (1.15,38.20)	0.17 (0.01,0.61)
LD RITUX IV + MTX		1.50 (0.41,6.39)	1.48 (0.43,5.83)	0.01 (‐0.05,0.11)
LD ABA IV + MTX		2.02 (0.49,9.52)	1.95 (0.51,8.30)	0.02 (‐0.04,0.17)
LD CERTO SC + MTX		2.62 (0.37,19.05)	2.46 (0.39,13.89)	0.04 (‐0.04,0.33)
LD ETN SC + MTX		0.81 (0.16,4.16)	0.82 (0.17,3.96)	0.00 (‐0.08,0.06)
LD GOLI IV + MTX		4.74 (0.59,42.79)	4.18 (0.61,26.98)	0.09 (‐0.02,0.48)
HD TOCI IV		1.51 (0.47,5.54)	1.48 (0.49,5.16)	0.01 (‐0.05,0.10)
HD TOFA PO		0.65 (0.10,3.67)	0.66 (0.11,3.62)	‐0.01 (‐0.12,0.02)
HD GOLI SC		2.17 (0.39,12.49)	2.08 (0.41,10.37)	0.03 (‐0.05,0.25)
HD ADA SC		1.22 (0.22,5.82)	1.21 (0.24,5.60)	0.01 (‐0.10,0.05)
HD GOLI SC + MTX		4.65 (0.93,26.84)	4.06 (0.94,18.35)	0.09 (0.00,0.41)
HD TOCI IV + MTX		1.76 (0.44,7.85)	1.71 (0.45,7.03)	0.02 (‐0.04,0.15)
HD TOFA PO + MTX		2.76 (0.60,12.01)	2.58 (0.62,10.29)	0.04 (‐0.03,0.23)
HD INF IV + MTX		1.70 (0.46,7.43)	1.66 (0.48,6.67)	0.02 (‐0.05,0.13)
HD CERTO SC + MTX		3.15 (0.73,15.95)	2.90 (0.75,12.41)	0.05 (‐0.02,0.30)
HD TOCI IV + DMARD		1.19 (0.39,3.55)	1.18 (0.41,3.42)	0.00 (‐0.06,0.05)
LD ETN SC	LD ADA SC	1.59 (0.28,9.81)	1.57 (0.29,8.54)	0.01 (‐0.03,0.15)
LD GOLI IV		10.84 (1.75,102.40)	8.64 (1.71,38.74)	0.18 (0.02,0.65)
LD RITUX IV + MTX		1.96 (0.39,10.77)	1.92 (0.41,9.33)	0.02 (‐0.02,0.16)
LD ABA IV + MTX		2.71 (0.51,16.21)	2.61 (0.52,13.13)	0.03 (‐0.02,0.21)
LD CERTO SC + MTX		3.47 (0.36,31.74)	3.24 (0.37,20.74)	0.05 (‐0.02,0.37)
LD ETN SC + MTX		1.00 (0.17,6.54)	1.00 (0.18,5.97)	0.00 (‐0.03,0.10)
LD GOLI IV + MTX		6.27 (0.89,56.60)	5.54 (0.90,29.64)	0.10 (0.00,0.52)
HD TOCI IV		1.94 (0.44,10.37)	1.89 (0.45,9.01)	0.02 (‐0.02,0.15)
HD TOFA PO		0.81 (0.25,2.64)	0.81 (0.26,2.59)	0.00 (‐0.04,0.02)
HD GOLI SC		2.75 (0.43,22.86)	2.63 (0.44,16.38)	0.04 (‐0.02,0.29)
HD ADA SC		1.53 (0.64,3.69)	1.51 (0.64,3.55)	0.01 (‐0.02,0.04)
HD GOLI SC + MTX		5.87 (0.92,45.19)	5.19 (0.92,26.11)	0.10 (0.00,0.46)
HD TOCI IV + MTX		2.28 (0.40,14.43)	2.21 (0.41,11.61)	0.03 (‐0.03,0.20)
HD TOFA PO + MTX		3.38 (0.66,22.14)	3.20 (0.67,16.02)	0.05 (‐0.01,0.29)
