Table 3.
Characteristics of trials (n = 189)
| Mortality primary outcome | 10% |
| Statistically significant for mortality | 9% |
| Mortality reported in primary paper | 98% |
| Multicenter | 37% |
| Centers, mean number | 10 |
| Domain | |
| Medicine | 43% |
| Obstetrics | 14% |
| Pediatrics | 21% |
| Surgery | 22% |
| Country | |
| Canada/USA | 33% |
| Europe | 53% |
| Asia | 4% |
| Other | 11% |
| Random sequence | |
| Unclear | 54% |
| Y | 46% |
| N | 1% |
| Allocation concealment, grade | |
| Adequate (A) | 34% |
| Unclear (B) | 27% |
| Inadequate (C) | 2% |
| Not Used (D) | 37% |
| Double-blind | 39% |
| Analysis | |
| Unclear | 30% |
| As treated | 29% |
| As randomized | 41% |
| Publication year, mean | 1993 |
| External funding | |
| Peer review | 47% |
| Industry | 42% |
| Not stated | 11% |
| Patients in analysis, mean number (median) | 563 (165) |
| Deaths, mean number (median) | 56 (21) |