Fig. 4. PMCZ-mediated amelioration of the tumor hypoxic microenvironment. (A) Representative immunochemistry images of HIF-1α in (1) intact tumor tissues, (2) 50 μg mL^–1 PMZ-treated tumor tissues, and (3) 50 μg mL^–1 PMCZ-treated tumor tissues. Scale bar, 50 μm. (B) Western blot assay of HIF-1α expression from (1) intact tumor tissues, (2) 50 μg mL^–1 PMZ-treated tumor tissues, and (3) 50 μg mL^–1 PMCZ-treated tumor tissues. (C) The corresponding quantitative analysis of (B).