SAEs in Established RA: Odds Ratios, Risk Ratios and Risk Difference for All Treatment Comparisons‐Random Effects Model
Treatment	Reference	OR (95% CrI)	RR (95% CrI)	RD % (95% Crl)
MTX	PL	1.96 (0.39,5.90)	1.90 (0.39,5.24)	0.02 (‐0.02,0.12)
DMARD		0.76 (0.20,2.86)	0.76 (0.20,2.73)	‐0.01 (‐0.03,0.05)
MTX + DMARD		1.08 (0.19,4.61)	1.08 (0.20,4.15)	0.00 (‐0.03,0.09)
SD ETN SC		2.30 (0.66,6.73)	2.22 (0.67,5.90)	0.04 (‐0.01,0.14)
SD ADA SC		1.52 (0.73,3.04)	1.49 (0.73,2.90)	0.01 (‐0.01,0.05)
SD TOCI IV		1.69 (0.57,4.79)	1.65 (0.58,4.33)	0.02 (‐0.01,0.10)
SD TOFA PO		0.37 (0.15,0.95)	0.38 (0.16,0.95)	‐0.02 (‐0.04,0.00)
SD CERTO SC		4.55 (1.35,24.41)	4.09 (1.34,16.75)	0.09 (0.01,0.31)
SD TOC SC + PL IV		1.46 (0.40,5.21)	1.44 (0.41,4.65)	0.01 (‐0.02,0.11)
SD GOLI IV		1.88 (0.12,52.25)	1.83 (0.12,24.92)	0.02 (‐0.03,0.51)
SD INF IV + MTX		1.89 (0.45,6.27)	1.84 (0.46,5.47)	0.02 (‐0.02,0.13)
SD ETN SC + MTX		1.85 (0.37,6.22)	1.81 (0.38,5.44)	0.02 (‐0.02,0.13)
SD ABA IV + MTX		1.52 (0.30,5.17)	1.50 (0.31,4.64)	0.01 (‐0.02,0.11)
SD CERTO SC + MTX		2.78 (0.59,10.08)	2.64 (0.60,8.00)	0.05 (‐0.01,0.21)
SD ADA SC + MTX		2.30 (0.36,7.68)	2.22 (0.37,6.52)	0.03 (‐0.02,0.16)
SD ABA SC + MTX		1.10 (0.21,4.40)	1.09 (0.22,4.02)	0.00 (‐0.03,0.09)
SD GOLI SC + MTX		4.26 (0.71,17.63)	3.89 (0.71,12.29)	0.08 (‐0.01,0.33)
SD RITUX IV + MTX		1.59 (0.31,5.87)	1.56 (0.31,5.16)	0.02 (‐0.02,0.12)
SD TOFA PO + MTX		4.59 (0.80,17.14)	4.14 (0.81,11.97)	0.09 (‐0.01,0.31)
SD GOLI IV + MTX		5.40 (0.45,107.10)	4.77 (0.46,32.58)	0.11 (‐0.02,0.71)
SD ETN SC + DMARD		2.12 (0.67,6.42)	2.05 (0.68,5.62)	0.03 (‐0.01,0.13)
SD ADA SC + DMARD		0.54 (0.11,2.58)	0.55 (0.12,2.47)	‐0.01 (‐0.04,0.04)
SD CERTO SC + DMARD		0.52 (0.09,3.17)	0.53 (0.09,2.99)	‐0.01 (‐0.04,0.05)
LD ADA SC		0.77 (0.30,1.68)	0.78 (0.31,1.65)	‐0.01 (‐0.03,0.02)
LD ETN SC		1.51 (0.33,6.09)	1.48 (0.34,5.28)	0.01 (‐0.02,0.13)
LD GOLI IV		9.67 (0.64,176.00)	7.62 (0.65,38.84)	0.20 (‐0.01,0.77)
LD RITUX IV + MTX		1.03 (0.19,3.98)	1.03 (0.20,3.67)	0.00 (‐0.03,0.08)
LD ABA IV + MTX		2.31 (0.39,9.43)	2.23 (0.40,7.69)	0.03 (‐0.02,0.20)
LD CERTO SC + MTX		2.65 (0.32,13.80)	2.52 (0.33,9.96)	0.04 (‐0.02,0.28)
LD ETN SC + MTX		0.94 (0.18,4.22)	0.94 (0.19,3.86)	0.00 (‐0.03,0.09)
LD GOLI IV + MTX		5.28 (0.35,98.46)	4.68 (0.36,33.02)	0.11 (‐0.02,0.67)
HD TOCI IV		1.62 (0.39,6.09)	1.59 (0.40,5.38)	0.02 (‐0.02,0.13)
HD TOFA PO		0.49 (0.20,1.18)	0.50 (0.21,1.17)	‐0.01 (‐0.03,0.00)
HD ADA SC		1.17 (0.51,2.71)	1.16 (0.52,2.61)	0.00 (‐0.02,0.04)
HD GOLI SC		2.50 (0.38,12.40)	2.39 (0.39,9.42)	0.04 (‐0.02,0.25)
HD GOLI SC + MTX		5.84 (0.85,23.62)	5.10 (0.86,14.31)	0.12 (0.00,0.40)
HD TOCI IV + MTX		1.98 (0.41,8.14)	1.92 (0.42,6.85)	0.03 (‐0.02,0.17)
HD TOFA PO + MTX		3.77 (0.70,14.44)	3.47 (0.71,10.70)	0.07 (‐0.01,0.28)
HD CERTO SC + MTX		3.56 (0.84,13.69)	3.31 (0.85,9.97)	0.07 (‐0.01,0.27)
HD INF IV + MTX		1.84 (0.36,6.84)	1.79 (0.37,5.88)	0.02 (‐0.02,0.14)
HD TOCI IV + DMARD		1.16 (0.27,5.05)	1.15 (0.27,4.52)	0.00 (‐0.03,0.10)
DMARD	MTX	0.41 (0.16,0.98)	0.42 (0.17,0.98)	‐0.03 (‐0.10,0.00)
MTX + DMARD		0.57 (0.18,1.64)	0.58 (0.19,1.59)	‐0.02 (‐0.09,0.03)
SD ETN SC		1.23 (0.58,2.42)	1.21 (0.60,2.32)	0.01 (‐0.04,0.06)
SD ADA SC		0.82 (0.22,3.48)	0.83 (0.25,3.36)	‐0.01 (‐0.11,0.04)
SD TOCI IV		0.89 (0.21,4.69)	0.90 (0.23,4.41)	‐0.01 (‐0.11,0.08)
SD TOFA PO		0.19 (0.05,1.01)	0.20 (0.06,1.01)	‐0.04 (‐0.15,0.00)
SD CERTO SC		2.31 (0.42,19.65)	2.15 (0.46,14.43)	0.06 (‐0.07,0.30)
SD TOC SC + PL IV		0.78 (0.15,4.75)	0.79 (0.17,4.40)	‐0.01 (‐0.11,0.08)
SD GOLI IV		0.93 (0.07,23.30)	0.94 (0.07,11.95)	0.00 (‐0.10,0.49)
SD INF IV + MTX		1.00 (0.62,1.57)	1.00 (0.64,1.54)	0.00 (‐0.03,0.04)
SD ETN SC + MTX		0.95 (0.47,1.96)	0.95 (0.49,1.87)	0.00 (‐0.05,0.05)
SD ABA IV + MTX		0.80 (0.49,1.19)	0.81 (0.51,1.18)	‐0.01 (‐0.05,0.01)
SD CERTO SC + MTX		1.51 (0.92,2.49)	1.46 (0.92,2.29)	0.02 (0.00,0.11)
SD ADA SC + MTX		1.11 (0.49,2.42)	1.11 (0.51,2.25)	0.00 (‐0.04,0.08)
SD ABA SC + MTX		0.59 (0.27,1.18)	0.60 (0.28,1.17)	‐0.02 (‐0.07,0.01)
SD GOLI SC + MTX		2.22 (0.64,6.56)	2.06 (0.66,5.32)	0.05 (‐0.02,0.26)
SD RITUX IV + MTX		0.85 (0.46,1.57)	0.86 (0.48,1.52)	‐0.01 (‐0.05,0.04)
SD TOFA PO + MTX		2.23 (0.97,5.52)	2.06 (0.98,4.48)	0.06 (0.00,0.22)
SD GOLI IV + MTX		2.67 (0.43,47.82)	2.40 (0.45,16.29)	0.08 (‐0.03,0.67)
SD ETN SC + DMARD		1.14 (0.43,2.79)	1.13 (0.45,2.67)	0.01 (‐0.06,0.07)
SD ADA SC + DMARD		0.29 (0.09,0.96)	0.31 (0.09,0.96)	‐0.03 (‐0.12,0.00)
SD CERTO SC + DMARD		0.28 (0.06,1.45)	0.29 (0.06,1.43)	‐0.03 (‐0.12,0.01)
LD ADA SC		0.42 (0.09,1.60)	0.43 (0.11,1.59)	‐0.03 (‐0.14,0.01)
LD ETN SC		0.80 (0.30,1.90)	0.81 (0.31,1.81)	‐0.01 (‐0.07,0.05)
LD GOLI IV		4.77 (0.85,81.13)	3.72 (0.86,19.33)	0.17 (‐0.01,0.73)
LD RITUX IV + MTX		0.56 (0.29,1.06)	0.57 (0.30,1.06)	‐0.02 (‐0.07,0.00)
LD ABA IV + MTX		1.19 (0.56,2.57)	1.18 (0.57,2.33)	0.01 (‐0.03,0.10)
LD CERTO SC + MTX		1.45 (0.24,5.28)	1.41 (0.25,4.30)	0.02 (‐0.05,0.21)
LD ETN SC + MTX		0.50 (0.17,1.32)	0.52 (0.18,1.29)	‐0.02 (‐0.09,0.02)
LD GOLI IV + MTX		2.68 (0.49,45.71)	2.42 (0.51,16.27)	0.08 (‐0.03,0.62)
HD TOCI IV		0.87 (0.41,1.83)	0.88 (0.43,1.75)	‐0.01 (‐0.06,0.05)
HD TOFA PO		0.26 (0.07,1.26)	0.27 (0.07,1.25)	‐0.04 (‐0.14,0.00)
HD ADA SC		0.61 (0.16,2.93)	0.63 (0.18,2.83)	‐0.02 (‐0.12,0.03)
HD GOLI SC		1.32 (0.35,4.40)	1.29 (0.36,3.74)	0.01 (‐0.05,0.17)
HD GOLI SC + MTX		3.00 (1.10,8.04)	2.64 (1.09,5.79)	0.09 (0.00,0.33)
HD TOCI IV + MTX		1.05 (0.42,2.61)	1.04 (0.44,2.41)	0.00 (‐0.05,0.09)
HD TOFA PO + MTX		1.88 (0.73,4.58)	1.77 (0.74,3.90)	0.04 (‐0.01,0.19)
HD CERTO SC + MTX		1.88 (0.89,3.98)	1.78 (0.90,3.50)	0.04 (‐0.01,0.18)
HD INF IV + MTX		0.97 (0.49,1.89)	0.97 (0.51,1.79)	0.00 (‐0.04,0.05)
HD TOCI IV + DMARD		0.62 (0.21,1.71)	0.64 (0.23,1.64)	‐0.02 (‐0.09,0.03)
MTX + DMARD	DMARD	1.36 (0.35,4.84)	1.35 (0.36,4.47)	0.01 (‐0.03,0.08)
SD ETN SC		2.95 (1.26,7.79)	2.80 (1.24,7.26)	0.04 (0.01,0.12)
SD ADA SC		1.98 (0.52,7.97)	1.93 (0.54,7.59)	0.02 (‐0.03,0.06)
SD TOCI IV		2.15 (0.48,10.49)	2.09 (0.50,9.63)	0.02 (‐0.03,0.10)
SD TOFA PO		0.47 (0.11,2.81)	0.48 (0.12,2.76)	‐0.01 (‐0.07,0.01)
SD CERTO SC		6.23 (0.92,44.44)	5.53 (0.92,32.46)	0.10 (0.00,0.31)
SD TOC SC + PL IV		1.94 (0.36,10.55)	1.89 (0.37,9.48)	0.02 (‐0.04,0.11)
SD GOLI IV		2.27 (0.18,57.03)	2.17 (0.18,27.77)	0.03 (‐0.04,0.51)
SD INF IV + MTX		2.45 (0.90,6.95)	2.35 (0.91,6.35)	0.03 (0.00,0.12)
SD ETN SC + MTX		2.34 (0.86,6.83)	2.25 (0.86,6.27)	0.03 (‐0.01,0.11)
SD ABA IV + MTX		1.90 (0.71,5.44)	1.86 (0.72,5.06)	0.02 (‐0.01,0.09)
SD CERTO SC + MTX		3.70 (1.33,10.74)	3.46 (1.31,9.24)	0.05 (0.01,0.19)
SD ADA SC + MTX		2.77 (0.81,8.47)	2.64 (0.82,7.66)	0.04 (‐0.01,0.15)
SD ABA SC + MTX		1.41 (0.44,4.63)	1.40 (0.45,4.36)	0.01 (‐0.03,0.08)
SD GOLI SC + MTX		5.36 (1.32,21.74)	4.75 (1.31,16.88)	0.09 (0.01,0.32)
SD RITUX IV + MTX		2.07 (0.65,6.43)	2.01 (0.66,5.91)	0.02 (‐0.01,0.11)
SD TOFA PO + MTX		5.58 (1.73,18.92)	4.94 (1.67,14.94)	0.09 (0.01,0.29)
SD GOLI IV + MTX		6.73 (0.82,121.50)	5.74 (0.82,37.64)	0.11 (0.00,0.71)
SD ETN SC + DMARD		2.72 (1.02,7.85)	2.61 (1.02,7.26)	0.03 (0.00,0.11)
SD ADA SC + DMARD		0.74 (0.31,1.65)	0.74 (0.31,1.62)	0.00 (‐0.03,0.02)
SD CERTO SC + DMARD		0.70 (0.18,2.38)	0.71 (0.18,2.29)	‐0.01 (‐0.04,0.04)
LD ADA SC		1.03 (0.21,4.28)	1.03 (0.22,4.17)	0.00 (‐0.06,0.03)
LD ETN SC		1.88 (0.61,6.75)	1.84 (0.62,6.19)	0.02 (‐0.02,0.11)
LD GOLI IV		11.82 (1.38,182.20)	8.82 (1.37,46.95)	0.20 (0.01,0.77)
LD RITUX IV + MTX		1.38 (0.43,4.39)	1.37 (0.44,4.15)	0.01 (‐0.03,0.07)
LD ABA IV + MTX		2.92 (0.88,10.07)	2.78 (0.88,8.61)	0.04 (0.00,0.18)
LD CERTO SC + MTX		3.43 (0.45,16.59)	3.22 (0.46,13.21)	0.05 (‐0.02,0.27)