HD INF IV + MTX		2.24 (0.46,12.53)	2.18 (0.47,10.32)	0.03 (‐0.02,0.18)
HD CERTO SC + MTX		3.96 (0.72,27.13)	3.69 (0.73,18.22)	0.06 (‐0.01,0.35)
HD TOCI IV + DMARD		1.51 (0.32,7.27)	1.49 (0.33,6.63)	0.01 (‐0.03,0.10)
LD GOLI IV	LD ETN SC	6.83 (1.04,49.43)	5.29 (1.03,27.62)	0.16 (0.00,0.59)
LD RITUX IV + MTX		1.21 (0.41,3.66)	1.20 (0.44,3.44)	0.01 (‐0.06,0.08)
LD ABA IV + MTX		1.63 (0.46,5.83)	1.59 (0.49,5.26)	0.02 (‐0.05,0.14)
LD CERTO SC + MTX		2.07 (0.34,11.64)	1.97 (0.36,8.95)	0.03 (‐0.05,0.30)
LD ETN SC + MTX		0.63 (0.14,2.73)	0.65 (0.15,2.64)	‐0.01 (‐0.11,0.05)
LD GOLI IV + MTX		3.93 (0.50,27.79)	3.41 (0.52,19.30)	0.08 (‐0.03,0.46)
HD TOCI IV		1.22 (0.38,4.00)	1.21 (0.41,3.73)	0.01 (‐0.07,0.08)
HD TOFA PO		0.51 (0.08,2.75)	0.52 (0.09,2.69)	‐0.02 (‐0.15,0.02)
HD GOLI SC		1.76 (0.37,7.99)	1.68 (0.38,6.77)	0.02 (‐0.06,0.21)
HD ADA SC		0.96 (0.17,4.65)	0.96 (0.19,4.47)	0.00 (‐0.14,0.04)
HD GOLI SC + MTX		3.83 (0.85,15.86)	3.35 (0.86,11.52)	0.08 (‐0.01,0.37)
HD TOCI IV + MTX		1.41 (0.37,5.43)	1.39 (0.39,4.85)	0.01 (‐0.06,0.14)
HD TOFA PO + MTX		2.14 (0.66,7.89)	2.03 (0.68,6.92)	0.03 (‐0.03,0.20)
HD INF IV + MTX		1.38 (0.42,4.39)	1.36 (0.45,4.10)	0.01 (‐0.06,0.10)
HD CERTO SC + MTX		2.55 (0.72,9.23)	2.35 (0.74,7.73)	0.05 (‐0.02,0.26)
HD TOCI IV + DMARD		0.95 (0.26,3.27)	0.95 (0.29,3.11)	0.00 (‐0.10,0.05)
LD RITUX IV + MTX	LD GOLI IV	0.17 (0.03,1.00)	0.22 (0.06,1.00)	‐0.15 (‐0.57,0.00)
LD ABA IV + MTX		0.24 (0.03,1.45)	0.30 (0.07,1.39)	‐0.13 (‐0.56,0.03)
LD CERTO SC + MTX		0.30 (0.03,2.89)	0.37 (0.05,2.40)	‐0.11 (‐0.54,0.13)
LD ETN SC + MTX		0.09 (0.01,0.61)	0.12 (0.02,0.64)	‐0.17 (‐0.62,‐0.02)
LD GOLI IV + MTX		0.56 (0.17,2.02)	0.64 (0.22,1.76)	‐0.06 (‐0.32,0.11)
HD TOCI IV		0.17 (0.03,1.09)	0.22 (0.05,1.08)	‐0.15 (‐0.58,0.00)
HD TOFA PO		0.08 (0.01,0.54)	0.10 (0.02,0.55)	‐0.18 (‐0.66,‐0.02)
HD GOLI SC		0.25 (0.03,2.00)	0.31 (0.06,1.80)	‐0.13 (‐0.55,0.07)
HD ADA SC		0.14 (0.02,0.86)	0.18 (0.04,0.86)	‐0.17 (‐0.64,‐0.01)
HD GOLI SC + MTX		0.54 (0.08,4.00)	0.61 (0.13,3.18)	‐0.06 (‐0.46,0.21)
