Table 1.
Summary of acute myeloid leukemia (AML) with numb chin syndrome case reports and some of the acute lymphocytic leukemia (ALL) with numb chin syndrome cases.
| Author | Year | Age | Gender | Primary diagnosis | Chromosome analysis | NCS timing |
|---|---|---|---|---|---|---|
| Barrett [17] | 1985 | 28 | M | ALL | NA | Progression |
| Nagano [15] | 1991 | 21 | F | AML | NA | Presentation |
| Ohno [16] | 1994 | 32 | F | AML-M5 | NA | Presentation |
| Kuklok [18] | 1997 | 35 | M | ALL | NA | Presentation |
| Kraigher-Krainer [2] | 2008 | 11 | M | ALL (B-cell) | NA | Presentation |
| Mantadakis [19] | 2008 | 17 | M | ALL (B-cell) | 46,XY,del(9)(p22.1),add(16)(q22) and 46,XY,add(9) (p22.1),del(9) (p11.2)add(16)(q22)] | Presentation |
| Liapis [20] | 2010 | 52 | M | AMKL | (+Y, +1, +3q, −3p, −4, −5q, +6, −7q, +8, −9q, −15) | Presentation |
| Lata [13] | 2010 | 45 | M | NHL | NA | Presentation |
| Sasaki [11] | 2011 | 48 | F | Burkitt’s cell acute lymphocytic leukemia | NA | Presentation |
| Fan [12] | 2011 | 51 | F | NHL | NA | Presentation |
| Jenkins [1] | 2012 | 33 | F | AML | t(8;21) translocation | Presentation |
| Romo [21] | 2014 | 22 | M | ALL | NA | Relapse |
| Algahtani [10] | 2016 | 57 | M | Burkitt’s lymphoma/leukemia | Translocation (8;14) | Presentation |
| Algahtani [10] | 2016 | 39 | M | Burkitt’s lymphoma/leukemia | t(8;14)(q24;q32) | Presentation |
| Quintela [22] | 2017 | 27 | M | AML | 47, XX, ?8[4]/46, XY[16] | Presentation |
| Present case | 2017 | 30 | M | AML | 45, X,-Y with t(8;21) (q22;q22);RUNX1-RUNX1T1 | Presentation |
AML – acute myeloid leukemia; AML-M5 – acute monoblastic leukemia; ALL – acute lymphoblastic leukemia; AMKL – acute megakaryoblastic leukemia; NA – not available; NHL – Non-Hodgkin’s lymphoma.