LD ETN SC + MTX		1.20 (0.33,4.69)	1.19 (0.34,4.41)	0.00 (‐0.04,0.08)
LD GOLI IV + MTX		6.52 (0.76,107.20)	5.63 (0.77,38.47)	0.11 (0.00,0.67)
HD TOCI IV		2.12 (1.07,4.54)	2.06 (1.06,4.29)	0.02 (0.00,0.10)
HD TOFA PO		0.63 (0.14,3.48)	0.64 (0.16,3.42)	‐0.01 (‐0.06,0.02)
HD ADA SC		1.56 (0.34,6.43)	1.54 (0.35,6.19)	0.01 (‐0.05,0.05)
HD GOLI SC		3.21 (0.60,16.83)	3.02 (0.61,13.75)	0.04 (‐0.01,0.24)
HD GOLI SC + MTX		7.20 (1.84,31.16)	6.09 (1.78,22.25)	0.12 (0.01,0.39)
HD TOCI IV + MTX		2.52 (0.93,7.29)	2.43 (0.93,6.54)	0.03 (0.00,0.15)
HD TOFA PO + MTX		4.63 (1.38,16.09)	4.20 (1.36,12.91)	0.07 (0.01,0.26)
HD CERTO SC + MTX		4.71 (1.42,14.36)	4.29 (1.39,11.75)	0.07 (0.01,0.26)
HD INF IV + MTX		2.36 (0.75,7.70)	2.27 (0.76,7.03)	0.03 (‐0.01,0.13)
HD TOCI IV + DMARD		1.51 (0.90,2.62)	1.49 (0.90,2.52)	0.01 (0.00,0.06)
SD ETN SC	MTX + DMARD	2.14 (0.69,7.09)	2.05 (0.71,6.66)	0.03 (‐0.02,0.10)
SD ADA SC		1.45 (0.30,7.18)	1.43 (0.32,6.81)	0.01 (‐0.08,0.06)
SD TOCI IV		1.60 (0.28,9.19)	1.57 (0.30,8.53)	0.02 (‐0.07,0.10)
SD TOFA PO		0.35 (0.07,2.21)	0.36 (0.07,2.18)	‐0.02 (‐0.11,0.01)
SD CERTO SC		4.18 (0.54,46.06)	3.77 (0.57,33.19)	0.09 (‐0.05,0.31)
SD TOC SC + PL IV		1.42 (0.22,9.70)	1.40 (0.24,8.97)	0.01 (‐0.08,0.10)
SD GOLI IV		1.69 (0.10,61.18)	1.65 (0.11,31.36)	0.02 (‐0.08,0.51)
SD INF IV + MTX		1.78 (0.57,5.86)	1.72 (0.59,5.43)	0.02 (‐0.03,0.10)
SD ETN SC + MTX		1.71 (0.64,4.59)	1.66 (0.67,4.35)	0.02 (‐0.03,0.08)
SD ABA IV + MTX		1.41 (0.43,4.65)	1.39 (0.45,4.41)	0.01 (‐0.05,0.07)
SD CERTO SC + MTX		2.69 (0.83,9.40)	2.52 (0.84,8.55)	0.04 (‐0.01,0.17)
SD ADA SC + MTX		2.00 (0.52,8.04)	1.92 (0.54,7.30)	0.03 (‐0.03,0.13)
SD ABA SC + MTX		1.07 (0.28,3.91)	1.07 (0.30,3.72)	0.00 (‐0.07,0.06)
SD GOLI SC + MTX		3.87 (0.80,22.09)	3.46 (0.81,17.69)	0.07 (‐0.01,0.31)
SD RITUX IV + MTX		1.50 (0.44,5.59)	1.47 (0.46,5.23)	0.01 (‐0.05,0.10)
SD TOFA PO + MTX		4.05 (1.05,17.25)	3.66 (1.04,14.00)	0.08 (0.00,0.28)
SD GOLI IV + MTX		4.85 (0.64,118.10)	4.14 (0.66,42.92)	0.10 (‐0.01,0.71)
SD ETN SC + DMARD		2.00 (0.54,7.48)	1.93 (0.57,7.01)	0.02 (‐0.04,0.10)
SD ADA SC + DMARD		0.52 (0.12,2.69)	0.53 (0.12,2.63)	‐0.01 (‐0.09,0.03)
SD CERTO SC + DMARD		0.50 (0.09,3.53)	0.51 (0.09,3.37)	‐0.01 (‐0.10,0.04)
LD ADA SC		0.75 (0.13,3.80)	0.75 (0.14,3.72)	‐0.01 (‐0.10,0.03)
LD ETN SC		1.42 (0.36,5.64)	1.39 (0.38,5.33)	0.01 (‐0.05,0.09)
LD GOLI IV		8.77 (1.13,208.10)	6.47 (1.13,53.45)	0.19 (0.00,0.76)
LD RITUX IV + MTX		0.99 (0.29,3.92)	0.99 (0.31,3.74)	0.00 (‐0.07,0.06)
LD ABA IV + MTX		2.12 (0.56,8.51)	2.02 (0.58,7.49)	0.03 (‐0.03,0.16)
LD CERTO SC + MTX		2.65 (0.32,14.88)	2.49 (0.33,12.20)	0.04 (‐0.04,0.25)
LD ETN SC + MTX		0.89 (0.22,3.61)	0.89 (0.23,3.47)	0.00 (‐0.08,0.06)
LD GOLI IV + MTX		4.84 (0.71,118.60)	4.13 (0.72,42.49)	0.10 (‐0.01,0.65)
HD TOCI IV		1.58 (0.46,5.65)	1.55 (0.48,5.24)	0.01 (‐0.04,0.10)
HD TOFA PO		0.48 (0.09,2.82)	0.49 (0.09,2.77)	‐0.02 (‐0.11,0.02)
HD ADA SC		1.11 (0.22,6.26)	1.11 (0.24,6.00)	0.00 (‐0.09,0.05)
HD GOLI SC		2.28 (0.40,14.03)	2.17 (0.42,11.53)	0.03 (‐0.04,0.22)
HD GOLI SC + MTX		5.21 (1.22,28.19)	4.44 (1.20,20.46)	0.11 (0.01,0.38)
HD TOCI IV + MTX		1.84 (0.45,7.48)	1.78 (0.47,6.76)	0.02 (‐0.05,0.14)
HD TOFA PO + MTX		3.36 (0.85,14.74)	3.08 (0.86,12.33)	0.06 (‐0.01,0.25)
HD CERTO SC + MTX		3.33 (0.94,13.50)	3.05 (0.95,11.55)	0.06 (0.00,0.23)
HD INF IV + MTX		1.72 (0.50,6.42)	1.67 (0.53,5.91)	0.02 (‐0.04,0.11)
HD TOCI IV + DMARD		1.11 (0.29,4.52)	1.10 (0.31,4.32)	0.00 (‐0.07,0.07)
SD ADA SC	SD ETN SC	0.68 (0.21,2.00)	0.69 (0.24,1.94)	‐0.02 (‐0.12,0.03)
SD TOCI IV		0.72 (0.19,2.97)	0.73 (0.21,2.78)	‐0.02 (‐0.12,0.07)
SD TOFA PO		0.16 (0.04,0.74)	0.17 (0.05,0.75)	‐0.05 (‐0.16,‐0.01)
SD CERTO SC		2.02 (0.37,13.99)	1.88 (0.40,10.33)	0.06 (‐0.09,0.29)
SD TOC SC + PL IV		0.64 (0.14,3.14)	0.66 (0.15,2.91)	‐0.02 (‐0.13,0.08)
SD GOLI IV		0.79 (0.05,19.56)	0.81 (0.06,9.33)	‐0.01 (‐0.12,0.48)
SD INF IV + MTX		0.82 (0.36,1.94)	0.83 (0.37,1.84)	‐0.01 (‐0.07,0.06)
SD ETN SC + MTX		0.78 (0.38,1.69)	0.79 (0.40,1.61)	‐0.01 (‐0.06,0.04)
SD ABA IV + MTX		0.65 (0.28,1.59)	0.67 (0.30,1.52)	‐0.02 (‐0.08,0.03)
SD CERTO SC + MTX		1.24 (0.53,3.02)	1.22 (0.55,2.69)	0.01 (‐0.04,0.12)
SD ADA SC + MTX		0.92 (0.32,2.57)	0.93 (0.33,2.38)	0.00 (‐0.06,0.08)
SD ABA SC + MTX		0.48 (0.17,1.37)	0.50 (0.19,1.34)	‐0.03 (‐0.10,0.02)
SD GOLI SC + MTX		1.80 (0.45,6.53)	1.70 (0.47,4.91)	0.04 (‐0.04,0.26)
SD RITUX IV + MTX		0.69 (0.28,1.85)	0.71 (0.29,1.76)	‐0.02 (‐0.08,0.05)
SD TOFA PO + MTX		1.88 (0.64,5.53)	1.75 (0.66,4.39)	0.05 (‐0.02,0.23)
SD GOLI IV + MTX		2.24 (0.31,43.59)	2.03 (0.33,13.85)	0.07 (‐0.05,0.66)
SD ETN SC + DMARD		0.92 (0.45,1.90)	0.93 (0.47,1.82)	0.00 (‐0.06,0.05)
SD ADA SC + DMARD		0.24 (0.07,0.79)	0.26 (0.08,0.81)	‐0.05 (‐0.13,‐0.01)
SD CERTO SC + DMARD		0.23 (0.05,1.09)	0.25 (0.05,1.09)	‐0.04 (‐0.14,0.00)
LD ADA SC		0.35 (0.09,1.16)	0.36 (0.10,1.15)	‐0.04 (‐0.15,0.00)
LD ETN SC		0.65 (0.25,1.65)	0.67 (0.27,1.58)	‐0.02 (‐0.08,0.04)
LD GOLI IV		3.94 (0.51,64.81)	3.19 (0.52,15.77)	0.15 (‐0.03,0.73)
LD RITUX IV + MTX		0.46 (0.18,1.25)	0.48 (0.19,1.22)	‐0.03 (‐0.10,0.01)
LD ABA IV + MTX		1.00 (0.34,2.96)	1.00 (0.36,2.64)	0.00 (‐0.06,0.11)
LD CERTO SC + MTX		1.22 (0.17,4.95)	1.20 (0.18,3.97)	0.01 (‐0.08,0.21)
LD ETN SC + MTX		0.41 (0.13,1.36)	0.43 (0.14,1.33)	‐0.03 (‐0.11,0.02)
LD GOLI IV + MTX		2.20 (0.28,34.53)	2.02 (0.29,13.51)	0.06 (‐0.05,0.62)
HD TOCI IV		0.72 (0.29,1.74)	0.73 (0.31,1.66)	‐0.01 (‐0.07,0.04)
HD TOFA PO		0.21 (0.06,0.92)	0.22 (0.07,0.93)	‐0.05 (‐0.15,0.00)
HD ADA SC		0.51 (0.14,1.82)	0.53 (0.16,1.78)	‐0.03 (‐0.14,0.02)
HD GOLI SC		1.09 (0.23,4.28)	1.08 (0.25,3.57)	0.00 (‐0.08,0.17)
HD GOLI SC + MTX		2.40 (0.73,8.31)	2.17 (0.75,5.84)	0.07 (‐0.02,0.33)
HD TOCI IV + MTX		0.86 (0.28,2.55)	0.87 (0.30,2.34)	‐0.01 (‐0.08,0.08)
HD TOFA PO + MTX		1.56 (0.47,4.79)	1.50 (0.49,3.89)	0.03 (‐0.04,0.20)
HD CERTO SC + MTX		1.53 (0.59,4.30)	1.47 (0.61,3.63)	0.03 (‐0.03,0.19)
HD INF IV + MTX		0.79 (0.30,2.16)	0.81 (0.32,2.02)	‐0.01 (‐0.07,0.07)
HD TOCI IV + DMARD		0.52 (0.18,1.43)	0.53 (0.19,1.39)	‐0.03 (‐0.10,0.02)
SD TOCI IV	SD ADA SC	1.09 (0.50,2.49)	1.08 (0.52,2.33)	0.00 (‐0.02,0.07)
SD TOFA PO		0.24 (0.08,0.76)	0.25 (0.09,0.77)	‐0.03 (‐0.08,‐0.01)
SD CERTO SC		3.06 (0.75,17.88)	2.79 (0.76,12.62)	0.08 (‐0.02,0.30)
SD TOC SC + PL IV		0.97 (0.34,2.76)	0.97 (0.35,2.54)	0.00 (‐0.04,0.08)
SD GOLI IV		1.27 (0.07,27.30)	1.25 (0.08,12.99)	0.01 (‐0.06,0.50)
SD INF IV + MTX		1.20 (0.33,4.77)	1.19 (0.34,4.25)	0.01 (‐0.04,0.12)
SD ETN SC + MTX		1.14 (0.29,4.42)	1.14 (0.30,3.95)	0.01 (‐0.04,0.11)
SD ABA IV + MTX		0.96 (0.23,3.86)	0.96 (0.24,3.51)	0.00 (‐0.05,0.09)
SD CERTO SC + MTX		1.80 (0.45,7.39)	1.74 (0.46,6.04)	0.03 (‐0.03,0.19)
SD ADA SC + MTX		1.42 (0.26,5.81)	1.39 (0.27,4.99)	0.02 (‐0.04,0.14)
SD ABA SC + MTX		0.70 (0.16,3.29)	0.71 (0.17,3.03)	‐0.01 (‐0.06,0.07)
SD GOLI SC + MTX		2.82 (0.51,12.81)	2.59 (0.52,8.93)	0.07 (‐0.03,0.32)
SD RITUX IV + MTX		1.04 (0.23,4.37)	1.04 (0.24,3.93)	0.00 (‐0.05,0.11)
SD TOFA PO + MTX		2.96 (0.57,11.61)	2.71 (0.59,8.51)	0.07 (‐0.02,0.29)
SD GOLI IV + MTX		3.68 (0.31,60.18)	3.28 (0.32,18.17)	0.10 (‐0.04,0.69)
SD ETN SC + DMARD		1.37 (0.52,3.89)	1.35 (0.54,3.51)	0.01 (‐0.03,0.10)
SD ADA SC + DMARD		0.37 (0.08,1.81)	0.38 (0.08,1.76)	‐0.03 (‐0.07,0.03)
SD CERTO SC + DMARD		0.36 (0.06,2.04)	0.37 (0.06,1.95)	‐0.03 (‐0.07,0.04)
LD ADA SC		0.50 (0.22,1.07)	0.51 (0.23,1.06)	‐0.02 (‐0.06,0.00)
LD ETN SC		0.97 (0.22,4.50)	0.97 (0.23,4.00)	0.00 (‐0.05,0.11)
LD GOLI IV		6.59 (0.46,83.79)	5.19 (0.47,21.73)	0.18 (‐0.02,0.75)
LD RITUX IV + MTX		0.68 (0.15,3.18)	0.69 (0.15,2.96)	‐0.01 (‐0.06,0.07)
LD ABA IV + MTX		1.47 (0.27,6.54)	1.44 (0.28,5.50)	0.02 (‐0.04,0.18)
