Table 1.
Differentially expressed genes of Turner Syndrome.
| Gene symbol | Adjusted P-value | Fold change | Gene title | Location | ||
|---|---|---|---|---|---|---|
| Xm-XX | Xp-XX | Xm-XX | Xp-XX | |||
| Up regulated genes | ||||||
| ACVR2B | 1.79E-02 | 8.62E-03 | 4.659 | 4.852 | Activin A receptor type 2B | Chromosome 3 |
| AGER | 2.44E-02 | 1.27E-02 | 3.434 | 3.729 | Advanced glycosylation end-product specific receptor | Chromosome 6 |
| ANK1 | 2.12E-02 | 3.55E-03 | 5.540 | 2.630 | Ankyrin 1 | Chromosome 8 |
| B3GAT1 | 4.31E-02 | 3.80E-02 | 4.993 | 5.448 | Beta-1,3-glucuronyltransferase 1 | Chromosome 11 |
| BAZ2A | 1.73E-02 | 1.35E-02 | 2.639 | 2.662 | Bromodomain adjacent to zinc finger domain 2A | Chromosome 12 |
| BCL11B | 2.50E-02 | 1.27E-02 | 3.074 | 3.550 | B-cell CLL/lymphoma 11B | Chromosome 14 |
| C11orf53 | 3.41E-02 | 1.31E-02 | 2.969 | 2.701 | Chromosome 11 open reading frame 53 | Chromosome 11 |
| CEMP1 | 3.83E-02 | 4.53E-03 | 2.114 | 2.665 | Cementum protein 1 | Chromosome 16 |
| CYBA | 4.90E-02 | 4.44E-03 | 2.428 | 2.951 | Cytochrome b-245 alpha chain | Chromosome 16 |
| DGKK | 9.00E-04 | 2.65E-02 | 6.916 | 4.562 | Diacylglycerol kinase kappa | Chromosome X |
| FAM229B | 4.53E-02 | 2.20E-02 | 2.969 | 2.821 | Family with sequence similarity 229 member B | Chromosome 6 |
| HDAC5 | 2.13E-02 | 2.05E-05 | 2.173 | 2.459 | Histone deacetylase 5 | Chromosome 17 |
| IGFBP2 | 4.73E-02 | 1.74E-02 | 4.347 | 3.908 | Insulin like growth factor binding protein 2 | Chromosome 2 |
| KDM6B | 7.00E-03 | 8.66E-03 | 3.387 | 3.502 | Lysine demethylase 6B | Chromosome 17 |
| KHSRP | 3.83E-02 | 2.97E-02 | 2.378 | 2.391 | KH-type splicing regulatory protein | Chromosome 19 |
| MED16 | 4.89E-02 | 1.17E-03 | 2.042 | 2.478 | Mediator complex subunit 16 | Chromosome 19 |
| MYL9 | 2.95E-02 | 3.45E-02 | 10.411 | 9.513 | Myosin light chain 9 | Chromosome 20 |
| OVCH1-AS1 | 3.83E-02 | 6.05E-03 | 3.387 | 4.555 | OVCH1 antisense RNA 1 | Chromosome 12 |
| PERM1 | 3.12E-02 | 3.24E-02 | 2.713 | 2.050 | PPARGC1 and ESRR induced regulator, muscle 1 | Chromosome 1 |
| PSMD5-AS1 | 4.12E-02 | 2.10E-02 | 2.908 | 2.748 | PSMD5 antisense RNA 1 (head to head) | Chromosome 9 |
| SAFB2 | 4.89E-02 | 5.15E-03 | 2.532 | 3.022 | Scaffold attachment factor B2 | Chromosome 19 |
| SRCAP | 1.37E-02 | 8.18E-05 | 4.563 | 6.930 | Snf2-related CREBBP activator protein | Chromosome 16 |
| STK11 | 6.00E-04 | 2.48E-03 | 6.063 | 6.820 | Serine/threonine kinase 11 | Chromosome 19 |
| UBE2O | 9.00E-03 | 4.44E-03 | 2.549 | 2.801 | Ubiquitin conjugating enzyme E2 O | Chromosome 17 |
| ZMIZ2 | 3.30E-02 | 2.81E-02 | 2.621 | 2.793 | Zinc finger MIZ-type containing 2 | Chromosome 7 |
| Down regulated genes | ||||||
| AFF3 | 2.54E-02 | 4.28E-02 | 0.1934 | 0.3026 | AF4/FMR2 family member 3 | Chromosome 2 |
| AGFG1 | 3.41E-02 | 3.37E-03 | 0.4033 | 0.4174 | ArfGAP with FG repeats 1 | Chromosome 2 |
| AHNAK | 6.80E-03 | 2.74E-02 | 0.2132 | 0.2273 | AHNAK nucleoprotein | Chromosome 11 |
