Table 1.
Diagnostic accuracy estimates and their 95%CI for all index tests
| Parameter | ViroTrack Dengue Acute NS1 | SD Dengue NS1 Ag ELISA | SD Bioline DD NS1 only | SD Bioline DD IgM only | SD Bioline DD IgG only | SD Bioline DD NS1 or IgM | SD Bioline DD NS1 or IgM or IgG |
|---|---|---|---|---|---|---|---|
| Sensitivitya, % (95%CI) | 139/223 | 151/227 | 119/227 | 103/227 | 63/227 | 172/227 | 187/227 |
| 62.3% | 66.5% | 52.4% | 45.4% | 27.8% | 75.8% | 82.4% | |
| (55.6–68.7) | (60.0–72.6) | (45.7–59.1) | (38.8–52.1) | (22.0–34.1) | (69.7–81.2) | (76.8–87.1) | |
| Specificitya, % (95%CI) | 249/262 | 250/262 | 256/262 | 258/262 | 233/262 | 253/262 | 229/262 |
| 95.0% | 95.4% | 97.7% | 98.5% | 88.9% | 96.6% | 87.4% | |
| (91.7–97.3) | (92.1–97.6) | (95.1–99.2) | (96.1–99.6) | (84.5–92.5) | (93.6–98.4) | (82.8–91.2) | |
| PPVa, % (95%CI) | 139/152 | 151/163 | 119/125 | 103/107 | 63/92 | 172/181 | 187/220 |
| 91.4% | 92.6% | 95.2% | 96.3% | 68.5% | 95.0% | 85.0% | |
| (85.8–95.4) | (87.5–96.1) | (89.8–98.2) | (90.7–99.0) | (58.0–77.8) | (90.8–97.7) | (79.6–89.4) | |
| NPVa, % (95%CI) | 249/333 | 250/326 | 256/364 | 258/382 | 233/397 | 253/308 | 229/269 |
| 74.8% | 76.7% | 70.3% | 67.5% | 58.7% | 82.1% | 85.1% | |
| (69.8–79.4) | (71.7–81.2) | (65.3–75.0) | (62.6–72.2) | (53.7–63.6) | (77.4–86.3) | (80.3–89.2) | |
|
LR + (95%CI) |
12.6 | 14.5 | 22.9 | 29.7 | 2.5 | 22.1 | 6.5 |
| (7.32–21.5) | (8.29–25.4) | (10.3–51.0) | (11.1–79.4) | (1.7–3.8) | (11.6–42.1) | (4.7–9.1) | |
|
LR - (95%CI) |
0.40 | 0.35 | 0.49 | 0.56 | 0.81 | 0.25 | 0.20 |
| (0.33–0.47) | (0.29–0.42) | (0.42–0.56) | (0.49–0.63) | (0.74–0.89) | (0.20–0.32) | (0.15–0.27) | |
|
AUC (95%CI) |
0.79 | 0.81 | 0.75 | 0.72 | 0.58 | 0.86 | 0.85 |
| (0.75–0.82) | (0.78–0.84) | (0.72–0.78) | (0.69–0.75) | (0.55–0.62) | (0.83–0.89) | (0.82–0.88) | |
|
DOR (95%CI) |
31.7 | 41.4 | 47 .0 | 53.6 | 3.1 | 87.9 | 32.4 |
| (17.2–58.5) | (22.0–77.9) | (20.5–108.0) | (20.0–143.0) | (1.9–5.0) | (42.8–180.0) | (19.7–53.4) |
aThe italic numbers shown before the parameter estimates are number of correct tests over number of all tests for each corresponding parameter