Fig. 7.

High HR deficiency score characterize most of TNBC and predicts platinum sensitivity in HGSOC. a) Distribution of HR deficiency score across 33 TCGA cancer types, b) across the breast cancer subtypes and c) across the HGSOC subtypes. The data was acquired from Cancer Research Institute iAtlas (https://www.cri-iatlas.org/about/). d) HR deficiency score in HGSOC, which are resistant or sensitive to platinum-based therapy. The sensitivity/resistance criteria were established according to Integrated genomic analysis of ovarian carcinoma [27] and applied to TCGA data (Additional file 10: Table S10). The dotted lines indicate mean HR deficiency score for all HGSOC (top line) and all breast cancers (bottom line)