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. 2020 Feb 18;10(8):3533–3545. doi: 10.7150/thno.39507

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The osteoinductivity of BCP is dependent on T cells. (A)T cells in mice were deleted by the supernatant of hybridoma cells. (B-D) BCP was implanted into mice injected with T cells antibody (T-Del group) or complete medium (Con group) every 3 days for 4 weeks. (B, C) H&E and Masson staining showed the formation of new bone. New bone (NB) area is circled by the red dotted line. (D) IHC of Col-1A1 showed the expression of osteogenic indicator marked by red arrows. (E) Quantitative comparison of positive Col-1A1 expression. (n=4) ***P < 0.001.