| SAEs, Short trial duration, Network 1: Odds Ratios, Risk Ratios and Risk Difference for All Treatment Comparisons‐Random Effects Model | ||||
| Treatment | Reference | OR (95% CrI) | RR (95% CrI) | RD % (95% Crl) |
| DMARD + PL | PL | 0.96 (0.14,6.18) | 0.96 (0.15,5.17) | 0.00 (‐0.04,0.15) |
| MTX + DMARD | 0.93 (0.06,13.23) | 0.93 (0.06,9.40) | 0.00 (‐0.04,0.28) | |
| SD ADA SC | 1.11 (0.59,2.11) | 1.11 (0.60,2.04) | 0.00 (‐0.02,0.04) | |
| SD ETN SC | 1.62 (0.21,13.99) | 1.58 (0.22,9.90) | 0.02 (‐0.03,0.29) | |
| SD TOC IV + PL SC | 1.27 (0.41,3.80) | 1.26 (0.42,3.48) | 0.01 (‐0.02,0.09) | |
| SD TOFA PO | 0.39 (0.14,1.05) | 0.40 (0.14,1.05) | ‐0.02 (‐0.04,0.00) | |
| SD CERTO SC | 4.43 (1.10,21.91) | 3.94 (1.10,13.92) | 0.10 (0.00,0.37) | |
| SD TOC SC + PL IV | 1.10 (0.26,4.60) | 1.09 (0.27,4.06) | 0.00 (‐0.03,0.11) | |
| SD ETN SC + MTX | 1.66 (0.15,21.12) | 1.62 (0.16,13.16) | 0.02 (‐0.04,0.38) | |
| SD ETN SC + DMARD | 1.45 (0.29,6.57) | 1.42 (0.30,5.47) | 0.01 (‐0.03,0.16) | |
| SD ADA SC + DMARD | 0.67 (0.08,5.30) | 0.68 (0.08,4.61) | ‐0.01 (‐0.04,0.13) | |
| SD ANA + DMARD | 0.95 (0.12,7.22) | 0.95 (0.12,5.96) | 0.00 (‐0.04,0.18) | |
| SD CERTO SC + DMARD | 0.66 (0.06,6.85) | 0.67 (0.06,5.67) | ‐0.01 (‐0.04,0.17) | |
| SD TOCI SC + DMARD | 1.25 (0.14,10.79) | 1.23 (0.14,8.01) | 0.01 (‐0.04,0.25) | |
| LD ADA SC | 0.65 (0.25,1.49) | 0.66 (0.26,1.47) | ‐0.01 (‐0.03,0.02) | |
| HD TOFA PO | 0.53 (0.22,1.37) | 0.54 (0.22,1.35) | ‐0.02 (‐0.04,0.01) | |
| HD ADA SC | 1.00 (0.45,2.30) | 1.00 (0.46,2.21) | 0.00 (‐0.02,0.04) | |
| HD TOCI IV + DMARD | 1.47 (0.20,10.44) | 1.45 (0.21,7.81) | 0.02 (‐0.03,0.25) | |
| MTX + DMARD | DMARD + PL | 0.91 (0.04,25.54) | 0.91 (0.04,19.57) | 0.00 (‐0.15,0.27) |
| SD ADA SC | 1.18 (0.20,7.16) | 1.18 (0.24,6.85) | 0.01 (‐0.14,0.05) | |
| SD ETN SC | 1.63 (0.11,29.72) | 1.59 (0.13,22.57) | 0.02 (‐0.13,0.28) | |
| SD TOC IV + PL SC | 1.34 (0.18,10.39) | 1.33 (0.21,9.65) | 0.01 (‐0.13,0.09) | |
| SD TOFA PO | 0.40 (0.04,3.31) | 0.41 (0.05,3.25) | ‐0.02 (‐0.18,0.02) | |
| SD CERTO SC | 4.76 (0.43,57.12) | 4.15 (0.49,40.20) | 0.10 (‐0.08,0.37) | |
