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. 2020 Feb 19;10(8):3708–3721. doi: 10.7150/thno.41677

Figure 1.

Figure 1

Overexpression of CREPT in pancreatic cancer promotes cell proliferation and tumorigenesis. (A) Ectopic expression of CREPT in K-ras/p53-driven pancreatic cancer tissues stained with anti-CREPT antibody. Scale bars, 100 μm. (B) Ectopic expression of CREPT in human pancreatic tumor tissues stained with anti-CREPT antibody. Scale bars, 50 μm. (C) Kaplan-Meier plot of cumulative disease-free survival (DFS) of 182 pancreatic adenocarcinoma samples in TCGA database. (CREPT high-expression group, purple line; CREPT low-expression group, blue line). The p-value obtained by comparing the two survival curves was 0.0154. (D-F) Overexpression of CREPT significantly increased the number of colonies and promoted cell viability. (G-I) Deletion of CREPT dramatically reduced the number of colonies and inhibited cell viability. The results are represented as the mean ± SD from three independent repeats.