Table 2.
Association analysis of rs2231142, rs10011796 (ABCG2) and rs11942223 (SLC2A9) with serum urate at recruitment (mmol/L) in European and NZ Polynesian controls
| SNP/allele | Combined sex* | Male only* | ||||
|---|---|---|---|---|---|---|
| N | β mmol/L (SE) | P | N | β mmol/L (SE) | P | |
| rs2231142/T | ||||||
| European control | 13,982 | 0.017 (1.5E−03) | 8.9E−30 | 6514 | 0.020 (2.2E−03) | 5.7E−20 |
| WP control | 234 | 0.019 (9.2E−03) | 0.035 | 134 | 0.027 (0.011) | 0.017 |
| EP control | 462 | 0.015 (0.012) | 0.19 | 190 | 0.009 (0.023) | 0.68 |
| Polynesian meta-analysis | 696 | 0.018 (7.2E−03) | 0.014 | 324 | 0.024 (0.010) | 0.019 |
| rs10011796/T | ||||||
| European control | 14,349 | 0.006 (9.2E−04) | 1.7E−10 | 6682 | 0.006 (4.7E−03) | 1.5E−06 |
| WP control | 234 | 0.006 (8.5E−03) | 0.51 | 134 | 0.006 (0.011) | 0.62 |
| EP control | 462 | 0.005 (5.0E−03) | 0.33 | 190 | 0.000 (8.1E−03) | 0.99 |
| Polynesian meta-analysis | 696 | 0.005 (4.3E−03) | 0.94 | 324 | 0.002 (6.6E−03) | 0.77 |
| rs11942223/C | ||||||
| European control | 14,349 | − 0.024 (1.1E−03) | 8.4E−106 | 6681 | − 0.017 (1.6E−03) | 8.1E−27 |
| WP control | 234 | − 0.021 (0.023) | 0.38 | 134 | − 0.038 (0.038) | 0.32 |
| EP control | 462 | − 0.008 (0.012) | 0.53 | 190 | 0.052 (0.022) | 0.022 |
| Polynesian meta-analysis^ | 696 | − 0.011 (0.011) | 0.63 | 324 | 0.012 (0.044) | 0.78 |
*European sample set adjusted by age and sex (combined sex only). Polynesian sample sets additionally adjusted by PCs 1–10
^As the test for heterogeneity between Western Polynesian (WP) and Eastern Polynesian (EP) was significant (p = 0.043), a random effects model was used