| SD TOC SC + PL IV | 1.18 (0.14,10.56) | 1.17 (0.16,9.81) | 0.00 (‐0.14,0.10) | |
| SD ETN SC + MTX | 1.71 (0.09,40.13) | 1.65 (0.10,28.01) | 0.02 (‐0.12,0.37) | |
| SD ETN SC + DMARD | 1.52 (0.57,4.02) | 1.48 (0.60,3.82) | 0.01 (‐0.04,0.08) | |
| SD ADA SC + DMARD | 0.70 (0.25,1.88) | 0.71 (0.26,1.80) | ‐0.01 (‐0.07,0.04) | |
| SD ANA + DMARD | 1.00 (0.42,2.36) | 1.00 (0.44,2.21) | 0.00 (‐0.04,0.07) | |
| SD CERTO SC + DMARD | 0.69 (0.15,2.76) | 0.71 (0.16,2.55) | ‐0.01 (‐0.08,0.08) | |
| SD TOCI SC + DMARD | 1.29 (0.46,4.02) | 1.28 (0.47,3.50) | 0.01 (‐0.03,0.15) | |
| LD ADA SC | 0.68 (0.09,5.06) | 0.69 (0.11,4.90) | ‐0.01 (‐0.16,0.03) | |
| HD TOFA PO | 0.56 (0.06,4.78) | 0.57 (0.08,4.64) | ‐0.01 (‐0.17,0.03) | |
| HD ADA SC | 1.04 (0.16,7.57) | 1.04 (0.19,7.26) | 0.00 (‐0.15,0.05) | |
| HD TOCI IV + DMARD | 1.52 (0.81,2.99) | 1.48 (0.82,2.76) | 0.01 (‐0.01,0.12) | |
| SD ADA SC | MTX + DMARD | 1.22 (0.08,20.81) | 1.21 (0.11,19.91) | 0.01 (‐0.27,0.06) |
| SD ETN SC | 1.76 (0.38,9.71) | 1.68 (0.44,9.08) | 0.02 (‐0.11,0.15) | |
| SD TOC IV + PL SC | 1.39 (0.08,26.66) | 1.37 (0.11,24.75) | 0.01 (‐0.26,0.10) | |
| SD TOFA PO | 0.42 (0.02,8.11) | 0.43 (0.03,7.96) | ‐0.02 (‐0.30,0.02) | |
| SD CERTO SC | 4.76 (0.23,123.50) | 4.17 (0.30,86.98) | 0.10 (‐0.19,0.37) | |
| SD TOC SC + PL IV | 1.22 (0.06,26.45) | 1.21 (0.08,24.20) | 0.01 (‐0.26,0.11) | |
| SD ETN SC + MTX | 1.81 (0.63,6.63) | 1.73 (0.66,6.05) | 0.02 (‐0.04,0.18) | |
| SD ETN SC + DMARD | 1.64 (0.07,34.32) | 1.60 (0.10,30.75) | 0.02 (‐0.25,0.16) | |
| SD ADA SC + DMARD | 0.74 (0.02,20.69) | 0.75 (0.03,18.63) | ‐0.01 (‐0.28,0.13) | |
| SD ANA + DMARD | 1.12 (0.04,27.80) | 1.12 (0.05,24.55) | 0.00 (‐0.27,0.17) | |
| SD CERTO SC + DMARD | 0.74 (0.02,25.08) | 0.75 (0.02,21.69) | ‐0.01 (‐0.28,0.17) | |
| SD TOCI SC + DMARD | 1.44 (0.04,39.90) | 1.41 (0.05,33.84) | 0.01 (‐0.26,0.24) | |
| LD ADA SC | 0.69 (0.04,12.56) | 0.70 (0.06,12.17) | ‐0.01 (‐0.29,0.04) | |
| HD TOFA PO | 0.58 (0.03,10.77) | 0.59 (0.05,10.42) | ‐0.01 (‐0.29,0.03) | |