LD CERTO SC + MTX		1.74 (0.20,10.56)	1.68 (0.21,7.95)	0.03 (‐0.05,0.26)
LD ETN SC + MTX		0.60 (0.12,2.94)	0.61 (0.13,2.72)	‐0.02 (‐0.06,0.07)
LD GOLI IV + MTX		3.63 (0.24,51.00)	3.22 (0.25,18.00)	0.09 (‐0.04,0.65)
HD TOCI IV		1.07 (0.28,4.37)	1.07 (0.29,3.89)	0.00 (‐0.04,0.11)
HD TOFA PO		0.32 (0.11,0.99)	0.33 (0.12,0.99)	‐0.03 (‐0.07,0.00)
HD ADA SC		0.78 (0.37,1.59)	0.79 (0.38,1.57)	‐0.01 (‐0.04,0.02)
HD GOLI SC		1.64 (0.26,8.47)	1.59 (0.27,6.60)	0.02 (‐0.04,0.23)
HD GOLI SC + MTX		3.70 (0.65,16.83)	3.30 (0.66,10.82)	0.10 (‐0.02,0.38)
HD TOCI IV + MTX		1.28 (0.27,6.06)	1.26 (0.28,5.17)	0.01 (‐0.04,0.15)
HD TOFA PO + MTX		2.42 (0.47,10.13)	2.26 (0.48,7.76)	0.06 (‐0.03,0.26)
HD CERTO SC + MTX		2.28 (0.57,10.24)	2.14 (0.58,7.74)	0.05 (‐0.02,0.26)
HD INF IV + MTX		1.20 (0.25,5.10)	1.18 (0.26,4.46)	0.01 (‐0.04,0.13)
HD TOCI IV + DMARD		0.78 (0.17,3.23)	0.79 (0.18,2.99)	‐0.01 (‐0.05,0.08)
SD TOFA PO	SD TOCI IV	0.22 (0.05,0.91)	0.23 (0.06,0.91)	‐0.04 (‐0.12,0.00)
SD CERTO SC		2.75 (0.54,20.04)	2.52 (0.57,14.46)	0.07 (‐0.05,0.30)
SD TOC SC + PL IV		0.88 (0.43,1.74)	0.88 (0.45,1.67)	0.00 (‐0.04,0.04)
SD GOLI IV		1.16 (0.06,27.62)	1.15 (0.07,13.48)	0.01 (‐0.09,0.49)
SD INF IV + MTX		1.12 (0.24,5.05)	1.11 (0.25,4.53)	0.00 (‐0.08,0.12)
SD ETN SC + MTX		1.06 (0.22,4.62)	1.06 (0.23,4.14)	0.00 (‐0.08,0.11)
SD ABA IV + MTX		0.89 (0.17,4.18)	0.90 (0.18,3.81)	0.00 (‐0.09,0.09)
SD CERTO SC + MTX		1.67 (0.34,7.87)	1.61 (0.36,6.57)	0.03 (‐0.06,0.19)
SD ADA SC + MTX		1.28 (0.20,6.39)	1.26 (0.21,5.59)	0.01 (‐0.07,0.14)
SD ABA SC + MTX		0.65 (0.12,3.39)	0.66 (0.13,3.14)	‐0.01 (‐0.10,0.08)
SD GOLI SC + MTX		2.56 (0.40,13.46)	2.35 (0.42,9.78)	0.06 (‐0.05,0.31)
SD RITUX IV + MTX		0.97 (0.18,4.75)	0.97 (0.19,4.30)	0.00 (‐0.08,0.11)
SD TOFA PO + MTX		2.64 (0.42,12.84)	2.41 (0.44,9.51)	0.07 (‐0.05,0.28)
SD GOLI IV + MTX		3.41 (0.22,61.85)	3.02 (0.24,19.34)	0.09 (‐0.06,0.69)
SD ETN SC + DMARD		1.27 (0.34,4.44)	1.26 (0.36,4.01)	0.01 (‐0.06,0.10)
SD ADA SC + DMARD		0.34 (0.06,1.91)	0.35 (0.06,1.86)	‐0.03 (‐0.11,0.03)
SD CERTO SC + DMARD		0.32 (0.04,2.17)	0.33 (0.05,2.07)	‐0.03 (‐0.11,0.03)
LD ADA SC		0.46 (0.15,1.35)	0.48 (0.16,1.34)	‐0.02 (‐0.10,0.01)
LD ETN SC		0.89 (0.16,4.48)	0.90 (0.18,4.08)	0.00 (‐0.09,0.10)
LD GOLI IV		5.99 (0.36,88.57)	4.66 (0.38,23.50)	0.18 (‐0.04,0.74)
LD RITUX IV + MTX		0.63 (0.11,3.31)	0.65 (0.12,3.11)	‐0.01 (‐0.10,0.07)
LD ABA IV + MTX		1.35 (0.20,7.19)	1.33 (0.21,6.07)	0.01 (‐0.07,0.18)
LD CERTO SC + MTX		1.61 (0.15,10.72)	1.55 (0.16,8.10)	0.03 (‐0.07,0.25)
LD ETN SC + MTX		0.55 (0.09,3.13)	0.57 (0.10,2.94)	‐0.02 (‐0.10,0.07)
LD GOLI IV + MTX		3.24 (0.19,51.29)	2.87 (0.20,18.93)	0.09 (‐0.06,0.64)
HD TOCI IV		1.00 (0.21,4.73)	1.00 (0.22,4.29)	0.00 (‐0.08,0.11)
HD TOFA PO		0.29 (0.08,1.15)	0.30 (0.08,1.15)	‐0.03 (‐0.12,0.00)
HD ADA SC		0.71 (0.24,2.05)	0.72 (0.26,2.00)	‐0.01 (‐0.09,0.03)
HD GOLI SC		1.49 (0.20,8.95)	1.46 (0.21,7.38)	0.02 (‐0.08,0.22)
HD GOLI SC + MTX		3.39 (0.47,18.48)	3.00 (0.50,12.23)	0.09 (‐0.04,0.37)
HD TOCI IV + MTX		1.18 (0.22,6.35)	1.17 (0.23,5.49)	0.01 (‐0.08,0.15)
HD TOFA PO + MTX		2.17 (0.35,10.99)	2.03 (0.37,8.57)	0.05 (‐0.06,0.25)
HD CERTO SC + MTX		2.09 (0.45,10.78)	1.97 (0.47,8.32)	0.05 (‐0.05,0.25)
HD INF IV + MTX		1.10 (0.18,5.34)	1.09 (0.20,4.74)	0.00 (‐0.08,0.13)
HD TOCI IV + DMARD		0.72 (0.13,3.49)	0.73 (0.14,3.22)	‐0.01 (‐0.09,0.07)
SD CERTO SC	SD TOFA PO	12.44 (2.55,73.20)	10.94 (2.45,52.33)	0.11 (0.03,0.32)
SD TOC SC + PL IV		3.99 (0.81,18.05)	3.85 (0.81,16.08)	0.03 (0.00,0.13)
SD GOLI IV		5.00 (0.25,137.40)	4.75 (0.25,67.34)	0.04 (‐0.01,0.53)
SD INF IV + MTX		5.05 (0.92,20.77)	4.83 (0.92,18.27)	0.04 (0.00,0.15)
SD ETN SC + MTX		4.93 (0.93,20.71)	4.71 (0.94,18.23)	0.04 (0.00,0.15)
SD ABA IV + MTX		4.04 (0.73,16.71)	3.90 (0.74,15.08)	0.03 (0.00,0.13)
SD CERTO SC + MTX		7.49 (1.44,33.76)	6.94 (1.43,27.00)	0.07 (0.01,0.23)
SD ADA SC + MTX		5.98 (0.93,25.95)	5.63 (0.93,21.85)	0.05 (0.00,0.18)
SD ABA SC + MTX		2.96 (0.49,15.03)	2.89 (0.50,13.55)	0.02 (‐0.01,0.11)
SD GOLI SC + MTX		11.33 (1.54,60.51)	10.03 (1.53,42.27)	0.10 (0.01,0.35)
SD RITUX IV + MTX		4.23 (0.77,19.73)	4.07 (0.77,17.37)	0.03 (0.00,0.14)
SD TOFA PO + MTX		12.35 (1.88,52.11)	10.85 (1.85,37.92)	0.11 (0.01,0.33)
SD GOLI IV + MTX		14.11 (1.10,325.50)	12.12 (1.09,104.00)	0.13 (0.00,0.73)
SD ETN SC + DMARD		5.66 (1.30,21.61)	5.35 (1.30,18.91)	0.05 (0.01,0.15)
SD ADA SC + DMARD		1.51 (0.24,7.91)	1.50 (0.24,7.46)	0.01 (‐0.02,0.06)
SD CERTO SC + DMARD		1.44 (0.18,9.45)	1.44 (0.19,8.88)	0.00 (‐0.02,0.07)
LD ADA SC		2.05 (0.59,6.36)	2.03 (0.60,6.19)	0.01 (‐0.01,0.04)
LD ETN SC		4.04 (0.69,18.56)	3.90 (0.70,16.21)	0.03 (‐0.01,0.14)
LD GOLI IV		24.13 (1.44,460.60)	18.77 (1.43,115.20)	0.21 (0.01,0.78)
LD RITUX IV + MTX		2.78 (0.50,13.35)	2.73 (0.50,12.22)	0.02 (‐0.01,0.10)
LD ABA IV + MTX		6.20 (0.89,30.14)	5.85 (0.89,24.31)	0.05 (0.00,0.22)
LD CERTO SC + MTX		7.22 (0.69,46.10)	6.70 (0.69,33.71)	0.06 (0.00,0.30)
LD ETN SC + MTX		2.49 (0.39,14.93)	2.45 (0.40,13.39)	0.02 (‐0.01,0.11)
LD GOLI IV + MTX		13.82 (0.71,270.00)	11.89 (0.72,95.32)	0.13 (0.00,0.69)
HD TOCI IV		4.39 (0.80,20.33)	4.22 (0.81,17.98)	0.04 (0.00,0.15)
HD TOFA PO		1.31 (0.54,3.37)	1.31 (0.54,3.31)	0.00 (‐0.01,0.02)
HD ADA SC		3.22 (0.94,9.73)	3.14 (0.94,9.28)	0.02 (0.00,0.06)
HD GOLI SC		6.55 (0.89,38.98)	6.14 (0.89,30.39)	0.06 (0.00,0.27)
HD GOLI SC + MTX		15.78 (2.00,79.86)	13.36 (1.96,50.15)	0.13 (0.01,0.42)
HD TOCI IV + MTX		5.32 (0.84,26.88)	5.05 (0.84,22.38)	0.04 (0.00,0.19)
HD TOFA PO + MTX		10.06 (1.46,44.56)	9.05 (1.45,33.23)	0.09 (0.01,0.30)
HD CERTO SC + MTX		9.49 (1.66,44.50)	8.60 (1.64,33.59)	0.09 (0.01,0.30)
HD INF IV + MTX		4.87 (0.82,21.86)	4.66 (0.82,18.99)	0.04 (0.00,0.17)
HD TOCI IV + DMARD		3.25 (0.54,16.14)	3.16 (0.54,14.37)	0.02 (‐0.01,0.12)
SD TOC SC + PL IV	SD CERTO SC	0.32 (0.04,1.88)	0.35 (0.05,1.77)	‐0.08 (‐0.30,0.05)
SD GOLI IV		0.39 (0.02,7.16)	0.43 (0.02,4.77)	‐0.06 (‐0.28,0.34)
SD INF IV + MTX		0.43 (0.05,2.44)	0.46 (0.07,2.23)	‐0.06 (‐0.30,0.08)
SD ETN SC + MTX		0.41 (0.05,2.40)	0.44 (0.06,2.19)	‐0.07 (‐0.30,0.08)
SD ABA IV + MTX		0.34 (0.04,1.98)	0.37 (0.05,1.87)	‐0.07 (‐0.30,0.05)
SD CERTO SC + MTX		0.65 (0.07,4.07)	0.68 (0.10,3.40)	‐0.04 (‐0.28,0.16)
SD ADA SC + MTX		0.45 (0.05,3.02)	0.49 (0.07,2.67)	‐0.06 (‐0.29,0.11)
SD ABA SC + MTX		0.25 (0.03,1.71)	0.27 (0.04,1.64)	‐0.08 (‐0.31,0.04)
SD GOLI SC + MTX		0.88 (0.08,6.96)	0.89 (0.11,5.01)	‐0.01 (‐0.25,0.27)
SD RITUX IV + MTX		0.36 (0.04,2.25)	0.40 (0.05,2.09)	‐0.07 (‐0.30,0.07)
SD TOFA PO + MTX		0.97 (0.10,6.22)	0.97 (0.13,4.70)	0.00 (‐0.26,0.24)
SD GOLI IV + MTX		1.22 (0.07,21.66)	1.19 (0.08,8.54)	0.02 (‐0.24,0.58)
SD ETN SC + DMARD		0.46 (0.07,2.53)	0.49 (0.09,2.30)	‐0.06 (‐0.29,0.08)
SD ADA SC + DMARD		0.11 (0.01,0.92)	0.13 (0.02,0.93)	‐0.10 (‐0.32,‐0.01)
SD CERTO SC + DMARD		0.11 (0.01,0.96)	0.13 (0.01,0.96)	‐0.10 (‐0.31,0.00)
LD ADA SC		0.16 (0.03,0.75)	0.18 (0.04,0.76)	‐0.10 (‐0.32,‐0.01)
LD ETN SC		0.33 (0.04,2.29)	0.36 (0.05,2.10)	‐0.07 (‐0.30,0.07)
LD GOLI IV		2.16 (0.09,35.08)	1.87 (0.11,10.26)	0.10 (‐0.22,0.66)
LD RITUX IV + MTX		0.24 (0.03,1.49)	0.27 (0.03,1.44)	‐0.09 (‐0.31,0.03)
LD ABA IV + MTX		0.51 (0.05,3.43)	0.54 (0.07,2.96)	‐0.05 (‐0.29,0.13)
LD CERTO SC + MTX		0.58 (0.04,5.23)	0.61 (0.05,4.03)	‐0.04 (‐0.29,0.21)
LD ETN SC + MTX		0.21 (0.02,1.44)	0.24 (0.03,1.39)	‐0.09 (‐0.31,0.03)
LD GOLI IV + MTX		1.20 (0.05,21.01)	1.17 (0.06,8.42)	0.02 (‐0.25,0.57)
HD TOCI IV		0.36 (0.05,2.32)	0.39 (0.06,2.13)	‐0.07 (‐0.30,0.07)
HD TOFA PO		0.11 (0.02,0.50)	0.12 (0.03,0.51)	‐0.11 (‐0.32,‐0.02)
HD ADA SC		0.25 (0.04,1.10)	0.28 (0.06,1.09)	‐0.09 (‐0.30,0.00)
