Table 3.

Doxycycline study - comparisons of enrollment and follow-up assessments*

Endpoint	N	Enrollment Mean (SD)	Follow-up Mean (SD)	Paired T-test p-value
Body Mass Index (kg/m2)	6	25.41 (4.41)	26.07 (4.45)	0.080
6 Minute Walk Test (feet)	5	1142 (159)	1283 (194)	0.110
St. George’s Respiratory Questionnaire – total score	6	50.90 (8.38)	18.40 (6.39)	0.002
FVC percent predicted (%)	6	61.38 (10.65)	67.67 (14.39)	0.311
MMP9 activity	6	6.19 (2.04)	2.59 (0.66)	0.006
MMP3 activity	6	9.03 (2.02)	4.83 (3.54)	0.041
MMP9 expression	6	3.39 (1.06)	1.45 (0.41)	0.004
TIMP-1 expression	6	5.28 (1.56)	2.72 (0.67)	0.018
VEGF expression	6	9.03 (2.02)	4.83 (3.54)	0.041

*Data are taken from [15]. Activities levels are determined from Western Blot. See [15] for more details