| HD ADA SC | 1.09 (0.07,21.03) | 1.08 (0.09,19.95) | 0.00 (‐0.28,0.06) | |
| HD TOCI IV + DMARD | 1.68 (0.06,42.31) | 1.64 (0.08,35.79) | 0.02 (‐0.25,0.24) | |
| SD ETN SC | SD ADA SC | 1.47 (0.17,13.61) | 1.44 (0.17,9.75) | 0.02 (‐0.05,0.28) |
| SD TOC IV + PL SC | 1.14 (0.45,2.86) | 1.13 (0.46,2.66) | 0.00 (‐0.02,0.07) | |
| SD TOFA PO | 0.35 (0.10,1.12) | 0.36 (0.11,1.12) | ‐0.02 (‐0.06,0.00) | |
| SD CERTO SC | 3.98 (0.83,23.16) | 3.55 (0.84,14.95) | 0.10 (‐0.01,0.37) | |
| SD TOC SC + PL IV | 0.99 (0.28,3.51) | 1.00 (0.28,3.18) | 0.00 (‐0.04,0.09) | |
| SD ETN SC + MTX | 1.50 (0.12,19.86) | 1.47 (0.13,12.19) | 0.02 (‐0.05,0.38) | |
| SD ETN SC + DMARD | 1.31 (0.30,5.28) | 1.29 (0.31,4.51) | 0.01 (‐0.03,0.15) | |
| SD ADA SC + DMARD | 0.60 (0.08,4.43) | 0.61 (0.08,3.83) | ‐0.01 (‐0.05,0.12) | |
| SD ANA + DMARD | 0.85 (0.12,6.02) | 0.85 (0.12,4.95) | ‐0.01 (‐0.05,0.17) | |
| SD CERTO SC + DMARD | 0.58 (0.06,5.65) | 0.59 (0.06,4.77) | ‐0.01 (‐0.05,0.16) | |
| SD TOCI SC + DMARD | 1.11 (0.14,8.73) | 1.10 (0.14,6.65) | 0.00 (‐0.04,0.23) | |
| LD ADA SC | 0.58 (0.23,1.32) | 0.59 (0.24,1.30) | ‐0.02 (‐0.05,0.01) | |
| HD TOFA PO | 0.47 (0.16,1.47) | 0.49 (0.16,1.44) | ‐0.02 (‐0.06,0.01) | |
| HD ADA SC | 0.90 (0.41,1.99) | 0.90 (0.42,1.93) | 0.00 (‐0.03,0.03) | |
| HD TOCI IV + DMARD | 1.31 (0.20,8.63) | 1.29 (0.20,6.50) | 0.01 (‐0.04,0.24) | |
| SD TOC IV + PL SC | SD ETN SC | 0.76 (0.07,7.99) | 0.77 (0.10,7.32) | ‐0.01 (‐0.28,0.09) |
| SD TOFA PO | 0.23 (0.02,2.47) | 0.25 (0.03,2.43) | ‐0.04 (‐0.31,0.01) | |
| SD CERTO SC | 2.71 (0.21,39.52) | 2.44 (0.27,27.00) | 0.07 (‐0.21,0.36) | |
| SD TOC SC + PL IV | 0.66 (0.05,7.95) | 0.67 (0.07,7.18) | ‐0.02 (‐0.28,0.10) | |
| SD ETN SC + MTX | 1.04 (0.33,3.10) | 1.03 (0.35,2.65) | 0.00 (‐0.07,0.16) | |
| SD ETN SC + DMARD | 0.90 (0.06,11.09) | 0.91 (0.09,9.54) | 0.00 (‐0.27,0.15) | |
| SD ADA SC + DMARD | 0.42 (0.02,7.51) | 0.44 (0.03,6.63) | ‐0.03 (‐0.29,0.11) | |
| SD ANA + DMARD | 0.60 (0.03,9.77) | 0.62 (0.04,8.48) | ‐0.02 (‐0.28,0.15) | |
| SD CERTO SC + DMARD | 0.41 (0.02,9.20) | 0.42 (0.02,7.82) | ‐0.03 (‐0.29,0.15) | |
