Table 7.
Association Between 3 Genetic Risk Scores (GRSs) and Different Bone Parameters in MrOS Sweden, Evaluated Using Stepwise Selection in Combined Linear Regression Models
| eBMDGRS | FN-BMDGRS | LS-BMDGRS | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| N | Beta | SE | P | Beta | SE | P | Beta | SE | P | |
| Ultrasound Calcaneus | ||||||||||
| eBMD | 1567 | −0.41 | 0.02 | 8.5E-68 | ||||||
| DXA | ||||||||||
| FN-BMD | 1861 | −0.17 | 0.02 | 3.0E-15 | −0.15 | 0.02 | 1.6E-11 | |||
| LS-BMD | 1865 | −0.17 | 0.02 | 3.4E-15 | −0.15 | 0.02 | 1.4E-11 | |||
| HRpQCT of Distal Radius | ||||||||||
| Failure Load | 354 | −0.34 | 0.05 | 3.9E-11 | −0.16 | 0.05 | 9.2E-04 | |||
| Trabecular parameters | ||||||||||
| vBMD | 403 | −0.35 | 0.05 | 4.3E-12 | −0.15 | 0.05 | 1.6E-03 | |||
| Trabecular Number | 357 | −0.29 | 0.05 | 1.1E-07 | −0.13 | 0.05 | 9.9E-03 | |||
| Trabecular Thickness | 357 | −0.31 | 0.05 | 9.7E-09 | ||||||
| Cortical parameters | ||||||||||
| Area | 426 | −0.19 | 0.05 | 4.9E-05 | −0.17 | 0.05 | 2.2E-04 | |||
| vBMD | 397 | −0.16 | 0.05 | 1.9E-03 | −0.18 | 0.05 | 3.5E-04 | |||
The models for ultrasound and dual energy absorptiometry (DXA) parameters, available both in the Gothenburg and the Malmö cohort of MrOS Sweden, are adjusted for age, height, weight, and MrOS site. The models for high resolution peripheral quantitative computed tomography (HRpQCT)-derived parameters in the distal radius, available only in the Gothenburg part of MrOS Sweden, are adjusted for age, height, and weight. Betas are expressed as SD change in bone parameter per SD increase in GRS of significant independent associations.
Abbreviations: eBMD, estimated bone mineral density analysed by ultrasound; FN-BMD, femoral neck bone mineral density analysed by DXA; LS-BMD, lumbar spine bone mineral density analysed by DXA; vBMD, volumetric bone mineral density.