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. 2020 Feb 18;10(8):3594–3611. doi: 10.7150/thno.40318

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Rectal delivery of sOKGM-PS-miR-31i/Cur microspheres suppressed colon tumor growth in vivo. (A) Schematics for rectal delivery of sOKGM-PS-miR-31i/Cur microspheres in treating AOM-DSS induced colon tumors. (B) Gross (upper panels) and Hematoxylin & eosin staining (bottom panels) images of colon tumors from mice rectally treated with indicated formulations for 2 weeks. Scale bar, 1 mm. (C and D) Quantification of tumor numbers (C) and volume (D) shown in panel B. The results are reported as the mean ± standard deviation (PBS, n = 5; n = 6 for the other treatments), *p < 0.05; **p < 0.01. (E) Quantification of the percentage of Ki67⁺ cells in tumors as shown in Figure S7A. The results are reported as the mean ± standard deviation (PBS, n = 5; n = 6 for the other treatments), *p < 0.05; **p < 0.01. (F) qRT-PCR analysis for miR-31 in colon tumors from mice rectally treated with indicated formulations for 2 weeks. The results are reported as the mean ± standard deviation (PBS, n = 5; n = 6 for the other treatments), *p < 0.05.