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. Author manuscript; available in PMC: 2021 Jan 1.
Published in final edited form as: DNA Repair (Amst). 2019 Nov 2;85:102741. doi: 10.1016/j.dnarep.2019.102741

Figure 1.

Figure 1.

NEIL1-catalyzed removal of oxidatively-induced DNA base lesions (A) from high-molecular weight genomic DNA. The calf thymus DNA exposed to 5 Gy (B-E) or 20 Gy (F-I) γ-irradiation dose was incubated with no enzyme or in the presence of the unedited or edited NEIL1. The released FapyAde (B & F), FapyGua (C & G), ThyGly (D & H), and 5-OH-Cyt (E & I) were measured by GC-MS/MS using their stable isotope-labeled analogues as internal standards. * = p < 0.05; ** = p < 0.01; *** = p < 0.001. The uncertainties are standard deviations.