HD GOLI SC		0.51 (0.05,4.48)	0.55 (0.06,3.58)	‐0.05 (‐0.29,0.18)
HD GOLI SC + MTX		1.26 (0.12,9.71)	1.22 (0.16,6.04)	0.02 (‐0.24,0.35)
HD TOCI IV + MTX		0.42 (0.05,3.00)	0.46 (0.07,2.63)	‐0.06 (‐0.29,0.11)
HD TOFA PO + MTX		0.79 (0.08,5.26)	0.81 (0.10,4.15)	‐0.02 (‐0.27,0.21)
HD CERTO SC + MTX		0.78 (0.09,5.39)	0.81 (0.12,4.17)	‐0.02 (‐0.28,0.22)
HD INF IV + MTX		0.41 (0.05,2.60)	0.45 (0.06,2.36)	‐0.06 (‐0.30,0.09)
HD TOCI IV + DMARD		0.25 (0.03,1.71)	0.27 (0.04,1.63)	‐0.08 (‐0.31,0.04)
SD GOLI IV	SD TOC SC + PL IV	1.31 (0.06,35.13)	1.29 (0.07,17.60)	0.01 (‐0.09,0.50)
SD INF IV + MTX		1.28 (0.23,6.92)	1.26 (0.25,6.17)	0.01 (‐0.09,0.12)
SD ETN SC + MTX		1.20 (0.20,6.39)	1.19 (0.22,5.75)	0.01 (‐0.08,0.11)
SD ABA IV + MTX		1.02 (0.16,5.64)	1.02 (0.17,5.09)	0.00 (‐0.09,0.10)
SD CERTO SC + MTX		1.93 (0.33,10.52)	1.85 (0.35,8.85)	0.03 (‐0.07,0.20)
SD ADA SC + MTX		1.45 (0.20,8.80)	1.42 (0.21,7.63)	0.02 (‐0.08,0.15)
SD ABA SC + MTX		0.75 (0.11,4.55)	0.76 (0.12,4.20)	‐0.01 (‐0.11,0.08)
SD GOLI SC + MTX		2.87 (0.40,18.47)	2.63 (0.42,13.74)	0.07 (‐0.05,0.32)
SD RITUX IV + MTX		1.10 (0.16,6.25)	1.10 (0.18,5.60)	0.00 (‐0.09,0.11)
SD TOFA PO + MTX		3.00 (0.41,17.48)	2.73 (0.43,13.40)	0.07 (‐0.05,0.29)
SD GOLI IV + MTX		3.87 (0.23,79.95)	3.35 (0.25,25.62)	0.09 (‐0.06,0.70)
SD ETN SC + DMARD		1.43 (0.33,6.22)	1.40 (0.36,5.65)	0.02 (‐0.07,0.11)
SD ADA SC + DMARD		0.37 (0.06,2.54)	0.38 (0.06,2.46)	‐0.02 (‐0.12,0.03)
SD CERTO SC + DMARD		0.36 (0.05,2.86)	0.37 (0.05,2.73)	‐0.02 (‐0.12,0.04)
LD ADA SC		0.52 (0.14,1.88)	0.53 (0.15,1.86)	‐0.02 (‐0.11,0.01)
LD ETN SC		1.02 (0.16,6.15)	1.02 (0.17,5.56)	0.00 (‐0.09,0.11)
LD GOLI IV		6.71 (0.39,114.40)	5.16 (0.41,31.45)	0.18 (‐0.04,0.75)
LD RITUX IV + MTX		0.73 (0.11,4.41)	0.74 (0.11,4.07)	‐0.01 (‐0.11,0.07)
LD ABA IV + MTX		1.56 (0.20,9.63)	1.52 (0.21,8.15)	0.02 (‐0.08,0.18)
LD CERTO SC + MTX		1.80 (0.16,13.73)	1.73 (0.17,10.47)	0.03 (‐0.08,0.26)
LD ETN SC + MTX		0.63 (0.09,4.02)	0.64 (0.10,3.74)	‐0.01 (‐0.11,0.07)
LD GOLI IV + MTX		3.69 (0.22,64.74)	3.23 (0.23,25.19)	0.09 (‐0.06,0.65)
HD TOCI IV		1.11 (0.19,6.52)	1.10 (0.21,5.79)	0.00 (‐0.09,0.12)
HD TOFA PO		0.33 (0.08,1.57)	0.34 (0.08,1.55)	‐0.03 (‐0.12,0.01)
HD ADA SC		0.79 (0.22,2.79)	0.80 (0.24,2.71)	‐0.01 (‐0.10,0.03)
HD GOLI SC		1.71 (0.20,12.11)	1.65 (0.22,9.83)	0.02 (‐0.08,0.22)
HD GOLI SC + MTX		3.84 (0.46,24.30)	3.38 (0.48,16.34)	0.10 (‐0.04,0.38)
HD TOCI IV + MTX		1.31 (0.20,8.60)	1.29 (0.22,7.37)	0.01 (‐0.08,0.15)
HD TOFA PO + MTX		2.48 (0.34,14.84)	2.29 (0.36,11.67)	0.05 (‐0.06,0.26)
HD CERTO SC + MTX		2.37 (0.42,14.34)	2.21 (0.45,11.46)	0.05 (‐0.05,0.26)
HD INF IV + MTX		1.24 (0.18,7.29)	1.23 (0.20,6.48)	0.01 (‐0.09,0.13)
HD TOCI IV + DMARD		0.79 (0.14,4.68)	0.80 (0.15,4.35)	‐0.01 (‐0.10,0.08)
SD INF IV + MTX	SD GOLI IV	1.06 (0.04,14.72)	1.06 (0.08,13.26)	0.00 (‐0.49,0.11)
SD ETN SC + MTX		1.00 (0.04,15.05)	1.00 (0.07,13.60)	0.00 (‐0.49,0.10)
SD ABA IV + MTX		0.84 (0.03,13.09)	0.85 (0.07,11.96)	‐0.01 (‐0.49,0.09)
SD CERTO SC + MTX		1.61 (0.05,25.92)	1.55 (0.10,22.04)	0.02 (‐0.47,0.18)
SD ADA SC + MTX		1.14 (0.05,16.99)	1.13 (0.10,15.00)	0.00 (‐0.47,0.14)
SD ABA SC + MTX		0.64 (0.02,9.88)	0.65 (0.04,9.23)	‐0.02 (‐0.50,0.07)
SD GOLI SC + MTX		2.20 (0.14,25.21)	2.03 (0.24,21.07)	0.04 (‐0.39,0.28)
SD RITUX IV + MTX		0.92 (0.03,12.15)	0.93 (0.05,11.13)	0.00 (‐0.49,0.09)
SD TOFA PO + MTX		2.29 (0.08,34.30)	2.11 (0.16,27.82)	0.04 (‐0.43,0.27)
SD GOLI IV + MTX		2.89 (0.49,28.72)	2.37 (0.53,22.84)	0.07 (‐0.07,0.44)
SD ETN SC + DMARD		1.16 (0.05,16.68)	1.15 (0.10,15.28)	0.01 (‐0.48,0.11)
SD ADA SC + DMARD		0.32 (0.01,5.03)	0.33 (0.02,4.87)	‐0.03 (‐0.52,0.03)
SD CERTO SC + DMARD		0.29 (0.01,4.92)	0.30 (0.02,4.77)	‐0.03 (‐0.51,0.03)
LD ADA SC		0.39 (0.02,6.60)	0.41 (0.04,6.44)	‐0.03 (‐0.51,0.03)
LD ETN SC		0.85 (0.03,14.28)	0.86 (0.06,13.00)	‐0.01 (‐0.49,0.10)
LD GOLI IV		4.52 (1.07,55.75)	3.34 (1.05,37.84)	0.14 (0.00,0.53)
LD RITUX IV + MTX		0.62 (0.02,8.93)	0.63 (0.04,8.43)	‐0.02 (‐0.50,0.06)
LD ABA IV + MTX		1.29 (0.06,18.60)	1.27 (0.11,16.42)	0.01 (‐0.47,0.16)
LD CERTO SC + MTX		1.51 (0.03,30.51)	1.46 (0.05,25.29)	0.02 (‐0.48,0.24)
LD ETN SC + MTX		0.53 (0.02,7.96)	0.55 (0.03,7.55)	‐0.02 (‐0.51,0.06)
LD GOLI IV + MTX		2.67 (0.51,27.32)	2.29 (0.56,21.59)	0.06 (‐0.08,0.45)
HD TOCI IV		0.93 (0.04,12.50)	0.94 (0.07,11.45)	0.00 (‐0.49,0.10)
HD TOFA PO		0.26 (0.01,5.24)	0.27 (0.02,5.12)	‐0.04 (‐0.52,0.02)
HD ADA SC		0.61 (0.03,10.74)	0.62 (0.06,10.32)	‐0.02 (‐0.50,0.05)
HD GOLI SC		1.40 (0.05,17.22)	1.36 (0.10,15.33)	0.01 (‐0.45,0.19)
HD GOLI SC + MTX		3.15 (0.16,34.11)	2.76 (0.27,27.90)	0.07 (‐0.37,0.34)
HD TOCI IV + MTX		1.11 (0.04,16.32)	1.10 (0.08,14.56)	0.00 (‐0.48,0.14)
HD TOFA PO + MTX		1.91 (0.07,28.08)	1.80 (0.13,23.61)	0.03 (‐0.44,0.24)
HD CERTO SC + MTX		2.04 (0.05,31.07)	1.91 (0.11,25.09)	0.03 (‐0.46,0.22)
HD INF IV + MTX		1.05 (0.04,13.99)	1.04 (0.07,12.82)	0.00 (‐0.49,0.11)
HD TOCI IV + DMARD		0.68 (0.03,8.51)	0.70 (0.05,7.99)	‐0.01 (‐0.50,0.07)
SD ETN SC + MTX	SD INF IV + MTX	0.95 (0.42,2.16)	0.95 (0.44,2.06)	0.00 (‐0.06,0.05)
SD ABA IV + MTX		0.80 (0.45,1.39)	0.81 (0.47,1.36)	‐0.01 (‐0.06,0.02)
SD CERTO SC + MTX		1.50 (0.75,3.07)	1.46 (0.77,2.81)	0.02 (‐0.02,0.11)
SD ADA SC + MTX		1.10 (0.45,2.72)	1.09 (0.47,2.52)	0.00 (‐0.05,0.09)
SD ABA SC + MTX		0.59 (0.25,1.32)	0.61 (0.26,1.29)	‐0.02 (‐0.08,0.01)
SD GOLI SC + MTX		2.16 (0.66,7.28)	2.00 (0.68,5.93)	0.05 (‐0.02,0.26)
SD RITUX IV + MTX		0.84 (0.40,1.87)	0.85 (0.42,1.79)	‐0.01 (‐0.07,0.04)
SD TOFA PO + MTX		2.21 (0.87,6.63)	2.04 (0.87,5.27)	0.06 (‐0.01,0.23)
SD GOLI IV + MTX		2.74 (0.41,48.63)	2.44 (0.42,17.20)	0.08 (‐0.04,0.67)
SD ETN SC + DMARD		1.14 (0.40,3.16)	1.13 (0.43,2.96)	0.01 (‐0.07,0.07)
SD ADA SC + DMARD		0.30 (0.08,1.09)	0.31 (0.09,1.09)	‐0.03 (‐0.13,0.00)
SD CERTO SC + DMARD		0.28 (0.06,1.46)	0.29 (0.06,1.44)	‐0.03 (‐0.13,0.02)
LD ADA SC		0.42 (0.09,1.74)	0.43 (0.10,1.71)	‐0.03 (‐0.15,0.01)
LD ETN SC		0.79 (0.28,2.14)	0.80 (0.30,2.04)	‐0.01 (‐0.08,0.05)
LD GOLI IV		4.85 (0.72,82.94)	3.81 (0.73,20.70)	0.16 (‐0.01,0.73)
LD RITUX IV + MTX		0.55 (0.26,1.27)	0.57 (0.27,1.25)	‐0.02 (‐0.09,0.01)
LD ABA IV + MTX		1.21 (0.50,2.89)	1.19 (0.52,2.62)	0.01 (‐0.04,0.11)
LD CERTO SC + MTX		1.45 (0.24,5.89)	1.41 (0.25,4.84)	0.02 (‐0.06,0.21)
LD ETN SC + MTX		0.50 (0.16,1.42)	0.51 (0.17,1.39)	‐0.02 (‐0.10,0.02)
LD GOLI IV + MTX		2.69 (0.43,50.10)	2.43 (0.45,17.39)	0.08 (‐0.04,0.62)
HD TOCI IV		0.88 (0.36,2.18)	0.89 (0.38,2.08)	0.00 (‐0.07,0.05)
HD TOFA PO		0.26 (0.06,1.33)	0.27 (0.07,1.33)	‐0.04 (‐0.15,0.01)
HD ADA SC		0.62 (0.15,2.63)	0.63 (0.17,2.56)	‐0.02 (‐0.13,0.03)
HD GOLI SC		1.29 (0.33,4.74)	1.27 (0.35,4.04)	0.01 (‐0.06,0.18)
HD GOLI SC + MTX		2.93 (1.03,8.58)	2.59 (1.03,6.38)	0.09 (0.00,0.33)
HD TOCI IV + MTX		1.03 (0.37,3.07)	1.03 (0.39,2.81)	0.00 (‐0.07,0.09)
HD TOFA PO + MTX		1.86 (0.68,5.16)	1.76 (0.68,4.36)	0.04 (‐0.02,0.20)
HD CERTO SC + MTX		1.87 (0.80,4.58)	1.77 (0.81,3.97)	0.04 (‐0.01,0.18)
HD INF IV + MTX		0.97 (0.50,1.92)	0.97 (0.51,1.83)	0.00 (‐0.04,0.05)
HD TOCI IV + DMARD		0.62 (0.20,1.93)	0.64 (0.22,1.86)	‐0.02 (‐0.10,0.04)
SD ABA IV + MTX	SD ETN SC + MTX	0.84 (0.35,1.84)	0.85 (0.37,1.78)	‐0.01 (‐0.07,0.04)
SD CERTO SC + MTX		1.57 (0.68,3.73)	1.52 (0.70,3.40)	0.02 (‐0.03,0.13)
SD ADA SC + MTX		1.17 (0.41,3.58)	1.16 (0.42,3.22)	0.01 (‐0.06,0.10)
SD ABA SC + MTX		0.63 (0.21,1.64)	0.65 (0.23,1.60)	‐0.02 (‐0.09,0.03)
SD GOLI SC + MTX		2.28 (0.56,8.90)	2.12 (0.59,6.95)	0.05 (‐0.03,0.28)
SD RITUX IV + MTX		0.87 (0.36,2.32)	0.88 (0.38,2.18)	0.00 (‐0.07,0.06)
SD TOFA PO + MTX		2.37 (0.78,7.41)	2.20 (0.80,6.04)	0.06 (‐0.01,0.24)
SD GOLI IV + MTX		2.72 (0.45,58.61)	2.45 (0.46,20.08)	0.08 (‐0.04,0.68)
