Table 1. pH-Responsive drug delivery systems based on Zn-MOFs.

Stimuli	Drug	MOFs	Rate (wt%)	Release rate	Ref.
Simple pH-responsive	5-FU	ZIF-8	66	85% (pH 5.0) in 12 h	31
		ZIF-8 + LP	54	80% (acetate buffer 5.0) in 10 h	67
		ZIF-8@FA-CHI-5-FAM	51	100% (pH 5.0) in 21 h	68
		UCNP@ZIF-8/FA	68.5	82% (pH 5.5) in 24 h	32
		nPANI@nZIF-8	68	68% (pH 5.2) in 6 h	33
		Zn3[(BTC)2(Me)-(H2O)2](MeOH)13	34.32	70.1% (pH 5.0) in 20 h	34
		APT-Mn-ZIF-90	67.93	80% (pH 5.5) in 5 h	69
	DOX	ZIF-8	20	95% (pH 5.0) in 2 days	22
		PAA@ZIF-8	190	75.9% (pH 5.5) in 60 h	35
		BSA/DOX@ZIF-8	10	80% (pH 5.0) in 14 h	36
		ZnO-DOX/ZIF-8	20	70% (pH 5.5) in 5 h	37
		HMS/ZIF-8	44	95% (pH 4) in 10 h	70
		ZIF-8-PAAS	385	60% (pH 5.0) in 3 h	71
		DOX@ZIF-8@AS1411	10	80% (pH 5.0) in 20 h	38
		DOX@ZIF-HA	8.92	70% (pH 5.0) in 50 h	72
		Fe3O4@OCMC@IRMOF-3/FA	163	55.1% (pH 5.5) in 24 h	27
		PEG-FA/(DOX + VER)@ZIF-8	40.9	41.61% (pH 5.0) in 132 h	39
		Fe3O4@PAA/AuNCs/ZIF-8	154	68% (pH 5.3) in 26.5 h	40
		ZIF-8@ZrO2@IL	28.28	22.5% (pH 5.5) in 72 h	73
		ZIF-90	13.5	20% (pH 7.4) in 4 h	41
		AP-ZIF-90	12.6	70.2% (pH 5.0 + 0.5 mM ATP) in 12 h	42
		UC@mSiO2-RB@ZIF-90-O2-PEGFA	6	75% (pH 5.5) in 200 min	43
		Fe3O4@C@ZIF-8	73	90% (pH 5.5) in 140 h	74
		PLNPs@ZIF-8	90	49% (pH 4.0) in 7 days	75
	Others
	CCM	ZIF-8	12.7	43.4% (pH 5.0) in 48 h	44
	CQ	FA-PEG/ZIF-8	18	96.5% (pH 5.0) in 24 h	45
	PEGCG	ZIF-8	19.9	90% (pH 6.0) in 10 h	76
	CRISPR/Cas9	ZIF-8	1.2	100% (pH 5.0) in 3 h	58
	Gelonin	ZIF-8	41	90% (pH 6.0) in 12 h	56
	MA	ZIF-8	19.8	100% (pH 5.0) in 35 h	77
	OVA	ZNPs	30.6	80% (pH 5.0) in 5 h	57
	ZnPc	ZIF-8	29.5	90% (pH 5.0) in 20 h	78
	Ceftazidime	ZIF-8	10.9	80% (pH 5.0) in 2 days	49
	2I-BodipyPhNO2	ZIF-90	28.8	39.2% (pH 5.0) in 24 h	79
	PseD	MAF-4	16.1	47.8% (pH 5.0) in 24 h	80
Multiple stimuli-responsive
pH and temperature	5-FU	5-Fu@Zn-copn-1	44.75	—	60
	MTX	Zn-TBDA/MTX	12.59	100% (pH 6.5 + 42 °C) in 40 h	61
pH and NIR	5-FU	mCNFs	31	80% (pH 5.0 + NIR) in 250 min	81
	QT	FA-BSA/CuS@ZIF-8	24	60% (pH 5.0 + NIR) in 48 h	82
	ICG	ZIF-8	10.2	—	83
	DOX	Pd@Au@ZIF-8	3.93	62% (pH 4.0 + NIR) in 300 min	84
		AuNR@ZIF-8	35.8	95% (pH 5.5 + NIR) in 12 h	62
		LA-AuNR/ZIF-8	30	83% (pH 5.3 + NIR) in 25 h	85
		CoFe2O4@PDA@ZIF-8	98	40% (pH 5.0 + NIR) in 12 h	63
		PDA-PCM@ZIF-8	37.86	78% (pH 7.4 + NIR) in 48 h	65
		CSD-MOF	85.73	50% (pH 5.0 + NIR) in 300 min	64
		H-ZIF-8/PDA-CD	42.0	75% (pH 5.3 + NIR) in 8 h	86
pH and ions	Rh6G	DNA/MOF	—	—	66
pH and redox	DOX	P@ZIF-8	19.1	100% (pH 4.2 + H2O2) in 10 h	19
		ZDOS	41.2	80% (pH 5.0 + DTT) in 50 h	87