HD TOCI IV + MTX		0.20 (0.03,1.35)	0.26 (0.05,1.31)	‐0.14 (‐0.56,0.02)
HD TOFA PO + MTX		0.31 (0.05,1.96)	0.38 (0.09,1.79)	‐0.12 (‐0.52,0.06)
HD INF IV + MTX		0.20 (0.03,1.12)	0.26 (0.06,1.11)	‐0.14 (‐0.56,0.01)
HD CERTO SC + MTX		0.38 (0.05,2.33)	0.45 (0.10,2.05)	‐0.10 (‐0.51,0.10)
HD TOCI IV + DMARD		0.14 (0.02,0.88)	0.17 (0.04,0.89)	‐0.16 (‐0.60,‐0.01)
LD ABA IV + MTX	LD RITUX IV + MTX	1.36 (0.52,3.30)	1.33 (0.54,3.04)	0.01 (‐0.04,0.11)
LD CERTO SC + MTX		1.71 (0.36,7.85)	1.64 (0.38,6.18)	0.03 (‐0.05,0.28)
LD ETN SC + MTX		0.52 (0.16,1.67)	0.53 (0.17,1.62)	‐0.02 (‐0.11,0.02)
LD GOLI IV + MTX		3.25 (0.50,19.21)	2.87 (0.51,12.56)	0.08 (‐0.03,0.44)
HD TOCI IV		1.03 (0.39,2.39)	1.02 (0.42,2.28)	0.00 (‐0.07,0.06)
HD TOFA PO		0.43 (0.07,2.03)	0.45 (0.09,2.00)	‐0.02 (‐0.16,0.02)
HD GOLI SC		1.42 (0.35,5.66)	1.38 (0.37,4.70)	0.01 (‐0.06,0.21)
HD ADA SC		0.79 (0.16,3.43)	0.80 (0.19,3.31)	‐0.01 (‐0.14,0.04)
HD GOLI SC + MTX		3.03 (0.94,11.06)	2.71 (0.94,8.04)	0.07 (0.00,0.35)
HD TOCI IV + MTX		1.15 (0.39,3.49)	1.15 (0.41,3.18)	0.01 (‐0.06,0.11)
HD TOFA PO + MTX		1.78 (0.69,4.56)	1.70 (0.71,4.01)	0.03 (‐0.02,0.18)
HD INF IV + MTX		1.15 (0.53,2.34)	1.14 (0.55,2.20)	0.00 (‐0.04,0.07)
HD CERTO SC + MTX		2.10 (0.84,5.76)	1.97 (0.85,4.67)	0.04 (‐0.01,0.24)
HD TOCI IV + DMARD		0.77 (0.26,2.20)	0.78 (0.28,2.12)	‐0.01 (‐0.10,0.04)
LD CERTO SC + MTX	LD ABA IV + MTX	1.26 (0.24,6.61)	1.23 (0.26,5.30)	0.01 (‐0.10,0.25)
LD ETN SC + MTX		0.39 (0.10,1.49)	0.41 (0.11,1.46)	‐0.03 (‐0.17,0.02)
LD GOLI IV + MTX		2.37 (0.35,16.71)	2.14 (0.39,10.92)	0.06 (‐0.07,0.42)
HD TOCI IV		0.74 (0.26,2.18)	0.75 (0.30,2.09)	‐0.01 (‐0.12,0.05)
HD TOFA PO		0.31 (0.05,1.76)	0.32 (0.07,1.73)	‐0.04 (‐0.22,0.01)
HD GOLI SC		1.05 (0.23,4.85)	1.05 (0.25,3.97)	0.00 (‐0.11,0.18)
HD ADA SC		0.58 (0.11,2.69)	0.60 (0.13,2.61)	‐0.02 (‐0.20,0.03)
HD GOLI SC + MTX		2.22 (0.61,9.17)	2.02 (0.64,6.89)	0.06 (‐0.04,0.33)
HD TOCI IV + MTX		0.83 (0.27,2.90)	0.85 (0.29,2.68)	‐0.01 (‐0.11,0.09)
HD TOFA PO + MTX		1.32 (0.46,4.03)	1.28 (0.49,3.58)	0.01 (‐0.07,0.16)
