Table 2.
Clinical factors associated with the change in diaphragm thickness during controlled mechanical ventilation
| Unchanged during CMV (n = 29) | Thinning during CMV (n = 33) | p | |
|---|---|---|---|
| Age (years) | 56.0 ± 16.2 | 55.7 ± 14.8 | 0.945 |
| Body weight (kg) | 78.9 ± 11.8 | 72 ± 12 | 0.033 |
| BMI (kg/cm2) | 26.2 ± 3.3 | 25 ± 3.8 | 0.197 |
| Chronic obstructive pulmonary disease, n (%) | 2/29 (6.9%) | 4/33 (12.1%) | 0.488 |
| Diabetes, n (%) | 2/29 (6.9%) | 7/33 (21.2%) | 0.110 |
| ARDS, n (%) | 10/29 (34.5%) | 15/33 (45.5%) | 0.380 |
| Septic shock, n (%) | 6/29 (20.7%) | 5/33 (15.2%) | 0.569 |
| NMBA (days) | 0 [0, 4] | 3 [0, 6.5] | 0.127 |
| NMBA days on CMV days (%) | 28.7 [0, 56.6] | 35.7 [0, 83.8] | 0.456 |
| Mean SOFA during ICU admission | 4.8 [3.4, 6.5] | 4.4 [3.3, 5.5] | 0.399 |
| TV/kg of ideal body weight | 6.6 ± 1.4 | 6.7 ± 1.5 | 0.968 |
| Respiratory rate during CMV (bpm) | 14 [11.5, 19.3] | 15 [11.5, 20.1] | 0.601 |
| Peak pressure during CMV (cmH2O) | 26.4 ± 5.7 | 27.5 ± 5.7 | 0.518 |
| PEEP during CMV (cmH2O) | 10.4 ± 4 | 12.6 ± 4 | 0.034 |
| Plateau pressure during CMV (cmH2O) | 21.9 ± 3.9 | 23.9 ± 3.5 | 0.063 |
| Driving pressure during CMV (cmH2O) | 10.6 ± 2.9 | 10.6 ± 1.9 | 0.948 |
| Compliance of respiratory system during CMV (cmH2O) | 44.5 [32.5, 50] | 44.1 [32.4, 48.8] | 0.887 |
| P/F during CMV | 212 [142, 261] | 189 [156, 236] | 0.527 |
| pH during CMV | 7.42 ± 0.04 | 7.42 ± 0.02 | 0.476 |
| Total water balance during CMV | 1699 [− 1109, 4240] | 1148 [− 1568, 3151] | 0.305 |
| Prealbumin (mg/dl) | 23.4 ± 7.6 | 18.5 ± 6.6 | 0.050 |
BMI body mass index, ARDS acute respiratory distress syndrome, NMBA neuromuscular blocking agents, CMV controlled mechanical ventilation, SOFA Sequential Organ Failure Assessment, ICU intensive care unit, AMV assisted mechanical ventilation, TV tidal volume, PEEP positive end-expiratory pressure