SD ETN SC + DMARD		1.18 (0.45,3.04)	1.17 (0.47,2.86)	0.01 (‐0.06,0.07)
SD ADA SC + DMARD		0.31 (0.08,1.11)	0.32 (0.09,1.10)	‐0.03 (‐0.12,0.00)
SD CERTO SC + DMARD		0.30 (0.06,1.55)	0.31 (0.06,1.53)	‐0.03 (‐0.13,0.02)
LD ADA SC		0.44 (0.09,1.71)	0.45 (0.11,1.68)	‐0.03 (‐0.14,0.01)
LD ETN SC		0.84 (0.28,2.41)	0.85 (0.30,2.29)	‐0.01 (‐0.08,0.06)
LD GOLI IV		5.01 (0.75,96.66)	3.88 (0.76,22.99)	0.17 (‐0.01,0.74)
LD RITUX IV + MTX		0.58 (0.23,1.56)	0.60 (0.25,1.53)	‐0.02 (‐0.09,0.02)
LD ABA IV + MTX		1.27 (0.43,3.63)	1.24 (0.45,3.25)	0.01 (‐0.05,0.12)
LD CERTO SC + MTX		1.51 (0.21,6.24)	1.46 (0.23,5.18)	0.02 (‐0.06,0.21)
LD ETN SC + MTX		0.52 (0.18,1.40)	0.54 (0.19,1.37)	‐0.02 (‐0.09,0.02)
LD GOLI IV + MTX		2.83 (0.44,53.74)	2.53 (0.45,20.04)	0.08 (‐0.04,0.63)
HD TOCI IV		0.92 (0.36,2.38)	0.93 (0.38,2.26)	0.00 (‐0.07,0.06)
HD TOFA PO		0.28 (0.06,1.33)	0.29 (0.07,1.32)	‐0.04 (‐0.15,0.01)
HD ADA SC		0.65 (0.16,3.13)	0.66 (0.18,3.03)	‐0.02 (‐0.13,0.03)
HD GOLI SC		1.37 (0.29,5.77)	1.35 (0.30,4.81)	0.01 (‐0.07,0.19)
HD GOLI SC + MTX		3.07 (0.90,11.35)	2.71 (0.91,8.03)	0.09 (‐0.01,0.34)
HD TOCI IV + MTX		1.08 (0.36,3.51)	1.07 (0.38,3.18)	0.00 (‐0.06,0.10)
HD TOFA PO + MTX		2.01 (0.60,6.31)	1.88 (0.62,5.17)	0.04 (‐0.03,0.21)
HD CERTO SC + MTX		1.98 (0.74,5.48)	1.85 (0.76,4.67)	0.04 (‐0.02,0.19)
HD INF IV + MTX		1.01 (0.40,2.69)	1.01 (0.42,2.52)	0.00 (‐0.06,0.07)
HD TOCI IV + DMARD		0.65 (0.21,2.04)	0.67 (0.22,1.95)	‐0.01 (‐0.10,0.04)
SD CERTO SC + MTX	SD ABA IV + MTX	1.90 (1.00,3.75)	1.81 (1.00,3.43)	0.03 (0.00,0.13)
SD ADA SC + MTX		1.38 (0.57,3.64)	1.36 (0.59,3.28)	0.01 (‐0.03,0.10)
SD ABA SC + MTX		0.74 (0.39,1.36)	0.75 (0.41,1.34)	‐0.01 (‐0.05,0.02)
SD GOLI SC + MTX		2.74 (0.82,9.31)	2.52 (0.83,7.34)	0.06 (‐0.01,0.28)
SD RITUX IV + MTX		1.08 (0.50,2.33)	1.07 (0.52,2.22)	0.00 (‐0.04,0.06)
SD TOFA PO + MTX		2.83 (1.12,7.91)	2.58 (1.12,6.37)	0.07 (0.00,0.25)
SD GOLI IV + MTX		3.47 (0.51,60.68)	3.05 (0.52,20.36)	0.09 (‐0.02,0.69)
SD ETN SC + DMARD		1.44 (0.49,3.89)	1.41 (0.52,3.64)	0.02 (‐0.05,0.09)
SD ADA SC + DMARD		0.38 (0.10,1.31)	0.39 (0.11,1.30)	‐0.02 (‐0.10,0.01)
SD CERTO SC + DMARD		0.35 (0.07,1.90)	0.36 (0.08,1.85)	‐0.02 (‐0.11,0.02)
LD ADA SC		0.53 (0.11,2.17)	0.54 (0.12,2.15)	‐0.02 (‐0.12,0.02)
LD ETN SC		1.01 (0.35,2.66)	1.00 (0.37,2.52)	0.00 (‐0.05,0.07)
LD GOLI IV		6.15 (1.03,98.16)	4.73 (1.02,24.52)	0.18 (0.00,0.74)
LD RITUX IV + MTX		0.70 (0.33,1.60)	0.71 (0.35,1.55)	‐0.01 (‐0.06,0.02)
LD ABA IV + MTX		1.51 (0.72,3.34)	1.47 (0.73,3.01)	0.02 (‐0.01,0.12)
LD CERTO SC + MTX		1.86 (0.30,7.15)	1.78 (0.31,5.90)	0.03 (‐0.04,0.22)
LD ETN SC + MTX		0.63 (0.21,1.82)	0.65 (0.22,1.76)	‐0.01 (‐0.08,0.03)
LD GOLI IV + MTX		3.47 (0.60,57.15)	3.08 (0.61,20.44)	0.09 (‐0.02,0.64)
HD TOCI IV		1.12 (0.44,2.77)	1.11 (0.46,2.62)	0.00 (‐0.05,0.07)
HD TOFA PO		0.33 (0.07,1.69)	0.34 (0.08,1.67)	‐0.03 (‐0.12,0.01)
HD ADA SC		0.78 (0.18,3.81)	0.79 (0.20,3.66)	‐0.01 (‐0.10,0.04)
HD GOLI SC		1.62 (0.42,6.28)	1.57 (0.43,5.32)	0.02 (‐0.04,0.19)
HD GOLI SC + MTX		3.65 (1.36,11.85)	3.20 (1.32,8.55)	0.09 (0.01,0.35)
HD TOCI IV + MTX		1.31 (0.49,3.78)	1.29 (0.50,3.44)	0.01 (‐0.04,0.11)
HD TOFA PO + MTX		2.34 (0.85,6.64)	2.19 (0.86,5.59)	0.05 (‐0.01,0.21)
HD CERTO SC + MTX		2.37 (1.05,5.68)	2.20 (1.05,4.92)	0.05 (0.00,0.20)
HD INF IV + MTX		1.22 (0.57,2.71)	1.21 (0.59,2.54)	0.01 (‐0.03,0.08)
HD TOCI IV + DMARD		0.80 (0.26,2.46)	0.81 (0.28,2.32)	‐0.01 (‐0.08,0.05)
SD ADA SC + MTX	SD CERTO SC + MTX	0.73 (0.28,1.92)	0.75 (0.31,1.82)	‐0.02 (‐0.11,0.05)
SD ABA SC + MTX		0.39 (0.15,0.93)	0.42 (0.17,0.94)	‐0.04 (‐0.15,0.00)
SD GOLI SC + MTX		1.45 (0.41,4.99)	1.39 (0.44,3.99)	0.03 (‐0.08,0.23)
SD RITUX IV + MTX		0.56 (0.26,1.24)	0.58 (0.29,1.22)	‐0.03 (‐0.14,0.02)
SD TOFA PO + MTX		1.48 (0.54,4.28)	1.42 (0.57,3.55)	0.03 (‐0.05,0.19)
SD GOLI IV + MTX		1.78 (0.27,40.10)	1.66 (0.29,13.19)	0.05 (‐0.09,0.65)
SD ETN SC + DMARD		0.76 (0.26,1.99)	0.78 (0.29,1.90)	‐0.02 (‐0.14,0.05)
SD ADA SC + DMARD		0.20 (0.05,0.71)	0.21 (0.06,0.73)	‐0.06 (‐0.21,‐0.01)
SD CERTO SC + DMARD		0.19 (0.04,0.96)	0.20 (0.04,0.96)	‐0.06 (‐0.21,0.00)
LD ADA SC		0.28 (0.05,1.11)	0.30 (0.07,1.11)	‐0.05 (‐0.22,0.00)
LD ETN SC		0.53 (0.18,1.50)	0.56 (0.20,1.45)	‐0.03 (‐0.15,0.03)
LD GOLI IV		3.11 (0.53,62.39)	2.57 (0.54,15.29)	0.13 (‐0.04,0.72)
LD RITUX IV + MTX		0.36 (0.16,0.85)	0.39 (0.18,0.86)	‐0.04 (‐0.16,‐0.01)
LD ABA IV + MTX		0.80 (0.32,1.99)	0.82 (0.34,1.86)	‐0.01 (‐0.10,0.07)
LD CERTO SC + MTX		0.97 (0.17,3.36)	0.97 (0.19,2.87)	0.00 (‐0.10,0.15)
LD ETN SC + MTX		0.33 (0.10,1.03)	0.35 (0.11,1.03)	‐0.05 (‐0.18,0.00)
LD GOLI IV + MTX		1.78 (0.30,34.81)	1.67 (0.31,12.62)	0.05 (‐0.08,0.60)
HD TOCI IV		0.59 (0.23,1.40)	0.62 (0.26,1.36)	‐0.03 (‐0.14,0.02)
HD TOFA PO		0.17 (0.04,0.88)	0.18 (0.05,0.88)	‐0.06 (‐0.23,0.00)
HD ADA SC		0.41 (0.09,1.95)	0.43 (0.12,1.90)	‐0.04 (‐0.21,0.02)
HD GOLI SC		0.88 (0.20,3.24)	0.89 (0.23,2.78)	‐0.01 (‐0.13,0.14)
HD GOLI SC + MTX		1.99 (0.63,6.11)	1.81 (0.66,4.57)	0.06 (‐0.04,0.29)
HD TOCI IV + MTX		0.69 (0.24,1.93)	0.71 (0.27,1.80)	‐0.02 (‐0.13,0.06)
HD TOFA PO + MTX		1.25 (0.43,3.53)	1.22 (0.46,3.02)	0.02 (‐0.06,0.16)
HD CERTO SC + MTX		1.26 (0.62,2.45)	1.23 (0.65,2.20)	0.02 (‐0.04,0.12)
HD INF IV + MTX		0.65 (0.27,1.47)	0.67 (0.30,1.42)	‐0.02 (‐0.12,0.03)
HD TOCI IV + DMARD		0.42 (0.13,1.31)	0.44 (0.15,1.28)	‐0.04 (‐0.17,0.01)
SD ABA SC + MTX	SD ADA SC + MTX	0.53 (0.17,1.57)	0.55 (0.19,1.54)	‐0.02 (‐0.12,0.02)
SD GOLI SC + MTX		2.01 (0.43,7.61)	1.86 (0.45,6.26)	0.05 (‐0.05,0.25)
SD RITUX IV + MTX		0.76 (0.28,2.16)	0.77 (0.31,2.07)	‐0.01 (‐0.10,0.05)
SD TOFA PO + MTX		2.03 (0.84,5.26)	1.89 (0.86,4.45)	0.05 (‐0.01,0.21)
SD GOLI IV + MTX		2.55 (0.29,45.08)	2.29 (0.31,15.26)	0.07 (‐0.07,0.66)
SD ETN SC + DMARD		1.00 (0.30,3.39)	1.00 (0.33,3.24)	0.00 (‐0.10,0.07)
SD ADA SC + DMARD		0.26 (0.07,1.10)	0.28 (0.07,1.10)	‐0.04 (‐0.16,0.00)
SD CERTO SC + DMARD		0.25 (0.05,1.58)	0.27 (0.05,1.55)	‐0.04 (‐0.16,0.01)
LD ADA SC		0.36 (0.07,1.97)	0.38 (0.09,1.94)	‐0.04 (‐0.17,0.02)
LD ETN SC		0.72 (0.20,2.36)	0.73 (0.22,2.26)	‐0.01 (‐0.11,0.05)
LD GOLI IV		4.47 (0.59,68.73)	3.51 (0.61,18.38)	0.16 (‐0.04,0.72)
LD RITUX IV + MTX		0.51 (0.18,1.44)	0.53 (0.20,1.42)	‐0.03 (‐0.12,0.01)
LD ABA IV + MTX		1.08 (0.35,3.32)	1.08 (0.38,3.03)	0.00 (‐0.08,0.11)
LD CERTO SC + MTX		1.31 (0.21,5.45)	1.28 (0.23,4.55)	0.01 (‐0.09,0.20)
LD ETN SC + MTX		0.44 (0.11,1.54)	0.46 (0.13,1.50)	‐0.03 (‐0.14,0.02)
LD GOLI IV + MTX		2.49 (0.38,38.28)	2.23 (0.40,15.17)	0.07 (‐0.06,0.61)
HD TOCI IV		0.79 (0.28,2.40)	0.80 (0.30,2.27)	‐0.01 (‐0.10,0.05)
HD TOFA PO		0.22 (0.05,1.42)	0.24 (0.06,1.41)	‐0.05 (‐0.18,0.01)
HD ADA SC		0.54 (0.12,3.30)	0.55 (0.14,3.17)	‐0.03 (‐0.16,0.04)
HD GOLI SC		1.19 (0.24,5.36)	1.17 (0.26,4.56)	0.01 (‐0.09,0.17)
HD GOLI SC + MTX		2.65 (0.74,10.32)	2.34 (0.76,7.75)	0.08 (‐0.02,0.33)
HD TOCI IV + MTX		0.93 (0.28,3.19)	0.93 (0.30,2.92)	0.00 (‐0.09,0.09)
HD TOFA PO + MTX		1.68 (0.67,4.64)	1.60 (0.68,3.99)	0.03 (‐0.03,0.18)
HD CERTO SC + MTX		1.70 (0.57,5.21)	1.61 (0.59,4.53)	0.03 (‐0.04,0.17)
HD INF IV + MTX		0.87 (0.31,2.44)	0.88 (0.34,2.33)	‐0.01 (‐0.09,0.06)
HD TOCI IV + DMARD		0.55 (0.16,2.05)	0.57 (0.17,1.96)	‐0.02 (‐0.13,0.04)
SD GOLI SC + MTX	SD ABA SC + MTX	3.69 (0.99,15.15)	3.31 (0.99,12.09)	0.07 (0.00,0.30)
SD RITUX IV + MTX		1.42 (0.57,4.03)	1.40 (0.59,3.76)	0.01 (‐0.03,0.08)
SD TOFA PO + MTX		3.83 (1.26,12.32)	3.44 (1.24,10.14)	0.08 (0.01,0.26)
SD GOLI IV + MTX		4.73 (0.63,90.95)	4.07 (0.64,32.54)	0.10 (‐0.01,0.70)
SD ETN SC + DMARD		1.92 (0.57,6.26)	1.86 (0.60,5.76)	0.02 (‐0.04,0.10)
SD ADA SC + DMARD		0.51 (0.13,2.07)	0.52 (0.14,2.03)	‐0.01 (‐0.09,0.02)