HD INF IV + MTX		0.84 (0.33,2.15)	0.85 (0.36,2.03)	‐0.01 (‐0.10,0.05)
HD CERTO SC + MTX		1.55 (0.52,4.90)	1.49 (0.54,4.11)	0.03 (‐0.05,0.20)
HD TOCI IV + DMARD		0.56 (0.16,1.93)	0.58 (0.19,1.89)	‐0.02 (‐0.16,0.03)
LD ETN SC + MTX	LD CERTO SC + MTX	0.30 (0.05,1.92)	0.32 (0.07,1.86)	‐0.05 (‐0.33,0.02)
LD GOLI IV + MTX		1.88 (0.19,18.68)	1.71 (0.24,12.62)	0.05 (‐0.20,0.41)
HD TOCI IV		0.59 (0.11,3.13)	0.61 (0.15,2.96)	‐0.03 (‐0.28,0.05)
HD TOFA PO		0.23 (0.03,1.92)	0.25 (0.04,1.90)	‐0.06 (‐0.37,0.01)
HD GOLI SC		0.83 (0.11,5.66)	0.84 (0.14,4.82)	‐0.01 (‐0.26,0.16)
HD ADA SC		0.44 (0.06,3.66)	0.46 (0.09,3.55)	‐0.04 (‐0.35,0.03)
HD GOLI SC + MTX		1.78 (0.32,10.84)	1.64 (0.39,8.10)	0.04 (‐0.15,0.31)
HD TOCI IV + MTX		0.68 (0.11,4.01)	0.70 (0.15,3.74)	‐0.02 (‐0.27,0.09)
HD TOFA PO + MTX		1.04 (0.19,6.11)	1.03 (0.24,5.45)	0.00 (‐0.22,0.15)
HD INF IV + MTX		0.66 (0.15,3.06)	0.69 (0.19,2.93)	‐0.02 (‐0.26,0.06)
HD CERTO SC + MTX		1.20 (0.31,5.73)	1.17 (0.37,5.12)	0.01 (‐0.16,0.17)
HD TOCI IV + DMARD		0.46 (0.07,2.65)	0.48 (0.10,2.57)	‐0.04 (‐0.32,0.03)
LD GOLI IV + MTX	LD ETN SC + MTX	6.13 (0.83,43.62)	5.25 (0.84,29.87)	0.10 (‐0.01,0.48)
HD TOCI IV		1.88 (0.56,7.62)	1.83 (0.58,7.10)	0.02 (‐0.03,0.11)
HD TOFA PO		0.82 (0.12,5.16)	0.83 (0.13,5.03)	0.00 (‐0.10,0.03)
HD GOLI SC		2.74 (0.49,14.78)	2.60 (0.51,12.17)	0.03 (‐0.03,0.25)
HD ADA SC		1.46 (0.26,8.32)	1.44 (0.28,7.97)	0.01 (‐0.08,0.05)
HD GOLI SC + MTX		5.83 (1.36,27.75)	5.02 (1.32,20.70)	0.09 (0.01,0.41)
HD TOCI IV + MTX		2.19 (0.52,10.32)	2.11 (0.54,9.41)	0.02 (‐0.03,0.16)
HD TOFA PO + MTX		3.42 (0.87,13.28)	3.18 (0.88,11.55)	0.05 (‐0.01,0.23)
HD INF IV + MTX		2.17 (0.65,7.50)	2.09 (0.67,6.91)	0.02 (‐0.02,0.13)
HD CERTO SC + MTX		3.95 (1.14,15.46)	3.60 (1.13,12.95)	0.06 (0.00,0.29)
HD TOCI IV + DMARD		1.46 (0.35,6.28)	1.44 (0.37,5.99)	0.01 (‐0.05,0.07)
HD TOCI IV	LD GOLI IV + MTX	0.30 (0.05,2.05)	0.34 (0.08,1.97)	‐0.08 (‐0.45,0.03)
HD TOFA PO		0.14 (0.01,1.02)	0.15 (0.03,1.02)	‐0.11 (‐0.53,0.00)
HD GOLI SC		0.44 (0.05,3.88)	0.48 (0.08,3.35)	‐0.06 (‐0.42,0.14)
