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. 2020 Mar 12;18:27. doi: 10.1186/s12915-020-0761-2

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© The Author(s). 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — TARE drive. a In the TARE drive, germline activity disrupts the target gene, followed by embryo activity in the progeny of drive-carrying females. The target gene is assumed to be essential and haplosufficient, so any individuals inheriting two disrupted (recessive lethal) target genes are nonviable. By contrast, all individuals with at least one wild-type or drive allele are assumed to be viable. b The speed at which a TARE drive is expected to reach 99% of individuals in the population with varying introduction frequency and drive fitness. The dashed line indicates the introduction frequency threshold in the deterministic model. c Same as b, but with varying germline and embryo cleavage rates. Gray means that the drive failed to reach 99% because it spread too slowly or was not able to spread at all