Table 2.

Estimated incidence of TdP among users* of specific TdP-classified antidepressants, antipsychotics or other central nervous system active drugs, in patients aged ≥65 and 18–64 years during 2006–2017 (the number of TdP cases using the specific drug is shown in parentheses)

Therapeutic group and specific drug	TdP class	TdP per 100 000 ≥65 years (number of TdP cases)	Number of users ≥65 years	TdP per 100 000 18–64 years (number of TdP cases)	Number of users 18–64 years
Antidepressant drugs
Citalopram	1	15.3 (59)	385 828	2.7 (13)	491 640
Escitalopram	1	4.1 (3)	73 769	0.7 (2)	267 733
Venlafaxine	2	3.7 (2)	54 392	0	225 566
Mirtazapine	2	7.5 (23)	307 734	1.2 (5)	402 370
Sertraline	3	5.2 (9)	172 728	0.9 (5)	588 495
Paroxetine	3	8.7 (2)	23 057	0	74 337
Fluoxetine	3	4.8 (1)	21 026	0	158 495
Clomipramine	3	13.2 (2)	15 181	7.4 (3)	40 364
Amitriptyline	3	3.2 (5)	145 624	0	280 218
Antipsychotic drugs
Haloperidol	1	3.1 (2)	63 815	4.4 (1)	22 730
Levomepromazine	1	0	18 355	4.0 (2)	49 666
Olanzapine	2	6.9 (2)	29 128	7.4 (7)	94 560
Aripiprazole	2	0	5546	2.2 (1)	46 073
Clozapine	2	0	3 420	11.1 (1)	8 661
Lithium	2	0	12 098	2.6 (1)	38 398
Perphenazine	2	19.2 (1)	5 208	0	11 164
Risperidone	2	0.9 (1)	110 645	0	51 641
Quetiapine	3	0	22 668	3.0 (3)	98 819
Anti-dementia drugs
Donepezil	1	8.1 (7)	86 426	0	2 487
Memantine	3	4.7 (3)	64 135	0	3 047
Opioid analgesics
Methadone	1	0	5 411	41.9 (4)	9 553
Buprenorphine	2	0.6 (1)	170 943	2.9 (1)	51 603
Anxiolytic drugs
Hydroxyzine	3	4.9 (14)	288 469	0.7 (6)	913 194
Promethazine	3	0	483 70	0.6 (2)	316 428

*A person is considered to have used a drug if the person has a dispensed prescription lasting until or beyond the TdP event day. See the Methods section for details.

TdP, torsades de pointes.