HD ADA SC		0.24 (0.03,1.75)	0.27 (0.06,1.71)	‐0.09 (‐0.50,0.02)
HD GOLI SC + MTX		0.94 (0.12,8.65)	0.94 (0.17,6.55)	‐0.01 (‐0.33,0.27)
HD TOCI IV + MTX		0.34 (0.05,2.58)	0.39 (0.08,2.40)	‐0.07 (‐0.43,0.06)
HD TOFA PO + MTX		0.54 (0.09,3.74)	0.59 (0.13,3.25)	‐0.05 (‐0.38,0.13)
HD INF IV + MTX		0.36 (0.06,2.22)	0.40 (0.09,2.10)	‐0.07 (‐0.43,0.04)
HD CERTO SC + MTX		0.67 (0.09,4.60)	0.71 (0.14,3.79)	‐0.03 (‐0.37,0.16)
HD TOCI IV + DMARD		0.24 (0.03,1.69)	0.27 (0.06,1.63)	‐0.09 (‐0.47,0.02)
HD TOFA PO	HD TOCI IV	0.43 (0.08,1.99)	0.44 (0.09,1.96)	‐0.02 (‐0.16,0.01)
HD GOLI SC		1.39 (0.35,6.05)	1.36 (0.37,4.99)	0.01 (‐0.06,0.21)
HD ADA SC		0.80 (0.17,3.09)	0.81 (0.19,2.99)	‐0.01 (‐0.13,0.04)
HD GOLI SC + MTX		3.05 (0.89,11.48)	2.72 (0.89,8.07)	0.07 (‐0.01,0.36)
HD TOCI IV + MTX		1.15 (0.53,2.56)	1.14 (0.55,2.36)	0.01 (‐0.04,0.09)
HD TOFA PO + MTX		1.80 (0.61,4.93)	1.72 (0.63,4.32)	0.03 (‐0.03,0.18)
HD INF IV + MTX		1.14 (0.45,2.80)	1.13 (0.47,2.64)	0.00 (‐0.05,0.08)
HD CERTO SC + MTX		2.11 (0.73,6.38)	1.98 (0.75,5.17)	0.04 (‐0.02,0.25)
HD TOCI IV + DMARD		0.77 (0.31,1.88)	0.78 (0.33,1.81)	‐0.01 (‐0.08,0.03)
HD GOLI SC	HD TOFA PO	3.40 (0.52,26.74)	3.23 (0.53,18.87)	0.04 (‐0.01,0.30)
HD ADA SC		1.83 (0.61,5.97)	1.80 (0.62,5.68)	0.01 (‐0.01,0.06)
HD GOLI SC + MTX		7.54 (1.02,53.03)	6.65 (1.02,30.60)	0.10 (0.00,0.46)
HD TOCI IV + MTX		2.71 (0.52,18.48)	2.62 (0.53,14.87)	0.03 (‐0.01,0.21)
HD TOFA PO + MTX		4.18 (0.88,27.29)	3.94 (0.88,20.32)	0.05 (0.00,0.29)
HD INF IV + MTX		2.59 (0.53,15.27)	2.51 (0.54,12.69)	0.03 (‐0.01,0.18)
HD CERTO SC + MTX		4.75 (0.85,34.40)	4.42 (0.85,23.12)	0.06 (0.00,0.36)
HD TOCI IV + DMARD		1.83 (0.38,9.43)	1.80 (0.39,8.52)	0.01 (‐0.02,0.11)
HD ADA SC	HD GOLI SC	0.53 (0.08,3.39)	0.54 (0.11,3.27)	‐0.03 (‐0.28,0.04)
HD GOLI SC + MTX		2.14 (0.65,7.60)	1.95 (0.69,6.20)	0.06 (‐0.04,0.28)
HD TOCI IV + MTX		0.81 (0.16,4.00)	0.82 (0.19,3.64)	‐0.01 (‐0.20,0.11)
HD TOFA PO + MTX		1.26 (0.27,5.74)	1.24 (0.32,4.99)	0.01 (‐0.15,0.17)
HD INF IV + MTX		0.79 (0.20,3.25)	0.80 (0.24,3.05)	‐0.01 (‐0.19,0.07)
