Table 3.
Relations between VMS and epigenetic aging, controlling for sleep disturbance
| DNA Phenotypic Aging | DNAm GimAge | ||
|---|---|---|---|
| B (SE) | B (SE) | ||
| Hot flashes at enrollment | Mild | −0.34 (0.54) | −0.42 (0.27) |
| Moderate | −0.47 (0.79) | 0.36 (0.39) | |
| Severe | 2.86 (1.39)a | 0.27 (0.70) | |
| Night sweats at enrollment | Mild | 0.22 (0.50) | 0.20 (0.25) |
| Moderate | 0.90 (0.79) | 0.29 (0.39) | |
| Severe | −0.79 (1.36) | 1.26 (0.68)b | |
| VMS timing | Early | 0.76 (0.65) | −0.33 (0.32) |
| Late | 1.84 (0.88)a | 1.08 (0.43)a | |
| Persistent | 0.75 (0.65) | −0.23 (0.32) |
Covariates: Age, race/ethnicity, education, body mass index, hysterectomy, (for DNAm GimAge models) smoking pack years, sleep disturbance
Note: Comparisons relative to no VMS
Abbreviation: vasomotor symptoms
a P < 0.05
b P < 0.10