Fig. 4.

Subtypes of hereditary and sporadic breast and ovarian cancers in the clinical trial and in TCGA database. a) List of clinical trial samples. Subtyping of tumors from this cohort was obtained using TNBCtype tool (http://cbc.mc.vanderbilt.edu/tnbc) for breast cancers and CLOVAR scheme [14] for ovarian cancers. b) List of hereditary breast tumors from TCGA. Subtyping of these tumors was acquired from Lehmann at al [16]. c) Distribution of TNBC subtypes within TCGA breast cancers (sporadic TNBC and hereditary BRCA1 and BRCA2 related breast tumors). d) Distribution of HGSOC subtypes within TCGA ovarian cancers (sporadic HGSOC and hereditary BRCA1 and BRCA2 related ovarian tumors). The list of breast germline mutation carriers was established according the information acquired from CBioPortal (http://www.cbioportal.org) and iAtlas https://www.cri-iatlas.org/about/. The list of ovarian germline mutation carriers was established from CBioPortal (http://www.cbioportal.org) and it is shown in Additional file 9: Table S9. Immune Subtypes for our cohort were identified using tool available in iAtlas interactive platform and for TCGA samples were download from the site