| AP1S2* | 2.95E-02 | 2.60E-03 | 0.4263 | 0.3898 | Adaptor related protein complex 1 sigma 2 subunit | Chromosome X |
| ASMTL | 3.60E-03 | 3.50E-04 | 0.4633 | 0.4923 | Acetylserotonin O-methyltransferase-like | Chromosome X |
| ATRX | 1.68E-02 | 1.32E-02 | 0.3950 | 0.4502 | ATRX, chromatin remodeler | Chromosome X |
| BID | 3.26E-02 | 3.38E-03 | 0.4796 | 0.4956 | BH3 interacting domain death agonist | Chromosome 22 |
| CARD16 | 2.03E-02 | 4.77E-03 | 0.4569 | 0.4879 | Caspase recruitment domain family member 16 | Chromosome 11 |
| CD99* | 2.01E-02 | 3.58E-03 | 0.4601 | 0.4851 | CD99 molecule | Chromosome X |
| CDC27 | 6.00E-04 | 1.08E-04 | 0.3711 | 0.3945 | Cell division cycle 27 | Chromosome 17 |
| CHD9 | 3.20E-03 | 8.23E-03 | 0.3078 | 0.3351 | Chromodomain helicase DNA binding protein 9 | Chromosome 16 |
| CSF2RA* | 8.81E-03 | 5.39E-04 | 0.3099 | 0.3510 | Colony stimulating factor 2 receptor alpha subunit | Chromosome X |
| CSGALNACT2 | 5.94E-03 | 1.18E-02 | 0.3842 | 0.3309 | Chondroitin sulfate N-acetylgalactosaminyltransferase 2 | Chromosome 10 |
| CXorf38 | 4.00E-04 | 3.40E-04 | 0.3869 | 0.3602 | Chromosome X open reading frame 38 | Chromosome X |
| DHRSX | 2.50E-02 | 6.05E-03 | 0.2736 | 0.2140 | Dehydrogenase/reductase X-linked | Chromosome X |
| DHX9 | 3.08E-02 | 2.78E-02 | 0.4569 | 0.4841 | DEAH-box helicase 9 | Chromosome 1 |
| EIF1AX | 3.41E-02 | 5.57E-03 | 0.4897 | 0.4475 | Eukaryotic translation initiation factor 1A, X-linked | Chromosome X |
| EPRS | 1.79E-03 | 5.92E-03 | 0.4005 | 0.3890 | Glutamyl-prolyl-tRNA synthetase | Chromosome 1 |
| EREG | 8.39E-03 | 4.73E-03 | 0.2952 | 0.3238 | Epiregulin | Chromosome 4 |
| FCGR2C | 3.23E-03 | 2.59E-02 | 0.2365 | 0.4009 | Fc fragment of IgG receptor Iic | Chromosome 1 |
| FKBP15 | 3.23E-03 | 6.31E-03 | 0.2813 | 0.2773 | FK506 binding protein 15 | Chromosome 9 |
| FRG1JP | 4.90E-02 | 1.61E-02 | 0.3345 | 0.3576 | FSHD region gene 1 family member J, pseudogene | Chromosome 9 |
| FXR1 | 3.23E-03 | 2.98E-03 | 0.3511 | 0.3833 | FMR1 autosomal homolog 1 | Chromosome 3 |
| HADHA | 2.40E-03 | 2.60E-03 | 0.4263 | 0.3944 | Hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit | Chromosome 2 |
| HECTD1 | 7.01E-03 | 8.16E-03 | 0.4730 | 0.4768 | HECT domain E3 ubiquitin protein ligase 1 | Chromosome 14 |
| HES1 | 4.11E-02 | 3.19E-02 | 0.2973 | 0.4613 | Hes family bHLH transcription factor 1 | Chromosome 3 |
| IL1R2 | 3.08E-02 | 1.99E-02 | 0.1627 | 0.3489 | Interleukin 1 receptor type 2 | Chromosome 2 |
| INO80D | 2.00E-02 | 5.42E-03 | 0.2736 | 0.2952 | INO80 complex subunit D | Chromosome 2 |
| IQGAP1 | 6.35E-04 | 2.48E-03 | 0.3487 | 0.3747 | IQ motif containing GTPase activating protein 1 | Chromosome 15 |
| JAK1 | 2.03E-02 | 1.30E-02 | 0.4538 | 0.4758 | Janus kinase 1 | Chromosome 1 |
| KDM6A | 1.51E-02 | 4.48E-03 | 0.3896 | 0.4880 | Lysine demethylase 6A | Chromosome X |
| KIAA1033 | 1.50E-03 | 2.77E-03 | 0.3789 | 0.4213 | KIAA1033 | Chromosome 12 |