SD CERTO SC + DMARD		0.47 (0.09,2.76)	0.48 (0.10,2.68)	‐0.01 (‐0.09,0.04)
LD ADA SC		0.72 (0.13,3.27)	0.73 (0.14,3.20)	‐0.01 (‐0.10,0.02)
LD ETN SC		1.36 (0.44,4.27)	1.34 (0.46,4.00)	0.01 (‐0.04,0.09)
LD GOLI IV		8.24 (1.28,164.20)	6.26 (1.26,40.30)	0.19 (0.00,0.76)
LD RITUX IV + MTX		0.92 (0.37,2.60)	0.93 (0.39,2.51)	0.00 (‐0.05,0.04)
LD ABA IV + MTX		2.05 (0.78,5.69)	1.97 (0.79,5.18)	0.03 (‐0.01,0.15)
LD CERTO SC + MTX		2.49 (0.38,10.82)	2.32 (0.39,9.07)	0.04 (‐0.03,0.24)
LD ETN SC + MTX		0.85 (0.25,2.92)	0.85 (0.26,2.79)	0.00 (‐0.06,0.05)
LD GOLI IV + MTX		4.69 (0.74,95.89)	4.05 (0.74,33.23)	0.10 (‐0.01,0.65)
HD TOCI IV		1.49 (0.50,4.41)	1.47 (0.53,4.14)	0.01 (‐0.04,0.09)
HD TOFA PO		0.45 (0.08,2.61)	0.45 (0.09,2.58)	‐0.02 (‐0.11,0.01)
HD ADA SC		1.06 (0.21,5.46)	1.06 (0.23,5.26)	0.00 (‐0.09,0.05)
HD GOLI SC		2.18 (0.50,9.75)	2.08 (0.51,8.02)	0.03 (‐0.03,0.21)
HD GOLI SC + MTX		4.91 (1.55,18.50)	4.24 (1.48,13.49)	0.11 (0.01,0.37)
HD TOCI IV + MTX		1.76 (0.57,5.91)	1.71 (0.58,5.43)	0.02 (‐0.03,0.13)
HD TOFA PO + MTX		3.23 (0.98,10.47)	2.97 (0.98,8.68)	0.06 (0.00,0.23)
HD CERTO SC + MTX		3.19 (1.18,9.28)	2.92 (1.17,7.96)	0.06 (0.01,0.22)
HD INF IV + MTX		1.61 (0.65,4.64)	1.57 (0.67,4.33)	0.02 (‐0.02,0.10)
HD TOCI IV + DMARD		1.07 (0.30,3.84)	1.07 (0.32,3.58)	0.00 (‐0.06,0.07)
SD RITUX IV + MTX	SD GOLI SC + MTX	0.38 (0.10,1.47)	0.42 (0.12,1.44)	‐0.06 (‐0.27,0.02)
SD TOFA PO + MTX		1.00 (0.27,6.16)	1.00 (0.32,4.94)	0.00 (‐0.17,0.19)
SD GOLI IV + MTX		1.36 (0.16,17.59)	1.30 (0.19,6.69)	0.03 (‐0.20,0.58)
SD ETN SC + DMARD		0.51 (0.13,2.10)	0.54 (0.17,2.02)	‐0.05 (‐0.28,0.04)
SD ADA SC + DMARD		0.14 (0.03,0.64)	0.16 (0.03,0.65)	‐0.09 (‐0.34,‐0.01)
SD CERTO SC + DMARD		0.13 (0.02,0.86)	0.14 (0.02,0.88)	‐0.09 (‐0.33,0.00)
LD ADA SC		0.18 (0.03,1.02)	0.20 (0.05,1.02)	‐0.09 (‐0.34,0.00)
LD ETN SC		0.37 (0.08,1.52)	0.40 (0.11,1.48)	‐0.06 (‐0.28,0.02)
LD GOLI IV		2.28 (0.32,25.66)	1.93 (0.34,8.10)	0.10 (‐0.14,0.65)
LD RITUX IV + MTX		0.26 (0.06,0.91)	0.29 (0.08,0.92)	‐0.08 (‐0.30,0.00)
LD ABA IV + MTX		0.55 (0.15,2.13)	0.59 (0.18,2.00)	‐0.04 (‐0.25,0.06)
LD CERTO SC + MTX		0.67 (0.08,3.57)	0.70 (0.09,3.12)	‐0.03 (‐0.24,0.15)
LD ETN SC + MTX		0.23 (0.05,1.05)	0.25 (0.06,1.04)	‐0.08 (‐0.32,0.00)
LD GOLI IV + MTX		1.33 (0.16,15.12)	1.28 (0.18,6.26)	0.02 (‐0.20,0.54)
HD TOCI IV		0.40 (0.11,1.47)	0.44 (0.14,1.44)	‐0.06 (‐0.27,0.02)
HD TOFA PO		0.12 (0.02,0.79)	0.13 (0.03,0.79)	‐0.10 (‐0.35,0.00)
HD ADA SC		0.27 (0.06,1.64)	0.30 (0.08,1.62)	‐0.08 (‐0.33,0.02)
HD GOLI SC		0.60 (0.14,2.04)	0.64 (0.17,1.88)	‐0.03 (‐0.21,0.08)
HD GOLI SC + MTX		1.36 (0.55,3.67)	1.29 (0.60,3.09)	0.03 (‐0.08,0.19)
HD TOCI IV + MTX		0.48 (0.12,2.02)	0.51 (0.14,1.93)	‐0.05 (‐0.27,0.05)
HD TOFA PO + MTX		0.83 (0.21,4.16)	0.85 (0.25,3.65)	‐0.01 (‐0.19,0.14)
HD CERTO SC + MTX		0.87 (0.21,3.58)	0.89 (0.26,3.19)	‐0.01 (‐0.21,0.13)
HD INF IV + MTX		0.44 (0.12,1.70)	0.48 (0.14,1.64)	‐0.05 (‐0.26,0.03)
HD TOCI IV + DMARD		0.29 (0.06,1.27)	0.32 (0.08,1.25)	‐0.07 (‐0.30,0.01)
SD TOFA PO + MTX	SD RITUX IV + MTX	2.72 (0.89,7.80)	2.47 (0.90,6.36)	0.07 (‐0.01,0.24)
SD GOLI IV + MTX		3.12 (0.48,76.53)	2.79 (0.49,25.89)	0.08 (‐0.03,0.68)
SD ETN SC + DMARD		1.33 (0.42,3.98)	1.31 (0.45,3.75)	0.01 (‐0.07,0.08)
SD ADA SC + DMARD		0.35 (0.09,1.52)	0.36 (0.10,1.49)	‐0.03 (‐0.12,0.01)
SD CERTO SC + DMARD		0.32 (0.06,2.05)	0.34 (0.07,2.00)	‐0.03 (‐0.12,0.03)
LD ADA SC		0.49 (0.10,2.03)	0.50 (0.11,2.00)	‐0.02 (‐0.13,0.02)
LD ETN SC		0.96 (0.29,2.70)	0.96 (0.31,2.55)	0.00 (‐0.08,0.06)
LD GOLI IV		5.72 (0.93,126.70)	4.39 (0.94,32.30)	0.17 (0.00,0.75)
LD RITUX IV + MTX		0.66 (0.33,1.27)	0.67 (0.35,1.25)	‐0.01 (‐0.07,0.01)
LD ABA IV + MTX		1.42 (0.51,3.91)	1.39 (0.54,3.60)	0.02 (‐0.04,0.13)
LD CERTO SC + MTX		1.70 (0.25,6.95)	1.64 (0.27,5.60)	0.02 (‐0.06,0.23)
LD ETN SC + MTX		0.61 (0.17,1.78)	0.62 (0.18,1.73)	‐0.02 (‐0.10,0.03)
LD GOLI IV + MTX		3.15 (0.53,72.16)	2.81 (0.54,27.02)	0.08 (‐0.02,0.64)
HD TOCI IV		1.03 (0.39,2.94)	1.02 (0.42,2.78)	0.00 (‐0.06,0.06)
HD TOFA PO		0.31 (0.07,1.63)	0.32 (0.08,1.61)	‐0.03 (‐0.14,0.01)
HD ADA SC		0.71 (0.17,3.74)	0.72 (0.19,3.62)	‐0.01 (‐0.12,0.04)
HD GOLI SC		1.54 (0.36,6.06)	1.50 (0.38,5.04)	0.02 (‐0.05,0.19)
HD GOLI SC + MTX		3.45 (1.07,11.28)	3.02 (1.06,8.47)	0.09 (0.00,0.34)
HD TOCI IV + MTX		1.23 (0.41,3.76)	1.21 (0.43,3.45)	0.01 (‐0.05,0.10)
HD TOFA PO + MTX		2.32 (0.68,6.53)	2.15 (0.69,5.46)	0.05 (‐0.02,0.21)
HD CERTO SC + MTX		2.25 (0.83,5.74)	2.11 (0.84,4.92)	0.05 (‐0.01,0.20)
HD INF IV + MTX		1.14 (0.46,2.79)	1.13 (0.48,2.61)	0.00 (‐0.05,0.08)
HD TOCI IV + DMARD		0.73 (0.21,2.45)	0.74 (0.23,2.36)	‐0.01 (‐0.09,0.05)
SD GOLI IV + MTX	SD TOFA PO + MTX	1.24 (0.14,25.44)	1.19 (0.17,9.33)	0.02 (‐0.18,0.60)
SD ETN SC + DMARD		0.50 (0.14,1.67)	0.54 (0.17,1.62)	‐0.05 (‐0.25,0.03)
SD ADA SC + DMARD		0.13 (0.03,0.53)	0.15 (0.04,0.56)	‐0.10 (‐0.30,‐0.01)
SD CERTO SC + DMARD		0.12 (0.02,0.73)	0.14 (0.02,0.75)	‐0.10 (‐0.30,‐0.01)
LD ADA SC		0.17 (0.04,0.97)	0.19 (0.05,0.97)	‐0.09 (‐0.32,0.00)
LD ETN SC		0.36 (0.09,1.23)	0.39 (0.11,1.22)	‐0.07 (‐0.26,0.01)
LD GOLI IV		2.22 (0.23,37.58)	1.88 (0.27,10.55)	0.10 (‐0.16,0.68)
LD RITUX IV + MTX		0.25 (0.08,0.73)	0.28 (0.10,0.75)	‐0.08 (‐0.27,‐0.01)
LD ABA IV + MTX		0.54 (0.17,1.69)	0.58 (0.20,1.62)	‐0.04 (‐0.22,0.04)
LD CERTO SC + MTX		0.62 (0.09,3.08)	0.66 (0.11,2.64)	‐0.03 (‐0.23,0.14)
LD ETN SC + MTX		0.22 (0.05,0.77)	0.25 (0.06,0.79)	‐0.08 (‐0.28,‐0.01)
LD GOLI IV + MTX		1.20 (0.17,22.16)	1.17 (0.19,8.91)	0.02 (‐0.19,0.57)
HD TOCI IV		0.39 (0.13,1.19)	0.42 (0.16,1.17)	‐0.06 (‐0.24,0.01)
HD TOFA PO		0.11 (0.02,0.71)	0.12 (0.03,0.71)	‐0.10 (‐0.33,‐0.01)
HD ADA SC		0.26 (0.06,1.51)	0.28 (0.08,1.49)	‐0.08 (‐0.30,0.01)
HD GOLI SC		0.58 (0.09,2.55)	0.62 (0.12,2.31)	‐0.04 (‐0.23,0.10)
HD GOLI SC + MTX		1.32 (0.31,4.99)	1.27 (0.36,3.95)	0.03 (‐0.15,0.25)
HD TOCI IV + MTX		0.45 (0.13,1.68)	0.49 (0.16,1.59)	‐0.05 (‐0.23,0.04)
HD TOFA PO + MTX		0.83 (0.42,1.64)	0.85 (0.46,1.53)	‐0.01 (‐0.11,0.06)
HD CERTO SC + MTX		0.84 (0.27,2.51)	0.86 (0.32,2.28)	‐0.01 (‐0.17,0.10)
HD INF IV + MTX		0.42 (0.14,1.25)	0.46 (0.17,1.23)	‐0.06 (‐0.23,0.01)
HD TOCI IV + DMARD		0.27 (0.07,0.98)	0.31 (0.09,0.98)	‐0.08 (‐0.27,0.00)
SD ETN SC + DMARD	SD GOLI IV + MTX	0.41 (0.02,3.36)	0.45 (0.07,3.18)	‐0.07 (‐0.67,0.06)
SD ADA SC + DMARD		0.11 (0.01,1.01)	0.13 (0.02,1.01)	‐0.12 (‐0.72,0.00)
SD CERTO SC + DMARD		0.09 (0.01,1.10)	0.11 (0.01,1.09)	‐0.12 (‐0.72,0.00)
LD ADA SC		0.13 (0.01,1.67)	0.16 (0.03,1.65)	‐0.12 (‐0.71,0.01)
LD ETN SC		0.30 (0.01,2.23)	0.34 (0.04,2.16)	‐0.08 (‐0.69,0.04)
LD GOLI IV		1.62 (0.50,6.95)	1.39 (0.57,5.18)	0.05 (‐0.12,0.33)
LD RITUX IV + MTX		0.21 (0.01,1.46)	0.24 (0.03,1.44)	‐0.10 (‐0.69,0.01)
LD ABA IV + MTX		0.44 (0.02,3.24)	0.48 (0.07,3.03)	‐0.06 (‐0.66,0.08)
LD CERTO SC + MTX		0.50 (0.01,5.23)	0.55 (0.03,4.67)	‐0.05 (‐0.67,0.15)
LD ETN SC + MTX		0.18 (0.01,1.35)	0.21 (0.02,1.33)	‐0.11 (‐0.70,0.01)
LD GOLI IV + MTX		0.93 (0.23,4.35)	0.95 (0.28,3.54)	‐0.01 (‐0.26,0.22)
HD TOCI IV		0.33 (0.02,2.36)	0.37 (0.05,2.28)	‐0.08 (‐0.68,0.03)
HD TOFA PO		0.09 (0.00,1.15)	0.10 (0.01,1.14)	‐0.12 (‐0.73,0.00)
HD ADA SC		0.20 (0.01,2.59)	0.23 (0.04,2.52)	‐0.11 (‐0.70,0.03)
HD GOLI SC		0.46 (0.02,4.11)	0.51 (0.06,3.64)	‐0.06 (‐0.65,0.12)
HD GOLI SC + MTX		1.07 (0.06,8.37)	1.06 (0.17,6.75)	0.00 (‐0.56,0.26)
HD TOCI IV + MTX		0.38 (0.02,3.04)	0.43 (0.05,2.86)	‐0.07 (‐0.68,0.06)
HD TOFA PO + MTX		0.66 (0.04,6.57)	0.71 (0.09,5.59)	‐0.04 (‐0.61,0.16)
HD CERTO SC + MTX		0.72 (0.03,4.74)	0.76 (0.08,4.30)	‐0.03 (‐0.64,0.13)
HD INF IV + MTX		0.36 (0.02,2.66)	0.40 (0.05,2.55)	‐0.08 (‐0.67,0.04)
HD TOCI IV + DMARD		0.23 (0.01,2.02)	0.26 (0.04,1.96)	‐0.10 (‐0.70,0.03)
