Table 5.

Area Under the ROC Curve (AUC) for 3 Genetic Risk Scores (GRSs) for Prediction of Risk of Forearm, Hip, and Vertebral Fractures, Evaluated in Separate Cohorts

	UFO Hip-Fracture N = 1873			UFO Forearm Fracture N = 1978			MrOS Sweden N = 1880*
	AUC	95% CI	N cases	AUC	95% CI	N cases	AUC	95% CI	N cases
Hip fracture			994						129
eBMDGRS	0.56	(0.54, 0.59)					0.56	(0.51, 0.61)
FN-BMDGRS	0.56	(0.53, 0.58)					0.57	(0.52, 0.62)
LS-BMDGRS	0.55	(0.52, 0.58)					0.56	(0.50, 0.62)
Forearm fracture						984			36
eBMDGRS				0.60	(0.57, 0.62)		0.66	(0.58, 0.75)
FN-BMDGRS				0.55	(0.52, 0.57)		0.60	(0.50, 0.70)
LS-BMDGRS				0.55	(0.53, 0.58)		0.58	(0.47, 0.69)
Vertebral fracture									288
eBMDGRS							0.57	(0.53, 0.61)
FN-BMDGRS							0.55	(0.51, 0.59)
LS-BMDGRS							0.54	(0.51, 0.58)

Area under the ROC curve (AUC) and 95% confidence intervals (CI) are given for each GRS in separate unadjusted models. N = number of participants. N cases = number of fracture cases.

Abbreviations: eBMD_GRS, genetic risk score for estimated bone mineral density of the heel; FN-BMD_GRS, genetic risk score for bone mineral density in femur neck; LS-BMD_GRS, genetic risk score for bone mineral density in lumbar spine.

*For vertebral fractures, only N = 1475 participants were included.