HD CERTO SC + MTX		1.44 (0.34,7.29)	1.39 (0.39,6.22)	0.02 (‐0.13,0.22)
HD TOCI IV + DMARD		0.55 (0.11,2.33)	0.57 (0.14,2.26)	‐0.02 (‐0.24,0.04)
HD GOLI SC + MTX	HD ADA SC	3.96 (0.66,25.40)	3.58 (0.67,14.63)	0.09 (‐0.01,0.43)
HD TOCI IV + MTX		1.43 (0.31,8.45)	1.41 (0.32,6.87)	0.01 (‐0.04,0.19)
HD TOFA PO + MTX		2.20 (0.53,12.89)	2.11 (0.55,9.58)	0.04 (‐0.02,0.27)
HD INF IV + MTX		1.42 (0.32,7.34)	1.40 (0.34,6.12)	0.01 (‐0.04,0.16)
HD CERTO SC + MTX		2.62 (0.57,15.86)	2.47 (0.58,10.84)	0.05 (‐0.02,0.34)
HD TOCI IV + DMARD		0.97 (0.25,4.31)	0.97 (0.26,3.94)	0.00 (‐0.04,0.09)
HD TOCI IV + MTX	HD GOLI SC + MTX	0.37 (0.09,1.50)	0.42 (0.12,1.45)	‐0.06 (‐0.35,0.03)
HD TOFA PO + MTX		0.59 (0.14,2.27)	0.64 (0.18,2.10)	‐0.04 (‐0.28,0.08)
HD INF IV + MTX		0.38 (0.11,1.22)	0.42 (0.15,1.20)	‐0.07 (‐0.33,0.01)
HD CERTO SC + MTX		0.69 (0.17,2.72)	0.73 (0.23,2.42)	‐0.03 (‐0.27,0.10)
HD TOCI IV + DMARD		0.25 (0.06,1.03)	0.28 (0.08,1.03)	‐0.08 (‐0.40,0.00)
HD TOFA PO + MTX	HD TOCI IV + MTX	1.54 (0.46,5.11)	1.48 (0.49,4.51)	0.02 (‐0.06,0.17)
HD INF IV + MTX		1.00 (0.31,2.85)	1.00 (0.34,2.69)	0.00 (‐0.10,0.07)
HD CERTO SC + MTX		1.83 (0.51,6.30)	1.74 (0.54,5.27)	0.03 (‐0.05,0.23)
HD TOCI IV + DMARD		0.67 (0.21,2.15)	0.68 (0.23,2.06)	‐0.01 (‐0.14,0.03)
HD INF IV + MTX	HD TOFA PO + MTX	0.63 (0.24,1.64)	0.66 (0.27,1.60)	‐0.02 (‐0.17,0.03)
HD CERTO SC + MTX		1.15 (0.37,3.77)	1.13 (0.41,3.25)	0.01 (‐0.10,0.17)
HD TOCI IV + DMARD		0.43 (0.12,1.46)	0.46 (0.15,1.44)	‐0.04 (‐0.22,0.02)
HD CERTO SC + MTX	HD INF IV + MTX	1.85 (0.72,5.14)	1.75 (0.74,4.24)	0.03 (‐0.02,0.22)
HD TOCI IV + DMARD		0.67 (0.21,2.04)	0.69 (0.24,1.98)	‐0.01 (‐0.12,0.03)
HD TOCI IV + DMARD	HD CERTO SC + MTX	0.37 (0.10,1.33)	0.40 (0.13,1.31)	‐0.05 (‐0.29,0.01)
Random‐Effect Model	Residual Deviance	152 vs 153 data points
	Deviance Information Criteria	843.894
Fixed‐Effect Model	Residual Deviance	161.1 vs 153 data points
	Deviance Information Criteria	845.774
Note:
Total Patients	28661
Total Studies	61
2‐arm	38
3‐arm	16
4‐arm	6
5‐arm	1