SD ADA SC + DMARD	SD ETN SC + DMARD	0.27 (0.07,0.92)	0.28 (0.08,0.92)	‐0.04 (‐0.12,0.00)
SD CERTO SC + DMARD		0.26 (0.05,1.22)	0.27 (0.05,1.20)	‐0.04 (‐0.13,0.01)
LD ADA SC		0.37 (0.10,1.16)	0.39 (0.11,1.15)	‐0.04 (‐0.14,0.00)
LD ETN SC		0.69 (0.22,2.35)	0.71 (0.24,2.20)	‐0.01 (‐0.09,0.06)
LD GOLI IV		4.34 (0.47,70.46)	3.48 (0.49,17.47)	0.16 (‐0.02,0.73)
LD RITUX IV + MTX		0.49 (0.16,1.62)	0.51 (0.17,1.57)	‐0.03 (‐0.10,0.03)
LD ABA IV + MTX		1.06 (0.31,3.65)	1.06 (0.32,3.22)	0.00 (‐0.07,0.13)
LD CERTO SC + MTX		1.27 (0.16,6.01)	1.25 (0.17,4.79)	0.01 (‐0.08,0.22)
LD ETN SC + MTX		0.44 (0.12,1.66)	0.46 (0.13,1.60)	‐0.03 (‐0.11,0.03)
LD GOLI IV + MTX		2.40 (0.27,37.95)	2.18 (0.29,14.36)	0.07 (‐0.04,0.62)
HD TOCI IV		0.78 (0.28,2.22)	0.79 (0.30,2.09)	‐0.01 (‐0.08,0.06)
HD TOFA PO		0.23 (0.06,0.95)	0.24 (0.07,0.95)	‐0.04 (‐0.15,0.00)
HD ADA SC		0.56 (0.16,1.80)	0.58 (0.18,1.76)	‐0.02 (‐0.12,0.02)
HD GOLI SC		1.20 (0.23,5.00)	1.18 (0.24,4.19)	0.01 (‐0.08,0.18)
HD GOLI SC + MTX		2.59 (0.65,10.42)	2.33 (0.66,7.23)	0.08 (‐0.02,0.34)
HD TOCI IV + MTX		0.90 (0.28,3.12)	0.91 (0.29,2.81)	0.00 (‐0.07,0.10)
HD TOFA PO + MTX		1.68 (0.46,6.35)	1.60 (0.47,5.13)	0.03 (‐0.04,0.21)
HD CERTO SC + MTX		1.67 (0.56,5.34)	1.59 (0.58,4.41)	0.03 (‐0.04,0.20)
HD INF IV + MTX		0.86 (0.27,2.78)	0.86 (0.29,2.57)	‐0.01 (‐0.08,0.09)
HD TOCI IV + DMARD		0.56 (0.17,1.71)	0.58 (0.18,1.64)	‐0.02 (‐0.09,0.04)
SD CERTO SC + DMARD	SD ADA SC + DMARD	0.96 (0.21,4.43)	0.96 (0.22,4.25)	0.00 (‐0.04,0.05)
LD ADA SC		1.42 (0.23,7.43)	1.41 (0.24,7.19)	0.01 (‐0.05,0.04)
LD ETN SC		2.62 (0.66,11.84)	2.53 (0.67,10.82)	0.02 (‐0.01,0.12)
LD GOLI IV		16.18 (1.71,259.20)	12.00 (1.68,79.82)	0.21 (0.01,0.77)
LD RITUX IV + MTX		1.90 (0.46,7.60)	1.86 (0.47,7.17)	0.01 (‐0.02,0.08)
LD ABA IV + MTX		4.02 (1.00,17.26)	3.79 (1.00,15.13)	0.04 (0.00,0.19)
LD CERTO SC + MTX		4.78 (0.53,27.51)	4.41 (0.54,22.26)	0.05 (‐0.01,0.28)
LD ETN SC + MTX		1.66 (0.37,8.11)	1.64 (0.37,7.66)	0.01 (‐0.03,0.09)
LD GOLI IV + MTX		9.11 (0.93,166.80)	7.76 (0.94,66.04)	0.12 (0.00,0.68)
HD TOCI IV		2.93 (1.03,9.02)	2.82 (1.03,8.43)	0.03 (0.00,0.11)
HD TOFA PO		0.90 (0.16,5.31)	0.91 (0.17,5.21)	0.00 (‐0.06,0.02)
HD ADA SC		2.14 (0.38,10.97)	2.09 (0.40,10.50)	0.02 (‐0.04,0.06)
HD GOLI SC		4.36 (0.71,27.18)	4.07 (0.72,21.91)	0.05 (‐0.01,0.25)
HD GOLI SC + MTX		9.74 (2.04,52.03)	8.24 (1.95,37.68)	0.12 (0.02,0.40)
HD TOCI IV + MTX		3.47 (0.97,13.17)	3.28 (0.97,11.99)	0.04 (0.00,0.16)
HD TOFA PO + MTX		6.38 (1.50,28.50)	5.71 (1.47,22.87)	0.08 (0.01,0.27)
HD CERTO SC + MTX		6.48 (1.48,26.19)	5.82 (1.45,21.42)	0.08 (0.01,0.27)
HD INF IV + MTX		3.28 (0.81,13.81)	3.14 (0.81,12.75)	0.03 (‐0.01,0.14)
HD TOCI IV + DMARD		2.08 (0.79,5.83)	2.04 (0.80,5.57)	0.02 (‐0.01,0.08)
LD ADA SC	SD CERTO SC + DMARD	1.43 (0.20,9.17)	1.42 (0.21,8.89)	0.01 (‐0.06,0.04)
LD ETN SC		2.83 (0.50,17.09)	2.73 (0.51,15.83)	0.02 (‐0.03,0.13)
LD GOLI IV		17.55 (1.27,287.30)	12.83 (1.26,94.88)	0.20 (0.00,0.77)
LD RITUX IV + MTX		2.03 (0.33,10.35)	1.99 (0.34,9.84)	0.01 (‐0.04,0.08)
LD ABA IV + MTX		4.36 (0.63,25.11)	4.09 (0.64,21.71)	0.04 (‐0.01,0.20)
LD CERTO SC + MTX		4.87 (0.42,40.97)	4.50 (0.43,32.29)	0.05 (‐0.02,0.29)
LD ETN SC + MTX		1.74 (0.28,11.44)	1.72 (0.29,10.66)	0.01 (‐0.04,0.09)
LD GOLI IV + MTX		10.24 (0.72,172.80)	8.78 (0.73,73.72)	0.12 (‐0.01,0.67)
HD TOCI IV		3.11 (0.74,13.65)	2.98 (0.75,12.82)	0.03 (‐0.01,0.12)
HD TOFA PO		0.89 (0.14,6.81)	0.90 (0.15,6.69)	0.00 (‐0.07,0.02)
HD ADA SC		2.20 (0.35,13.64)	2.16 (0.36,13.11)	0.02 (‐0.05,0.06)
HD GOLI SC		4.77 (0.54,33.58)	4.46 (0.55,28.50)	0.05 (‐0.02,0.25)
HD GOLI SC + MTX		10.91 (1.43,69.85)	9.17 (1.39,51.80)	0.12 (0.01,0.40)
HD TOCI IV + MTX		3.60 (0.73,19.77)	3.42 (0.74,17.76)	0.04 (‐0.01,0.16)
HD TOFA PO + MTX		6.65 (1.16,39.61)	5.97 (1.15,33.50)	0.08 (0.00,0.27)
HD CERTO SC + MTX		6.65 (1.12,35.45)	6.00 (1.11,29.35)	0.08 (0.00,0.27)
HD INF IV + MTX		3.54 (0.55,18.29)	3.37 (0.56,16.76)	0.03 (‐0.02,0.14)
HD TOCI IV + DMARD		2.20 (0.57,9.58)	2.14 (0.58,9.14)	0.02 (‐0.02,0.08)
LD ETN SC	LD ADA SC	1.89 (0.42,10.33)	1.85 (0.43,9.07)	0.02 (‐0.02,0.13)
LD GOLI IV		13.34 (0.97,180.00)	10.13 (0.97,49.19)	0.20 (0.00,0.77)
LD RITUX IV + MTX		1.35 (0.30,7.16)	1.34 (0.31,6.55)	0.01 (‐0.03,0.09)
LD ABA IV + MTX		2.89 (0.58,15.87)	2.76 (0.59,13.02)	0.04 (‐0.01,0.20)
LD CERTO SC + MTX		3.42 (0.37,24.54)	3.21 (0.38,17.98)	0.05 (‐0.02,0.29)
LD ETN SC + MTX		1.16 (0.23,6.78)	1.16 (0.23,6.22)	0.00 (‐0.03,0.09)
LD GOLI IV + MTX		7.43 (0.45,113.80)	6.40 (0.46,40.22)	0.12 (‐0.01,0.67)
HD TOCI IV		2.10 (0.51,10.85)	2.05 (0.52,9.53)	0.02 (‐0.02,0.14)
HD TOFA PO		0.64 (0.21,2.12)	0.64 (0.21,2.08)	‐0.01 (‐0.04,0.01)
HD ADA SC		1.53 (0.68,3.54)	1.51 (0.69,3.40)	0.01 (‐0.01,0.04)
HD GOLI SC		3.25 (0.50,19.74)	3.07 (0.51,15.16)	0.05 (‐0.02,0.25)
HD GOLI SC + MTX		7.31 (1.33,41.87)	6.35 (1.32,26.06)	0.12 (0.01,0.41)
HD TOCI IV + MTX		2.46 (0.52,14.10)	2.38 (0.53,11.88)	0.03 (‐0.01,0.18)
HD TOFA PO + MTX		4.64 (0.90,24.96)	4.24 (0.90,18.78)	0.08 (0.00,0.28)
HD CERTO SC + MTX		4.57 (1.08,25.10)	4.20 (1.08,18.91)	0.07 (0.00,0.28)
HD INF IV + MTX		2.34 (0.52,12.01)	2.27 (0.53,10.29)	0.03 (‐0.01,0.16)
HD TOCI IV + DMARD		1.49 (0.32,8.08)	1.48 (0.33,7.24)	0.01 (‐0.02,0.11)
LD GOLI IV	LD ETN SC	5.85 (0.87,122.00)	4.57 (0.87,31.29)	0.17 (0.00,0.75)
LD RITUX IV + MTX		0.68 (0.24,2.34)	0.69 (0.26,2.23)	‐0.01 (‐0.09,0.04)
LD ABA IV + MTX		1.49 (0.47,5.17)	1.45 (0.49,4.57)	0.02 (‐0.05,0.14)
LD CERTO SC + MTX		1.85 (0.25,8.58)	1.77 (0.26,7.16)	0.03 (‐0.06,0.23)
LD ETN SC + MTX		0.62 (0.16,2.50)	0.63 (0.18,2.40)	‐0.01 (‐0.10,0.05)
LD GOLI IV + MTX		3.32 (0.45,69.20)	2.95 (0.47,25.84)	0.08 (‐0.03,0.64)
HD TOCI IV		1.11 (0.36,3.54)	1.10 (0.38,3.31)	0.00 (‐0.07,0.08)
HD TOFA PO		0.33 (0.07,1.76)	0.34 (0.08,1.73)	‐0.03 (‐0.14,0.01)
HD ADA SC		0.80 (0.15,3.82)	0.80 (0.17,3.69)	‐0.01 (‐0.12,0.04)
HD GOLI SC		1.59 (0.33,7.69)	1.54 (0.35,6.42)	0.02 (‐0.06,0.20)
HD GOLI SC + MTX		3.67 (0.94,15.33)	3.20 (0.95,11.05)	0.09 (0.00,0.35)
HD TOCI IV + MTX		1.29 (0.37,4.83)	1.27 (0.39,4.39)	0.01 (‐0.06,0.12)
HD TOFA PO + MTX		2.34 (0.64,8.99)	2.19 (0.66,7.42)	0.05 (‐0.02,0.23)
HD CERTO SC + MTX		2.38 (0.72,7.52)	2.22 (0.75,6.48)	0.05 (‐0.02,0.21)
HD INF IV + MTX		1.20 (0.41,3.91)	1.19 (0.44,3.64)	0.01 (‐0.06,0.09)
HD TOCI IV + DMARD		0.81 (0.21,2.75)	0.82 (0.23,2.61)	‐0.01 (‐0.09,0.05)
LD RITUX IV + MTX	LD GOLI IV	0.12 (0.01,0.67)	0.16 (0.02,0.68)	‐0.19 (‐0.76,‐0.01)
LD ABA IV + MTX		0.25 (0.02,1.57)	0.31 (0.06,1.51)	‐0.15 (‐0.72,0.03)
LD CERTO SC + MTX		0.29 (0.01,2.81)	0.37 (0.03,2.66)	‐0.13 (‐0.74,0.10)
LD ETN SC + MTX		0.10 (0.00,0.76)	0.14 (0.02,0.77)	‐0.19 (‐0.77,0.00)
LD GOLI IV + MTX		0.59 (0.15,1.96)	0.69 (0.22,1.66)	‐0.06 (‐0.34,0.11)
HD TOCI IV		0.19 (0.01,1.30)	0.24 (0.04,1.29)	‐0.17 (‐0.74,0.01)
HD TOFA PO		0.05 (0.00,0.85)	0.07 (0.01,0.85)	‐0.21 (‐0.78,0.00)
HD ADA SC		0.11 (0.01,1.72)	0.15 (0.04,1.69)	‐0.19 (‐0.75,0.02)
HD GOLI SC		0.27 (0.02,1.97)	0.34 (0.04,1.83)	‐0.14 (‐0.71,0.06)
HD GOLI SC + MTX		0.61 (0.04,3.92)	0.69 (0.15,3.19)	‐0.06 (‐0.63,0.19)
HD TOCI IV + MTX		0.22 (0.01,1.51)	0.28 (0.04,1.48)	‐0.16 (‐0.74,0.02)
HD TOFA PO + MTX		0.38 (0.02,3.10)	0.47 (0.08,2.83)	‐0.12 (‐0.70,0.10)
HD CERTO SC + MTX		0.40 (0.02,2.81)	0.48 (0.07,2.58)	‐0.11 (‐0.71,0.08)
HD INF IV + MTX		0.20 (0.01,1.24)	0.26 (0.04,1.22)	‐0.17 (‐0.74,0.01)
HD TOCI IV + DMARD		0.13 (0.01,1.13)	0.17 (0.03,1.13)	‐0.18 (‐0.75,0.00)
LD ABA IV + MTX	LD RITUX IV + MTX	2.17 (0.77,6.04)	2.08 (0.78,5.48)	0.03 (‐0.01,0.15)
LD CERTO SC + MTX		2.60 (0.36,10.41)	2.45 (0.37,8.54)	0.04 (‐0.03,0.24)
LD ETN SC + MTX		0.91 (0.25,2.83)	0.92 (0.26,2.71)	0.00 (‐0.06,0.05)