| SD TOCI SC + DMARD | 0.78 (0.04,14.46) | 0.79 (0.04,11.43) | ‐0.01 (‐0.27,0.22) | |
| LD ADA SC | 0.39 (0.04,3.55) | 0.41 (0.05,3.45) | ‐0.03 (‐0.30,0.03) | |
| HD TOFA PO | 0.32 (0.03,3.15) | 0.33 (0.05,3.09) | ‐0.04 (‐0.30,0.02) | |
| HD ADA SC | 0.60 (0.06,5.72) | 0.62 (0.09,5.48) | ‐0.02 (‐0.29,0.05) | |
| HD TOCI IV + DMARD | 0.94 (0.05,14.51) | 0.94 (0.06,11.74) | 0.00 (‐0.27,0.21) | |
| SD TOFA PO | SD TOC IV + PL SC | 0.31 (0.07,1.32) | 0.32 (0.07,1.31) | ‐0.03 (‐0.11,0.01) |
| SD CERTO SC | 3.51 (0.60,25.56) | 3.13 (0.62,17.15) | 0.09 (‐0.03,0.36) | |
| SD TOC SC + PL IV | 0.87 (0.37,2.09) | 0.88 (0.38,1.98) | 0.00 (‐0.04,0.05) | |
| SD ETN SC + MTX | 1.35 (0.10,19.89) | 1.33 (0.10,12.73) | 0.01 (‐0.09,0.36) | |
| SD ETN SC + DMARD | 1.14 (0.20,6.39) | 1.14 (0.21,5.47) | 0.01 (‐0.07,0.15) | |
| SD ADA SC + DMARD | 0.53 (0.05,4.81) | 0.54 (0.06,4.23) | ‐0.02 (‐0.10,0.11) | |
| SD ANA + DMARD | 0.75 (0.08,6.39) | 0.76 (0.09,5.39) | ‐0.01 (‐0.09,0.16) | |
| SD CERTO SC + DMARD | 0.51 (0.04,5.99) | 0.53 (0.05,5.09) | ‐0.02 (‐0.10,0.15) | |
| SD TOCI SC + DMARD | 0.97 (0.10,9.56) | 0.98 (0.11,7.46) | 0.00 (‐0.08,0.23) | |
| LD ADA SC | 0.51 (0.14,1.74) | 0.52 (0.15,1.71) | ‐0.02 (‐0.10,0.01) | |
| HD TOFA PO | 0.42 (0.10,1.83) | 0.43 (0.11,1.81) | ‐0.02 (‐0.11,0.01) | |
| HD ADA SC | 0.79 (0.24,2.69) | 0.80 (0.26,2.60) | ‐0.01 (‐0.08,0.04) | |
| HD TOCI IV + DMARD | 1.15 (0.14,8.99) | 1.14 (0.15,7.16) | 0.01 (‐0.08,0.23) | |
| SD CERTO SC | SD TOFA PO | 11.21 (2.11,79.76) | 9.71 (2.05,51.52) | 0.12 (0.02,0.39) |
| SD TOC SC + PL IV | 2.80 (0.52,16.83) | 2.72 (0.52,14.73) | 0.02 (‐0.01,0.13) | |
| SD ETN SC + MTX | 4.42 (0.32,64.65) | 4.20 (0.33,40.39) | 0.04 (‐0.02,0.40) | |
| SD ETN SC + DMARD | 3.74 (0.58,23.89) | 3.59 (0.58,19.88) | 0.04 (‐0.01,0.19) | |
| SD ADA SC + DMARD | 1.74 (0.17,18.47) | 1.72 (0.17,15.85) | 0.01 (‐0.02,0.15) | |
| SD ANA + DMARD | 2.46 (0.25,25.78) | 2.40 (0.26,20.60) | 0.02 (‐0.02,0.21) | |
| SD CERTO SC + DMARD | 1.69 (0.12,22.75) | 1.67 (0.12,18.34) | 0.01 (‐0.02,0.19) | |
