Table 2. Antibacterial activity against drug-resistant S. aureus and cytotoxicity against mammalian cell lines.

Compound	Minimum inhibitory concentration (μg mL–1)						Cytotoxicity ( b EC50; μg mL–1)
	MRSA ATCC33591	MRSA R3545	MRSA R3889	MRSA R3890	a VRSA-1	VRSA-4	c MDCK cell line	d A549 cell line
SAM-6	1–2	1–2	1	4	2	2	45	44
SAM-17	1–2	1–2	1–2	2	2	2	188	194
Methicillin	>32	16–32	16–32	>32	ND	ND	e ND	ND
Vancomycin	0.5	1	1	2	512	512	ND	ND

^aVancomycin-resistant S. aureus.

^bConcentration at which 50% cell viability occurs.

^cMadin–Darby canine kidney epithelial cells.

^dAdenocarcinomic human alveolar basal epithelial cells.

^eNot determined.