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. Author manuscript; available in PMC: 2021 Jan 1.
Published in final edited form as: DNA Repair (Amst). 2019 Nov 2;85:102741. doi: 10.1016/j.dnarep.2019.102741

Figure 2.

Figure 2.

NEIL1-catalyzed excision of AFB1-FapyGua. The reactions were conducted using 24-mer double-stranded DNA substrate that contained a centrally-located AFB1-FapyGua (A). Representative gel images for the edited (B) and unedited (C) NEIL1 are shown. The data shown in plot (D) demonstrate the time-dependent product accumulation, with fit of these data that were obtained from three independent experiments (average ± standard deviation) to a single exponential equation (correlation coefficient R > 0.99 for each enzyme).