| SD TOCI SC + DMARD | 3.20 (0.29,36.23) | 3.09 (0.30,26.52) | 0.03 (‐0.02,0.27) | |
| LD ADA SC | 1.65 (0.45,6.49) | 1.64 (0.46,6.22) | 0.01 (‐0.02,0.04) | |
| HD TOFA PO | 1.36 (0.51,3.82) | 1.35 (0.52,3.74) | 0.00 (‐0.01,0.03) | |
| HD ADA SC | 2.53 (0.75,9.86) | 2.47 (0.75,9.32) | 0.02 (‐0.01,0.07) | |
| HD TOCI IV + DMARD | 3.79 (0.42,38.62) | 3.63 (0.42,28.27) | 0.04 (‐0.01,0.27) | |
| SD TOC SC + PL IV | SD CERTO SC | 0.25 (0.03,1.75) | 0.28 (0.04,1.65) | ‐0.10 (‐0.36,0.04) |
| SD ETN SC + MTX | 0.38 (0.02,6.87) | 0.42 (0.03,4.60) | ‐0.07 (‐0.35,0.30) | |
| SD ETN SC + DMARD | 0.32 (0.03,2.65) | 0.36 (0.05,2.36) | ‐0.08 (‐0.35,0.09) | |
| SD ADA SC + DMARD | 0.15 (0.01,1.89) | 0.17 (0.01,1.76) | ‐0.11 (‐0.37,0.06) | |
| SD ANA + DMARD | 0.21 (0.01,2.69) | 0.24 (0.02,2.33) | ‐0.10 (‐0.37,0.10) | |
| SD CERTO SC + DMARD | 0.15 (0.01,2.31) | 0.17 (0.01,2.09) | ‐0.11 (‐0.37,0.09) | |
| SD TOCI SC + DMARD | 0.28 (0.02,3.62) | 0.32 (0.03,2.96) | ‐0.09 (‐0.36,0.16) | |
| LD ADA SC | 0.14 (0.02,0.73) | 0.17 (0.03,0.74) | ‐0.12 (‐0.38,‐0.01) | |
| HD TOFA PO | 0.12 (0.02,0.68) | 0.14 (0.03,0.69) | ‐0.12 (‐0.38,‐0.01) | |
| HD ADA SC | 0.22 (0.03,1.18) | 0.25 (0.05,1.17) | ‐0.10 (‐0.37,0.01) | |
| HD TOCI IV + DMARD | 0.32 (0.02,3.90) | 0.36 (0.03,3.14) | ‐0.08 (‐0.35,0.17) | |
| SD ETN SC + MTX | SD TOC SC + PL IV | 1.57 (0.10,26.25) | 1.53 (0.11,17.17) | 0.02 (‐0.10,0.37) |
| SD ETN SC + DMARD | 1.31 (0.19,8.95) | 1.29 (0.21,7.69) | 0.01 (‐0.09,0.15) | |
| SD ADA SC + DMARD | 0.61 (0.05,6.35) | 0.62 (0.06,5.57) | ‐0.01 (‐0.11,0.11) | |
| SD ANA + DMARD | 0.86 (0.08,8.52) | 0.87 (0.09,7.35) | 0.00 (‐0.10,0.17) | |
| SD CERTO SC + DMARD | 0.59 (0.04,8.07) | 0.60 (0.05,6.79) | ‐0.01 (‐0.11,0.16) | |
| SD TOCI SC + DMARD | 1.11 (0.10,12.81) | 1.10 (0.11,10.24) | 0.00 (‐0.10,0.23) | |
| LD ADA SC | 0.58 (0.12,2.68) | 0.59 (0.14,2.61) | ‐0.01 (‐0.12,0.02) | |
| HD TOFA PO | 0.48 (0.09,2.65) | 0.49 (0.10,2.59) | ‐0.02 (‐0.13,0.02) | |
| HD ADA SC | 0.91 (0.21,4.07) | 0.91 (0.23,3.91) | 0.00 (‐0.10,0.04) | |
| HD TOCI IV + DMARD | 1.30 (0.14,12.44) | 1.28 (0.15,9.98) | 0.01 (‐0.09,0.23) | |
