Table 1.
Subject characteristics of the KCNQ1 R670K carrier (KCNQ1) and KCNE1 G60D carrier (KCNE1) and their BMI, sex and age matched control participants. Subject characteristics and fasting baseline of glucose and hormone levels of the mutation carriers and their matched control participants (n = 6), and baseline of ECG (n = 4), mean ± SD
| KCNQ1 | KCNE1 | Control | |
|---|---|---|---|
| Sex | Male | Male | Male |
| Age | 48 | 49 | 48 ± 1 |
| BMI (kg/m2) | 28.0 | 20.7 | 24.7 ± 4.3 |
| Fat percentage | 25.6 | 14.2 | 21.8 ± 5.8 |
| HbA1c (mmol/mol) | 31.0 | 34.0 | 34.0 ± 3.6 |
| Hgb (mmol/l) | 9.0 | 9.1 | 8.9 ± 0.8 |
| Cholesterol (mmol/l) | 4.0 | 5.9 | 4.7 ± 0.7 |
| Creatinine (μmol/l) | 62 | 71 | 77 ± 7 |
| ECG characteristics in fasting state | |||
| QTcB (ms) | 434.6 | 449.5 | 410.5 ± 26.8 |
| QTcF (ms) | 427.8 | 458.8 | 417.9 ± 17.2 |
| Heart rate (beats/min.) | 66.4 | 53.5 | 54.7 ± 10.7 |
| Fasting glucose and hormone levels | |||
| Serum C-peptide (pmol/l) | 774 | 403 | 576 ± 301 |
| Serum Insulin (pmol/l) | 88 | 21 | 42 ± 47 |
| Plasma total GIP (pmol/l) | 15 | 7 | 9 ± 2 |
| Plasma total GLP-1 (pmol/l) | 18 | 14 | 12 ± 2 |
| Plasma Glucagon (pmol/l) | 7 | 3 | 7 ± 4 |
| Plasma Glucose (mmol/l) | 5.6 | 5.2 | 5.1 ± 0.4 |