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. Author manuscript; available in PMC: 2020 Mar 13.
Published in final edited form as: Cell Rep. 2020 Jan 28;30(4):1235–1245.e4. doi: 10.1016/j.celrep.2019.12.067

Figure 4. Detection of Enzymatic DPCs Induced by Topoisomerase Inhibitors with the ARK Assay.

Figure 4.

(A) 293A, HeLa, and TK6 cells were exposed to various doses of CPT for 1 h and analyzed by the ARK assay to generate DPC fold induction by normalizing the DPC coefficient of each sample against that of the mock-treated control.

(B) HeLa, 293A, and TK6 cells were exposed to various doses of etoposide for 1 h and analyzed by the ARK assay to generate the DPC fold induction by normalizing the DPC coefficient of each sample against that of the mock-treated control.

Each data point was generated from no less than 5 biological repeats with triplication. The error bars depict standard deviations.