| SD ETN SC + DMARD | SD ETN SC + MTX | 0.87 (0.05,14.52) | 0.88 (0.07,12.70) | ‐0.01 (‐0.36,0.14) |
| SD ADA SC + DMARD | 0.40 (0.02,8.85) | 0.42 (0.02,8.05) | ‐0.03 (‐0.38,0.11) | |
| SD ANA + DMARD | 0.58 (0.02,11.97) | 0.60 (0.03,10.31) | ‐0.02 (‐0.37,0.15) | |
| SD CERTO SC + DMARD | 0.40 (0.01,10.37) | 0.42 (0.02,8.96) | ‐0.03 (‐0.38,0.14) | |
| SD TOCI SC + DMARD | 0.75 (0.03,17.16) | 0.76 (0.04,13.90) | ‐0.01 (‐0.36,0.21) | |
| LD ADA SC | 0.37 (0.03,4.99) | 0.39 (0.04,4.85) | ‐0.03 (‐0.39,0.03) | |
| HD TOFA PO | 0.31 (0.02,4.21) | 0.33 (0.04,4.10) | ‐0.04 (‐0.39,0.02) | |
| HD ADA SC | 0.60 (0.04,7.95) | 0.61 (0.07,7.59) | ‐0.02 (‐0.38,0.05) | |
| HD TOCI IV + DMARD | 0.90 (0.04,17.66) | 0.91 (0.05,14.64) | 0.00 (‐0.36,0.21) | |
| SD ADA SC + DMARD | SD ETN SC + DMARD | 0.47 (0.11,1.82) | 0.48 (0.12,1.72) | ‐0.02 (‐0.11,0.04) |
| SD ANA + DMARD | 0.66 (0.18,2.43) | 0.67 (0.19,2.21) | ‐0.01 (‐0.09,0.08) | |
| SD CERTO SC + DMARD | 0.46 (0.08,2.47) | 0.48 (0.08,2.22) | ‐0.02 (‐0.12,0.08) | |
| SD TOCI SC + DMARD | 0.85 (0.21,3.82) | 0.86 (0.22,3.21) | 0.00 (‐0.08,0.15) | |
| LD ADA SC | 0.44 (0.08,2.38) | 0.46 (0.10,2.34) | ‐0.03 (‐0.18,0.02) | |
| HD TOFA PO | 0.37 (0.06,2.42) | 0.38 (0.07,2.38) | ‐0.03 (‐0.18,0.02) | |
| HD ADA SC | 0.68 (0.14,3.82) | 0.70 (0.17,3.67) | ‐0.01 (‐0.16,0.04) | |
| HD TOCI IV + DMARD | 1.01 (0.32,3.26) | 1.01 (0.33,2.86) | 0.00 (‐0.06,0.14) | |
| SD ANA + DMARD | SD ADA SC + DMARD | 1.43 (0.38,5.47) | 1.40 (0.40,5.10) | 0.01 (‐0.05,0.11) |
| SD CERTO SC + DMARD | 1.00 (0.16,5.64) | 1.00 (0.17,5.15) | 0.00 (‐0.08,0.11) | |
| SD TOCI SC + DMARD | 1.87 (0.43,8.46) | 1.81 (0.45,7.40) | 0.02 (‐0.04,0.18) | |
| LD ADA SC | 0.95 (0.11,9.15) | 0.95 (0.12,8.93) | 0.00 (‐0.14,0.04) | |
| HD TOFA PO | 0.80 (0.08,8.40) | 0.80 (0.09,8.19) | 0.00 (‐0.15,0.03) | |
| HD ADA SC | 1.46 (0.18,14.45) | 1.44 (0.21,13.87) | 0.01 (‐0.13,0.06) | |
| HD TOCI IV + DMARD | 2.18 (0.68,7.44) | 2.09 (0.70,6.80) | 0.02 (‐0.02,0.16) | |
| SD CERTO SC + DMARD | SD ANA + DMARD | 0.68 (0.12,3.59) | 0.70 (0.13,3.29) | ‐0.01 (‐0.11,0.08) |