| LOC100289090 | 6.35E-04 | 5.41E-03 | 0.3392 | 0.4276 | Uncharacterized LOC100289090 | Chromosome 15 |
| LOC101930114 | 1.52E-02 | 9.33E-03 | 0.4005 | 0.4218 | Uncharacterized LOC101930114 | Chromosome 1 |
| MAP4 | 1.93E-02 | 1.15E-02 | 0.2774 | 0.3805 | Microtubule associated protein 4 | Chromosome 3 |
| MYLPF | 3.41E-02 | 3.58E-03 | 0.2872 | 0.1968 | Myosin light chain, phosphorylatable, fast skeletal muscle | Chromosome 16 |
| NLRC4 | 2.48E-02 | 2.60E-02 | 0.2793 | 0.2312 | NLR family CARD domain containing 4 | Chromosome 2 |
| NSMAF | 8.98E-04 | 5.51E-03 | 0.3487 | 0.2810 | Neutral sphingomyelinase activation associated factor | Chromosome 8 |
| PLXNC1 | 1.92E-02 | 1.00E-02 | 0.3487 | 0.3616 | Plexin C1 | Chromosome 12 |
| PTPN12 | 2.82E-02 | 3.06E-02 | 0.4147 | 0.4630 | Protein tyrosine phosphatase, non-receptor type 12 | Chromosome 7 |
| RPL37A | 2.50E-02 | 2.10E-02 | 0.3209 | 0.3612 | Ribosomal protein L37a | Chromosome 2 |
| SAMHD1 | 6.88E-03 | 6.57E-03 | 0.3842 | 0.3232 | SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 | Chromosome 20 |
| SLC25A6 | 9.11E-04 | 5.97E-06 | 0.3711 | 0.3762 | Solute carrier family 25 member 6 | Chromosome X |
| SMC1A | 8.81E-03 | 2.03E-03 | 0.1661 | 0.3258 | Structural maintenance of chromosomes 1A | Chromosome X |
| SON | 9.93E-03 | 6.67E-03 | 0.4175 | 0.4495 | SON DNA binding protein | Chromosome 21 |
| SSFA2 | 1.68E-02 | 9.56E-03 | 0.3164 | 0.3670 | Sperm specific antigen 2 | Chromosome 2 |
| TAOK1 | 2.66E-02 | 3.55E-03 | 0.4965 | 0.4375 | TAO kinase 1 | Chromosome 17 |
| TIA1 | 2.30E-02 | 8.62E-03 | 0.3978 | 0.4613 | TIA1 cytotoxic granule-associated RNA binding protein | Chromosome 2 |
| TOB1 | 3.41E-02 | 3.21E-02 | 0.3711 | 0.4056 | Transducer of ERBB2, 1 | Chromosome 17 |
| TOP1 | 3.83E-02 | 4.06E-03 | 0.4538 | 0.4516 | Topoisomerase (DNA) I | Chromosome 20 |
| TPP2 | 4.59E-02 | 2.60E-03 | 0.4601 | 0.4281 | Tripeptidyl peptidase 2 | Chromosome 13 |
| TSIX | 2.52E-06 | 8.18E-05 | 0.0769 | 0.0495 | TSIX transcript, XIST antisense RNA | Chromosome X |
| USP10 | 8.02E-03 | 2.97E-03 | 0.3842 | 0.4655 | Ubiquitin specific peptidase 10 | Chromosome 16 |
| VPS13B | 1.94E-02 | 3.46E-02 | 0.3816 | 0.3808 | Vacuolar protein sorting 13 homolog B | Chromosome 8 |
| VPS35 | 2.50E-02 | 8.24E-03 | 0.3392 | 0.3926 | VPS35 retromer complex component | Chromosome 16 |
| XIST | 3.48E-14 | 2.64E-08 | 0.0042 | 0.0019 | X inactive specific transcript (non-protein coding) | Chromosome X |
| ZBTB38 | 2.43E-03 | 1.34E-02 | 0.4538 | 0.4446 | Zinc finger and BTB domain containing 38 | Chromosome 3 |
| ZFX | 2.95E-02 | 5.70E-03 | 0.4353 | 0.4679 | Zinc finger protein, X-linked | Chromosome X |
| ZG16B | 1.30E-03 | 6.51E-03 | 0.2031 | 0.2638 | Zymogen granule protein 16B | Chromosome 16 |
| ZNF652 | 3.41E-02 | 1.99E-02 | 0.3439 | 0.3698 | Zinc finger protein 652 | Chromosome 17 |
*
Genes that were involved in the immune system and on the X chromosome.