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Overall irritable bowel syndrome symptom assessment by the patients. Values represent the mean overall improvement scores graded weekly by the patients using a Likert Scale. The total effect size reported as Cohen d was 20% between the treatment groups (P=0.13). Data are expressed as mean±SEM. V0=baseline visit, V1=4 weeks of treatment, V2=8 weeks of treatment, and V3=12 weeks. PB+S indicates pinaverium bromide 100 mg plus simethicone 300 mg.