| SD TOCI SC + DMARD | 1.30 (0.33,5.29) | 1.28 (0.35,4.65) | 0.01 (‐0.07,0.15) | |
| LD ADA SC | 0.68 (0.08,5.77) | 0.69 (0.10,5.61) | ‐0.01 (‐0.19,0.03) | |
| HD TOFA PO | 0.56 (0.05,5.63) | 0.57 (0.07,5.47) | ‐0.01 (‐0.20,0.03) | |
| HD ADA SC | 1.05 (0.13,8.86) | 1.05 (0.16,8.49) | 0.00 (‐0.17,0.05) | |
| HD TOCI IV + DMARD | 1.53 (0.54,4.55) | 1.49 (0.56,4.16) | 0.01 (‐0.04,0.13) | |
| SD TOCI SC + DMARD | SD CERTO SC + DMARD | 1.90 (0.33,11.57) | 1.83 (0.36,10.40) | 0.01 (‐0.07,0.18) |
| LD ADA SC | 0.98 (0.08,12.31) | 0.98 (0.10,11.89) | 0.00 (‐0.18,0.04) | |
| HD TOFA PO | 0.81 (0.07,12.06) | 0.81 (0.08,11.72) | 0.00 (‐0.19,0.03) | |
| HD ADA SC | 1.51 (0.14,18.93) | 1.49 (0.17,18.07) | 0.01 (‐0.16,0.06) | |
| HD TOCI IV + DMARD | 2.21 (0.47,11.44) | 2.10 (0.51,10.48) | 0.02 (‐0.05,0.17) | |
| LD ADA SC | SD TOCI SC + DMARD | 0.52 (0.05,4.94) | 0.53 (0.07,4.78) | ‐0.02 (‐0.26,0.03) |
| HD TOFA PO | 0.43 (0.04,4.68) | 0.44 (0.06,4.56) | ‐0.02 (‐0.26,0.03) | |
| HD ADA SC | 0.81 (0.09,7.72) | 0.82 (0.12,7.37) | ‐0.01 (‐0.24,0.05) | |
| HD TOCI IV + DMARD | 1.17 (0.33,4.05) | 1.16 (0.37,3.75) | 0.00 (‐0.11,0.12) | |
| HD TOFA PO | LD ADA SC | 0.82 (0.24,2.89) | 0.82 (0.25,2.82) | 0.00 (‐0.04,0.03) |
| HD ADA SC | 1.54 (0.64,4.18) | 1.52 (0.65,4.01) | 0.01 (‐0.01,0.05) | |
| HD TOCI IV + DMARD | 2.27 (0.27,18.38) | 2.20 (0.28,13.99) | 0.03 (‐0.03,0.26) | |
| HD ADA SC | HD TOFA PO | 1.90 (0.55,6.60) | 1.86 (0.56,6.22) | 0.02 (‐0.02,0.06) |
| HD TOCI IV + DMARD | 2.71 (0.30,26.42) | 2.61 (0.30,19.47) | 0.03 (‐0.02,0.27) | |
| HD TOCI IV + DMARD | HD ADA SC | 1.47 (0.18,10.69) | 1.45 (0.19,8.12) | 0.01 (‐0.05,0.24) |
| Random‐Effect Model | Residual Deviance | 54.1 vs 52 data points | ||
| Deviance Information Criteria | 294.538 | |||
| Fixed‐Effect Model | Residual Deviance | 56.54 vs 52 data points | ||
| Deviance Information Criteria | 294.2 | |||
| Note: | ||||
| Total Patients | 11146 | |||
| Total Studies | 23 | |||
| 2‐arm | 19 | |||
| 3‐arm | 2 | |||
| 4‐arm | 2 | |||
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