Table 2.

Subgroup analysis of the diagnostic and prognostic value of suPAR based on different variables

Study type	Variables	Studies, no. (patients, no.)	Sensitivity (95% CI)	Specificity (95% CI)	PLR (95% CI)	NLR (95% CI)	DOR (95% CI)	AUC (95% CI)
Diagnostic value	Sepsis	17 (2722)	0.76 (0.63–0.86)	0.78 (0.72–0.83)	3.50 (2.60–4.70)	0.30 (0.18–0.50)	12 (6–24)	0.83 (0.80–0.86)
	Sepsis from SIRS	5 (637)	0.67 (0.58–0.76)	0.82 (0.73–0.88)	3.70 (2.40–5.80)	0.40 (0.30–0.53)	9 (5–18)	0.81 (0.77–0.84)
	Bacterial Sepsis	8 (1316)	0.81 (0.57–0.94)	0.73 (0.66–0.79)	3.10 (2.30–4.00)	0.25 (0.10–0.66)	12 (4–38)	0.79 (0.75–0.82)
	Cutoff <7.5 ng/mL	8 (1471)	0.85 (0.67–0.94)	0.77 (0.70–0.82)	3.60 (2.50–5.40)	0.20 (0.08–0.50)	18 (5–66)	0.83 (0.80–0.86)
	Cutoff ≥7.5 ng/mL	9 (1251)	0.66 (0.50–0.78)	0.79 (0.69–0.87)	3.20 (2.10–4.90)	0.43 (0.29–0.64)	7 (4–15)	0.80 (0.76–0.83)
Prognostic value	Sepsis	19 (5622)	0.74 (0.67–0.80)	0.70 (0.63–0.76)	2.50 (2.00–3.00)	0.38 (0.30–0.47)	7 (5–9)	0.78 (0.74–0.82)
	Bacterial Sepsis	8 (2114)	0.68 (0.59–0.76)	0.77 (0.66–0.85)	2.90 (2.10–4.10)	0.41 (0.34–0.51)	7 (5–10)	0.77 (0.73–0.81)
	Cutoff <9.6 ng/mL	9 (2386)	0.72 (0.66–0.77)	0.65 (0.58–0.72)	2.10 (1.60–2.60)	0.43 (0.34–0.56)	5 (3–8)	0.74 (0.70–0.78)
	Cutoff ≥9.6 ng/mL	10 (3236)	0.74 (0.61–0.84)	0.75 (0.64–0.83)	3.00 (2.10–4.10)	0.35 (0.24–0.51)	9 (5–14)	0.81 (0.77–0.84)

AUC, area under the receiver-operating characteristic curve; CI, confidence interval; DOR, diagnostic odds ratio; NLR, negative likelihood ratio; PLR, positive likelihood ratio.