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. 2020 Mar 12;18:27. doi: 10.1186/s12915-020-0761-2

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© The Author(s). 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 7 — TADS suppression drive. a The TADS suppression drive is distant-site, located in a male fertility gene and modeled here with a target gene that is unlinked from the drive allele. Male drive homozygotes are thus sterile (“drive homozygote fitness” does not apply). Germline activity disrupts the target gene, followed by embryo activity in the progeny of drive-carrying females. The target gene is expressed in male gametocytes after meiosis I, and such expression is necessary for the development of a viable sperm. Thus, sperm with a disrupted target allele are nonviable unless they also have a drive allele. b The speed at which the TADS suppression drive is expected to reach 99% of individuals in the population with varying introduction frequency and drive fitness. Full suppression would occur within a few generations of this point. c Same as b, but with varying germline and embryo cleavage rate