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. 2020 Mar 1;4(1):292–314. doi: 10.1162/netn_a_00124

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© 2020 Massachusetts Institute of Technology

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. For a full description of the license, please visit https://creativecommons.org/licenses/by/4.0/legalcode.

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Figure 1. — Reducing higher order network structure in a neocortical microcircuit model. (A1) Neurons in the neocortical microcircuit (NMC-) model. (A2) Deriving synaptic connectivity between neocortical neurons: Connectivity in the NMC-model is based on appositions of dendrites and axons (Reimann et al., 2015). Connectivity in the control cloud-model considers overlap of average dendritic and axonal clouds (Reimann, Horlemann, et al., 2017). (B1) We computed network properties for seven statistical instantiations of the microcircuit (apposition-based connectomes AC_1–7, orange diamonds and red star; Markram et al., 2015), and simulated one of them in this study (the NMC-model with connectome AC₁, red star). Additionally, we studied versions of the model using the existing NMC-neurons, but synaptic connectivity derived according to the cloud-based approach (cloud-connectomes CC_1–5, blue diamonds). We then implemented one of the alternative connectomes within the existing synapses of the NMC-neurons, resulting in the cloud-model that we simulated, with connectome C_1* (blue star). The rewiring of the cloud-model was restricted to excitatory connections. (B2) Number of connections across connectomes. By design, the cloud-connectomes CC_1–5 have the same number of connections as the NMC-model connectome AC₁. However, the connectome implemented in the cloud-model CC_1* has 0.12% fewer connections than CC₁ because of a mismatch in new connections and available synapses (see Figure 2A). To control for this loss, we generate a copy of the NMC-model with the same fraction of excitatory connections randomly removed, the NMC*-model (green star).