Study	Reason for exclusion
Axelsen 2015	Duplicate of Horslev 2014
Bathon 2000	Duplicate of Genovese 2002
Bejarano 2008	Wrong drug exposure
Bonafede 2015	Not a RCT
Boyle 2015	Wrong drug exposure
Breedveld 2006	Wrong drug exposure
Bresnihan 1998	Wrong drug exposure
Burmester 2014	Comparing two routes of administration of a biologic
Burmester 2015	Wrong drug exposure
Cheng 2014	Conference abstract
Cohen 2003	Wrong drug exposure
Cohen 2006	Wrong drug exposure
Coombs 2009	Wrong drug exposure
Conaghan 2014	Sub‐study of Huizinga 2015
Dougados 2014	Duplicate of Huizinga 2015
Doyle 2013	Wrong drug exposure
Durez 2004	Wrong drug exposure
Emery 2008	Wrong drug exposure
Emery 2014a	Duplicate
Emery 2014b	Conference abstract
Erickson 2015	Follow‐up at two years of Vollenhoven 2012 NCT00764725
Fleischmann 2012a	Comparing multiple doses of a biologic
Fleischmann 2012b	Comparing multiple doses of biologics
Fleischmann 2013	Conference abstract
Furst 2015	Open label study
Gabay 2013	Comparing two doses of a biologic
Genovese 2002	Wrong drug exposure
Genovese 2005	Wrong drug exposure
Genovese 2015	Wrong drug exposure
Gherge 2014	Conference abstract
Haroui 2014	Duplicate of Pope 2014
Heimans 2014	Wrong drug exposure
Hobbs 2015	Wrong drug exposure
Hørslev‐Petersen 2014	Open label study
Iannone 2014	Open label study
Johnsen 2006	Wrong drug exposure
Jones 2010	Wrong drug exposure
Kameda 2011	Wrong drug exposure
Kavanaugh 2014	Conference abstract
Kennedy 2014	Wrong drug exposure
Keystone 2014	Conference abstract
Koroleva 2014a	Conference abstract
Koroleva 2014b	Conference abstract
Kremer 2015	Cross over study design
Kremer 2009	Wrong drug exposure
Kremer 2013	Wrong drug exposure
Landewe 2015	Conference abstract
Manders 2015	Trial patients switched therapy within one year/before completion of study period
Mathias 2000	Wrong drug exposure
McInnes 2015	Compares lipid levels in those randomzied to CZP or PL, in MTX‐IR patients
Miyasaka 2008	Wrong drug exposure
Moreland 1999	Wrong drug exposure
Moreland 2002	Wrong drug exposure
Navarro 2014	Conference abstract
Nishimoto 2004	Wrong drug exposure
Nishimoto 2007	Wrong drug exposure
Oakley 2014	Conference abstract
Ostergaard 2015	Wrong drug exposure
Quinn 2005	Wrong drug exposure
Pavelka 2013	Sub‐group analysis of Smolen 2013 NCT00565409
Smolen 2014	Patients in the control group also received the intervention
Sonomoto 2014	Open label study
St Clair 2004	Wrong drug exposure
Tada 2012	Wrong drug exposure
Takeuchi 2013a	Wrong drug exposure
Takeuchi 2013b	Wrong drug exposure
Takeuchi 2013c	Wrong drug exposure
Takeuchi 2014	Wrong drug exposure
Van de Putte 2003	Wrong drug exposure
Van de Putte 2004	Wrong drug exposure
Van Vollenhoven 2009	Duplicate of Van Vollenhoven 2012
Vital 2015	B cell depletion study
Weinblatt 2007	Wrong drug exposure
Weinblatt 2014	Results at 1 year of Weinblatt 2013b GO‐FURTHER trial, NCT00973479
Westhovens 2014	Conference abstract
Yamamoto 2014b	Wrong drug exposure
Yamanaka 2014	Post hoc analysis of Takeuchi 2014