LD GOLI IV + MTX		4.82 (0.79,95.19)	4.16 (0.80,34.24)	0.10 (0.00,0.66)
HD TOCI IV		1.58 (0.58,4.42)	1.54 (0.60,4.17)	0.01 (‐0.03,0.09)
HD TOFA PO		0.47 (0.10,2.50)	0.47 (0.11,2.47)	‐0.01 (‐0.10,0.01)
HD ADA SC		1.12 (0.23,5.97)	1.11 (0.25,5.74)	0.00 (‐0.08,0.05)
HD GOLI SC		2.36 (0.53,9.25)	2.24 (0.54,7.73)	0.03 (‐0.02,0.21)
HD GOLI SC + MTX		5.23 (1.59,18.35)	4.50 (1.54,13.09)	0.11 (0.01,0.37)
HD TOCI IV + MTX		1.86 (0.62,5.73)	1.80 (0.63,5.25)	0.02 (‐0.02,0.13)
HD TOFA PO + MTX		3.43 (1.05,10.42)	3.14 (1.04,8.72)	0.07 (0.00,0.24)
HD CERTO SC + MTX		3.44 (1.27,9.01)	3.15 (1.25,7.74)	0.06 (0.01,0.23)
HD INF IV + MTX		1.75 (0.67,4.42)	1.70 (0.68,4.11)	0.02 (‐0.02,0.10)
HD TOCI IV + DMARD		1.12 (0.31,3.79)	1.11 (0.32,3.58)	0.00 (‐0.05,0.07)
LD CERTO SC + MTX	LD ABA IV + MTX	1.20 (0.17,5.21)	1.18 (0.18,4.38)	0.01 (‐0.11,0.19)
LD ETN SC + MTX		0.41 (0.11,1.43)	0.43 (0.13,1.40)	‐0.03 (‐0.16,0.02)
LD GOLI IV + MTX		2.28 (0.37,32.76)	2.08 (0.40,12.94)	0.06 (‐0.08,0.61)
HD TOCI IV		0.73 (0.24,2.17)	0.75 (0.27,2.08)	‐0.01 (‐0.13,0.05)
HD TOFA PO		0.21 (0.04,1.39)	0.22 (0.05,1.39)	‐0.05 (‐0.21,0.01)
HD ADA SC		0.52 (0.10,3.23)	0.54 (0.12,3.11)	‐0.03 (‐0.19,0.03)
HD GOLI SC		1.08 (0.24,4.61)	1.08 (0.27,3.93)	0.00 (‐0.11,0.16)
HD GOLI SC + MTX		2.42 (0.71,8.77)	2.17 (0.74,6.58)	0.07 (‐0.03,0.32)
HD TOCI IV + MTX		0.86 (0.26,2.93)	0.87 (0.28,2.71)	‐0.01 (‐0.12,0.08)
HD TOFA PO + MTX		1.58 (0.46,5.21)	1.50 (0.49,4.41)	0.03 (‐0.06,0.18)
HD CERTO SC + MTX		1.56 (0.55,4.52)	1.49 (0.58,3.98)	0.03 (‐0.06,0.17)
HD INF IV + MTX		0.81 (0.29,2.28)	0.82 (0.32,2.16)	‐0.01 (‐0.11,0.05)
HD TOCI IV + DMARD		0.52 (0.13,1.90)	0.54 (0.15,1.84)	‐0.03 (‐0.16,0.03)
LD ETN SC + MTX	LD CERTO SC + MTX	0.34 (0.07,2.73)	0.36 (0.09,2.64)	‐0.04 (‐0.25,0.03)
LD GOLI IV + MTX		1.95 (0.20,68.80)	1.79 (0.23,28.25)	0.05 (‐0.16,0.63)
HD TOCI IV		0.61 (0.14,4.32)	0.63 (0.17,4.11)	‐0.02 (‐0.23,0.07)
HD TOFA PO		0.19 (0.03,1.86)	0.20 (0.03,1.84)	‐0.06 (‐0.30,0.01)
HD ADA SC		0.44 (0.07,4.81)	0.46 (0.09,4.54)	‐0.04 (‐0.28,0.04)
HD GOLI SC		0.94 (0.14,8.93)	0.94 (0.16,7.66)	0.00 (‐0.20,0.16)
HD GOLI SC + MTX		2.09 (0.37,17.72)	1.88 (0.42,13.69)	0.06 (‐0.12,0.31)
HD TOCI IV + MTX		0.72 (0.15,4.92)	0.74 (0.18,4.57)	‐0.02 (‐0.22,0.09)
HD TOFA PO + MTX		1.33 (0.26,9.72)	1.29 (0.30,8.11)	0.02 (‐0.16,0.20)
HD CERTO SC + MTX		1.29 (0.38,6.96)	1.26 (0.43,6.26)	0.02 (‐0.12,0.15)
HD INF IV + MTX		0.67 (0.16,4.26)	0.70 (0.19,3.98)	‐0.02 (‐0.21,0.07)
HD TOCI IV + DMARD		0.44 (0.09,3.58)	0.46 (0.11,3.45)	‐0.04 (‐0.25,0.04)
LD GOLI IV + MTX	LD ETN SC + MTX	5.52 (0.74,109.30)	4.70 (0.74,40.75)	0.10 (‐0.01,0.66)
HD TOCI IV		1.79 (0.49,6.20)	1.74 (0.51,5.76)	0.02 (‐0.04,0.10)
HD TOFA PO		0.55 (0.08,3.44)	0.55 (0.09,3.39)	‐0.01 (‐0.10,0.02)
HD ADA SC		1.28 (0.24,6.59)	1.27 (0.26,6.37)	0.01 (‐0.08,0.05)
HD GOLI SC		2.57 (0.48,14.56)	2.44 (0.50,12.02)	0.04 (‐0.03,0.23)
HD GOLI SC + MTX		5.95 (1.41,26.39)	5.10 (1.38,19.11)	0.11 (0.01,0.38)
HD TOCI IV + MTX		2.11 (0.52,8.39)	2.03 (0.54,7.44)	0.02 (‐0.03,0.14)
HD TOFA PO + MTX		3.80 (1.00,16.97)	3.45 (1.00,13.75)	0.07 (0.00,0.25)
HD CERTO SC + MTX		3.74 (1.16,14.09)	3.42 (1.15,12.04)	0.06 (0.01,0.24)
HD INF IV + MTX		1.90 (0.62,6.79)	1.85 (0.63,6.26)	0.02 (‐0.02,0.11)
HD TOCI IV + DMARD		1.27 (0.30,5.18)	1.26 (0.32,4.84)	0.01 (‐0.06,0.08)
HD TOCI IV	LD GOLI IV + MTX	0.33 (0.02,2.33)	0.37 (0.05,2.28)	‐0.08 (‐0.64,0.03)
HD TOFA PO		0.09 (0.01,1.73)	0.10 (0.01,1.72)	‐0.12 (‐0.69,0.01)
HD ADA SC		0.21 (0.02,3.37)	0.24 (0.04,3.27)	‐0.10 (‐0.66,0.03)
HD GOLI SC		0.48 (0.03,3.51)	0.52 (0.06,3.22)	‐0.05 (‐0.61,0.11)
HD GOLI SC + MTX		1.11 (0.08,7.30)	1.09 (0.18,5.87)	0.01 (‐0.52,0.26)
HD TOCI IV + MTX		0.39 (0.02,2.70)	0.43 (0.05,2.60)	‐0.07 (‐0.64,0.05)
HD TOFA PO + MTX		0.67 (0.03,5.31)	0.71 (0.09,4.94)	‐0.03 (‐0.59,0.15)
HD CERTO SC + MTX		0.69 (0.03,5.01)	0.73 (0.08,4.55)	‐0.03 (‐0.60,0.13)
HD INF IV + MTX		0.36 (0.02,2.11)	0.40 (0.05,2.03)	‐0.08 (‐0.62,0.04)
HD TOCI IV + DMARD		0.23 (0.01,2.04)	0.27 (0.04,2.00)	‐0.10 (‐0.66,0.02)
HD TOFA PO	HD TOCI IV	0.29 (0.07,1.56)	0.30 (0.08,1.55)	‐0.03 (‐0.14,0.01)
HD ADA SC		0.72 (0.16,3.15)	0.73 (0.18,3.03)	‐0.01 (‐0.12,0.04)
HD GOLI SC		1.49 (0.31,6.74)	1.45 (0.32,5.68)	0.02 (‐0.06,0.19)
HD GOLI SC + MTX		3.31 (0.97,12.50)	2.91 (0.98,8.99)	0.09 (0.00,0.35)
HD TOCI IV + MTX		1.16 (0.55,2.52)	1.15 (0.57,2.34)	0.01 (‐0.04,0.08)
HD TOFA PO + MTX		2.16 (0.68,6.69)	2.02 (0.70,5.58)	0.05 (‐0.02,0.22)
HD CERTO SC + MTX		2.19 (0.73,6.02)	2.06 (0.74,5.12)	0.04 (‐0.02,0.21)
HD INF IV + MTX		1.10 (0.39,3.12)	1.10 (0.41,2.85)	0.00 (‐0.06,0.09)
HD TOCI IV + DMARD		0.72 (0.28,1.73)	0.73 (0.30,1.67)	‐0.01 (‐0.08,0.03)
HD ADA SC	HD TOFA PO	2.36 (0.77,7.53)	2.32 (0.77,7.13)	0.02 (‐0.01,0.06)
HD GOLI SC		5.11 (0.67,28.98)	4.80 (0.68,22.31)	0.05 (‐0.01,0.26)
HD GOLI SC + MTX		11.88 (1.52,62.49)	10.12 (1.50,40.49)	0.13 (0.01,0.42)
HD TOCI IV + MTX		4.05 (0.67,19.24)	3.85 (0.68,16.06)	0.04 (‐0.01,0.18)
HD TOFA PO + MTX		7.48 (1.14,35.73)	6.75 (1.14,27.02)	0.09 (0.00,0.29)
HD CERTO SC + MTX		7.27 (1.36,33.78)	6.61 (1.35,25.82)	0.08 (0.01,0.29)
HD INF IV + MTX		3.73 (0.64,18.72)	3.58 (0.65,16.11)	0.04 (‐0.01,0.16)
HD TOCI IV + DMARD		2.47 (0.42,11.88)	2.41 (0.43,10.69)	0.02 (‐0.01,0.11)
HD GOLI SC	HD ADA SC	2.15 (0.30,12.14)	2.07 (0.31,9.45)	0.03 (‐0.03,0.24)
HD GOLI SC + MTX		4.89 (0.75,23.04)	4.28 (0.75,15.01)	0.11 (‐0.01,0.40)
HD TOCI IV + MTX		1.66 (0.32,8.66)	1.63 (0.33,7.37)	0.02 (‐0.03,0.17)
HD TOFA PO + MTX		3.17 (0.57,14.30)	2.92 (0.58,10.85)	0.07 (‐0.02,0.27)
HD CERTO SC + MTX		3.05 (0.68,14.59)	2.82 (0.69,10.97)	0.06 (‐0.01,0.27)
HD INF IV + MTX		1.57 (0.30,7.33)	1.54 (0.31,6.34)	0.02 (‐0.04,0.14)
HD TOCI IV + DMARD		0.99 (0.22,4.96)	0.99 (0.23,4.47)	0.00 (‐0.04,0.09)
HD GOLI SC + MTX	HD GOLI SC	2.28 (0.71,8.29)	2.04 (0.75,6.87)	0.07 (‐0.03,0.28)
HD TOCI IV + MTX		0.80 (0.16,4.19)	0.81 (0.19,3.84)	‐0.01 (‐0.18,0.10)
HD TOFA PO + MTX		1.47 (0.31,7.45)	1.40 (0.35,6.40)	0.02 (‐0.12,0.19)
HD CERTO SC + MTX		1.44 (0.34,6.72)	1.38 (0.38,5.78)	0.02 (‐0.12,0.18)
HD INF IV + MTX		0.74 (0.19,3.34)	0.76 (0.22,3.13)	‐0.01 (‐0.18,0.07)
HD TOCI IV + DMARD		0.47 (0.09,2.69)	0.49 (0.10,2.57)	‐0.03 (‐0.22,0.04)
HD TOCI IV + MTX	HD GOLI SC + MTX	0.36 (0.08,1.32)	0.40 (0.12,1.28)	‐0.08 (‐0.34,0.02)
HD TOFA PO + MTX		0.62 (0.16,2.68)	0.67 (0.20,2.37)	‐0.04 (‐0.26,0.12)
HD CERTO SC + MTX		0.63 (0.18,2.17)	0.67 (0.23,1.99)	‐0.04 (‐0.27,0.09)
HD INF IV + MTX		0.33 (0.10,1.06)	0.38 (0.13,1.06)	‐0.09 (‐0.33,0.00)
HD TOCI IV + DMARD		0.21 (0.05,0.91)	0.25 (0.06,0.91)	‐0.10 (‐0.37,0.00)
HD TOFA PO + MTX	HD TOCI IV + MTX	1.88 (0.49,6.42)	1.77 (0.51,5.44)	0.04 (‐0.05,0.21)
HD CERTO SC + MTX		1.84 (0.57,5.76)	1.74 (0.60,4.89)	0.04 (‐0.04,0.19)
HD INF IV + MTX		0.93 (0.30,2.85)	0.93 (0.32,2.68)	0.00 (‐0.10,0.08)
HD TOCI IV + DMARD		0.61 (0.19,1.90)	0.62 (0.21,1.83)	‐0.02 (‐0.12,0.03)
HD CERTO SC + MTX	HD TOFA PO + MTX	1.00 (0.31,3.23)	1.00 (0.37,2.90)	0.00 (‐0.14,0.12)
HD INF IV + MTX		0.51 (0.17,1.59)	0.54 (0.21,1.54)	‐0.04 (‐0.20,0.02)
HD TOCI IV + DMARD		0.33 (0.09,1.24)	0.36 (0.11,1.23)	‐0.06 (‐0.24,0.01)
HD INF IV + MTX	HD CERTO SC + MTX	0.51 (0.19,1.40)	0.55 (0.22,1.36)	‐0.04 (‐0.19,0.02)
HD TOCI IV + DMARD		0.33 (0.09,1.13)	0.35 (0.11,1.12)	‐0.06 (‐0.24,0.01)
HD TOCI IV + DMARD	HD INF IV + MTX	0.65 (0.18,2.20)	0.67 (0.20,2.11)	‐0.01 (‐0.11,0.04)
Random‐Effect Model	Residual Deviance	125.1 vs 127 data points
	Deviance Information Criteria	688.58
Fixed‐Effect Model	Residual Deviance	130.2 vs 127 data points
	Deviance Information Criteria	689.019
Note:
Total Patients	22022
Total Studies	50
2‐arm	30
3‐arm	14
4‐arm	5
5‐arm	1