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. 2020 Mar 12;20:209. doi: 10.1186/s12885-020-6695-9

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© The Author(s). 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Patient survival according to tumor budding. a Disease specific survival. b Recurrence free survival. On both disease specific survival (DSS) and recurrence free survival (RFS), patients in high TB group had significantly poor survival compared to patients in low TB group (p < 0.001 in DSS, p = 0.001 in RFS). Interestingly, DSS in high TB group did not show statistical difference compared to that in 28 unresected patients at our institution in the same period (p = 0.103). *Eleven patients with R2 resection (distant metastasis or cancer positive surgical margin) were excluded from RFS study